Superfund Research Program

The MIT Superfund Research Program: A Systems Approach for the Protection of Human Health from Hazardous Chemicals

Center Director: Bevin P. Engelward
Grant Number: P42ES027707
Funding Period: 2017-2027

Program Links

Publications

2024

• Agee A, Pace G, Yang V, Segalman R, Furst A. 2024. Mixed conducting polymers alter electron transfer thermodynamics to boost current generation from electroactive microbes. J Am Chem Soc 146(29):19728-19736. doi:10.1021/jacs.4c01288 PMID:39001879 PMCID:11276794
• Anderson G, Agee A, Furst A. 2024. Imidazolium-based ionic liquids support biosimilar flavin electron transfer. Mater Adv doi:10.1039/d4ma00558a PMID:39176076
• Sedenho G, Nascimento S, Zamani M, Crespilho F, Furst A. 2024. Secondary structure in enzyme-inspired polymer catalysts impacts water oxidation efficiency. Adv Sci doi:10.1002/advs.202402234

2023

• Armijo AL, Thongararm P, Fedeles BI, Yau J, Kay JE, Corrigan JJ, Chancharoen M, Chawanthayatham S, Samson LD, Carrasco SE, Engelward BP, Fox JG, Croy RG, Essigmann JM. 2023. Molecular origins of mutational spectra produced by the environmental carcinogen N-nitrosodimethylamine and SN1 chemotherapeutic agents. NAR Cancer 5(2):doi:10.1093/narcan/zcad015 PMID:36992846 PMCID:PMC1004153
• Baskaran B, Gill TM, Furst A. 2023. An improved spectrophotometric method for toluene-4-monooxygenase activity. Chem Eur J doi:10.1002/chem.202203322 PMID:36593585 PMCID:PMC10423644
• Beard JC, Swager TM. 2023. Improved procedures for the synthesis of 9,9-disubstituted 9,10-dihydroacridines. J Org Chem 88(3):1918-1921. doi:10.1021/acs.joc.2c03004 PMID:36661076 PMCID:PMC10265378
• Burke B, Fan G, Wasuwanich P, Moore EB, Furst A. 2023. Self-assembled nanocoatings protect microbial fertilizers for climate-resilient agriculture. JACS Au 3(11):2973-2980. doi:10.1021/jacsau.3c00426 PMID:38034965 PMCID:PMC10685410
• Collins AR, Moller P, Gajski G, Vodenkova S, Abdulwahed A, Anderson D, Bankoglu EE, Bonassi S, Boutet-Robinet E, Brunborg G, Chao C, Cooke MS, Costa C, Costa S, Dhawan A, de Lapuente J, Bo CD, Dubus J, Dusinska M, Dunthie SJ, Yamani NE, Engelward BP, Gaivao I, Giovannelli L, Godschalk RW, Guilherme S, Gutzkow KB, Habas K, Hernandez A, Herrero O, Isidori M, Jha AN, Kooter IM, Knasmuller s, Koppen G, Kruszewski M, Ladeira C, Laffon B, Larramendy M, Hegarat LL, Lewies A, Lewinska A, Liwszyc GE, Lopez de Cerain Salsamendi A, Manjanatha M, Marcos R, Milic M, de Andrade VM, Moretti M, Muruzabal D, Novak M, Oliveira R, Olsen A, Owiti NA, Pacheco M, Pandey AK, Pfuhler S, Pourrut B, Reisinger K, Rojas E, Runden-Pran E, Sanz-Serrano J, Shaposhnikov S, Sipinen V, Smeets K, Stopper H, Teixeira JP, Valdiglesias V, Valverde M, van Acker F, van Schooten F, Vasquez M, Wentzel JF, Wnuk M, Wouters A, Zegura B, Zikmund T, Langie SA, Azqueta A. 2023. Measuring DNA modifications with the comet assay: a compendium of protocols. Nat Protoc doi:10.1038/s41596-022-00754-y PMID:36707722 PMCID:PMC10281087
• Feng H, Luo S, Croy RG, Essigmann JM, Swager TM. 2023. Interaction of N-nitrosamines with binuclear copper complexes for luminescent detection. Dalton Trans 52(10):3219-3233. doi:10.1039/d2dt03848j PMID:36799554 PMCID:PMC9990372
• Leddy O, White FM, Bryson BD. 2023. Immunopeptidomics reveals determinants of Mycobacterium tuberculosis antigen presentation on MHC class I. Elife 12:doi:10.7554/eLife.84070 PMID:37073954 PMCID:PMC10159623

