Superfund Research Program

Administrative Core

Project Leader: Carolyn J. Mattingly
Co-Investigator: Detlef Knappe
Grant Number: P42ES031009
Funding Period: 2020-2025

Project-Specific Links

Publications

2023

• Chappel JR, King ME, Fleming J, Eberlin LS, Reif DM, Baker ES. 2023. Aggregated molecular phenotype scores: Enhancing assessment and visualization of mass spectrometry imaging data for tissue-based diagnostics. Anal Chem 95(34):12913-12922. doi:10.1021/acs.analchem.3c02389 PMID:37579019
• Cuffney M, Wilkie AA, Kotlarz N, Knappe D, Lea CS, Collier D, DeWitt JC, Hoppin JA. 2023. Factors associated with per- and polyfluoroalkyl substances (PFAS) serum concentrations in residents of New Hanover County, North Carolina: The GenX exposure study. Environ Res 237:117020. doi:10.1016/j.envres.2023.117020 PMID:37673120
• Kirkwood-Donelson KI, Dodds J, Schnetzer A, Hall N, Baker ES. 2023. Uncovering per- and polyfluoroalkyl substances (PFAS) with nontargeted ion mobility spectrometry-mass spectrometry analyses. Sci Adv 9(43):eadj7048. doi:10.1126/sciadv.adj7048 PMID:37878714 PMCID:PMC10599621
• Phelps D, Palekar AI, Conley HE, Ferrero G, Driggers JH, Linder KE, Kullman SW, Reif DM, Sheats MK, DeWitt JC, Yoder J. 2023. Legacy and emerging per- and polyfluoroalkyl substances suppress the neutrophil respiratory burst. J Immunotoxicol 20(1):2176953. doi:10.1080/1547691X.2023.2176953 PMID:36788734 PMCID:PMC10361455
• Rock KD, Polera ME, Guillette TC, Starnes HM, Dean K, Watters M, Stevens-Stewart D, Belcher SM. 2023. Domestic Dogs and Horses as Sentinels of Per- and Polyfluoroalkyl Substance Exposure and Associated Health Biomarkers in Gray's Creek North Carolina. Environ Sci Technol 57(26):9567-9579. doi:10.1021/acs.est.3c01146 PMID:37340551
• Taylor KD, Woodlief TL, Ahmed A, Hu Q, Duncker PC. 2023. Quantifying the impact of PFOA exposure on B cell development and antibody production. Toxicol Sci doi:10.1093/toxsci/kfad043 PMID:37162486 PMCID:PMC10306397
• Wallis DJ, Kotlarz N, Knappe D, Collier D, Lea CS, Reif DM, McCord JP, Strynar M, DeWitt JC, Hoppin JA. 2023. Estimation of the half-lives of recently detected per- and polyfluorinated alkyl ethers in an exposed community. Environ Sci Technol 57(41):15348-15355. doi:10.1021/acs.est.2c08241 PMID:37801709
• Zhang C, Tang T, Knappe D. 2023. Oxidation of per- and polyfluoroalkyl ether acids and other per- and polyfluoroalkyl substances by sulfate and hydroxyl radicals: kinetic insights from experiments and models. Environ Sci Technol doi:10.1021/acs.est.3c00947 PMID:37223990

