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Program Publications: Baylor College of Medicine: Polycyclic Aromatic Hydrocarbons: Ultrasensitive Detection, Early-Life Exposures - Clinical Outcomes (Preterm Births, Chronic Lung Disease, and Neurocognitive Deficits), Prevention and Remediation

Superfund Research Program

Polycyclic Aromatic Hydrocarbons: Ultrasensitive Detection, Early-Life Exposures - Clinical Outcomes (Preterm Births, Chronic Lung Disease, and Neurocognitive Deficits), Prevention and Remediation

Center Director: Bhagavatula Moorthy
Grant Number: P42ES027725
Funding Period: 2020-2025
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Publications

2024

  • Ahn S, Park J, Grimm SL, Piyarathna DW, Samanta T, Putluri V, Mezquita D, Fuqua SA, Putluri N, Coarfa C, Kaipparettu B. 2024. Metabolomic rewiring promotes endocrine therapy resistance in breast cancer. Cancer Res 84(2):291-304. doi:10.1158/0008-5472.Can-23-0184 PMID:37906431 PMCID:10842725
  • Amara C, Kami Reddy K, Yuntao Y, Chan Y, Piyarathna DW, Dobrolecki L, Shih D, Shi Z, Xu J, Huang S, Ellis M, Apolo A, Ballester L, Gao J, Hansel D, Lotan Y, Hodges H, Lerner S, Creighton C, Sreekumar A, Zheng W, Msaouel P, Kavuri S, Putluri N. 2024. The IL6/JAK/STAT3 signaling axis is a therapeutic vulnerability in SMARCB1-deficient bladder cancer. Nat Commun 15(1):1373. doi:10.1038/s41467-024-45132-2 PMID:38355560 PMCID:10867091
  • Barrozo ER, Seferovic MD, Hamilton MP, Moorshead DN, Jochum MD, Do T, O'Neil DS, Suter MA, Aagaard KM. 2024. Zika virus co-opts microRNA networks to persist in placental niches detected by spatial transcriptomics. Am J Obstet Gynecol 230(2):1-17. doi:10.1016/j.ajog.2023.08.012 PMID:37598997 PMCID:10840961
  • Joshi C, Salazar A, Wang C, Ligon M, Chappidi R, Fashemi B, Felder P, Mora A, Grimm SL, Coarfa C, Mysorekar I. 2024. D-Mannose reduces cellular senescence and NLRP3/GasderminD/IL-18-driven pyroptotic uroepithelial cell shedding in the murine bladder. Dev Cell 59(1):doi:10.1016/j.devcel.2023.11.017
  • Napoli M, Deshpande A, Chakravarti D, Rajapakshe K, Gunaratne PH, Coarfa C, Flores ER. 2024. Genome-wide p63-target gene analyses reveal TAp63/NRF2-dependent oxidative stress responses. Cancer Res Commun doi:10.1158/2767-9764.Crc-23-0358 PMID:38165157 PMCID:10832605
  • Neumann O, Zhou J, Ju Y, Bajomo MM, Sanchez-Alvarado A, Dolive J, Kumela B, Kumela M, Patel AB, Nordlander P, Halas N. 2024. Surface-enhanced raman spectroscopy: from the few-analyte limit to hot-spot saturation. Journal of Physical Chemistry C 128(21):8649-8659. doi:10.1021/acs.jpcc.4c00227
  • Padilla J, Osman N, Bissig-Choisat B, Grimm SL, Qin X, Major A, Yang L, Lopez-Terrada D, Coarfa C, Li F, Bissig K, Moore DD, Fu L. 2024. Circadian dysfunction induces NAFLD-related human liver cancer in a mouse model. J Hepatol 80(2):282-292. doi:10.1016/j.jhep.2023.10.018 PMID:37890720
  • Stading R, Swanson L, Xia G, Jiang W, Wang L, Couroucli XI, Lingappan K, Moorthy B. 2024. Prenatal exposure to polycyclic aromatic hydrocarbons (PAHs) augments neonatal hyperoxic lung injury: Role of cytochrome P450 (CYP)1A1, 1A2, and 1B1. Free Radic Biol Med 211:35-46. doi:10.1016/j.freeradbiomed.2023.12.001 PMID:38081439
  • Xia G, Zhou G, Jiang W, Chu C, Wang L, Moorthy B. 2024. Attenuation of polycyclic aromatic hydrocarbon (PAH)-induced carcinogenesis and tumorigenesis by omega-3 fatty acids in mice in vivo. Int J Mol Sci 25(7):doi:10.3390/ijms25073781 PMID:38612589 PMCID:11012139

