Superfund Research Program

Research Support Core: Synthesis Core

Project Leader: Hans-Joachim Lehmler
Co-Investigator: Xueshu Li
Grant Number: P42ES013661
Funding Period: 2006-2025

Project-Specific Links

Publications

2024

• Griffin J, Li X, Lehmler H, Holland EB. 2024. Predicted versus observed activity of PCB mixtures toward the ryanodine receptor. Neurotoxicology 100:25-34. doi:10.1016/j.neuro.2023.12.003 PMID:38065417 PMCID:10842331

2023

• Behan-Bush RM, Liszewski JN, Schrodt MV, Vats B, Li X, Lehmler H, Klingelhutz AJ, Ankrum J. 2023. Toxicity impacts on human adipose mesenchymal stem/stronal cells acutely exposed to aroclor and non-aroclor mixtures of polychorinated biphenyl. Environ Sci Technol 57(4):1731-1742. doi:10.1021/acs.est.2c07281 PMID:36651682 PMCID:PMC9893815
• Bullert AJ, Li X, Chunyun Z, Lee K, Pulliam CF, Cagle B, Doorn JA, Klingelhutz AJ, Robertson LW, Lehmler H. 2023. Disposition and metabolomic effects of 2,2',5,5'-tetrachlorobiphenyl in female rats following intraperitoneal exposure. Environ Toxicol Pharmacol 102:104245. doi:10.1016/j.etap.2023.104245 PMID:37572994
• Gourronc FA, Chimenti MS, Lehmler H, Ankrum J, Klingelhutz AJ. 2023. Updating Dataset of transcriptomic changes that occur in human preadipocytes over a 3-day course of exposure to 3,3',4,4',5-pentachlorobiphenyl (PCB126) with additional data on exposure to 2,2',5,5'-tetrachlorobiphenyl (PCB52) or its 4-hydroxy metabolite (4-OH-PCB52). Data Brief 49:109415. doi:10.1016/j.dib.2023.109415 PMID:37520642 PMCID:PMC10375549
• Li X, Bullert AJ, Han W, Yang W, Zhang Q, Ding X, Lehmler H. 2023. Enantiomeric fractions reveal differences in the atroposelective disposition of 2,2',3,5',6-pentachlorobiphenyl (PCB 95) in wildtype, cyp2abfgs-null, and CYP2A6-humanized mice. Chem Res Toxicol doi:10.1021/acs.chemrestox.3c00128 PMID:37467352
• Mouat JS, Li X, Neier K, Zhu Y, Mordaunt CE, La Merrill MA, Lehmler H, Jones MP, Lein PJ, Schmidt RJ, LaSalle J. 2023. Networks of placental DNA methylation correlate with maternal serum PCB concentrations and child neurodevelopment. Environ Res 220:115227. doi:10.1016/j.envres.2023.115227 PMID:36608759
• Wang H, Bullert AJ, Li X, Stevens HE, Klingelhutz AJ, Ankrum J, Adamcakova-Dodd A, Thorne PS, Lehmler H. 2023. Use of a polymeric implant system to assess the neurotoxicity of subacute exposure to 2,2',5,5'-tetrachlorobiphenyl-4-ol, a human metabolite of PCB 52, in male adolescent rats. Toxicology 500:153677. doi:10.1016/j.tox.2023.153677 PMID:37995827 PMCID:PMC10757425
• Zhang C, Li X, Stietz KP, Sethi S, Yang W, Marek RF, Ding X, Lein PJ, Hornbuckle KC, Lehmler H. 2023. Rebuttal to correspondence on "machine learning-assisted identification and quantification of hydroxylated metabolites of polychlorinated biphenyls in animal samples". Environ Sci Technol 57(15):6251-6252. doi:10.1021/acs.est.3c01659 PMID:37017328

2022

• Eti N, Flor S, Iqbal K, Scott RL, Klenov V, Gibson-Corley KN, Soares M, Ludewig G, Robertson LW. 2022. PCB126 induced toxic actions on liver energy metabolism is mediated by AhR in rats. Toxicology 466:153054. doi:10.1016/j.tox.2021.153054 PMID:34848246 PMCID:PMC8748418
• Gourronc FA, Helm BK, Robertson LW, Chimenti MS, Lehmler H, Ankrum J, Klingelhutz AJ. 2022. Dataset of transcriptomic changes that occur in human preadipocytes over a 3-day course of exposure to 3,3',4,4',5-Pentachlorobiphenyl (PCB126). Data Brief 45:108571. doi:10.1016/j.dib.2022.108571 PMID:36131953 PMCID:PMC9483567
• Kennedy CL, Spiegelhoff A, Lavery T, Wang K, Manuel R, Wang Z, Wildermuth H, Stietz KP. 2022. Developmental polychlorinated biphenyl (PCB) exposure alters voiding physiology in young adult male and female mice. Am J Clin Exp Urol PMID:35528463 PMCID:PMC9077147
• Li X, Hefti MM, Marek RF, Hornbuckle KC, Wang K, Lehmler H. 2022. Assessment of polychlorinated biphenyls and their hydroxylated metabolites in postmortem human brain samples: Age and brain region differences. Environ Sci Technol 56(13):9515-9526. doi:10.1021/acs.est.2c00581 PMID:35658127 PMCID:PMC9260965
• Li X, Lim JJ, Wang K, Prasad B, Bhatt D, Cui JY, Lehmler H. 2022. The disposition of polychlorinated biphenyls (PCBs) differs between germ-free and conventional mice. Environ Toxicol Pharmacol 92:103854. doi:10.1016/j.etap.2022.103854 PMID:35331926 PMCID:PMC9090986
• Saktrakulkla P, Li X, Martinez A, Lehmler H, Hornbuckle KC. 2022. Hydroxylated polychlorinated biphenyls are emerging legacy pollutants in contaminated sediments. Environ Sci Technol 56:2269-2278. doi:10.1021/acs.est.1c04780 PMID:35107261 PMCID:PMC8851693
• Yaghoobi B, Miller GW, Holland EB, Li X, Harvey D, Li S, Lehmler H, Pessah IN, Lein PJ. 2022. Ryanodine receptor-active non-dioxin-like polychlorinated biphenyls cause neurobehavioral deficits in larval zebrafish. Front Toxicol 4:947795. doi:10.3389/ftox.2022.947795 PMID:36278027 PMCID:PMC9582434
• Zhang C, Li X, Flor S, Ruiz P, Kruve A, Ludewig G, Lehmler H. 2022. Metabolism of 3-chlorobiphenyl (PCB 2) in a human-relevant cell line: evidence of dechlorinated metabolites. Environ Sci Technol 56(17):12460-12472. doi:10.1021/acs.est.2c03687 PMID:35994059 PMCID:PMC9573771
• Zhang C, Li X, Stietz KP, Sethi S, Yang W, Marek RF, Ding X, Lein PJ, Hornbuckle KC, Joachim-Lehmler H. 2022. Machine learning-assisted identification and quantification of hydroxylated metabolites of polychlorinated biphenyls in animal samples. Environ Sci Technol 56(18):13169-13178. doi:10.1021/acs.est.2c02027 PMID:36047920