2022

• Belcher SM, Guillette MP, Robb F, Rock KD. 2022. Comparative assessment of blood mercury in American alligators (Alligator mississippiensis) from Coastal North Carolina and Florida. Ecotoxicology 31(7):1137-1146. doi:10.1007/s10646-022-02573-z PMID:35918620
• Bilbao A, Gibbons BC, Stow SM, Kyle AD, Bloodsworth KJ, Payne SH, Smith RD, Ibrahim YM, Baker ES, Fjeldsted JC. 2022. A preprocessing tool for enhanced ion mobility-mass spectrometry-based omics workflows. J Proteome Res 21:798-807. doi:10.1021/acs.jproteome.1c00425 PMID:34382401 PMCID:PMC8837709
• Butler KE, Baker ES. 2022. A high-throughput ion mobility spectrometry-mass spectrometry screening method for opioid profiling. J Am Soc Mass Spectrom 33(10):1904-1913. doi:10.1021/jasms.2c00186 PMID:36136315
• Butler KE, Dodds J, Flick T, Campuzano ID, Baker ES. 2022. High-resolution demultiplexing (HRdm) ion mobility spectrometry-mass spectrometry for aspartic and isoaspartic acid determination and screening. Anal Chem doi:10.1021/acs.analchem.1c05533 PMID:35421308
• Cohen Hubal EA, DeLuca NM, Mullikin A, Slover R, Little JC, Reif DM. 2022. Demonstrating a systems approach for integrating disparate data streams to inform decisions on children's environmental health. BMC Public Health 22(1):313. doi:10.1186/s12889-022-12682-3 PMID:35168583 PMCID:PMC8845296
• Ducatman A, LaPier J, Fuoco RE, DeWitt JC. 2022. Official health communications are failing PFAS-contaminated communities. Environmental Health doi:10.1186/s12940-022-00857-9 PMID:35538533 PMCID:PMC9092686
• Enders J, Weed RA, Griffith EH, Muddiman DC. 2022. Development and validation of a high resolving power absolute quantitative per- and polyfluoroalkyl substances method incorporating Skyline data processing. Rapid Commun Mass Spectrom 36:e9295. doi:10.1002/rcm.9295 PMID:35275435
• Evich MG, Davis MJ, McCord JP, Acrey B, Awkerman JA, Knappe D, Lindstrom AB, Speth TF, Tebes-Stevens C, Strynar M, Wang Z, Weber EJ, Henderson WM, Washington JW. 2022. Per- and polyfluoroalkyl substances in the environment. Science 375:doi:10.1126/science.abg9065 PMID:35113710 PMCID:PMC8902460
• Foster MR, Rainey M, Watson C, Dodds J, Kirkwood KI, Fernandez FM, Baker ES. 2022. Uncovering PFAS and other xenobiotics in the dark metabolome using ion mobility spectrometry, mass defect analysis, and machine learning. Environ Sci Technol 56:doi:10.1021/acs.est.2c00201 PMID:35653285 PMCID:PMC9474714
• Guillette TC, Jackson TW, Guillette MP, McCord JP, Belcher SM. 2022. Blood concentrations of per- and polyfluoroalkyl substances are associated with autoimmune-like effects in American alligators from Wilmington, North Carolina. Front Toxicol 4:doi:10.3389/ftox.2022.1010185
• Kirkwood KI, Fleming J, Nguyen H, Reif DM, Baker ES, Belcher SM. 2022. Utilizing pine needles to temporally and spatially profile per- and polyfluoroalkyl substances (PFAS). Environ Sci Technol 56:3441-3451. doi:10.1021/acs.est.1c06483 PMID:35175744
• Kirkwood KI, Pratt BS, Shulman N, Tamura K, MacCoss MJ, MacLean BX, Baker ES. 2022. Utilizing Skyline to analyze lipidomics data containing liquid chromatography, ion mobility spectrometry and mass spectrometry dimensions. Nat Protoc doi:10.1038/s41596-022-00714-6 PMID:35831612
• Roell K, Koval L, Boyles R, Patlewicz G, Ring C, Rider CV, Ward-Caviness C, Reif DM, Jaspers I, Fry RC, Rager JE. 2022. Development of the InTelligence and Machine LEarning (TAME) Toolkit for introductory data science, chemical-biological analyses, predictive modeling, and database mining for environmental health research. Front Toxicol 4:doi:10.3389/ftox.2022.893924 PMID:35812168 PMCID:PMC9257219
• Rosen EM, Kotlarz N, Knappe D, Lea CS, Collier D, Richardson DB, Hoppin JA. 2022. Drinking water-associated PFAS and fluroethers and lipid outcomes in the GenX exposure study. Environ Health Perspect 130(9):97002. doi:10.1289/EHP11033 PMID:36069575 PMCID:PMC9450637
• Starnes HM, Rock KD, Jackson TW, Belcher SM. 2022. A critical review and meta-analysis of impacts of per- and polyfluorinated substances on the brain and behavior. Front Toxicol 4:doi:10.3389/ftox.2022.881584 PMID:35480070 PMCID:PMC9035516
• Truong L, Rericha Y, Thunga P, Marvel S, Wallis DJ, Simonich MT, Field JA, Cao D, Reif DM, Tanguay RL. 2022. Systematic developmental toxicity assessment of a structurally diverse library of PFAS in zebrafish. J Hazard Mater doi:10.1016/j.jhazmat.2022.128615 PMID:35263707 PMCID:PMC8970529
• Wallis DJ, Barton KE, Knappe D, Kotlarz N, McDonough CA, Higgins CP, Hoppin JA, Adgate JL. 2022. Source apportionment of serum PFASs in two highly exposed communities. Sci Total Environ 855:158842. doi:10.1016/j.scitotenv.2022.158842 PMID:36122706
• Weed RA, Boatman AK, Enders J. 2022. Recovery of per- and polyfluoroalkyl substances after solvent evaporation. Environ Sci Process Impacts doi:10.1039/d2em00269h PMID:36281820
• Witchey SK, Doyle MG, Fredenburg JD, Armour GS, Horman BM, Odenkirk MT, Aylor DL, Baker ES, Patisaul HB. 2022. Impacts of gestational FireMaster 550 (FM 550) exposure on the neonatal cortex are sex specific and largely attributable to the organophosphate esters. Neuroendocrinology doi:10.1159/000526959 PMID:36075192
• Zhang C, McElroy AC, Liberatore H, Alexander NL, Knappe D. 2022. Stability of per- and polyfluoroalkyl substances in solvents relevant to environmental and toxicological analysis. Environ Sci Technol doi:10.1021/acs.est.1c03979 PMID:34734715 PMCID:PMC9065217