2023

  • Barrozo ER, Seferovic MD, Castro EC, Major A, Moorshead DN, Jochum MD, Rojas RF, Shope C, Aagaard KM. 2023. SARS-CoV-2 niches in human placenta revealed by spatial transcriptomics. Med 4(9):612-634. doi:10.1016/j.medj.2023.06.003 PMID:37423216 PMCID:10527005
  • Dasgupta A, Kurenbekova L, Patel TD, Rajapakshe K, Ghosal G, Nirala B, Coarfa C, Yustein JT. 2023. Modeling ewing sarcoma lung metastasis. Curr Protoc 3(2):e670. doi:10.1002/cpz1.670 PMID:36799651 PMCID:PMC9942121
  • Denison SB, Jin P, Dias Da Silva P, Chu C, Moorthy B, Senftle TP, Zygourakis K, Alvarez PJ. 2023. Pyro-catalytic degradation of pyrene by bentonite-supported transition metals: Mechanistic insights and trade-offs with low pyrolysis temperature. Environ Sci Technol 57(38):14373-14383. doi:10.1021/acs.est.3c04487 PMID:37683087
  • Grimm SL, Mendez EF, Stertz L, Meyer TD, Fries GR, Gandhi T, Kanchi R, Selvaraj S, Teixeira AL, Kosten TR, Gunaratne PH, Coarfa C, Walss-Bass C. 2023. MicroRNA-mRNA networks are dysregulated in opioid use disorder postmortem brain: Further evidence for opioid-induced neurovascular alterations. Front Psychiatry 13:1025346. doi:10.3389/fpsyt.2022.1025346 PMID:36713930 PMCID:PMC9878702
  • Grimm SL, Reddick S, Dong X, Leek C, Wang AX, Gutierrez MC, Hartig SM, Moorthy B, Coarfa C, Lingappan K. 2023. Loss of microRNA-30a and sex-specific effects on the neonatal hyperoxic lung injury. Biol Sex Differ 14(1):50. doi:10.1186/s13293-023-00535-6 PMID:37553579 PMCID:PMC10408139
  • Grimm SL, Stading R, Robertson M, Gandhi T, Fu C, Jiang W, Xia G, Lingappan K, Coarfa C, Moorthy B. 2023. Loss of cytochrome P450 (CYP)1B1 mitigates hyperoxia response in adult mouse lung by reprogramming metabolism and translation. Redox Biol 64:102790. doi:10.1016/j.redox.2023.102790 PMID:37348155 PMCID:PMC10271936
  • Hunter R, Baird B, Garcia M, Begay J, Goitom S, Lucas S, Herbert G, Scieszka D, Padilla J, Brayer K, Ottens AK, Suter MA, Barrozo ER, Hines C, Bleske B, Campen M. 2023. Gestational ozone inhalation elicits maternal cardiac dysfunction and transcriptional changes to placental pericytes and endothelial cells. Toxicol Sci 196(2):238-249. doi:10.1093/toxsci/kfad092 PMID:37695302 PMCID:10682975
  • Ju Y, Neumann O, Bajomo MM, Zhao Y, Nordlander P, Halas N, Patel AB. 2023. Identifying surface-enhanced Raman spectra with a Raman library using machine learning. ACS Nano 17(21):21251-21261. doi:10.1021/acsnano.3c05510 PMID:37910670
  • Mendez EF, Grimm SL, Stertz L, Gorski D, Movva SV, Najera K, Moriel K, Meyer TD, Fries GR, Coarfa C, Walss-Bass C. 2023. A human stem cell-derived neuronal model of morphine exposure reflects brain dysregulation in opioid use disorder: Transcriptomic and epigenetic characterization of postmortem-derived iPSC neurons. Front Psychiatry 14:1070556. doi:10.3389/fpsyt.2023.1070556 PMID:36873219 PMCID:PMC9978009
