Superfund Research Program
Research Support Core: Synthesis Core
Project Leader: Hans-Joachim Lehmler
Co-Investigator: Xueshu Li
Grant Number: P42ES013661
Funding Period: 2006-2025
Project-Specific Links
Title: RNAseq of zebrafish (Danio rerio) developmentally exposed to the polychlorinated biphenyl 3,3'-dichlorobiphenyl (PCB-11)
Accession Number: GSE118955
Link to Dataset: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE118955
Repository: Gene Expression Omnibus (GEO)
Data Type(s): Gene Expression
Experiment Type(s): Expression profiling by high throughput sequencing
Organism(s): Danio rerio
Summary: 3,3’-Dichlorobiphenyl (PCB-11) is a non-legacy PCB congener widely detected in environmental samples and has been detected in human serum, but its toxicity potential is poorly understood. Zebrafish statically exposed to 4,500 µg/L PCB-11 at 24 hours post fertilization (hpf) were collected at 96 hpf for RNA sequencing.
Publication(s) associated with this dataset:- Roy MA, Sant KE, Venezia OL, Shipman AB, McCormick SD, Saktrakulkla P, Hornbuckle KC, Timme-Laragy AR. 2019. The emerging contaminant 3,3'-dichlorobiphenyl (PCB-11) impedes Ahr activation and Cyp1a activity to modify embryotoxicity of Ahr ligands in the zebrafish embryo model (Danio rerio). Environ Pollut 254:113027. doi:10.1016/j.envpol.2019.113027 PMID:31421573 PMCID:PMC7027435