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Your Environment. Your Health.

Progress Reports: University of California-Davis: Development and Application of Integrated In Vitro and Cell-Based Bioassays

Superfund Research Program

Development and Application of Integrated In Vitro and Cell-Based Bioassays

Project Leader: Michael S. Denison
Co-Investigator: Isaac N. Pessah
Grant Number: P42ES004699
Funding Period: 1995-2015
View this project in the NIH Research Portfolio Online Reporting Tools (RePORT)

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Progress Reports

Year:   2016  2014  2013  2012  2011  2010  2009  2008  2007  2006  2005  2004  2001  2000  1999  1998  1997  1996  1995 

Protecting human health from environmental hazard is necessary to understand how xenobiotics affect health. This project continues to used its EPA-approved cell bioassay system called the Estrogen Receptor-Chemically Activated Luciferase Expression (ER-CALUX) for the detection of compounds that interfere with a person's hormones in waterways but also on indoor dusts at kindergartens. This bioassay allows identification of chemicals that react with the estrogen receptor, but cannot individually identify the particular chemical. Nonetheless, this method was used on products labeled BPA-free and found that those products still leached the same or more chemicals possessing estrogenic activity as those that contained BPA. This evidence was provided to the collaborating Center for Environmental Health (CEH) in efforts to encourage the chemical and product manufacturing companies to reevaluate their processes and testing procedures. Separately, it was observed that exposure to xenobiotics increase cellular stresses, especially mitochondrial oxidative stress and endoplasmic reticulum stress, which have been associated with various chronic illnesses such as cardiovascular diseases, diabetes, metabolic syndrome, organ failure and Alzheimer. This project continues to obtain tools and knowledge to predict toxic effects from chronic exposure to low levels of xenobiotics.

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