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Project Publications: University of Iowa: Research Support Core: Synthesis Core

Superfund Research Program

Research Support Core: Synthesis Core

Project Leader: Hans-Joachim Lehmler
Co-Investigator: Xueshu Li
Grant Number: P42ES013661
Funding Period: 2006-2025
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  • Behan-Bush RM, Liszewski JN, Schrodt MV, Vats B, Li X, Lehmler H, Klingelhutz AJ, Ankrum J. 2023. Toxicity impacts on human adipose mesenchymal stem/stronal cells acutely exposed to aroclor and non-aroclor mixtures of polychorinated biphenyl. Environ Sci Technol 57(4):1731-1742. doi:10.1021/acs.est.2c07281 PMID:36651682 PMCID:PMC9893815
  • Bullert AJ, Li X, Chunyun Z, Lee K, Pulliam CF, Cagle B, Doorn JA, Klingelhutz AJ, Robertson LW, Lehmler H. 2023. Disposition and metabolomic effects of 2,2',5,5'-tetrachlorobiphenyl in female rats following intraperitoneal exposure. Environ Toxicol Pharmacol 102:104245. doi:10.1016/j.etap.2023.104245 PMID:37572994
  • Gourronc FA, Chimenti MS, Lehmler H, Ankrum J, Klingelhutz AJ. 2023. Updating Dataset of transcriptomic changes that occur in human preadipocytes over a 3-day course of exposure to 3,3',4,4',5-pentachlorobiphenyl (PCB126) with additional data on exposure to 2,2',5,5'-tetrachlorobiphenyl (PCB52) or its 4-hydroxy metabolite (4-OH-PCB52). Data Brief 49:109415. doi:10.1016/j.dib.2023.109415 PMID:37520642 PMCID:PMC10375549
  • Li X, Bullert AJ, Han W, Yang W, Zhang Q, Ding X, Lehmler H. 2023. Enantiomeric fractions reveal differences in the atroposelective disposition of 2,2',3,5',6-pentachlorobiphenyl (PCB 95) in wildtype, cyp2abfgs-null, and CYP2A6-humanized mice. Chem Res Toxicol doi:10.1021/acs.chemrestox.3c00128 PMID:37467352
  • Mouat JS, Li X, Neier K, Zhu Y, Mordaunt CE, La Merrill MA, Lehmler H, Jones MP, Lein PJ, Schmidt RJ, LaSalle J. 2023. Networks of placental DNA methylation correlate with maternal serum PCB concentrations and child neurodevelopment. Environ Res 220:115227. doi:10.1016/j.envres.2023.115227 PMID:36608759
  • Wang H, Bullert AJ, Li X, Stevens HE, Klingelhutz AJ, Ankrum J, Adamcakova-Dodd A, Thorne PS, Lehmler H. 2023. Use of a polymeric implant system to assess the neurotoxicity of subacute exposure to 2,2',5,5'-tetrachlorobiphenyl-4-ol, a human metabolite of PCB 52, in male adolescent rats. Toxicology 500:153677. doi:10.1016/j.tox.2023.153677 PMID:37995827 PMCID:PMC10757425
  • Zhang C, Li X, Stietz KP, Sethi S, Yang W, Marek RF, Ding X, Lein PJ, Hornbuckle KC, Lehmler H. 2023. Rebuttal to correspondence on "machine learning-assisted identification and quantification of hydroxylated metabolites of polychlorinated biphenyls in animal samples". Environ Sci Technol 57(15):6251-6252. doi:10.1021/acs.est.3c01659 PMID:37017328


