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University of Iowa: Dataset Details, ID=GSE118955

Superfund Research Program

Research Support Core: Synthesis Core

Project Leader: Hans-Joachim Lehmler
Co-Investigator: Xueshu Li
Grant Number: P42ES013661
Funding Period: 2006-2025
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Title: RNAseq of zebrafish (Danio rerio) developmentally exposed to the polychlorinated biphenyl 3,3'-dichlorobiphenyl (PCB-11)

Accession Number: GSE118955

Link to Dataset:

Repository: Gene Expression Omnibus (GEO)

Data Type(s): Gene Expression

Experiment Type(s): Expression profiling by high throughput sequencing

Organism(s): Danio rerio

Summary: 3,3’-Dichlorobiphenyl (PCB-11) is a non-legacy PCB congener widely detected in environmental samples and has been detected in human serum, but its toxicity potential is poorly understood. Zebrafish statically exposed to 4,500 µg/L PCB-11 at 24 hours post fertilization (hpf) were collected at 96 hpf for RNA sequencing.

Publication(s) associated with this dataset:
  • Roy MA, Sant KE, Venezia OL, Shipman AB, McCormick SD, Saktrakulkla P, Hornbuckle KC, Timme-Laragy AR. 2019. The emerging contaminant 3,3'-dichlorobiphenyl (PCB-11) impedes Ahr activation and Cyp1a activity to modify embryotoxicity of Ahr ligands in the zebrafish embryo model (Danio rerio). Environ Pollut 254:113027. doi:10.1016/j.envpol.2019.113027 PMID:31421573 PMCID:PMC7027435
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