2022

• Basu AK, Essigmann JM. 2022. Establishing linkages among DNA damage, mutagenesis, and genetic diseases. Chem Res Toxicol doi:10.1021/acs.chemrestox.2c00155 PMID:35881568
• Buick JK, Rowan-Carroll A, Gagne R, Williams A, Chen R, Li H, Fornace AJ, Chao C, Engelward BP, Frotschl R, Ellinger-Ziegelbauer H, Pettit S, Aubrecht J, Yauk C. 2022. Integrated Genotoxicity Testing of three anti-infective drugs using the TGx-DDI transcriptomic biomarker and high-throughput CometChip assay in TK6 cells. Front Toxicol 4:991590. doi:10.3389/ftox.2022.991590 PMID:36211197 PMCID:PMC9540394
• Fedeles BI, Li D, Singh V. 2022. Structural insights into tautomeric dynamics in nucleic acids and in antiviral nucleoside analogs. Front Mol Biosci 8:823253. doi:10.3389/fmolb.2021.823253 PMID:35145998 PMCID:PMC8822119
• Hrdina AI, Kohale I, Kaushal S, Kelly J, Selin NE, Engelward BP, Kroll JH. 2022. The parallel transformations of polycyclic aromatic hydrocarbons in the body and in the atmosphere. Environ Health Perspect 130(2):doi:10.1289/EHP9984 PMID:35225689 PMCID:PMC8884122
• Hu IH, Hemond HF. 2022. Benthic fluxes of fluorescent dissolved organic material, salt, and heat measured by multiple-sensor aquatic eddy covariance. Sensors (Basel) 22(22):8984. doi:10.3390/s22228984 PMID:36433578
• Jimenez-Macias JL, Lee YC, Miller E, Finkelberg T, Zdioruk M, Berger G, Farquhar CE, Nowicki MO, Cho CF, Fedeles BI, Loas A, Pentelute BL, Lawler SE. 2022. A Pt(IV)-conjugated brain penetrant macrocyclic peptide shows pre-clinical efficacy in glioblastoma. Journal of Controlled Release 352:623-636. doi:10.1016/j.jconrel.2022.10.051 PMID:36349615
• Kohale I, Yu J, Zhuang Y, Fan X, Reddy RJ, Sinnwell J, Kalari KR, Boughey J, Carter JM, Goetz MP, Wang L, White FM. 2022. Identification of Src family kinases as potential therapeutic targets for chemotherapy-resistant triple negative breast cancer. Cancers (Basel) 14(17):4220. doi:10.3390/cancers14174220 PMID:36077757 PMCID:PMC9454481
• Lu R, Yuan W, Feng H, Luo S, Wu YM, Etkind SI, Kumar M, Swager TM. 2022. Porous polymers containing metallocalix 4 arene for the extraction of tobacco-specific nitrosamines. Chemistry of Materials 34(23):10623-10630. doi:10.1021/acs.chemmater.2c02713
• Moise AC, Kay JE, Engelward BP. 2022. Transgenic mice harboring direct repeat substrates reveal key underlying causes of homologous recombination in vivo. DNA Repair (Amst) 120:103419. doi:10.1016/j.dnarep.2022.103419 PMID:36257175
• Owiti NA, Corrigan JJ, Pribyl LJ, Kay J, Engelward BP. 2022. Novel in vivo CometChip reveals NDMA-induced DNA damage and repair in multiple mouse tissues. Int J Mol Sci 23(19):11776. doi:10.3390/ijms231911776 PMID:36233095 PMCID:PMC9569458
• Owiti NA, Kaushal S, Martin L, Sly J, Swartz CD, Fowler J, Corrigan JJ, Recio L, Engelward BP. 2022. Using the HepaCometChip assay for broad-spectrum DNA damage analysis. Curr Protoc 2(9):e563. doi:10.1002/cpz1.563 PMID:36165707 PMCID:PMC9522315
• Pradhan D, Ding H, Zhu J, Engelward BP, Levine SS. 2022. NExtSEEK: Extending SEEK for active management of interoperable metadata. J Biomol Tech 33(1):doi:10.7171/3fc1f5fe.db404124 PMID:35836998 PMCID:PMC9258913
• Vandiver KM, Erdei E, Mayer AG, Ricciardi C, O'Leary M, Burke K, Zelikoff J. 2022. Building environmental health and genomics literacy among healthcare providers serving vulnerable communities: An innovative educational framework. Int J Environ Res Public Health 19(2):doi:10.3390/ijerph19020929 PMID:35055751 PMCID:PMC8776035