2021

• Duffel MW, Tuttle K, Lehmler H, Robertson LW. 2021. Human hepatic microsomal sulfatase catalyzes the hydrolysis of polychlorinated biphenyl sulfates: A potential mechanism for retention of hydroxylated PCBs. Environ Toxicol Pharmacol 88(6):103757. doi:10.1016/j.etap.2021.103757 PMID:34688910 PMCID:PMC8595862
• Keil KP, Kennedy CL, Sethi S, Valenzuela A, Nunez A, Wang K, Wang Z, Wang P, Spiegelhoff A, Puschner B, Bjorling DE, Lein PJ. 2021. In utero and lactational PCB exposure drives anatomic changes in the juvenile mouse bladder. Curr Res Toxicol 2:1-18. doi:10.1016/j.crtox.2021.01.002 PMID:34337439 PMCID:PMC8317607
• Klenov V, Flor S, Ganesan S, Adur M, Eti N, Iqbal K, Soares M, Ludewig G, Ross J, Robertson LW, Keating A. 2021. The aryl hydrocarbon receptor mediates reproductive toxicity of polychlorinated biphenyl congener 126 in rats. Toxicol Appl Pharmacol 426:115639. doi:10.1016/j.taap.2021.115639 PMID:34256052 PMCID:PMC8500329
• Li X, Liu Y, Martin JW, Cui JY, Lehmler H. 2021. Nontarget analysis reveals gut microbiome-dependent differences in the fecal PCB metabolite profiles of germ-free and conventional mice. Environ Pollut doi:10.1016/j.envpol.2020.115726 PMID:33032095 PMCID:PMC7746632
• Li Y, Bako CM, Saktrakulkla P, Lehmler H, Hornbuckle KC, Schnoor JL. 2021. Interconversion between methoxylated, hydroxylated and sulfated metabolites of PCB 3 in whole poplar plants. Sci Total Environ 785:147341. doi:10.1016/j.scitotenv.2021.147341 PMID:33933776 PMCID:PMC8610232
• Zhang C, Flor S, Ruiz P, Ludewig G, Lehmler H. 2021. Characterization of the metabolic pathways of 4-chlorobiphenyl (PCB3) in HepG2 cells using the metabolite profiles of its hydroxylated metabolites. Environ Sci Technol 55:9052-9062. doi:10.1021/acs.est.1c01076 PMID:34125531 PMCID:PMC8264946
• Zhang C, Klocke CR, Lein PJ, Lehmler H. 2021. Disposition of PCB 11 in mice following acute oral exposure. Chem Res Toxicol 34:988-991. doi:10.1021/acs.chemrestox.1c00067 PMID:33734669 PMCID:PMC8058299
• Zhang D, Saktrakulkla P, Tuttle K, Marek RF, Lehmler H, Wang K, Hornbuckle KC, Duffel MW. 2021. Detection and quantification of polychlorinated biphenyl sulfates in human serum. Environ Sci Technol 55:2473-2481. doi:10.1021/acs.est.0c06983 PMID:33502843 PMCID:PMC7924310

2020

• Dhakal RC, Li X, Parkin S, Lehmler H. 2020. Synthesis of mono- and dimethoxylated polychlorinated biphenyl derivatives starting from fluoroarene derivatives. Environ Sci Pollut Res Int 27:8905-8925. doi:10.1007/s11356-019-07133-3
• Egusquiza RJ, Ambrosio ME, Wang SG, Kay KM, Zhang C, Lehmler H, Blumberg B. 2020. Evaluating the role of the steroid and xenobiotic receptor (SXR/PXR) in PCB-153 metabolism and protection against associated adverse effects during perinatal and chronic exposure in mice. Environ Health Perspect 128:16. doi:10.1289/EHP6262 PMID:32352317 PMCID:PMC7228131
• Lim JJ, Li X, Lehmler H, Wang D, Gu H, Cui JY. 2020. Gut microbiome critically impacts PCB-induced changes in metabolic fingerprints and the hepatic transcriptome in mice. Toxicol Sci 177:168-187. doi:10.1093/toxsci/kfaa090 PMID:32544245 PMCID:PMC7553702
• Roy MA, Duche PR, Timme-Laragy AR. 2020. The sulfate metabolite of 3,3'-dichlorobiphenyl (PCB-11) impairs Cyp1a activity and increases hepatic neutral lipids in zebrafish larvae (Danio rerio). Chemosphere 260:doi:10.1016/j.chemosphere.2020.127609 PMID:32693259 PMCID:PMC7530052
• Wang H, Adamcakova-Dodd A, Flor S, Gosse L, Klenov V, Stolwijk J, Lehmler H, Hornbuckle KC, Ludewig G, Thorne PS. 2020. Comprehensive subchronic inhalation toxicity assessment of an indoor school air mixture of PCBs. Environ Sci Technol 54:15976-15985. doi:10.1021/acs.est.0c04470 PMID:33256405 PMCID:PMC7879961
• Williams AE, Watt J, Robertson LW, Gadupudi GS, Osborn ML, Soares M, Iqbal K, Pedersen KB, Shankar K, Littleton S, Maimone C, Eti N, Suva LJ, Ronis M. 2020. Skeletal toxicity of coplanar polychlorinated biphenyl congener 126 in the rat is aryl hydrocarbon receptor dependent. Toxicol Sci 175:113-125. doi:10.1093/toxsci/kfaa030 PMID:32119087 PMCID:PMC7197949

2019

• Dhakal RC, Parkin S, Lehmler H. 2019. 3,5-Dichloro-3 ,4 -dimethoxybiphenyl. IUCrData 4:doi:10.1107/S2414314619005182
• Gourronc FA, Perdew GH, Robertson LW, Klingelhutz AJ. 2019. PCB126 blocks the thermogenic beiging response of adipocytes. Environ Sci Pollut Res Int 27:doi:10.1007/s11356-019-06663-0 PMID:31721030 PMCID:PMC7098842
• Li X, Wu X, Kelly KM, Veng-Pedersen P, Lehmler H. 2019. Toxicokinetics of chiral PCB 136 and its hydroxylated metabolites in mice with a liver-specific deletion of cytochrome P450 reductase. Chem Res Toxicol 32:727-736. doi:10.1021/acs.chemrestox.8b00389 PMID:30729780 PMCID:PMC6465157
• Roy MA, Sant KE, Venezia OL, Shipman AB, McCormick SD, Saktrakulkla P, Hornbuckle KC, Timme-Laragy AR. 2019. The emerging contaminant 3,3'-dichlorobiphenyl (PCB-11) impedes Ahr activation and Cyp1a activity to modify embryotoxicity of Ahr ligands in the zebrafish embryo model (Danio rerio). Environ Pollut 254:113027. doi:10.1016/j.envpol.2019.113027 PMID:31421573 PMCID:PMC7027435
• Saktrakulkla P, Dhakal RC, Lehmler H, Hornbuckle KC. 2019. A semi-target analytical method for quantification of OH-PCBs in environmental samples. Environ Sci Pollut Res Int 1-13. doi:10.1007/s11356-019-05775-x PMID:31359319 PMCID:PMC6986979
• Sethi S, Morgan RK, Feng W, Lin Y, Li X, Luna C, Koch M, Bansal R, Duffel MW, Puschner B, Zoeller RT, Lehmler H, Pessah IN, Lein PJ. 2019. Comparative analyses of the 12 most abundant PCB congeners detected in human maternal serum for activity at the thyroid hormone receptor and ryanodine receptor. Environ Sci Technol 53:3948-3958. doi:10.1021/acs.est.9b00535 PMID:30821444 PMCID:PMC6457253
• Subramanian S, Tehrani R, Van Aken B. 2019. Transcriptomic response of Arabidopsis thaliana exposed to hydroxylated polychlorinated biphenyls (OH-PCBs). Int J Phytoremediation 21(1):52-59. doi:10.1080/15226514.2018.1523872 PMID:30648423 PMCID:PMC6548195
• Uwimana E, Ruiz P, Li X, Lehmler H. 2019. Human CYP2A6, CYP2B6, and CYP2E1 atropselectively metabolize polychlorinated biphenyls to hydroxylated metabolites. Environ Sci Technol 53(4):2114-2123. doi:10.1021/acs.est.8b05250 PMID:30576102 PMCID:PMC6380921

