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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Project Publications: Massachusetts Institute of Technology: Assessment of the Health Effects of N-Nitrosamines and Development of Disease Mitigation Strategies

Superfund Research Program

Assessment of the Health Effects of N-Nitrosamines and Development of Disease Mitigation Strategies

Project Leader: Bevin P. Engelward
Grant Number: P42ES027707
Funding Period: 2022-2027
View this project in the NIH Research Portfolio Online Reporting Tools (RePORT)

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Publications

2023

  • Armijo AL, Thongararm P, Fedeles BI, Yau J, Kay JE, Corrigan JJ, Chancharoen M, Chawanthayatham S, Samson LD, Carrasco SE, Engelward BP, Fox JG, Croy RG, Essigmann JM. 2023. Molecular origins of mutational spectra produced by the environmental carcinogen N-nitrosodimethylamine and SN1 chemotherapeutic agents. NAR Cancer 5(2):doi:10.1093/narcan/zcad015 PMID:36992846 PMCID:PMC1004153
  • Collins AR, Moller P, Gajski G, Vodenkova S, Abdulwahed A, Anderson D, Bankoglu EE, Bonassi S, Boutet-Robinet E, Brunborg G, Chao C, Cooke MS, Costa C, Costa S, Dhawan A, de Lapuente J, Bo CD, Dubus J, Dusinska M, Dunthie SJ, Yamani NE, Engelward BP, Gaivao I, Giovannelli L, Godschalk RW, Guilherme S, Gutzkow KB, Habas K, Hernandez A, Herrero O, Isidori M, Jha AN, Kooter IM, Knasmuller s, Koppen G, Kruszewski M, Ladeira C, Laffon B, Larramendy M, Hegarat LL, Lewies A, Lewinska A, Liwszyc GE, Lopez de Cerain Salsamendi A, Manjanatha M, Marcos R, Milic M, de Andrade VM, Moretti M, Muruzabal D, Novak M, Oliveira R, Olsen A, Owiti NA, Pacheco M, Pandey AK, Pfuhler S, Pourrut B, Reisinger K, Rojas E, Runden-Pran E, Sanz-Serrano J, Shaposhnikov S, Sipinen V, Smeets K, Stopper H, Teixeira JP, Valdiglesias V, Valverde M, van Acker F, van Schooten F, Vasquez M, Wentzel JF, Wnuk M, Wouters A, Zegura B, Zikmund T, Langie SA, Azqueta A. 2023. Measuring DNA modifications with the comet assay: a compendium of protocols. Nat Protoc doi:10.1038/s41596-022-00754-y PMID:36707722 PMCID:PMC10281087

2022

  • Buick JK, Rowan-Carroll A, Gagne R, Williams A, Chen R, Li H, Fornace AJ, Chao C, Engelward BP, Frotschl R, Ellinger-Ziegelbauer H, Pettit S, Aubrecht J, Yauk C. 2022. Integrated Genotoxicity Testing of three anti-infective drugs using the TGx-DDI transcriptomic biomarker and high-throughput CometChip assay in TK6 cells. Front Toxicol 4:991590. doi:10.3389/ftox.2022.991590 PMID:36211197 PMCID:PMC9540394
  • Moise AC, Kay JE, Engelward BP. 2022. Transgenic mice harboring direct repeat substrates reveal key underlying causes of homologous recombination in vivo. DNA Repair (Amst) 120:103419. doi:10.1016/j.dnarep.2022.103419 PMID:36257175
  • Owiti NA, Corrigan JJ, Pribyl LJ, Kay J, Engelward BP. 2022. Novel in vivo CometChip reveals NDMA-induced DNA damage and repair in multiple mouse tissues. Int J Mol Sci 23(19):11776. doi:10.3390/ijms231911776 PMID:36233095 PMCID:PMC9569458
  • Owiti NA, Kaushal S, Martin L, Sly J, Swartz CD, Fowler J, Corrigan JJ, Recio L, Engelward BP. 2022. Using the HepaCometChip assay for broad-spectrum DNA damage analysis. Curr Protoc 2(9):e563. doi:10.1002/cpz1.563 PMID:36165707 PMCID:PMC9522315
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