2021

• Beard JC, Swager TM. 2021. An organic chemist's guide to N-Nitrosamines: Their structure, reactivity, and role as contaminants. J Org Chem 86:2037-2057. doi:10.1021/acs.joc.0c02774 PMID:33474939 PMCID:PMC7885798
• Buick JK, Williams A, Meier MJ, Swartz C, Recio L, Gagne R, Ferguson SS, Engelward BP, Yauk C. 2021. A modern genotoxicity testing paradigm: Integration of the high-throughput CometChip and the TGx-DDI transcriptomic biomarker in human HepaRG cell cultures. Front Public Health 9:doi:10.3389/fpubh.2021.694834 PMID:34485225 PMCID:PMC8416458
• Engelward BP. 2021. Implications of an epidemiological study showing an association between in utero NDMA exposure and childhood cancer. Environ Mol Mutagen 62:288-292. doi:10.1002/em.22434 PMID:33963777
• Fedeles BI, Essigmann JM. 2021. Mutational spectra provide insight into the mechanisms bridging DNA damage to genetic disease. DNA Damage, DNA Repair and Disease 15:214-253.
• Ge J, Ngo LP, Kaushal S, Tay IJ, Thadhani E, Kay J, Mazzucato P, Chow DN, Fessler JL, Weingeist DM, Sobol RW, Samson LD, Floyd SR, Engelward BP. 2021. CometChip enables parallel analysis of multiple DNA repair activities. DNA Repair (Amst) 106(11):doi:10.1016/j.dnarep.2021.103176 PMID:34365116 PMCID:PMC8439179
• Ji X, Zhao J, Jung SM, Hrdina AI, Wolf MJ, Yang X, Vaartstra G, Xie H, Luo S, Lu A, Welsch RE, Wang EN, Li L, Kong J. 2021. Bottom-up synthesized all-thermal-catalyst aerogels for heat-regenerative air filtration. Nano Lett 21:PMID:34543039
• Kay J, Corrigan JJ, Armijo AL, Nazari IS, Kohale I, Torous DK, Avlasevich SL, Croy RG, Wadduwage DN, Carrasco SE, Dertinger SD, White FM, Essigmann JM, Samson LD, Engelward BP. 2021. Excision of mutagenic replication-blocking lesions suppresses cancer but promotes cytotoxicity and lethality in nitrosamine-exposed mice. Cell Rep 34(11):108864. doi:10.1016/j.celrep.2021.108864 PMID:33730582
• Kelly JM, Ivatt PD, Evans MJ, Kroll JH, Hrdina AI, Kohale I, White FM, Engelward BP, Selin NE. 2021. Global cancer risk from unregulated polycyclic aromatic hydrocarbons. Geohealth 5(9):doi:10.1029/2021GH000401 PMID:34589640 PMCID:PMC8460132
• Kohale I, Burgenske DM, Mladek AC, Bakken KK, Kuang J, Boughey J, Wang L, Carter JM, Haura EB, Goetz MP, Sarkaria JN, White FM. 2021. Quantitative analysis of tyrosine phosphorylation from FFPE tissues reveals patient-specific signaling networks. Cancer Res doi:10.1158/0008-5472.CAN-21-0214 PMID:34016623
• Lu R, Yuan W, Croy RG, Essigmann JM, Swager TM. 2021. Metallocalix[4]arene polymers for gravimetric detection of N-nitrosodialkylamines. J Am Chem Soc 143:doi:10.1021/jacs.1c08739 PMID:34793165 PMCID:PMC8811785
• Luo S, Liu R, Lee S, Swager TM. 2021. Electrocatalytic Isoxazoline-Nanocarbon Metal Complexes. J Am Chem Soc 143:10441-10453. doi:10.1021/jacs.1c05439 PMID:34213315
• Owiti NA, Nagel Z, Engelward BP. 2021. Fluorescence sheds light on DNA damage, DNA repair, and mutations. Trends Cancer 7(3):240-248. doi:10.1016/j.trecan.2020.10.006 PMID:33203608 PMCID:PMC7889721
• Segev T, Harvey AP, Ajmani A, Johnson C, Longfellow W, Vandiver KM, Hemond HF. 2021. A case study in participatory science with mutual capacity building between university and tribal researchers to investigate drinking water quality in rural Maine. Environ Res 192:doi:10.1016/j.envres.2020.110460 PMID:33217437 PMCID:PMC7787195
• Stopfer LE, Flower CT, Gajadhar AS, Patel B, Gallien S, Lopez-Ferrer D, White FM. 2021. High-density, targeted monitoring of tyrosine phosphorylation reveals activated signaling networks in human tumors. Cancer Res 81:2495-2509. doi:10.1158/0008-5472.CAN-20-3804 PMID:33509940 PMCID:PMC8137532
• Tajai P, Suriyo T, Rangkadilok N, Fedeles BI, Essigmann JM, Satayavivad J. 2021. Andrographolide, an antioxidant, counteracts paraquat-induced mutagenesis in mammalian cells. Asian Pac. J. Cancer Prev 22:PMID:33576206