2018

• Alam S, Carter GS, Krager KJ, Li X, Lehmler H, Aykin-Burns N. 2018. PCB11 metabolite, 3,3-dichlorobiphenyl-4-ol, exposure alters the expression of genes governing fatty acid metabolism in the absence of functional sirtuin 3: examining the contribution of MnSOD. Antioxidants (Basel) 7(9):121. doi:10.3390/antiox7090121 PMID:30223548
• Cheng SL, Li X, Lehmler H, Phillips B, Shen D, Cui JY. 2018. Gut microbiota modulates interactions between polychlorinated biphenyls and bile acid homeostasis. Toxicol Sci 166:269-287. doi:10.1093/toxsci/kfy208 PMID:30496569 PMCID:PMC6260149
• Das S, Oldham E, Lehmler H, Knutson BL, Rankin S. 2018. Tuning the position of head groups by surfactant design in mixed micelles of cationic and carbohydrate surfactants. Journal of Colloid and Interface Science 517:428-438. doi:10.1016/j.jcis.2017.10.066 PMID:29096103
• Dhakal K, Gadupudi GS, Lehmler H, Ludewig G, Duffel MW, Robertson LW. 2018. Sources and toxicities of phenolic polychlorinated biphenyls (OH-PCBs). Environ Sci Pollut Res Int 25:16277-16290. doi:10.1007/s11356-017-9694-x PMID:28744683 PMCID:PMC5785587
• Gadupudi GS, Elser BA, Sandgruber FA, Li X, Gibson-Corley KN, Robertson LW. 2018. PCB126 inhibits the activation of AMPK-CREB signal transduction required for energy sensing in liver. Toxicol Sci 163:440-453. doi:10.1093/toxsci/kfy041 PMID:29474705 PMCID:PMC5974782
• Gourronc FA, Robertson LW, Klingelhutz AJ. 2018. A delayed proinflammatory response of human preadipocytes to PCB126 is dependent on the aryl hydrocarbon receptor. Environ Sci Pollut Res Int 25:16481-16492. doi:10.1007/s11356-017-9676-z PMID:28699004 PMCID:PMC5764822
• Klaren WD, Vine D, Vogt S, Robertson LW. 2018. Spatial distribution of metals within the liver acinus and their perturbation by PCB126. Environ Sci Pollut Res Int 25(17):16427-16433. doi:10.1007/s11356-017-0202-0 PMID:28940161 PMCID:PMC5866157
• Li X, Holland EB, Feng W, Zheng J, Dong Y, Pessah IN, Duffel MW, Robertson LW, Lehmler H. 2018. Authentication of synthetic environmental contaminants and their (bio)transformation products in toxicology: polychlorinated biphenyls as an example. Environ Sci Pollut Res Int 25(17):1-14. doi:10.1007/s11356-017-1162-0 PMID:29322390 PMCID:PMC6015536
• Li X, Parkin S, Lehmler H. 2018. Absolute configuration of 2,2',3,3',6-pentachlorinatedbiphenyl (PCB 84) atropisomers. Environ Sci Pollut Res Int 25:16402-16410. doi:10.1007/s11356-017-9259-z PMID:28537024 PMCID:PMC5823790
• Liu Y, Richardson ES, Derocher AE, Lunn NJ, Lehmler H, Li X, Zhang Y, Cui JY, Cheng L, Martin JW. 2018. Hundreds of unrecognized halogenated contaminants discovered in polar bear serum. Angew Chem Int Ed Engl 57:16401-16406. doi:10.1002/anie.201809906 PMID:30376612
• Parker VS, Squirewell EJ, Lehmler H, Robertson LW, Duffel MW. 2018. Hydroxylated and sulfated metabolites of commonly occurring airborne polychlorinated biphenyls inhibit human steroid sulfotransferases SULT1E1 and SULT2A1. Environ Toxicol Pharmacol 58:196-201. doi:10.1016/j.etap.2018.01.010 PMID:29408762 PMCID:PMC6078096
• Pencikova K, Svrzkova L, Strapacova S, Neca J, Bartonkova I, Dvorak Z, Hyzdalova M, Pivnicka J, Palkova L, Lehmler H, Li X, Vondracek J, Machala M. 2018. In vitro profiling of toxic effects of prominent environmental lower-chlorinated PCB congeners linked with endocrine disruption and tumor promotion. Environ Pollut 237:473-486. doi:10.1016/j.envpol.2018.02.067 PMID:29518658 PMCID:PMC5908724
• Rodriguez EA, Vanle BC, Doorn JA, Lehmler H, Robertson LW, Duffel MW. 2018. Hydroxylated and sulfated metabolites of commonly observed airborne polychlorinated biphenyls display selective uptake and toxicity in N27, SH-SY5Y, and HepG2 cells. Environ Toxicol Pharmacol 62:69-78. doi:10.1016/j.etap.2018.06.010 PMID:29986280 PMCID:PMC609219
• Sethi S, Keil KP, Lein PJ. 2018. 3,3-Dichlorobiphenyl (PCB 11) promotes dendritic arborization in primary rat cortical neurons via a CREB-dependent mechanism. Arch Toxicol 1-9. doi:10.1007/s00204-018-2307-8 PMID:30225637 PMCID:PMC6196112
• Uwimana E, Li X, Lehmler H. 2018. Human liver microsomes atropselectively metabolize 2,2 ',3,4 ',6-pentachlorobiphenyl (PCB 91) to a 1,2-shift product as the major metabolite. Environ Sci Technol 52:6000-6008. doi:10.1021/acs.est.8b00612 PMID:29659268 PMCID:PMC5966832