  • Eti N, Flor S, Iqbal K, Scott RL, Klenov V, Gibson-Corley KN, Soares M, Ludewig G, Robertson LW. 2022. PCB126 induced toxic actions on liver energy metabolism is mediated by AhR in rats. Toxicology 466:153054. doi:10.1016/j.tox.2021.153054 PMID:34848246 PMCID:PMC8748418
  • Gourronc FA, Helm BK, Robertson LW, Chimenti MS, Lehmler H, Ankrum J, Klingelhutz AJ. 2022. Dataset of transcriptomic changes that occur in human preadipocytes over a 3-day course of exposure to 3,3',4,4',5-Pentachlorobiphenyl (PCB126). Data Brief 45:108571. doi:10.1016/j.dib.2022.108571 PMID:36131953 PMCID:PMC9483567
  • Kennedy CL, Spiegelhoff A, Lavery T, Wang K, Manuel R, Wang Z, Wildermuth H, Stietz KP. 2022. Developmental polychlorinated biphenyl (PCB) exposure alters voiding physiology in young adult male and female mice. Am J Clin Exp Urol PMID:35528463 PMCID:PMC9077147
  • Li X, Hefti MM, Marek RF, Hornbuckle KC, Wang K, Lehmler H. 2022. Assessment of polychlorinated biphenyls and their hydroxylated metabolites in postmortem human brain samples: Age and brain region differences. Environ Sci Technol 56(13):9515-9526. doi:10.1021/acs.est.2c00581 PMID:35658127 PMCID:PMC9260965
  • Li X, Lim JJ, Wang K, Prasad B, Bhatt D, Cui JY, Lehmler H. 2022. The disposition of polychlorinated biphenyls (PCBs) differs between germ-free and conventional mice. Environ Toxicol Pharmacol 92:103854. doi:10.1016/j.etap.2022.103854 PMID:35331926 PMCID:PMC9090986
  • Saktrakulkla P, Li X, Martinez A, Lehmler H, Hornbuckle KC. 2022. Hydroxylated polychlorinated biphenyls are emerging legacy pollutants in contaminated sediments. Environ Sci Technol 56:2269-2278. doi:10.1021/acs.est.1c04780 PMID:35107261 PMCID:PMC8851693
  • Yaghoobi B, Miller GW, Holland EB, Li X, Harvey D, Li S, Lehmler H, Pessah IN, Lein PJ. 2022. Ryanodine receptor-active non-dioxin-like polychlorinated biphenyls cause neurobehavioral deficits in larval zebrafish. Front Toxicol 4:947795. doi:10.3389/ftox.2022.947795 PMID:36278027 PMCID:PMC9582434
  • Zhang C, Li X, Flor S, Ruiz P, Kruve A, Ludewig G, Lehmler H. 2022. Metabolism of 3-chlorobiphenyl (PCB 2) in a human-relevant cell line: evidence of dechlorinated metabolites. Environ Sci Technol 56(17):12460-12472. doi:10.1021/acs.est.2c03687 PMID:35994059 PMCID:PMC9573771
  • Zhang C, Li X, Stietz KP, Sethi S, Yang W, Marek RF, Ding X, Lein PJ, Hornbuckle KC, Joachim-Lehmler H. 2022. Machine learning-assisted identification and quantification of hydroxylated metabolites of polychlorinated biphenyls in animal samples. Environ Sci Technol 56(18):13169-13178. doi:10.1021/acs.est.2c02027 PMID:36047920



  • Dhakal RC, Li X, Parkin S, Lehmler H. 2020. Synthesis of mono- and dimethoxylated polychlorinated biphenyl derivatives starting from fluoroarene derivatives. Environ Sci Pollut Res Int 27:8905-8925. doi:10.1007/s11356-019-07133-3
  • Egusquiza RJ, Ambrosio ME, Wang SG, Kay KM, Zhang C, Lehmler H, Blumberg B. 2020. Evaluating the role of the steroid and xenobiotic receptor (SXR/PXR) in PCB-153 metabolism and protection against associated adverse effects during perinatal and chronic exposure in mice. Environ Health Perspect 128:16. doi:10.1289/EHP6262 PMID:32352317 PMCID:PMC7228131
  • Lim JJ, Li X, Lehmler H, Wang D, Gu H, Cui JY. 2020. Gut microbiome critically impacts PCB-induced changes in metabolic fingerprints and the hepatic transcriptome in mice. Toxicol Sci 177:168-187. doi:10.1093/toxsci/kfaa090 PMID:32544245 PMCID:PMC7553702
  • Roy MA, Duche PR, Timme-Laragy AR. 2020. The sulfate metabolite of 3,3'-dichlorobiphenyl (PCB-11) impairs Cyp1a activity and increases hepatic neutral lipids in zebrafish larvae (Danio rerio). Chemosphere 260:doi:10.1016/j.chemosphere.2020.127609 PMID:32693259 PMCID:PMC7530052
  • Wang H, Adamcakova-Dodd A, Flor S, Gosse L, Klenov V, Stolwijk J, Lehmler H, Hornbuckle KC, Ludewig G, Thorne PS. 2020. Comprehensive subchronic inhalation toxicity assessment of an indoor school air mixture of PCBs. Environ Sci Technol 54:15976-15985. doi:10.1021/acs.est.0c04470 PMID:33256405 PMCID:PMC7879961
  • Williams AE, Watt J, Robertson LW, Gadupudi GS, Osborn ML, Soares M, Iqbal K, Pedersen KB, Shankar K, Littleton S, Maimone C, Eti N, Suva LJ, Ronis M. 2020. Skeletal toxicity of coplanar polychlorinated biphenyl congener 126 in the rat is aryl hydrocarbon receptor dependent. Toxicol Sci 175:113-125. doi:10.1093/toxsci/kfaa030 PMID:32119087 PMCID:PMC7197949