  • Poplaski V, Bomidi C, Kambal A, Nguyen-Phuc H, Di Rienzi SC, Danhof HA, Zeng X, Feagins LA, Deng N, Vilar E, McAllister F, Coarfa C, Min S, Kim HJ, Shukla R, Britton R, Estes MK, Blutt SE. 2023. Human intestinal organoids from Cronkhite-Canada syndrome patients reveal link between serotonin and proliferation. J Clin Invest 133(21):e166884. doi:10.1172/JCI166884 PMID:37909332 PMCID:PMC10617781
  • Purushothaman A, Olivia-Ramirez J, Treekitkarnmongkol W, Sankaran D, Hurd MW, Putluri N, Maitra A, Haymaker C, Sen S. 2023. Differential effects of pancreatic cancer-derived extracellular vesicles driving a suppressive environment. Int J Mol Sci 24(19):14652. doi:10.3390/ijms241914652 PMID:37834100 PMCID:PMC10572854
  • Suh J, Heo MJ, Lee SH, Poulsen KL, An YA, Moorthy B, Hartig SM, Moore DD, Kim K. 2023. Aryl hydrocarbon receptor maintains hepatic mitochondrial homeostasis in mice. Mol Metab 72:101717. doi:10.1016/j.molmet.2023.101717 PMID:37004989 PMCID:PMC1010651
  • Suter MA, Aagaard KM. 2023. Natural disasters resulting from climate change: The impact of hurricanes and flooding on perinatal outcomes. Semin Perinatol 47(8):doi:10.1016/j.semperi.2023.151840 PMID:37839903
  • Sánchez-Alvarado A, Zhou J, Jin P, Neumann O, Senftle TP, Nordlander P, Halas N. 2023. Combined surface-enhanced raman and infrared absorption spectroscopies for streamlined chemical detection of polycyclic aromatic hydrocarbon-derived compounds. ACS Nano 17(24):25697-25706. doi:10.1021/acsnano.3c10746 PMID:38063501
  • Thaiparambil J, Amara CS, Sen S, Putluri N, El-Zein R. 2023. Cigarette smoke condensate induces centrosome clustering in normal lung epithelial cells. Cancer Med doi:10.1002/cam4.5599 PMID:36621828 PMCID:PMC10134322
  • Volckens J, Haynes E, Croisant S, Cui Y, Errett NA, Henry HF, Horney JA, Kwok RK, Magzamen S, Rappold AG, Ravichandran L, Reinlib L, Ryan P, Shaughnessy DT. 2023. Health research in the wake of disasters: Challenges and opportunities for sensor science. Environ Health Perspect 131(6):doi:10.1289/ehp12270
  • Whitworth K, Moussa I, Salihu H, Chardon Fabien A, Suter M, Aagaard K, Symanski E. 2023. Environmental justice burden and Black-White disparities in spontaneous preterm birth in Harris County, Texas. Front Reprod Health 5:1296590. doi:10.3389/frph.2023.1296590 PMID:38179111 PMCID:10766384
  • Yu W, Chen Y, Putluri N, Osman A, Coarfa C, Putluri V, Kamal AH, Asmussen JK, Katsonis P, Meyers JN, Lai SY, Lu W, Stephan C, Powell R, Johnson FM, Skinner HD, Kazi J, Ahmed KM, Hu L, Threet A, Meyer MD, Bankson JA, Wang T, Davis J, Parker KR, Harris MA, Baek ML, Echeverria GV, Qi X, Wang J, Frederick AI, Walsh AJ, Lichtarge O, Frederick MJ, Sandulache VC. 2023. Evolution of cisplatin resistance through coordinated metabolic reprogramming of the cellular reductive state. Br J Cancer 128(11):2013-2024. doi:10.1038/s41416-023-02253-7 PMID:37012319 PMCID:PMC10205814