2017

• Das S, Xu W, Lehmler H, Miller A, Knutson BL, Rankin S. 2017. Inverted micelle-in-micelle configuration in cationic/carbohydrate surfactant mixtures. Chemphyschem 18(1):79-86. doi:10.1002/cphc.201600908 PMID:27788284
• Grimm FA, Lehmler H, Koh W, DeWall J, Teesch LM, Hornbuckle KC, Thorne PS, Robertson LW, Duffel MW. 2017. Identification of a sulfate metabolite of PCB 11 in human serum. Environ Int 98:120-128. doi:10.1016/j.envint.2016.10.023 PMID:27816204 PMCID:PMC5127762
• Holland EB, Feng W, Zheng J, Dong Y, Li X, Lehmler H, Pessah IN. 2017. An extended structure-activity relationship of nondioxin-like PCBs evaluates and supports modeling predictions and identifies picomolar potency of PCB 202 towards ryanodine receptors. Toxicol Sci 155(1):170-181. doi:10.1093/toxsci/kfw189 PMID:27655348 PMCID:PMC5216651
• Joshi S, Lehmler H, Knutson BL, Rankin S. 2017. Imprinting of Stöber particles for chirally-resolved adsorption of target monosaccharides and disaccharides. New J Chem 20(41):11525-11532. doi:10.1039/C7NJ01938F
• Kania-Korwel I, Lukasiewicz T, Barnhart CD, Stamou M, Chung H, Kelly KM, Bandiera SM, Lein PJ, Lehmler H. 2017. Congener-specific disposition of chiral polychlorinated biphenyls in lactating mice and their offspring: Implications for PCB developmental neurotoxicity. Toxicol Sci 158(1):101-115. doi:10.1093/toxsci/kfx071 PMID:28431184 PMCID:PMC6070089
• Kania-Korwel I, Wu X, Wang K, Lehmler H. 2017. Identification of lipidomic markers of chronic 3,3 ,4,4 ,5-pentachlorobiphenyl (PCB 126) exposure in the male rat liver. Toxicology 390:124-134. doi:10.1016/j.tox.2017.09.005 PMID:28890136 PMCID:PMC5633524
• Klinefelter K, Hoover MK, Bates C, Colter BT, Dailey A, Infante SK, Kania-Korwel I, Lehmler H, Lopez-Juarez A, Ludwig CP, Curran CP. 2017. Genetic differences in the aryl hydrocarbon receptor and CYP1A2 affect sensitivity to developmental polychlorinated biphenyl exposure in mice: relevance to studies of human neurological disorders. Mamm Genome 1-16. doi:10.1007/s00335-017-9728-1 PMID:29197979
• Liu B, Lehmler H, Sun Y, Xu G, Sun Q, Hu F, Wallace RB, Boa W, Hu FB, Zhong G, Liu Y. 2017. Bisphenol A substitutes and obesity in US adults: analysis of a population-based, cross-sectional study. Lancet Planet Health 1(3):e114-e122. doi:10.1016/S2542-5196(17)30049-9 PMID:29308453 PMCID:PMC5751959
• Marek RF, Thorne PS, Herkert N, Awad AM, Hornbuckle KC. 2017. Airborne PCBs and OH-PCBs inside and outside urban and rural U.S. schools. Environ Sci Technol 51(14):7853-7860. doi:10.1021/acs.est.7b01910 PMID:28656752 PMCID:PMC5777175
• Schroer HW, Langenfeld KL, Li X, Lehmler H, Just CL. 2017. Biotransformation of 2,4-dinitroanisole by a fungal Penicillium sp. Biodegradation 28(1):95-109. doi:10.1007/s10532-016-9780-7 PMID:27913891
• Sethi S, Keil KP, Chen H, Hayakawa K, Li X, Lin Y, Lehmler H, Puschner B, Lein PJ. 2017. Detection of 3,3 '-dichlorobiphenyl in human maternal plasma and its effects on axonal and dendritic growth in primary rat neurons. Toxicol Sci 158(2):401-411. doi:10.1093/toxsci/kfx100 PMID:28510766 PMCID:PMC5837364
• Zhao H, Lehmler H, Chen J, Liu S, Cai X. 2017. Antibiotic pollution in marine food webs in laizhou bay, north China: trophodynamics and human exposure implication. Environ Sci Technol 51(4):doi:10.1021/acs.est.6b04556 PMID:28106989 PMCID:PMC5618103
• . 2017. Atropisomers of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) exhibit stereoselective effects on activation of nuclear receptors in vitro. Environ Sci Pollut Res Int 25(17):1-9. doi:10.1007/s11356-017-0683-x PMID:29124635 PMCID:PMC5943194

2016

• Flor S, He X, Lehmler H, Ludewig G. 2016. Estrogenicity and androgenicity screening of PCB sulfate monoesters in human breast cancer MCF-7 cells. Environ Sci Pollut Res Int 23(3):2186-2200. doi:10.1007/s11356-015-5142-y PMID:26300354 PMCID:PMC4718780
• Gadupudi GS, Klaren WD, Olivier AK, Klingelhutz AJ, Robertson LW. 2016. PCB126-induced disruption in gluconeogenesis and fatty acid oxidation precedes fatty liver in male rats. Toxicol Sci 149(1):98-110. doi:10.1093/toxsci/kfv215 PMID:26396156 PMCID:PMC4731404
• Gadupudi GS, Klingelhutz AJ, Robertson LW. 2016. Diminished phosphorylation of CREB is a key event in the dysregulation of gluconeogenesis and glycogenolysis in PCB126 hepatotoxicity. Chem Res Toxicol 29(9):1504-1509. doi:10.1021/acs.chemrestox.6b00172 PMID:27509375
• Kania-Korwel I, Lehmler H. 2016. Chiral polychlorinated biphenyls: absorption, metabolism and excretion--a review. Environ Sci Pollut Res Int 23(3):2042-2057. doi:10.1007/s11356-015-4150-2 PMID:25651810 PMCID:PMC4527964
• Kania-Korwel I, Lehmler H. 2016. Toxicokinetics of chiral polychlorinated biphenyls across different species--a review. Environ Sci Pollut Res Int 23(3):2058-2080. doi:10.1007/s11356-015-4383-0 PMID:25824003 PMCID:PMC4591098
• Klaren WD, Gibson-Corley KN, Wels B, Simmons DL, McCormick ML, Spitz DR, Robertson LW. 2016. Assessment of the mitigative capacity of dietary zinc on PCB126 hepatotoxicity and the contribution of zinc to toxicity. Chem Res Toxicol 29(5):851-859. doi:10.1021/acs.chemrestox.6b00022 PMID:26967026 PMCID:PMC5100827
• Koh WX, Hornbuckle KC, Marek RF, Wang K, Thorne PS. 2016. Hydroxylated polychlorinated biphenyls in human sera from adolescents and their mothers living in two US Midwestern communities. Chemosphere 147:389-395. doi:10.1016/j.chemosphere.2015.12.113 PMID:26774304 PMCID:PMC4747419
• Li M, Teesch LM, Murry DJ, Pope RM, Li Y, Robertson LW, Ludewig G. 2016. Cytochrome c adducts with PCB quinoid metabolites. Environ Sci Pollut Res Int 23(3):2148-2159. doi:10.1007/s11356-015-4801-3 PMID:26062463 PMCID:PMC4676959
• Ma C, Zhai G, Wu H, Kania-Korwel I, Lehmler H, Schnoor JL. 2016. Identification of a novel hydroxylated metabolite of 2,2',3,5',6-pentachlorobiphenyl formed in whole poplar plants. Environ Sci Pollut Res Int 23(3):2089-2098. doi:10.1007/s11356-015-5939-8 PMID:26676542 PMCID:PMC4718877
• Rodriguez EA, Li X, Lehmler H, Robertson LW, Duffel MW. 2016. Sulfation of lower chlorinated polychlorinated biphenyls increases their affinity for the major drug-binding sites of human serum albumin. Environ Sci Technol 50(10):5320-5327. doi:10.1021/acs.est.6b00484 PMID:27116425 PMCID:PMC4883002
• Shen H, Robertson LW, Ludewig G. 2016. Regulatory effects of dioxin-like and non-dioxin-like PCBs and other AhR ligands on the antioxidant enzymes paraoxonase 1/2/3. Environ Sci Pollut Res Int 23(3):2108-2118. doi:10.1007/s11356-015-4722-1 PMID:26006071 PMCID:PMC4662644
• Uwimana E, Li X, Lehmler H. 2016. 2,2',3,5',6-Pentachlorobiphenyl (PCB 95) is atropselectively metabolized to para-hydroxylated metabolites by human liver microsomes. Chem Res Toxicol 29(12):2108-2110. doi:10.1021/acs.chemrestox.6b00371 PMID:27989147 PMCID:PMC5175585
• Wang B, Klaren WD, Wels B, Simmons DL, Olivier AK, Wang K, Robertson LW, Ludewig G. 2016. Dietary manganese modulates PCB126 toxicity, metal status, and MnSOD in the rat. Toxicol Sci 150(1):15-26. doi:10.1093/toxsci/kfv312 PMID:26660635 PMCID:PMC5009614
• Wu X, Lehmler H. 2016. Effects of thiol antioxidants on the atropselective oxidation of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) by rat liver microsomes. Environ Sci Pollut Res Int 23(3):2081-2088. doi:10.1007/s11356-015-4987-4 PMID:26155892 PMCID:PMC4706823
• Wu X, Yang J, Morisseau C, Robertson LW, Hammock BD, Lehmler H. 2016. 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) decreases hepatic and systemic ratios of epoxide to diol metabolites of unsaturated fatty acids in male rats. Toxicol Sci 152(2):309-322. doi:10.1093/toxsci/kfw084 PMID:27208083 PMCID:PMC4960907