2020

• Chao C, Engelward BP. 2020. Applications of CometChip for environmental health studies. Chem Res Toxicol 33:1528-1538. doi:10.1021/acs.chemrestox.9b00393 PMID:32519858
• Chao C, Ngo LP, Engelward BP. 2020. SpheroidChip: patterned agarose microwell compartments harboring HepG2 spheroids are compatible with genotoxicity testing. ACS Biomater Sci Eng 6:2427-2439. doi:10.1021/acsbiomaterials.9b01951
• Delwiche K, Gu J, Hemond HF, Preheim SP. 2020. Vertical transport of sediment-associated metals and cyanobacteria by ebullition in a stratified lake. Biogeosciences 17:3135-3147. doi:10.5194/bg-17-3135-2020
• Hu IH, Hemond HF. 2020. A multi-function sensor for eddy correlation measurements of benthic flux. IEEE Sens J 20(3):1509-1526. doi:10.1109/JSEN.2019.2946968 PMID:32158362 PMCID:PMC7063697
• Kay J, Engelward BP. 2020. Tackling chemically contaminated sites in the United States. https://www.openaccessgovernment.org/tackling-chemically-contaminated-sites-in-the-united-states/89025/
• Luo S, Lin C, Ku K, Yoshinaga K, Swager TM. 2020. Pentiptycene polymer/single-walled carbon nanotube complexes: applications in benzene, toluene, and o-xylene detection. ACS Nano 14:7297-7307. doi:10.1021/acsnano.0c02570 PMID:32510203 PMCID:PMC7370303
• Ngo LP, Owiti NA, Swartz C, Winters J, Su Y, Ge J, Xiong A, Han J, Recio L, Samson LD, Engelward BP. 2020. Sensitive CometChip assay for screening potentially carcinogenic DNA adducts by trapping DNA repair intermediates. Nucleic Acids Res 48(3):e13. doi:10.1093/nar/gkz1077 PMID:31822921 PMCID:PMC7026589
• Thackray CP, Selin NE, Young CJ. 2020. A global atmospheric chemistry model for the fate and transport of PFCAs and their precursors. Environ Sci Process Impacts 22:doi:10.1039/C9EM00326F PMID:31942888 PMCID:PMC7050637
• Thongararm P, Fedeles BI, Khumsubdee S, Armijo AL, Kim L, Thiantanawat A, Promvijit J, Navasumrit P, Ruchirawat K, Croy RG, Essigmann JM. 2020. Modulation of N-Methyl-N-nitrosourea mutagenesis in mouse embryo fibroblasts derived from the gpt delta mouse by an inhibitor of the O6-Methylguanine Methyltransferase, MGMT. Chem Res Toxicol 33:625-633. doi:10.1021/acs.chemrestox.9b00444 PMID:31841318 PMCID:PMC7033946