2022

  • Almudares F, Hagan J, Chen X, Devaraj S, Moorthy B, Lingappan K. 2022. Growth and differentiation factor 15 (GDF15) levels predict adverse respiratory outcomes in premature neonates. Pediatr Pulmonol doi:10.1002/ppul.26197 PMID:36205439
  • Bajomo MM, Ju Y, Zhou J, Elefterescu S, Farr C, Zhao Y, Neumann O, Nordlander P, Patel AB, Halas N. 2022. Computational chromatography: a machine learning strategy for demixing individual chemical components in complex mixtures. Proc Natl Acad Sci U S A 119(52):e2211406119. doi:10.1073/pnas.2211406119 PMID:36534806
  • Banerjee S, Suter MA, Aagaard KM. 2022. Understanding the placental biology of tobacco smoke, nicotine, and marijuana (THC) exposures during pregnancy. Clin Obstet Gynecol 2:347-359. doi:10.1097/GRF.0000000000000691 PMID:35125390 PMCID:PMC9042338
  • Bobak C, Abhimanyu A, Natarajan H, Gandhi T, Grimm SL, Nishiguchi T, Koster K, Longlax SC, Dlamini Q, Kahari J, Mtetwa G, Cirillo JD, O'Malley J, Hill J, Coarfa C, DiNardo AR. 2022. Increased DNA methylation, cellular senescence and premature epigenetic aging in guinea pigs and humans with tuberculosis. Aging-US 14(5):2174-2193. doi:10.18632/aging.203936 PMID:35256539 PMCID:PMC8954968
  • Chacon-Alberty L, Kanchi R, Ye S, Hochman-Mendez C, Daoud D, Coarfa C, Li M, Grimm SL, Baz M, Rosas I, Loor G. 2022. Plasma protein biomarkers for primary graft dysfunction after lung transplantation: a single-center cohort analysis. Sci Rep 12(1):16137. doi:10.1038/s41598-022-20085-y PMID:36167867 PMCID:PMC9515157
  • Denison SB, Dias Da Silva P, Koester CP, Alvarez PJ, Zygourakis K. 2022. Clays play a catalytic role in pyrolytic treatment of crude-oil contaminated soils that is enhanced by ion-exchanged transition metals. J Hazard Mater 437:doi:10.1016/j.jhazmat.2022.129295 PMID:35717817
  • DiNardo AR, Gandhi T, Heyckendorf J, Grimm SL, Rajapakshe K, Nishiguchi T, Reimann M, Kirchner HL, Kahari J, Dlamini Q, Lange C, Goldmann T, Marwitz S, Abhimanyu ., Cirillo JD, Kaufmann SH, Netea MG, Crevel Rv, Mandalakas AM, Coarfa C. 2022. Gene expression signatures identify biologically and clinically distinct tuberculosis endotypes. European Respiratory Journal 60(3):2102263. doi:10.1183/13993003.02263-2021 PMID:35169026 PMCID:PMC9474892
  • Ghosh S, Moorthy B, Haribabu B, Jala VR. 2022. Cytochrome P450 1A1 is essential for the microbial metabolite, Urolithin A-mediated protection against colitis. Front Immunol 13:doi:10.3389/fimmu.2022.1004603 PMID:36159798 PMCID:PMC9493474
  • Hallmark C, Bohn K, Hallberg L, Croisant S. 2022. Addressing institutional and community barriers to development and implementation of community-engaged research through competency-based academic and community training. Front Public Health 10:1070475. doi:10.3389/fpubh.2022.1070475 PMID:36711424 PMCID:9877443
  • Napoli M, Wu SJ, Gore BL, Abbas H, Lee K, Checker R, Dhar S, Rajapakshe K, Tan AC, Lee MG, Coarfa C, Flores ER. 2022. Np63 regulates a common landscape of enhancer associated genes in non-small cell lung cancer. Nat Commun 13:doi:10.1038/s41467-022-28202-1 PMID:35105868 PMCID:PMC8807845
