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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Research Briefs: University of Iowa

Superfund Research Program

Research Support Core: Synthesis Core

Project Leader: Hans-Joachim Lehmler
Co-Investigator: Xueshu Li
Grant Number: P42ES013661
Funding Period: 2006-2025
View this project in the NIH Research Portfolio Online Reporting Tools (RePORT)

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Research Briefs

  • 330 - Study Sheds Light on Breakdown Products of PCBs in the Environment -- Hornbuckle
    Release Date: 06/01/2022

    NIEHS Superfund Research program (SRP) grantees discovered toxic breakdown products of polychlorinated biphenyls (PCBs) in contaminated sediments at proportionally higher levels than found in commercial PCB mixtures. According to the team, these findings point to environmental processes, such as metabolism by animals, plants, or bacteria, in generating the harmful chemicals.

  • 293 - Study Sheds Light on Breakdown of PCBs to Potentially Harmful Metabolites in Humans -- Lehmler
    Release Date: 05/01/2019

    New research out of the University of Iowa Superfund Research Program (SRP) Center identified specific cytochrome P450 (CYP) enzymes and underlying mechanisms involved in the breakdown, or metabolism, of polychlorinated biphenyls (PCBs) into compounds that may be more toxic.

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Last Reviewed: October 02, 2024