2015

• Gadupudi GS, Gourronc FA, Ludewig G, Robertson LW, Klingelhutz AJ. 2015. PCB126 inhibits adipogenesis of human preadipocytes. Toxicol In Vitro 29(1):132-141. doi:10.1016/j.tiv.2014.09.015 PMID:25304490 PMCID:PMC4250299
• Grimm FA, He X, Teesch LM, Lehmler H, Robertson LW, Duffel MW. 2015. Tissue distribution, metabolism, and excretion of 3,3'-dichloro-4'-sulfooxy-biphenyl in the rat. Environ Sci Technol 49(13):8087-8095. doi:10.1021/acs.est.5b01499 PMID:26046945 PMCID:PMC4496304
• Grimm FA, Hu D, Kania-Korwel I, Lehmler H, Ludewig G, Hornbuckle KC, Duffel MW, Bergman A, Robertson LW. 2015. Metabolism and metabolites of polychlorinated biphenyls. Crit Rev Toxicol 45(3):245-272. doi:10.3109/10408444.2014.999365 PMID:25629923 PMCID:PMC4383295
• Grimm FA, Lehmler H, He X, Robertson LW, Duffel MW. 2015. Modulating inhibitors of transthyretin fibrillogenesis via sulfation: polychlorinated biphenyl sulfates as models. Chem Biol Interact 228:1-8. doi:10.1016/j.cbi.2015.01.002 PMID:25595224 PMCID:PMC4327905
• Hu X, Adamcakova-Dodd A, Lehmler H, Gibson-Corley KN, Thorne PS. 2015. Toxicity evaluation of exposure to an atmospheric mixture of polychlorinated biphenyls by nose-only and whole-body inhalation regimens. Environ Sci Technol 49(19):11875-11883. doi:10.1021/acs.est.5b02865 PMID:26348937 PMCID:PMC4711378
• Klaren WD, Gadupudi GS, Wels B, Simmons DL, Olivier AK, Robertson LW. 2015. Progression of micronutrient alteration and hepatotoxicity following acute PCB126 exposure. Toxicology 338:1-7. doi:10.1016/j.tox.2015.09.004 PMID:26410179 PMCID:PMC4658301
• Oldham E, Nunes LM, Varela-Ramirez A, Rankin S, Knutson BL, Aguilera RJ, Lehmler H. 2015. Cytotoxic activity of triazole-containing alkyl β-D-glucopyranosides on a human T-cell leukemia cell line. Chem Cent J 9:3. doi:10.1186/s13065-014-0072-1 PMID:25705252 PMCID:PMC4333309
• Stamou M, Uwimana E, Flannery BM, Kania-Korwel I, Lehmler H, Lein PJ. 2015. Subacute nicotine co-exposure has no effect on 2,2',3,5',6- pentachlorobiphenyl disposition but alters hepatic cytochrome P450 expression in the male rat. Toxicology 338:59-68. doi:10.1016/j.tox.2015.10.002 PMID:26463278 PMCID:PMC4658283
• Wu X, Barnhart CD, Lein PJ, Lehmler H. 2015. Hepatic metabolism affects the atropselective disposition of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) in mice. Environ Sci Technol 49(1):616-625. doi:10.1021/es504766p PMID:25420130 PMCID:PMC4291784