  • Pammi M, Aghaeepour N, Neu J. 2022. Multiomics, artificial intelligence, and precision medicine in perinatology. Pediatric Research 8:doi:10.1038/s41390-022-02181-x PMID:35804156
  • Reddy KR, Piyarathna DW, Kamal AH, Putluri V, Ravi SS, Bollag RJ, Terris MK, Lotan Y, Putluri N. 2022. Lipidomic profiling identifies a novel lipid signature associated with ethnicity-specific disparity of bladder cancer. Metabolites 12(6):doi:10.3390/metabo12060544 PMID:35736477 PMCID:PMC9230655
  • Roy ER, Chiu G, Li S, Propson NE, Kanchi R, Wang B, Coarfa C, Zheng H, Cao W. 2022. Concerted type I interferon signaling in microglia and neural cells promotes memory impairment associated with amyloid β plaques. Immunity 55:879-894. doi:10.1016/j.immuni.2022.03.018 PMID:35443157 PMCID:PMC9109419
  • Saie AE, Fu C, Grimm SL, Robertson M, Hoffman K, Putluri V, Ambati CS, Putluri N, Shivanna B, Coarfa C, Pammi M. 2022. Metabolome and microbiome multi-omics integration from a murine lung inflammation model of bronchopulmonary dysplasia. Pediatric Research 10:doi:10.1038/s41390-022-02002-1 PMID:35338351
  • Smith E, Anderson EE, Deer R, Prochaska J, Bohn K, Croisant S. 2022. Reviewing fair subject selection considerations for the unique case of post sequelae COVID-19 translational studies. J Clin Transl Sci 6(1):91. doi:10.1017/cts.2022.425 PMID:36003210 PMCID:9389279
  • Thaiparambil J, Dong J, Grimm SL, Perera D, Ambati CS, Putluri V, Robertson M, Patel TD, Mistretta B, Gunaratne PH, Kim MP, Yustein JT, Putluri N, Coarfa C, El-Zein R. 2022. Integrative metabolomics and transcriptomics analysis reveals novel therapeutic vulnerabilities in lung cancer. Cancer Med doi:10.1002/cam4.4933 PMID:35676822
  • Thompson D, Fu C, Gandhi T, Fowler JC, Frueh BC, Weinstein BL, Petrosino J, Hadden JK, Carlson M, Coarfa C, Madan A. 2022. Differential co-expression networks of the gut microbiota are associated with depression and anxiety treatment resistance among psychiatric inpatients. Prog Neuropsychopharmacol Biol Psychiatry 120:110638. doi:10.1016/j.pnpbp.2022.110638 PMID:36122838
  • Wei Y, Miao J, Alvarez PJ, Long M. 2022. How to accurately assess the intrinsic activity of catalysts in peroxy activation?. Environ Sci Technol 56(15):10557-10559. doi:10.1021/acs.est.2c04032 PMID:35822807
  • Wei Y, Miao J, Ge J, Lang J, Yu C, Zhang L, Alvarez PJ, Long M. 2022. Ultrahigh peroxymonosulfate utilization efficiency over CuO nanosheets via heterogeneous Cu(III) formation and preferential electron transfer during degradation of phenols. Environ Sci Technol 56:doi:10.1021/acs.est.2c01968
  • Zhang S, Wei Y, Metz J, He S, Alvarez PJ, Long M. 2022. Persistent free radicals in biochar enhance superoxide-mediated Fe(III)/Fe(II) cycling and the efficacy of CaO(2) Fenton-like treatment. J Hazard Mater 421:doi:10.1016/j.jhazmat.2021.126805 PMID:34388929
  • Zhou G, Jiang W, Xia G, Wang L, Richardson MB, Chu C, Moorthy B. 2022. Attenuation of polycyclic aromatic hydrocarbon (PAH)-mediated pulmonary DNA adducts and cytochrome P450 (CYP)1B1 by dietary antioxidants, omega-3 fatty acids, in mice. Antioxidants (Basel) 11(1):doi:10.3390/antiox11010119 PMID:35052622 PMCID:8773186

