Superfund Research Program

Uncovering the Mechanisms of PFAS-Induced Immunotoxicity: An Important Public Health Endpoint

Project Leader: Seth W. Kullman
Co-Investigators: Jamie C. DeWitt (Oregon State University), Jeffrey Yoder
Grant Number: P42ES031009
Funding Period: 2020-2025

Project-Specific Links

Publications

2024

• Bline A, DeWitt JC, Kwiatkowski C, Pelch KE, Reade A, Varshavsky J. 2024. Public health risks of PFAS-related immunotoxicity are real. Curr Environ Health Rep doi:10.1007/s40572-024-00441-y PMID:38526771
• DeWitt JC, Gluge J, Cousins IT, Goldenman G, Herzke D, Lohmann R, Miller M, Ng CA, Patton S, Trier X, Vierke L, Wang Z, Adu-Kumi S, Balan SA, Buser A, Fletcher T, Haug L, Heggelund A, Huang J, Kaserzon S, Leonel J, Sheriff I, Shi Y, Valsecchi S, Scheringer M. 2024. Zurich II statement on per- and polyfluoroalkyl substances (PFASs): scientific and regulatory needs. Environ Sci Technol Lett 11(8):786-797. doi:10.1021/acs.estlett.4c00147 PMID:39156923 PMCID:11325642
• Kirkwood-Donelson KI, Chappel JR, Tobin E, Dodds J, Reif DM, DeWitt JC, Baker ES. 2024. Investigating mouse hepatic lipidome dysregulation following exposure to emerging per- and polyfluoroalkyl substances (PFAS). Chemosphere 354:141654. doi:10.1016/j.chemosphere.2024.141654 PMID:38462188 PMCID:10995748
• Phelps D, Connors A, Ferrero G, DeWitt JC, Yoder J. 2024. Per- and polyfluoroalkyl substances alter innate immune function: evidence and data gaps. J Immunotoxicol 21(1):doi:10.1080/1547691x.2024.2343362 PMID:38712868

2023

• Cuffney M, Wilkie AA, Kotlarz N, Knappe D, Lea CS, Collier D, DeWitt JC, Hoppin JA. 2023. Factors associated with per- and polyfluoroalkyl substances (PFAS) serum concentrations in residents of New Hanover County, North Carolina: The GenX exposure study. Environ Res 237:117020. doi:10.1016/j.envres.2023.117020 PMID:37673120
• Efromson J, Ferrero G, Begue A, Doman TJ, Dugo C, Barker A, Saliu V, Reamey P, Kim K, Harfouche M, Yoder J. 2023. Automated, high-throughput quantification of EGFP-expressing neutrophils in zebrafish by machine learning and a highly-parallelized microscope. PLoS One 18(12):e0295711. doi:10.1371/journal.pone.0295711 PMID:38060605 PMCID:PMC10703246
• Phelps D, Palekar AI, Conley HE, Ferrero G, Driggers JH, Linder KE, Kullman SW, Reif DM, Sheats MK, DeWitt JC, Yoder J. 2023. Legacy and emerging per- and polyfluoroalkyl substances suppress the neutrophil respiratory burst. J Immunotoxicol 20(1):2176953. doi:10.1080/1547691X.2023.2176953 PMID:36788734 PMCID:PMC10361455
• Taylor KD, Woodlief TL, Ahmed A, Hu Q, Duncker PC. 2023. Quantifying the impact of PFOA exposure on B cell development and antibody production. Toxicol Sci doi:10.1093/toxsci/kfad043 PMID:37162486 PMCID:PMC10306397
• Wallis DJ, Kotlarz N, Knappe D, Collier D, Lea CS, Reif DM, McCord JP, Strynar M, DeWitt JC, Hoppin JA. 2023. Estimation of the half-lives of recently detected per- and polyfluorinated alkyl ethers in an exposed community. Environ Sci Technol 57(41):15348-15355. doi:10.1021/acs.est.2c08241 PMID:37801709

2022

• Ducatman A, LaPier J, Fuoco RE, DeWitt JC. 2022. Official health communications are failing PFAS-contaminated communities. Environmental Health doi:10.1186/s12940-022-00857-9 PMID:35538533 PMCID:PMC9092686
• McDonough CA, Li W, Bischel HN, De Silva AO, DeWitt JC. 2022. Widening the lens on PFASs: Direct human exposure to perfluoroalkyl acid precursors (pre-PFAAs). Environ Sci Technol 56(10):6004-6013. doi:10.1021/acs.est.2c00254 PMID:35324171