2014

• Aqil F, Shen H, Jeyabalan J, Xin X, Lehmler H, Ludewig G, Robertson LW, Gupta RC. 2014. Sustained expression of CYPs and DNA adduct accumulation with continuous exposure to PCB126 and PCB153 through a new delivery method: Polymeric implants. Toxicol Rep 1:820-833. doi:10.1016/j.toxrep.2014.09.010 PMID:25530946 PMCID:PMC4266188
• Dhakal K, Uwimana E, Adamcakova-Dodd A, Thorne PS, Lehmler H, Robertson LW. 2014. Disposition of phenolic and sulfated metabolites after inhalation exposure to 4-chlorobiphenyl (PCB3) in female rats. Chem Res Toxicol 27(8):1411-1420. doi:10.1021/tx500150h PMID:24988477 PMCID:PMC4137987
• Ekuase EJ, Lehmler H, Robertson LW, Duffel MW. 2014. Binding interactions of hydroxylated polychlorinated biphenyls (OHPCBs) with human hydroxysteroid sulfotransferase hSULT2A1. Chem Biol Interact 212:56-64. doi:10.1016/j.cbi.2014.01.018 PMID:24508592 PMCID:PMC3994546
• Hu X, Adamcakova-Dodd A, Thorne PS. 2014. The fate of inhaled (14)C-labeled PCB11 and its metabolites in vivo. Environ Int 63:92-100. doi:10.1016/j.envint.2013.10.017 PMID:24275706 PMCID:PMC3950335
• Li X, Parkin S, Lehmler H. 2014. 2,4-Di-chloro-1-iodo-6-nitro-benzene. Acta Crystallogr B 70(Pt5):o607. doi:10.1107/S1600536814008733 PMID:24860400 PMCID:PMC4011245
• Stamou M, Wu X, Kania-Korwel I, Lehmler H, Lein PJ. 2014. Cytochrome p450 mRNA expression in the rodent brain: species-, sex-, and region-dependent differences. Drug Metab Dispos 42(2):239-244. doi:10.1124/dmd.113.054239 PMID:24255117 PMCID:PMC3912540
• Staudt S, Kundu S, Lehmler H, He X, Cui T, Lin Y, Kristensen K, Glasius M, Zhang X, Weber R, Surratt JD, Stone EA. 2014. Aromatic organosulfates in atmospheric aerosols: synthesis, characterization, and abundance. Atmos Environ (1994) 94:366-373. doi:10.1016/j.atmosenv.2014.05.049 PMID:24976783 PMCID:PMC4071301
• Sueyoshi T, Li L, Wang H, Moore R, Kodavanti PS, Lehmler H, Negishi M, Birnbaum LS. 2014. Flame retardant BDE-47 effectively activates nuclear receptor CAR in human primary hepatocytes. Toxicol Sci 137(2):292-302. doi:10.1093/toxsci/kft243 PMID:24218150 PMCID:PMC3908718
• Vorrink SU, Hudachek DR, Domann FE. 2014. Epigenetic determinants of CYP1A1 induction by the aryl hydrocarbon receptor agonist 3,3',4,4',5-pentachlorobiphenyl (PCB 126). Int J Mol Sci 15(8):13916-13931. doi:10.3390/ijms150813916 PMID:25116688 PMCID:PMC4159831
• Vorrink SU, Sarsour EH, Olivier AK, Robertson LW, Goswami PC, Domann FE. 2014. PCB 126 perturbs hypoxia-induced HIF-1α activity and glucose consumption in human HepG2 cells. Exp Toxicol Pathol 66(8):377-382. doi:10.1016/j.etp.2014.05.005 PMID:24916446 PMCID:PMC4143452
• Vorrink SU, Severson PL, Kulak MV, Futscher BW, Domann FE. 2014. Hypoxia perturbs aryl hydrocarbon receptor signaling and CYP1A1 expression induced by PCB 126 in human skin and liver-derived cell lines. Toxicol Appl Pharmacol 274(3):408-416. doi:10.1016/j.taap.2013.12.002 PMID:24355420 PMCID:PMC3919493
• Wu X, Kammerer A, Lehmler H. 2014. Microsomal oxidation of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) results in species-dependent chiral signatures of the hydroxylated metabolites. Environ Sci Technol 48(4):2436-2444. doi:10.1021/es405433t PMID:24467194 PMCID:PMC3983324
• Yang DR, Kania-Korwel I, Ghogha A, Chen H, Stamou M, Bose DD, Pessah IN, Lehmler H, Lein PJ. 2014. PCB 136 atropselectively alters morphometric and functional parameters of neuronal connectivity in cultured rat hippocampal neurons via ryanodine receptor-dependent mechanisms. Toxicol Sci 138(2):379-392. doi:10.1093/toxsci/kft334 PMID:24385416 PMCID:PMC4007107
• Zhai G, Lehmler H, Schnoor JL, Gutowski SM. 2014. Enantioselective transport and biotransformation of chiral hydroxylated metabolites of polychlorinated biphenyls in whole poplar plants. Environ Sci Technol 48(20):12213-12220. doi:10.1021/es503443e PMID:25238141 PMCID:PMC4207536

2013

• Dhakal K, Adamcakova-Dodd A, Lehmler H, Thorne PS, Robertson LW. 2013. Sulfate conjugates are urinary markers of inhalation exposure to 4-chlorobiphenyl (PCB3). Chem Res Toxicol 26(6):853-855. doi:10.1021/tx4001539 PMID:23713983 PMCID:PMC3703249
• Grimm FA, Lehmler H, He X, Robertson LW, Duffel MW. 2013. Sulfated metabolites of polychlorinated biphenyls are high-affinity ligands for the thyroid hormone transport protein transthyretin. Environ Health Perspect 121(6):657-662. doi:10.1289/ehp.1206198 PMID:23584369 PMCID:PMC3672920
• Hu X, Lehmler H, Adamcakova-Dodd A, Thorne PS. 2013. Elimination of inhaled 3,3'-dichlorobiphenyl and the formation of the 4-hydroxylated metabolite. Environ Sci Technol 47(9):4743-4751. doi:10.1021/es3049114 PMID:23582014 PMCID:PMC3962796
• Kania-Korwel I, Lehmler H. 2013. Chlordane and heptachlor are metabolized enantioselectively by rat liver microsomes. Environ Sci Technol 47(15):8913–8922. doi:10.1021/es401916a PMID:23799267 PMCID:PMC3748599
• Lehmler H, He X, Duffel MW, Parkin S. 2013. 3,4',5-Trichloro-biphenyl-4-yl 2,2,2-trichloro-ethyl sulfate. Acta Crystallogr B 69(Pt4):o620. doi:10.1107/S1600536813007976 PMID:23634142 PMCID:PMC3629655
• Lehmler H, He X, Li X, Duffel MW, Parkin S. 2013. Effective synthesis of sulfate metabolites of chlorinated phenols. Chemosphere 93(9):1965-1971. doi:10.1016/j.chemosphere.2013.06.087 PMID:23906814 PMCID:PMC3815985
• Lehmler H, Wu H, Parkin S. 2013. 2,2',5',6-Tetra-chloro-4-[(1S)-1-methyl-prop-oxy]biphen-yl. Acta Crystallogr B 69:o983. doi:10.1107/S1600536813014098 PMID:23795135 PMCID:PMC3685116
• Lehmler H, Wu H, Parkin S. 2013. 5,5'-Dichloro-2,2'-dimeth-oxy-biphen-yl. Acta Crystallogr B 69:o650. doi:10.1107/S160053681300826X PMID:23723814 PMCID:PMC3647848
• Lu Z, Kania-Korwel I, Lehmler H, Wong CS. 2013. Stereoselective formation of mono- and dihydroxylated polychlorinated biphenyls by rat cytochrome P450 2B1. Environ Sci Technol doi:10.1021/es402838f PMID:24060104 PMCID:PMC3870094
• Niknam Y, Feng W, Cherednichenko G, Dong Y, Joshi SN, Vyas SM, Lehmler H, Pessah IN. 2013. Structure-activity relationship of selected meta- and para-hydroxylated non-dioxin like polychlorinated biphenyls: from single RyR1 channels to muscle dysfunction. Toxicol Sci 136(2):500-513. doi:10.1093/toxsci/kft202 PMID:24014653 PMCID:PMC3858193
• Qin X, Lehmler H, Teesch LM, Robertson LW, Duffel MW. 2013. Chlorinated biphenyl quinones and phenyl- 2,5-benzoquinone differentially modify the catalytic activity of human hydroxysteroid sulfotransferase hSULT2A1. Chem Res Toxicol 26(10):1474-1485. doi:10.1021/tx400207q PMID:24059442 PMCID:PMC3846294
• Rignall B, Grote K, Gavrilov A, Weimer M, Kopp-Schneider A, Krause E, Appel KE, Buchmann A, Robertson LW, Lehmler H, Kania-Korwel I, Chahoud I, Schwarz M. 2013. Biological and tumor-promoting effects of dioxin-like and non-dioxin-like polychlorinated biphenyls in mouse liver after single or combined treatment. Toxicol Sci 133(1):29-41. doi:10.1093/toxsci/kft034 PMID:23457121 PMCID:PMC3627557
• Wu X, Duffel MW, Lehmler H. 2013. Oxidation of polychlorinated biphenyls by liver tissue slices from phenobarbital-pretreated mice is congener-specific and atropselective. Chem Res Toxicol 26(11):16421651. doi:10.1021/tx400229e PMID:24107130 PMCID:PMC3857157
• Wu X, Kania-Korwel I, Chen H, Stamou M, Dammanahalli KJ, Duffel MW, Lein PJ, Lehmler H. 2013. Metabolism of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) atropisomers in tissue slices from phenobarbital or dexamethasone-induced rats is sex-dependent. Xenobiotica 43(11):933-947. doi:10.3109/00498254.2013.785626 PMID:23581876 PMCID:PMC3878182
• Zhai G, Lehmler H, Schnoor JL. 2013. Inhibition of cytochromes p450 and the hydroxylation of 4-monochlorobiphenyl in whole poplar. Environ Sci Technol 47(13):6829-6835. doi:10.1021/es304298m PMID:23320482 PMCID:PMC3652898
• Zhai G, Lehmler H, Schnoor JL. 2013. Sulfate Metabolites of 4-monochlorobiphenyl in whole poplar plants. Environ Sci Technol 47:557-562. doi:10.1021/es303807f PMID:23215248 PMCID:PMC3565590
• Zhai G, Wu X, Lehmler H, Schnoor JL. 2013. Atropisomeric determination of chiral hydroxylated metabolites of polychlorinated biphenyls using HPLC-MS. Chem Cent J 7(1):183. doi:10.1186/1752-153X-7-183 PMID:24360245 PMCID:PMC3879188
• Zhu Y, Mapuskar KA, Marek RF, Xu W, Lehmler H, Robertson LW, Hornbuckle KC, Spitz DR, Aykin-Burns N. 2013. A new player in environmentally induced oxidative stress: polychlorinated biphenyl congener, 3,3'-dichlorobiphenyl (PCB11). Toxicol Sci 136(1):39-50. doi:10.1093/toxsci/kft186 PMID:23997111 PMCID:PMC3829572