2019

• He M, Croy RG, Essigmann JM, Swager TM. 2019. Chemiresistive carbon nanotube sensors for n-nitrosodialkylamines. ACS Sens 4(10):2819-2824. doi:10.1021/acssensors.9b01532 PMID:31573183 PMCID:PMC6939299
• Hu I, Hemond HF. 2019. Sensing volume and bandwidth characteristics of a multi-function sensor for eddy correlation measurements of benthic flux. Oceans 2019 Mts/ IEEE Seattle doi:10.23919/OCEANS40490.2019.8962789
• Kay J, Thadhani E, Samson LD, Engelward BP. 2019. Inflammation-induced DNA damage, mutations and cancer. DNA Repair (Amst) 83:doi:10.1016/j.dnarep.2019.102673 PMID:31387777 PMCID:PMC6801086
• Ngo LP, Chan TK, Ge J, Samson LD, Engelward BP. 2019. Microcolony Size Distribution Assay Enables High-Throughput Cell Survival Quantitation. Cell Rep 26:1668-1678. doi:10.1016/j.celrep.2019.01.053 PMID:30726746 PMCID:PMC6431241
• Schroeder V, Savagatrup S, He M, Lin S, Swager TM. 2019. Carbon nanotube chemical sensors. Chem Rev 119:599-663. doi:10.1021/acs.chemrev.8b00340 PMID:30226055 PMCID:PMC6399066
• Swager TM, Mirica KA. 2019. Introduction: Chemical Sensors. Chem Rev 119(1):1-2. doi:10.1021/acs.chemrev.8b00764 PMID:30829042
• Vandiver KM. 2019. Tactile Approaches to Help Learners Visualize Key Processes in Environmental Health Sciences. Chapter 12 in: Environmental Health Literacy. Springer, pp.315-332.
• Zaytsev A, Breitenlechner M, Koss A, Lim C, Rowe JC, Kroll JH, Keutsch FN. 2019. Using collision-induced dissociation to constrain sensitivity of ammonia chemical ionization mass spectrometry (NH4+ CIMS) to oxygenated volatile organic compounds. Atmos Meas Tech 12:1861-1870. doi:10.5194/amt-12-1861-2019
• Zaytsev A, Koss A, Breitenlechner M, Krechmer JE, Nihill KJ, Lim C, Rowe JC, Cox JL, Moss JA, Roscioli JR, Canagaratna MR, Worsnop DR, Kroll JH, Keutsch FN. 2019. Mechanistic study of the formation of ring-retaining and ring-opening products from the oxidation of aromatic compounds under urban atmospheric conditions. Atmos Chem Phys 19(23):15117-15129. doi:10.5194/acp-19-15117-2019 (in press)

