Superfund Research Program

Gut Microbiome-Arsenic-Diabetes Interactions

Project Leader: Kun Lu
Co-Investigators: Fei Zou, Timothy McDermott (Montana State University), Ryan B. Sartor, Miroslav Styblo
Grant Number: P42ES031007
Funding Period: 2020-2025

Project-Specific Links

Publications

2023

• Alowaifeer AM, Clingenpeel S, Kan J, Bigelow PE, Yoshinaga M, Bothner B, McDermott T. 2023. Arsenic and mercury distribution in an aquatic food chain: importance of femtoplankton and picoplankton filtration fractions. Environ Toxicol Chem 42(1):225-241. doi:10.1002/etc.5516 PMID:36349954
• Hsiao Y, Johnson G, Yang Y, Liu C, Feng J, Zhao H, Moy SS, Harper KM, Lu K. 2023. Evaluation of neurological behavior alterations and metabolic changes in mice under chronic glyphosate exposure. Arch Toxicol doi:10.1007/s00204-023-03622-0 PMID:37922104
• Ji M, Xu X, Xu Q, Hsiao Y, Martin C, Ukraintseva S, Popov V, Arbeev KG, Randall TA, Wu X, Garcia-Peterson LM, Liu J, Xu X, Azcarte-Peril MA, Wan Y, Yashin AI, Anantharaman K, Lu K, Li J, Shats I, Li X. 2023. Methionine restriction-induced sulfur deficiency impairs antitumour immunity partially through gut microbiota. Nat Metab doi:10.1038/s42255-023-00854-3 PMID:37537369
• Yang Y, Chi L, Liu C, Hsiao Y, Lu K. 2023. Chronic arsenic exposure perturbs gut microbiota and bile acid homeostasis in mice. Chem Res Toxicol 36(7):1037-1043. doi:10.1021/acs.chemrestox.2c00410 PMID:37295807
• Yang Y, Hsiao Y, Liu C, Lu K. 2023. The role of nuclear receptor FXR in arsenic-induced glucose intolerance in mice. Toxics 11(10):833. doi:10.3390/toxics11100833 PMID:37888683 PMCID:PMC10611046

2022

• Avery CL, Howard AG, Ballou AF, Buchanan VL, Collins JM, Downie CG, Engel SM, Graff M, Highland HM, Lee MP, Lilly AG, Lu K, Rager JE, Staley BS, North KE, Gordon-Larsen P. 2022. Strengthening Causal Inference in Exposomics Research: Application of Genetic Data and Methods. Environ Health Perspect 130(5):55001. doi:10.1289/EHP9098 PMID:35533073 PMCID:PMC9084332
• Koval L, Carberry C, Kim YH, McDermott E, Hartwell HJ, Jaspers I, Gilmour MI, Rager JE. 2022. Wildfire variable toxicity: identifying biomass smoke exposure groupings through transcriptomic similarity scoring. Environ Sci Technol 56(23):17131-17142. doi:10.1021/acs.est.2c06043 PMID:36399130
• Lai Y, Dhingra R, Zhang Z, Ball LM, Zylka MJ, Lu K. 2022. Toward elucidating the human gut microbiota-brain axis: molecules, biochemistry, and implications for health and diseases. Biochemistry 61(24):2806-2821. doi:10.1021/acs.biochem.1c00656 PMID:34910469
• Pollard JA, Furutani E, Liu S, Esrick E, Cohen LE, Bledsoe J, Liu C, Lu K, Ramirez de Haro MJ, Surralles J, Malsch M, Kuniholm A, Galvin A, Armant M, Kim AS, Ballotti K, Moreau L, Zhou Y, Babushok D, Boulad F, Carroll C, Hartung H, Hont A, Nakano T, Olson T, Sze S, Thompson AA, Wlodarski MW, Gu X, Libermann TA, D'Andrea A, Grompe M, Weller E, Shimamura A. 2022. Metformin for treatment of cytopenias in children and young adults with Fanconi anemia. Blood Adv 6(12):3803-3811. doi:10.1182/bloodadvances.2021006490 PMID:35500223
• Todero JE, Koch-Laskowski K, Shi Q, Kanke M, Hung Y, Beck R, Styblo M, Sethupathy P. 2022. Candidate master microRNA regulator of arsenic-induced pancreatic beta cell impairment revealed by multi-omics analysis. Arch Toxicol 96(6):1685-1699. doi:10.1007/s00204-022-03263-9 PMID:35314868 PMCID:PMC9095563
• Tu P, Chi L, Bian X, Gao B, Ru H, Lu K. 2022. A black raspberry-rich diet protects from dextran sulfate sodium-induced intestinal inflammation and host metabolic perturbation in association with increased aryl hydrocarbon receptor ligands in the gut microbiota of mice. Front Nutr 9:doi:10.3389/fnut.2022.842298 PMID:35734371 PMCID:PMC9208328

2021

• Beaudry MS, Wang J, Kieran T, Thomas J, Bayona-Vasquez NJ, Gao B, Devault A, Brunelle B, Lu K, Wang J, Rhodes O, Glenn TC. 2021. Improved microbial community characterization of 16S rRNA via metagenome hybridization capture enrichment. Front Microbiol doi:10.3389/fmicb.2021.644662 PMID:33986735 PMCID:PMC8110821
• Chi L, Tu P, Ru H, Lu K. 2021. Studies of xenobiotic-induced gut microbiota dysbiosis: From correlation to mechanisms. Gut Microbes 13:19. doi:10.1080/19490976.2021.1921912 PMID:34313531 PMCID:PMC8346244
• Lai Y, Liu C, Yang Y, Hsiao Y, Ru H, Lu K. 2021. High-coverage metabolomics uncovers microbiota-driven biochemical landscape of interorgan transport and gut-brain communication in mice. Nat Commun 12(1):6000. doi:10.1038/s41467-021-26209-8 PMID:34667167 PMCID:PMC8526691
• Manuck TA, Lai Y, Ru H, Glover AV, Rager JE, Fry RC, Lu K. 2021. Metabolites from mid-trimester plasma of pregnant patients at high-risk for preterm birth. Am J Obstet Gynecol 3(4):doi:10.1016/j.ajogmf.2021.100393 PMID:33991707 (ahead of print)
• van der Lelie D, Oka A, Taghavi S, Umeno J, Fan T, Merrell KE, Watson SD, Ouellette L, Liu B, Awoniyi M, Lai Y, Chi L, Lu K, Henry CS, Sartor RB. 2021. Rationally designed bacterial consortia to treat chronic immune-mediated colitis and restore intestinal homeostasis. Nat Commun 12:3105. doi:10.1038/s41467-021-23460-x PMID:34050144
• Xue J, Chi L, Tu P, Lai Y, Liu C, Ru H, Lu K. 2021. Detection of gut microbiota and pathogen produced N-acyl homoserine in host circulation and tissues. NPJ Biofilms Microbiomes 7(1):53. doi:10.1038/s41522-021-00224-5 PMID:34183673 PMCID:PMC8239043
• Yang Y, Chi L, Lai Y, Hsiao Y, Ru H, Lu K. 2021. The gut microbiome and arsenic-induced disease-iAs metabolism in mice. Curr Environ Health Rep 8(2):doi:10.1007/s40572-021-00305-9 PMID:33852125 (ahead of print)

2020

• Hsiao Y, Liu C, Chi L, Yang Y, Lu K. 2020. Effects of gut microbiome on carcinogenic DNA damage. Chem Res Toxicol 33:2130-2138. doi:10.1021/acs.chemrestox.0c00142 PMID:32677427