2012

• Dhakal K, He X, Lehmler H, Teesch LM, Duffel MW, Robertson LW. 2012. Identification of sulfated metabolites of 4-chlorobiphenyl (PCB3) in the serum and urine of male rats. Chem Res Toxicol 25(12):2796-2804. doi:10.1021/tx300416v PMID:23137097 PMCID:PMC3524396

2011

• Ekuase EJ, Liu Y, Lehmler H, Robertson LW, Duffel MW. 2011. Structure-activity relationships for hydroxylated polychlorinated biphenyls as inhibitors of the sulfation of dehydroepiandrosterone catalyzed by human hydroxysteroid sulfotransferase SULT2A1. Chem Res Toxicol 24:1720-1728. doi:10.1021/tx200260h PMID:21913674 PMCID:PMC3196794
• Joshi SN, Vyas SM, Duffel MW, Parkin S, Lehmler H. 2011. Synthesis of sterically hindered polychlorinated biphenyl derivatives. Synthesis 7:1045-1054. doi:10.1055/s-0030-1258454 PMID:21516177 PMCID:PMC3080045
• Joshi SN, Vyas SM, Wu H, Duffel MW, Parkin S, Lehmler H. 2011. Regioselective iodination of chlorinated aromatic compounds using silver salts. Tetrahedron 67(39):7461-7469. doi:10.1016/j.tet.2011.07.064 PMID:21918585 PMCID:PMC3170769
• Liu Y, Lehmler H, Robertson LW, Duffel MW. 2011. Physicochemical properties of hydroxylated polychlorinated biphenyls aid in predicting their interactions with rat sulfotransferase 1A1 (rSULT1A1). Chem Biol Interact 189:153-160. doi:10.1016/j.cbi.2010.11.009 PMID:21130751 PMCID:PMC3032042
• Senthilkumar PK, Klingelhutz AJ, Jacobus JA, Lehmler H, Robertson LW, Ludewig G. 2011. Airborne polychlorinated biphenyls (PCBs) reduce telomerase activity and shorten telomere length in immortal human skin keratinocytes (HaCat). Toxicol Lett 204:64-70. doi:10.1016/j.toxlet.2011.04.012 PMID:21530622 PMCID:PMC3109099
• Song Y, Ambati J, Parkin S, Rankin S, Robertson LW, Lehmler H. 2011. Crystal structure and density functional theory studies of toxic quinone metabolites of polychlorinated biphenyls. Chemosphere 85:386-392. doi:10.1016/j.chemosphere.2011.07.004 PMID:21824639 PMCID:PMC3206982
• Zhai G, Lehmler H, Schnoor JL, Hu D. 2011. Enantioselective biotransformation of chiral PCBs in whole poplar plants. Environ Sci Technol 45(6):2308-2316. doi:10.1021/es1033662 PMID:21329345 PMCID:PMC3066656

2010

• Chan K, Lehmler H, Sivagnanam M, Yan Feng C, Robertson LW, O'Brien P. 2010. Cytotoxic effects of polychlorinated biphenyl hydroquinone metabolites in rat hepatocytes. J Appl Toxicol 30:163-171. doi:10.1002/jat.1483 PMID:19830680
• Chan K, Parkin S, Lehmler H. 2010. 1-Bromo-2,3,6-trichloro-4,5-dimethoxy-benzene. Acta Crystallogr B E66:o487. doi:10.1107/S1600536810002977 PMID:21579894 PMCID:PMC2979667
• Hu X, Adamcakova-Dodd A, Lehmler H, Hu D, Kania-Korwel I, Hornbuckle KC, Thorne PS. 2010. Time course of congener uptake and elimination in rats after short-term inhalation exposure to an airborne polychlorinated biphenyl (PCB) mixture. Environ Sci Technol 44(17):6893-6900. doi:10.1021/es101274b PMID:20698547 PMCID:PMC3408216
• Kania-Korwel I, El-Komy MH, Veng-Pedersen P, Lehmler H. 2010. Clearance of polychlorinated biphenyl atropisomers is enantioselective in female C57BI/6 mice. Environ Sci Technol 44(8):2828-2835. doi:10.1021/es901781p PMID:20384376 PMCID:PMC2855138
• Lehmler H, Harrad SJ, Huhnerfuss H, Kania-Korwel I, Lee CM, Lu Z, Wong CS. 2010. Chiral polychlorinated biphenyl transport, metabolism, and distribution: a review. Environ Sci Technol 44(8):2757-2766. doi:10.1021/es902208u PMID:20384371 PMCID:PMC2855137
• Lehmler H, Martinez A, Wang K, Hornbuckle KC, Hu D. 2010. Atmospheric PCB congeners across Chicago. Atmos Environ (1994) 44(12):1550-1557. doi:10.1016/j.atmosenv.2010.01.006 PMID:21918637 PMCID:PMC3171135
• Li X, Parkin S, Duffel MW, Robertson LW, Lehmler H. 2010. 3',4'-Dichlorobiphenyl-4-yl 2,2,2- trichloroethyl sulfate. Acta Crystallogr B E66:o1615-o1616. doi:10.1107/S1600536810020362 PMID:21587847 PMCID:PMC3006693
• Li X, Parkin S, Duffel MW, Robertson LW, Lehmler H. 2010. 4 '-Chlorobiphenyl-3-yl 2,2,2-trichloroethyl sulfate. Acta Crystallogr B 66:O2306-U305. doi:10.1107/s1600536810031338 PMID:25681997 PMCID:PMC3008081
• Li X, Parkin S, Duffel MW, Robertson LW, Lehmler H. 2010. An efficient approach to sulfate metabolites of polychlorinated biphenyls. Environ Int 36:843-848. doi:10.1016/j.envint.2009.02.005 PMID:19345419 PMCID:PMC2939219
• Li X, Parkin S, Duffel MW, Robertson LW, Lehmler H. 2010. Biphenyl-4-yl 2,2,2-trichloroethyl sulfate. Acta Crystallogr B E66:o1073. doi:10.1107/S1600536810012845 PMID:21579128 PMCID:PMC2979148
• Milanowski B, Luiek J, Lehmler H, Kania-Korwel I. 2010. Assessment of the disposition of chiral polychlorinated biphenyls in female mdr 1a/b knockout versus wild-type mice using multivariate analyses. Environ Int 36:884-892. doi:10.1016/j.envint.2009.10.007 PMID:19923000 PMCID:PMC2891895
• Song Y, Parkin S, Lehmler H. 2010. 1-Bromo-2-chloro-4,5-dimethoxybenzene. Acta Crystallogr B 66:o813. doi:10.1107/S1600536810008445 PMID:21580645 PMCID:PMC2984005
• Song Y, Parkin S, Lehmler H. 2010. 1-Bromo-4-chloro-2,5-dimethoxy­benzene. Acta Crystallogr B E66:o339. doi:10.1107/S1600536810000504 PMID:21579768 PMCID:PMC2979742
• Telu S, Parkin S, Robertson LW, Lehmler H. 2010. Improved syntheses of non-dioxin-like polychlorinated biphenyls (PCBs) and some of their sulfur-containing metabolites. Environ Int 36:828-834. doi:10.1016/j.envint.2009.01.013 PMID:19261331 PMCID:PMC2948577
• Zhai G, Lehmler H, Schnoor JL. 2010. Hydroxylated metabolites of 4-monochlorobiphenyl and its metabolic pathway in whole poplar plants. Environ Sci Technol 44(10):3901-3907. doi:10.1021/es100230m PMID:20402517 PMCID:PMC2891041
• Zhai G, Lehmler H, Schnoor JL. 2010. Identification of hydroxylated metabolites of 3,3 ',4,4 '-tetrachlorobiphenyl and metabolic pathway in whole poplar plants. Chemosphere 81:523-528. doi:10.1016/j.chemosphere.2010.07.036 PMID:20708213 PMCID:PMC2943055
• Zhao H, Adamcakova-Dodd A, Hu D, Hornbuckle KC, Just CL, Robertson LW, Thorne PS, Lehmler H. 2010. Development of a synthetic PCB mixture resembling the average polychlorinated biphenyl profile in Chicago air. Environ Int 36(8):819-827. doi:10.1016/j.envint.2009.03.003 PMID:19375801 PMCID:PMC2888912