2021

  • Antony K, Romezi M, Lindgren K, Mitchell KB, Venable SF, Racusin DA, Suter MA, Aagaard KM. 2021. Maternal metabolic biomarkers are associated with obesity and excess gestational weight gain. Am J Perinatol 38:e173-e181. doi:10.1055/s-0040-1708855 PMID:32232816
  • Anvari S, Watkin L, Rajapakshe K, Hassan O, Schuster K, Coarfa C, Davis CM. 2021. Memory and naive gamma delta regulatory T-cell gene expression in the first 24-weeks of peanut oral immunotherapy. Clin Immunol 230:108820. doi:10.1016/j.clim.2021.108820 PMID:34365017 PMCID:PMC8607808
  • Bomidi C, Robertson M, Coarfa C, Estes MK, Blutt SE. 2021. Single-cell sequencing of rotavirus-infected intestinal epithelium reveals cell-type specific epithelial repair and tuft cell infection. Proc Natl Acad Sci U S A 118(45):doi:10.1073/pnas.2112814118 PMID:34732579 PMCID:PMC8609316
  • Burke R, Chu C, Zhou G, Putluri V, Putluri N, Stading R, Couroucli XI, Lingappan K, Moorthy B. 2021. Role of human NADPH quinone oxidoreductase (NQO1) in oxygen-mediated cellular injury and oxidative DNA damage in human pulmonary cells. Oxid Med Cell Longev 2021:5544600. doi:10.1155/2021/5544600 PMID:34691356 PMCID:PMC8536466
  • Coarfa C, Grimm SL, Rajapakshe K, Perera D, Lu H, Wang X, Christensen KR, Mo Q, Edwards D, Huang S. 2021. Reverse-phase protein array: technology, application, data processing, and integration. J Biomol Tech doi:10.7171/jbt.2021-3202-001 PMID:33584151 PMCID:PMC7861052 (ahead of print)
  • Croisant S, Anthony AL, Kotarba JA. 2021. The SCI Cafe and health literacy education: a qualitative analysis. Stud Symb Interact 52:
  • Dias Da Silva P, Wong MS, Zygourakis K. 2021. JP-8 desulfurization by CuNa-Y zeolite at elevated temperatures has two distinct stages: chemisorption followed by surface reactions. Ind Eng Chem Res 60(40):14534-14546. doi:10.1021/acs.iecr.1c02131
  • Eder MM, Millay TA, Cottler LB. 2021. A compendium of community engagement responses to the COVID-19 pandemic. J Clin Transl Sci 5(1):e133. doi:10.1017/cts.2021.800 PMID:34367677 PMCID:PMC8326670
  • Ettayebi K, Tenge VR, Cortes-Penfield NW, Crawford SE, Neill FH, Zeng X, Yu X, Ayyar BV, Burrin D, Ramani S, Atmar RL, Estes MK. 2021. New insights and enhanced human norovirus cultivation in human intestinal enteroids. mSphere 6(1):e01136-20. doi:10.1128/mSphere.01136-20 PMID:33504663 PMCID:PMC7885322
  • Fan C, Qu H, Wang X, Sobhani N, Wang L, Liu S, Xiong W, Zeng Z, Li Y. 2021. Cancer/testis antigens: From serology to mRNA cancer vaccine. Semin Cancer Biol 76:218-231. doi:10.1016/j.semcancer.2021.04.016 PMID:33910064
  • Gao Y, Dias Da Silva P, Alvarez PJ, Zygourakis K. 2021. Integrating thermal analysis and reaction modeling for rational design of pyrolytic processes to remediate soils contaminated with heavy crude oil. Environ Sci Technol 55:11987-11996. doi:10.1021/acs.est.1c03607 PMID:34432440 PMCID:PMC8719924
  • Grimm SL, Dong X, Zhang Y, Carisey AF, Arnold AP, Moorthy B, Coarfa C, Lingappan K. 2021. Effect of sex chromosomes versus hormones in neonatal lung injury. JCI Insight 6(13):e146863. doi:10.1172/jci.insight.146863 PMID:34061778 PMCID:PMC8410054
  • Kaochar S, Rusin A, Foley C, Rajapakshe K, Robertson M, Skapura D, Mason C, Ruiz CB, Tyryshkin AM, Deng J, Shin JN, Fiskus W, Dong J, Huang S, Navone NM, Davis CM, Ehli EA, Coarfa C, Mitsiades N. 2021. Inhibition of GATA2 in prostate cancer by a clinically available small molecule. Endocr Relat Cancer 29(1):15-31. doi:10.1530/ERC-21-0085 PMID:34636746 PMCID:PMC8634153
  • Mao H, Li L, Fan Q, Angelini A, Saha PK, Coarfa C, Rajapakshe K, Perera D, Cheng J, Wu H, Ballantyne CM, Sun Z, Pi X, Xie L. 2021. Endothelium-specific depletion of LRP1 improves glucose homeostasis through inducing osteocalcin. Nat Commun 12:doi:10.1038/s41467-021-25673-6 PMID:34489478 PMCID:PMC8421392
  • Stading R, Gastelum G, Chu C, Jiang W, Moorthy B. 2021. Molecular mechanisms of pulmonary carcinogenesis by polycyclic aromatic hydrocarbons (PAHs): Implications for human lung cancer. Semin Cancer Biol 76:3-16. doi:10.1016/j.semcancer.2021.07.001 PMID:34242741
  • Yu X, Li W, Deng Q, Liu H, Wang X, Hu H, Cao Y, Xu-Monette ZY, Li L, Zhang M, Lu Z, Young KH, Li Y. 2021. MYD88 L265P elicits mutation-specific ubiquitination to drive NF-(kappa)B activation and lymphomagenesis. Blood 137(12):1615-1627. doi:10.1182/blood.2020004918 PMID:33025009 PMCID:PMC7995293
  • Yu X, Li W, Young KH, Li Y. 2021. Posttranslational modifications in PD-L1 turnover and function: From cradle to grave. Biomedicine 9(11):1702. doi:10.3390/biomedicines9111702 PMID:34829931 PMCID:PMC8615371
  • Zhou S, Fan C, Zeng Z, Young KH, Li Y. 2021. Clinical and immunological effects of p53-targeting vaccines. Front Cell Dev Biol 9:762796. doi:10.3389/fcell.2021.762796 PMID:34805170 PMCID:PMC8595300