  • Alam S, Carter GS, Krager KJ, Li X, Lehmler H, Aykin-Burns N. 2018. PCB11 metabolite, 3,3-dichlorobiphenyl-4-ol, exposure alters the expression of genes governing fatty acid metabolism in the absence of functional sirtuin 3: examining the contribution of MnSOD. Antioxidants (Basel) 7(9):121. doi:10.3390/antiox7090121 PMID:30223548
  • Cheng SL, Li X, Lehmler H, Phillips B, Shen D, Cui JY. 2018. Gut microbiota modulates interactions between polychlorinated biphenyls and bile acid homeostasis. Toxicol Sci 166:269-287. doi:10.1093/toxsci/kfy208 PMID:30496569 PMCID:PMC6260149
  • Das S, Oldham E, Lehmler H, Knutson BL, Rankin S. 2018. Tuning the position of head groups by surfactant design in mixed micelles of cationic and carbohydrate surfactants. Journal of Colloid and Interface Science 517:428-438. doi:10.1016/j.jcis.2017.10.066 PMID:29096103
  • Dhakal K, Gadupudi GS, Lehmler H, Ludewig G, Duffel MW, Robertson LW. 2018. Sources and toxicities of phenolic polychlorinated biphenyls (OH-PCBs). Environ Sci Pollut Res Int 25:16277-16290. doi:10.1007/s11356-017-9694-x PMID:28744683 PMCID:PMC5785587
  • Gadupudi GS, Elser BA, Sandgruber FA, Li X, Gibson-Corley KN, Robertson LW. 2018. PCB126 inhibits the activation of AMPK-CREB signal transduction required for energy sensing in liver. Toxicol Sci 163:440-453. doi:10.1093/toxsci/kfy041 PMID:29474705 PMCID:PMC5974782
  • Gourronc FA, Robertson LW, Klingelhutz AJ. 2018. A delayed proinflammatory response of human preadipocytes to PCB126 is dependent on the aryl hydrocarbon receptor. Environ Sci Pollut Res Int 25:16481-16492. doi:10.1007/s11356-017-9676-z PMID:28699004 PMCID:PMC5764822
  • Klaren WD, Vine D, Vogt S, Robertson LW. 2018. Spatial distribution of metals within the liver acinus and their perturbation by PCB126. Environ Sci Pollut Res Int 25(17):16427-16433. doi:10.1007/s11356-017-0202-0 PMID:28940161 PMCID:PMC5866157
  • Li X, Holland EB, Feng W, Zheng J, Dong Y, Pessah IN, Duffel MW, Robertson LW, Lehmler H. 2018. Authentication of synthetic environmental contaminants and their (bio)transformation products in toxicology: polychlorinated biphenyls as an example. Environ Sci Pollut Res Int 25(17):1-14. doi:10.1007/s11356-017-1162-0 PMID:29322390 PMCID:PMC6015536
  • Li X, Parkin S, Lehmler H. 2018. Absolute configuration of 2,2',3,3',6-pentachlorinatedbiphenyl (PCB 84) atropisomers. Environ Sci Pollut Res Int 25:16402-16410. doi:10.1007/s11356-017-9259-z PMID:28537024 PMCID:PMC5823790
  • Liu Y, Richardson ES, Derocher AE, Lunn NJ, Lehmler H, Li X, Zhang Y, Cui JY, Cheng L, Martin JW. 2018. Hundreds of unrecognized halogenated contaminants discovered in polar bear serum. Angew Chem Int Ed Engl 57:16401-16406. doi:10.1002/anie.201809906 PMID:30376612
  • Parker VS, Squirewell EJ, Lehmler H, Robertson LW, Duffel MW. 2018. Hydroxylated and sulfated metabolites of commonly occurring airborne polychlorinated biphenyls inhibit human steroid sulfotransferases SULT1E1 and SULT2A1. Environ Toxicol Pharmacol 58:196-201. doi:10.1016/j.etap.2018.01.010 PMID:29408762 PMCID:PMC6078096
  • Pencikova K, Svrzkova L, Strapacova S, Neca J, Bartonkova I, Dvorak Z, Hyzdalova M, Pivnicka J, Palkova L, Lehmler H, Li X, Vondracek J, Machala M. 2018. In vitro profiling of toxic effects of prominent environmental lower-chlorinated PCB congeners linked with endocrine disruption and tumor promotion. Environ Pollut 237:473-486. doi:10.1016/j.envpol.2018.02.067 PMID:29518658 PMCID:PMC5908724
  • Rodriguez EA, Vanle BC, Doorn JA, Lehmler H, Robertson LW, Duffel MW. 2018. Hydroxylated and sulfated metabolites of commonly observed airborne polychlorinated biphenyls display selective uptake and toxicity in N27, SH-SY5Y, and HepG2 cells. Environ Toxicol Pharmacol 62:69-78. doi:10.1016/j.etap.2018.06.010 PMID:29986280 PMCID:PMC609219
  • Sethi S, Keil KP, Lein PJ. 2018. 3,3-Dichlorobiphenyl (PCB 11) promotes dendritic arborization in primary rat cortical neurons via a CREB-dependent mechanism. Arch Toxicol 1-9. doi:10.1007/s00204-018-2307-8 PMID:30225637 PMCID:PMC6196112
  • Uwimana E, Li X, Lehmler H. 2018. Human liver microsomes atropselectively metabolize 2,2 ',3,4 ',6-pentachlorobiphenyl (PCB 91) to a 1,2-shift product as the major metabolite. Environ Sci Technol 52:6000-6008. doi:10.1021/acs.est.8b00612 PMID:29659268 PMCID:PMC5966832