2009

• Klosener J, Peters TM, Adamcakova-Dodd A, Teesch LM, Thorne PS, Robertson LW, Luthe G. 2009. Innovative application of fluoro tagging to trace airborne particulate and gas-phase polybrominated diphenyl ether exposures. Chem Res Toxicol 22(1):179-186. doi:10.1021/tx8003032 PMID:19111055 PMCID:PMC3120107
• Pessah IN, Lehmler H, Robertson LW, Perez CF, Cabrales E, Bose DD, Feng W. 2009. Enantiomeric specificity of (-)-2,2',3,3',6,6'-hexachlorobiphenyl toward ryanodine receptor types 1 and 2. Chem Res Toxicol 22(1):201-207. doi:10.1021/tx800328u PMID:18954145 PMCID:PMC2662366
• Wangpradit O, Teesch LM, Mariappan S, Duffel MW, Norstrom K, Robertson LW, Luthe G. 2009. Oxidation of 4-chlorobiphenyl metabolites to electrophilic species by prostaglandin H synthase. Chem Res Toxicol 22(1):64-71. doi:10.1021/tx800300t PMID:19105592 PMCID:PMC2637223

2008

• Glauert HP, Tharappel JC, Banerjee S, Chan NL, Kania-Korwel I, Lehmler H, Lee EY, Robertson LW, Spear BT. 2008. Inhibition of the promotion of hepatocarcinogenesis by 2,2',4,4',5,5'-hexachlorobiphenyl (PCB-153) by the deletion of the p50 subunit of NF-kappa B in mice. Toxicol Appl Pharmacol 232(2):302-308. doi:10.1016/j.taap.2008.06.013 PMID:18644402 PMCID:PMC2583134
• Kania-Korwel I, Hrycay EG, Bandiera SM, Lehmler H. 2008. 2,2',3,3',6,6'-Hexachlorobiphenyl (PCB 136) atropisomers interact enantioselectively with hepatic microsomal cytochrome P450 enzymes. Chem Res Toxicol 21(6):1295-1303. doi:10.1021/tx800059j PMID:18494506 PMCID:PMC2574739
• Kania-Korwel I, Vyas SM, Song Y, Lehmler H. 2008. Gas chromatographic separation of methoxylated polychlorinated biphenyl atropisomers. J Chromatogr A 1207:146-154. PMID:18760792
• Kania-Korwel I, Zhao H, Norstrom K, Li X, Hornbuckle KC, Lehmler H. 2008. Simultaneous extraction and clean-up of polychlorinated biphenyls and their metabolites from small tissue samples using pressurized liquid extraction. J Chromatogr A 1214(1-2):37-46. doi:10.1016/j.chroma.2008.10.089 PMID:19019378 PMCID:PMC2648864
• Liu J, Schnoor JL. 2008. Uptake and translocation of lesser-chlorinated polychlorinated biphenyls (PCBs) in whole hybrid poplar plants after hydroponic exposure. Chemosphere 73(10):1608-1616. doi:10.1016/j.chemosphere.2008.08.009 PMID:18793792 PMCID:PMC2668963
• Song Y, Buettner GR, Parkin S, Wagner BA, Robertson LW, Lehmler H. 2008. Chlorination increases the persistence of semiquinone free radicals derived from polychlorinated biphenyl hydroquinones and quinones. J Org Chem 73(21):8296-8304. doi:10.1021/jo801397g PMID:18839991 PMCID:PMC2629131
• Tharappel JC, Lehmler H, Srinivasan C, Robertson LW, Spear BT, Glauert HP. 2008. Effect of antioxidant phytochemicals on the hepatic tumor promoting activity of 3,3',4,4'-tetrachlorobiphenyl (PCB-77). Food Chem Toxicol 46(11):3467-3474. doi:10.1016/j.fct.2008.08.023 PMID:18796325 PMCID:PMC2597727
• Venkatesha VA, Venkataraman S, Sarsour EH, Kalen AL, Buettner GR, Robertson LW, Lehmler H, Goswami PC. 2008. Catalase ameliorates polychlorinated biphenyl-induced cytotoxicity in nonmalignant human breast epithelial cells. Free Radic Biol Med 45(8):1094-1102. doi:10.1016/j.freeradbiomed.2008.07.007 PMID:18691649 PMCID:PMC2614346

2006

• Shaikh NS, Swenson DC, Lehmler H. 2006. 2,3,6-Trichloroiodobenzene. Acta Crystallogr B E62,Part10:o4672-o4673.
• Vyas SM, Parkin S, Robertson LW, Lehmler H. 2006. 2,5-Dichloro-4'-methoxybiphenyl. Acta Crystallogr B E62,Part9:o4162-o4163.
• Vyas SM, Parkin S, Robertson LW, Lehmler H. 2006. 4-Chloro-2',3'-dimethoxybiphenyl. Acta Crystallogr B E62,Part9:o3639-o3640.