2020

  • Banerjee S, Suter MA, Aagaard KM. 2020. Interactions between environmental exposures and the microbiome: Implications for fetal programming. Curr Opin Endocr Metab Res 13:39-48. doi:10.1016/j.coemr.2020.09.003 PMID:33283070 PMCID:PMC771673
  • Callaway DA, Jiang W, Wang L, Lingappan K, Moorthy B. 2020. Oxygen-mediated lung injury in mice lacking the gene for NRF2: Rescue with the cytochrome P4501A-inducer, beta-naphthoflavone (BNF), and differential sex-specific effects. Free Radic Biol Med 160:208-218. doi:10.1016/j.freeradbiomed.2020.07.027 PMID:32791187 PMCID:PMC7704914
  • Coarfa C, Grimm SL, Katz T, Zhang Y, Jangid RK, Walker C, Moorthy B, Lingappan K. 2020. Epigenetic response to hyperoxia in the neonatal lung is sexually dimorphic. Redox Biol 37:101718. doi:10.1016/j.redox.2020.101718 PMID:32961439 PMCID:PMC7509469
  • Eaves LA, Nguyen HT, Rager JE, Sexton K, Howard T, Smeester L, Freedman AN, Aagaard KM, Shope C, Lefer B, Flynn JH, Erickson MH, Fry RC, Vizuete W. 2020. Identifying the transcriptional response of cancer and inflammation-related genes in lung cells in relation to ambient air chemical mixtures in Houston, Texas. Environ Sci Technol 54:13807-13816. doi:10.1021/acs.est.0c02250 PMID:33064461 PMCID:PMC7757424
  • Flores-Villanueva P, Sobhani N, Wang X, Li Y. 2020. MR1-restricted T Cells in cancer immunotherapy. Cancers (Basel) 12:doi:10.3390/cancers12082145 PMID:32756356
  • Gastelum G, Jiang W, Wang L, Zhou G, Borkar R, Putluri N, Moorthy B. 2020. Polycyclic aromatic hydrocarbon-induced pulmonary carcinogenesis in cytochrome P450 (CYP)1A1-and 1A2-null mice: roles of CYP1A1 and CYP1A2. Toxicol Sci 177:347-361. doi:10.1093/toxsci/kfaa107 PMID:32726451
  • Gu G, Tian L, Herzog SK, Rechoum Y, Gelsomino L, Gao M, Du L, Kim J, Dustin D, Lo H, Beyer AR, Edwards DG, Gonzalez T, Tsimelzon A, Huang HJ, Fernandez NM, Grimm SL, Hilsenbeck SG, Liu D, Xu J, Alaniz A, Li S, Mills GB, Janku F, Kittler R, Zhang XH, Coarfa C, Foulds CE, Symmans W, Ando S, Fuqua SA. 2020. Hormonal modulation of ESR1 mutant metastasis. Oncogene 40(5):doi:10.1038/s41388-020-01563-x PMID:33323970 (ahead of print)
  • Liu M, Wang X, Li W, Yu X, Flores-Villanueva P, Xu-Monette ZY, Li L, Zhang M, Young KH, Ma X, Li Y. 2020. Targeting PD-L1 in non-small cell lung cancer using CAR T cells. Oncogenesis 9:72. doi:10.1038/s41389-020-00257-z PMID:32792499 PMCID:PMC7426958
  • Preidis GA, Soni KG, Suh J, Halder T, Kim K, Choi J, Li F, Devaraj S, Connor ME, Coarfa C, Jung SY, Moore DD. 2020. Coagulopathy in Malnourished Mice is Sexually Dimorphic and Regulated by Nutrient-sensing Nuclear Receptors. Hepatol Commun 4:1835-1850. doi:10.1002/hep4.1622 PMID:33305154 PMCID:PMC7706303
  • Rowe GT, Fernando H, Elferink CJ, Ansari G, Sullivan J, Heathman T, Quigg A, Croisant S, Wade TL, Santschi P. 2020. Polycyclic aromatic hydrocarbons (PAHs) cycling and fates in Galveston Bay, Texas, USA. PLoS One 15:e0243734. doi:10.1371/journal.pone.0243734 PMID:33370322 PMCID:PMC7769252
  • Sanchez-Lopez E, Ghia EM, Antonucci L, Sharma N, Rassenti LZ, Xu J, Sun B, Kipps TJ, Karin M. 2020. NF-kB-p62-NRF2 survival signaling is associated with high ROR1 expression in chronic lymphocytic leukemia. Cell Death Differ 27:doi:10.1038/s41418-020-0496-1 PMID:31992855 PMCID:PMC7308363
  • Stading R, Chu C, Couroucli XI, Lingappan K, Moorthy B. 2020. Molecular role of cytochrome P4501A enzymes in oxidative stress. Curr Opin Toxicol 20-21:77-84. doi:10.1016/j.cotox.2020.07.001 PMID:33283080 PMCID:PMC7709944
  • Stading R, Couroucli XI, Lingappan K, Moorthy B. 2020. The role of cytochrome P450 (CYP) enzymes in hyperoxic lung injury. Expert Opin Drug Metab Toxicol 8:doi:10.1080/17425255.2021.1853705 PMID:33215946
  • Tao G, Huang J, Moorthy B, Wang C, Hu M, Gao S, Ghose R. 2020. Potential role of drug metabolizing enzymes in chemotherapy-induced gastrointestinal toxicity and hepatotoxicity. Expert Opin Drug Metab Toxicol 16:doi:10.1080/17425255.2020.1815705 PMID:32841068

