Title: Fecal PCB metabolites in germ-free mice compared to conventional mice

Accession Number: doi:10.25820/data.006119

Link to Dataset: https://doi.org/10.25820/data.006119

Repository: Iowa Research Online

Data Type(s): Metabolomics

Organism(s): Mus musculus

Summary: The PCB metabolome in feces of germ-free (GF) and conventional (CV) mice was systematically explored with nontarget high-resolution mass spectrometry (Nt-HRMS). The total PCB metabolite levels were dose and gut microbiome dependent. This finding demonstrate that the gut microbiome plays a role in the metabolism and excretion of PCB metabolites. This dataset summarizes relative levels of individual PCB metabolites in feces of both CV and GF mice, including the raw data files collected from instrument and raw data extracted for the mass chromatograms (i.e., area integration, putative molecular formulas, and analysis of isotope patterns).

Publication(s) associated with this dataset:

• Li X, Liu Y, Martin JW, Cui JY, Lehmler H. 2021. Nontarget analysis reveals gut microbiome-dependent differences in the fecal PCB metabolite profiles of germ-free and conventional mice. Environ Pollut doi:10.1016/j.envpol.2020.115726 PMID:33032095 PMCID:PMC7746632