2018

• Angot H, Hoffman N, Giang A, Thackray CP, Hendricks AN, Urban NR, Selin NE. 2018. Global and local impacts of delayed mercury mitigation efforts. Environ Sci Technol 52:12968-12977. doi:10.1021/acs.est.8b04542 PMID:30376303
• Fedeles BI, Essigmann JM. 2018. Impact of DNA lesion repair, replication and formation on the mutational spectra of environmental carcinogens: Aflatoxin B1 as a case study. DNA Repair (Amst) 71:12-22. doi:10.1016/j.dnarep.2018.08.008 PMID:30309820 PMCID:PMC6340726
• Isaacman-VanWertz G, Massoli P, O'Brien R, Lim C, Franklin JP, Moss JA, Hunter JF, Nowak JB, Canagaratna MR, Misztal PK, Arata C, Roscioli JR, Herndon ST, Onasch TB, Lambe AT, Jayne JT, Su L, Knopf DA, Goldstein AH, Worsnop DR, Kroll JH. 2018. Chemical evolution of atmospheric organic carbon over multiple generations of oxidation. Nat Chem 10(4):462-468. doi:10.1038/s41557-018-0002-2 PMID:29483638 PMCID:PMC6431740
• Jeon I, Yoon B, He M, Swager TM. 2018. Hyperstage Graphite: Electrochemical Synthesis and Spontaneous Reactive Exfoliation. Advanced Materials 30(3):doi:10.1002/adma.201704538 PMID:29194799 PMCID:PMC6415547
• Kay J. 2018. Staining for Ki67 in paraffin-embedded tissue sections. https://nextgen-protocols.org/wp-content/uploads/2018/11/Ki67-staining-tissues-v2.pdf
• Kohale I. 2018. Making cell line samples for proteomic analysis. https://nextgen-protocols.org/wp-content/uploads/2018/10/NGP_IK_UreaLysis.pdf
• Luo S, He M. 2018. Preparing a Chemiresistive Sensor Based on Functionalized CNTs. https://nextgen-protocols.org/protocol/preparing-a-chemiresistive-sensor-based-on-functionalized-cnts/
• Ng C, Kai F, Tee M, Tan N, Hemond HF. 2018. A Prototype Sensor for In Situ Sensing of Fine Particulate Matter and Volatile Organic Compounds. Sensors (Basel) 18(1):E265. doi:10.3390/s18010265 PMID:29346281 PMCID:PMC5795789
• Paoletti C, He M, Salvo P, Melai B, Calisi N, Mannini M, Cortigiani B, Bellagambi FG, Swager TM, Di Francesco F, Pucci A. 2018. Room temperature amine sensors enabled by sidewall functionalization of single-walled carbon nanotubes. RSC Adv 8(10):5578-5585. doi:10.1039/C7RA13304A PMID:30820317 PMCID:PMC6390973
• Rothenberg DA, Taliaferro M, Huber SM, Begley TJ, Dedon PC, White FM. 2018. A Proteomics Approach to Profiling the Temporal Translational Response to Stress and Growth. iScience 9:367-381. doi:10.1016/j.isci.2018.11.004 PMID:30466063 PMCID:PMC6249402
• Selin H, Keane SE, Wang S, Selin NE, Davis K, Bally D. 2018. Linking science and policy to support the implementation of the Minamata Convention on Mercury. Ambio 47:198-215. doi:10.1007/s13280-017-1003-x PMID:29388129 PMCID:PMC579468
• Zeininger L, He M, Hobson ST, Swager TM. 2018. Resistive and capacitive gamma-ray dosimeters based on triggered depolymerization in carbon nanotube composites. ACS Sens 3(5):976-983. doi:10.1021/acssensors.8b00108 PMID:29558118 PMCID:PMC6372115

2017

• Savagatrup S, Schroeder V, He X, Lin S, He M, Yassine O, Salama KN, Zhang X, Swager TM. 2017. Bio-inspired carbon monoxide sensors with voltage-activated sensitivity. Angew Chem Int Ed Engl 56:14066-14070. doi:10.1002/anie.201707491 PMID:28952172 PMCID:PMC5658252