2019

  • Hassanin AA, Tavera-Garcia MA, Moorthy B, Zhou GD, Ramos KS. 2019. Lung genotoxicity of benzo(a)pyrene in vivo involves reactivation of LINE-1 retrotransposon and early reprogramming of oncogenic regulatory networks. Am J Physiol Lung Cell Mol Physiol 317:L816-L822. doi:10.1152/ajplung.00304.2019 PMID:31596105 PMCID:PMC6962597 (accepted for publication)
  • Song W, Vidonish JE, Kamath R, Yu P, Chu C, Moorthy B, Gao B, Zygourakis K, Alvarez PJ. 2019. Pilot-scale pyrolytic remediation of crude-oil-contaminated soil in a continuously-fed reactor: treatment intensity trade-offs. Environ Sci Technol 53(4):2045-2053. doi:10.1021/acs.est.8b05825 PMID:30681845 PMCID:PMC8037193
  • Suter MA, Aagaard KM, Coarfa C, Robertson M, Zhou GD, Jackson BP, Thompson D, Putluri V, Putluri N, Hagan J, Wang L, Jiang W, Lingappan K, Moorthy B. 2019. Association between elevated placental polycyclic aromatic hydrocarbons (PAHs) and PAH-DNA adducts from Superfund sites in Harris County, and increased risk of preterm birth (PTB). Biochem Biophys Res Commun 516(2):344-349. doi:10.1016/j.bbrc.2019.06.049 PMID:31208719 PMCID:PMC6637943
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