  • Das S, Xu W, Lehmler H, Miller A, Knutson BL, Rankin S. 2017. Inverted micelle-in-micelle configuration in cationic/carbohydrate surfactant mixtures. Chemphyschem 18(1):79-86. doi:10.1002/cphc.201600908 PMID:27788284
  • Grimm FA, Lehmler H, Koh W, DeWall J, Teesch LM, Hornbuckle KC, Thorne PS, Robertson LW, Duffel MW. 2017. Identification of a sulfate metabolite of PCB 11 in human serum. Environ Int 98:120-128. doi:10.1016/j.envint.2016.10.023 PMID:27816204 PMCID:PMC5127762
  • Holland EB, Feng W, Zheng J, Dong Y, Li X, Lehmler H, Pessah IN. 2017. An extended structure-activity relationship of nondioxin-like PCBs evaluates and supports modeling predictions and identifies picomolar potency of PCB 202 towards ryanodine receptors. Toxicol Sci 155(1):170-181. doi:10.1093/toxsci/kfw189 PMID:27655348 PMCID:PMC5216651
  • Joshi S, Lehmler H, Knutson BL, Rankin S. 2017. Imprinting of Stöber particles for chirally-resolved adsorption of target monosaccharides and disaccharides. New J Chem 20(41):11525-11532. doi:10.1039/C7NJ01938F
  • Kania-Korwel I, Lukasiewicz T, Barnhart CD, Stamou M, Chung H, Kelly KM, Bandiera SM, Lein PJ, Lehmler H. 2017. Congener-specific disposition of chiral polychlorinated biphenyls in lactating mice and their offspring: Implications for PCB developmental neurotoxicity. Toxicol Sci 158(1):101-115. doi:10.1093/toxsci/kfx071 PMID:28431184 PMCID:PMC6070089
  • Kania-Korwel I, Wu X, Wang K, Lehmler H. 2017. Identification of lipidomic markers of chronic 3,3 ,4,4 ,5-pentachlorobiphenyl (PCB 126) exposure in the male rat liver. Toxicology 390:124-134. doi:10.1016/j.tox.2017.09.005 PMID:28890136 PMCID:PMC5633524
  • Klinefelter K, Hoover MK, Bates C, Colter BT, Dailey A, Infante SK, Kania-Korwel I, Lehmler H, Lopez-Juarez A, Ludwig CP, Curran CP. 2017. Genetic differences in the aryl hydrocarbon receptor and CYP1A2 affect sensitivity to developmental polychlorinated biphenyl exposure in mice: relevance to studies of human neurological disorders. Mamm Genome 1-16. doi:10.1007/s00335-017-9728-1 PMID:29197979
  • Liu B, Lehmler H, Sun Y, Xu G, Sun Q, Hu F, Wallace RB, Boa W, Hu FB, Zhong G, Liu Y. 2017. Bisphenol A substitutes and obesity in US adults: analysis of a population-based, cross-sectional study. Lancet Planet Health 1(3):e114-e122. doi:10.1016/S2542-5196(17)30049-9 PMID:29308453 PMCID:PMC5751959
  • Marek RF, Thorne PS, Herkert N, Awad AM, Hornbuckle KC. 2017. Airborne PCBs and OH-PCBs inside and outside urban and rural U.S. schools. Environ Sci Technol 51(14):7853-7860. doi:10.1021/acs.est.7b01910 PMID:28656752 PMCID:PMC5777175
  • Schroer HW, Langenfeld KL, Li X, Lehmler H, Just CL. 2017. Biotransformation of 2,4-dinitroanisole by a fungal Penicillium sp. Biodegradation 28(1):95-109. doi:10.1007/s10532-016-9780-7 PMID:27913891
  • Sethi S, Keil KP, Chen H, Hayakawa K, Li X, Lin Y, Lehmler H, Puschner B, Lein PJ. 2017. Detection of 3,3 '-dichlorobiphenyl in human maternal plasma and its effects on axonal and dendritic growth in primary rat neurons. Toxicol Sci 158(2):401-411. doi:10.1093/toxsci/kfx100 PMID:28510766 PMCID:PMC5837364
  • Zhao H, Lehmler H, Chen J, Liu S, Cai X. 2017. Antibiotic pollution in marine food webs in laizhou bay, north China: trophodynamics and human exposure implication. Environ Sci Technol 51(4):doi:10.1021/acs.est.6b04556 PMID:28106989 PMCID:PMC5618103
  • . 2017. Atropisomers of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) exhibit stereoselective effects on activation of nuclear receptors in vitro. Environ Sci Pollut Res Int 25(17):1-9. doi:10.1007/s11356-017-0683-x PMID:29124635 PMCID:PMC5943194






  • Dhakal K, He X, Lehmler H, Teesch LM, Duffel MW, Robertson LW. 2012. Identification of sulfated metabolites of 4-chlorobiphenyl (PCB3) in the serum and urine of male rats. Chem Res Toxicol 25(12):2796-2804. doi:10.1021/tx300416v PMID:23137097 PMCID:PMC3524396




  • Klosener J, Peters TM, Adamcakova-Dodd A, Teesch LM, Thorne PS, Robertson LW, Luthe G. 2009. Innovative application of fluoro tagging to trace airborne particulate and gas-phase polybrominated diphenyl ether exposures. Chem Res Toxicol 22(1):179-186. doi:10.1021/tx8003032 PMID:19111055 PMCID:PMC3120107
  • Pessah IN, Lehmler H, Robertson LW, Perez CF, Cabrales E, Bose DD, Feng W. 2009. Enantiomeric specificity of (-)-2,2',3,3',6,6'-hexachlorobiphenyl toward ryanodine receptor types 1 and 2. Chem Res Toxicol 22(1):201-207. doi:10.1021/tx800328u PMID:18954145 PMCID:PMC2662366
  • Wangpradit O, Teesch LM, Mariappan S, Duffel MW, Norstrom K, Robertson LW, Luthe G. 2009. Oxidation of 4-chlorobiphenyl metabolites to electrophilic species by prostaglandin H synthase. Chem Res Toxicol 22(1):64-71. doi:10.1021/tx800300t PMID:19105592 PMCID:PMC2637223


  • Glauert HP, Tharappel JC, Banerjee S, Chan NL, Kania-Korwel I, Lehmler H, Lee EY, Robertson LW, Spear BT. 2008. Inhibition of the promotion of hepatocarcinogenesis by 2,2',4,4',5,5'-hexachlorobiphenyl (PCB-153) by the deletion of the p50 subunit of NF-kappa B in mice. Toxicol Appl Pharmacol 232(2):302-308. doi:10.1016/j.taap.2008.06.013 PMID:18644402 PMCID:PMC2583134
  • Kania-Korwel I, Hrycay EG, Bandiera SM, Lehmler H. 2008. 2,2',3,3',6,6'-Hexachlorobiphenyl (PCB 136) atropisomers interact enantioselectively with hepatic microsomal cytochrome P450 enzymes. Chem Res Toxicol 21(6):1295-1303. doi:10.1021/tx800059j PMID:18494506 PMCID:PMC2574739
  • Kania-Korwel I, Vyas SM, Song Y, Lehmler H. 2008. Gas chromatographic separation of methoxylated polychlorinated biphenyl atropisomers. J Chromatogr A 1207:146-154. PMID:18760792
  • Kania-Korwel I, Zhao H, Norstrom K, Li X, Hornbuckle KC, Lehmler H. 2008. Simultaneous extraction and clean-up of polychlorinated biphenyls and their metabolites from small tissue samples using pressurized liquid extraction. J Chromatogr A 1214(1-2):37-46. doi:10.1016/j.chroma.2008.10.089 PMID:19019378 PMCID:PMC2648864
  • Liu J, Schnoor JL. 2008. Uptake and translocation of lesser-chlorinated polychlorinated biphenyls (PCBs) in whole hybrid poplar plants after hydroponic exposure. Chemosphere 73(10):1608-1616. doi:10.1016/j.chemosphere.2008.08.009 PMID:18793792 PMCID:PMC2668963
  • Song Y, Buettner GR, Parkin S, Wagner BA, Robertson LW, Lehmler H. 2008. Chlorination increases the persistence of semiquinone free radicals derived from polychlorinated biphenyl hydroquinones and quinones. J Org Chem 73(21):8296-8304. doi:10.1021/jo801397g PMID:18839991 PMCID:PMC2629131
  • Tharappel JC, Lehmler H, Srinivasan C, Robertson LW, Spear BT, Glauert HP. 2008. Effect of antioxidant phytochemicals on the hepatic tumor promoting activity of 3,3',4,4'-tetrachlorobiphenyl (PCB-77). Food Chem Toxicol 46(11):3467-3474. doi:10.1016/j.fct.2008.08.023 PMID:18796325 PMCID:PMC2597727
  • Venkatesha VA, Venkataraman S, Sarsour EH, Kalen AL, Buettner GR, Robertson LW, Lehmler H, Goswami PC. 2008. Catalase ameliorates polychlorinated biphenyl-induced cytotoxicity in nonmalignant human breast epithelial cells. Free Radic Biol Med 45(8):1094-1102. doi:10.1016/j.freeradbiomed.2008.07.007 PMID:18691649 PMCID:PMC2614346


  • Shaikh NS, Swenson DC, Lehmler H. 2006. 2,3,6-Trichloroiodobenzene. Acta Crystallogr B E62,Part10:o4672-o4673.
  • Vyas SM, Parkin S, Robertson LW, Lehmler H. 2006. 2,5-Dichloro-4'-methoxybiphenyl. Acta Crystallogr B E62,Part9:o4162-o4163.
  • Vyas SM, Parkin S, Robertson LW, Lehmler H. 2006. 4-Chloro-2',3'-dimethoxybiphenyl. Acta Crystallogr B E62,Part9:o3639-o3640.
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