Skip Navigation

Project Publications: University of California-Davis: Development and Application of Integrated In Vitro and Cell-Based Bioassays

Superfund Research Program

Development and Application of Integrated In Vitro and Cell-Based Bioassays

Project Leader: Michael S. Denison
Co-Investigator: Isaac N. Pessah
Grant Number: P42ES004699
Funding Period: 1995-2015
View this project in the NIH Research Portfolio Online Reporting Tools (RePORT)

Project-Specific Links

Connect with the Grant Recipients

Visit the grantee's eNewsletter page Visit the grantee's Facebook page



  • Holland EB, Pessah IN. 2021. Non-dioxin-like polychlorinated biphenyl neurotoxic equivalents found in environmental and human samples. Regul Toxicol Pharmacol 120:104842. doi:10.1016/j.yrtph.2020.104842 PMID:33346014
  • My TT, Dat ND, Van Langenhove K, Denison MS, Long HT, Elskens M. 2021. Evaluation of the dioxin-like toxicity in soil samples from Thua Thien Hue province using the AhR-CALUX bioassay - An update of Agent Orange contamination in Vietnam. Ecotoxicol Environ Saf 212:111971. doi:10.1016/j.ecoenv.2021.111971 PMID:33513480
  • Tomasek I, Damby DE, Andronico D, Baxter PJ, Boonen I, Claeys P, Denison MS, Horwell CJ, Kervyn M, Kueppers U, Romanias MN, Elskens M. 2021. Assessing the biological reactivity of organic compounds on volcanic ash: Implications for human health hazard. Bull Volcanol 83:11. doi:10.1007/s00445-021-01453-4
  • Zhao F, Wang S, Wang J, Wang Y, Li Y, Zhang C, Li Y, Huang L, Yu Y, Zheng J, Yu B, Pessah IN, Cao Z. 2021. Surfactant cocamide monoethanolamide causes eye irritation by activating nociceptor TRPV1 channels. Br J Pharmacol 178(17):doi:10.1111/bph.15491 PMID:33837959 (ahead of print)


  • Aleman M, Zhang R, Feng W, Qi L, Lopez JR, Crowe C, Dong Y, Cherednichenko G, Pessah IN. 2020. Dietary Caffeine Synergizes Adverse Peripheral and Central Responses to Anesthesia in Malignant Hyperthermia Susceptible Mice. Mol Pharmacol 98:351-363. doi:10.1124/mol.120.119412 PMID:32764093 PMCID:PMC7491310


  • Pessah IN, Lein PJ, Seegal R, Sagiv SK. 2019. Neurotoxicity of polychlorinated biphenyls and related organohalogens. Acta Neuropathol 138(3):363-387. doi:10.1007/s00401-019-01978-1 PMID:30976975 PMCID:PMC6708608
  • Vandermarken T, Boonen I, Gryspeirt C, Croes K, Van Den Houwe K, Denison MS, Gaoa Y, Van Hoeck E, Elskens M. 2019. Assessment of estrogenic compounds in paperboard for dry food packaging with the ERE-CALUX bioassay. Chemosphere 221:99-106. doi:10.1016/j.chemosphere.2018.12.192 PMID:30634153
  • Zheng J, Chen J, Zou X, Zhao F, Guo M, Wang H, Zhang TC, Zhang C, Feng W, Pessah IN, Cao Z. 2019. Saikosaponin d causes apoptotic death of cultured neocortical neurons by increasing membrane permeability and elevating intracellular Ca2+ concentration. Neurotoxicology 70:112-121. doi:10.1016/j.neuro.2018.11.006 PMID:30458186 PMCID:PMC6342622
  • Zheng J, Yu Y, Feng W, Li J, Liu J, Zhang C, Dong Y, Pessah IN, Cao Z. 2019. Influence of nanomolar deltamethrin on the hallmarks of primary cultured cortical neuronal network and the role of ryanodine receptors. Environ Health Perspect 127(6):67003. doi:10.1289/EHP4583 PMID:31166131 PMCID:PMC6792378


  • Vandermarken T, Croes K, Van Langenhove K, Boonen I, Servais P, Garcia-Armisen T, Brion N, Denison MS, Goeyens L, Elskens M. 2018. Endocrine activity in an urban river system and the biodegradation of estrogen-like endocrine disrupting chemicals through a bio-analytical approach using DRE- and ERE-CALUX bioassays. Chemosphere 201:540-549. doi:10.1016/j.chemosphere.2018.03.036 PMID:29533803
  • Vandermarken T, Gaoa Y, Baeyens W, Denison MS, Croes K. 2018. Dioxins, furans and dioxin-like PCBs in sediment samples and suspended particulate matter from the Scheldt estuary and the North Sea Coast: comparison of CALUX concentration levels in historical and recent samples. Sci Total Environ 626:109-116. doi:10.1016/j.scitotenv.2018.01.084 PMID:29335165


  • Feng W, Zheng J, Robin G, Dong Y, Ichikawa M, Inoue Y, Mori T, Nakano T, Pessah IN. 2017. Enantioselectivity of 2,2 ',3,5 ',6-Pentachlorobiphenyl (PCB 95) Atropisomers toward Ryanodine Receptors (RyRs) and their influences on hippocampal neuronal networks. Environ Sci Technol 51:14406-14416. doi:10.1021/acs.est.7b04446 PMID:29131945
  • Guo W, Van Langenhove K, Denison MS, Baeyens W, Elskens M, Gao Y. 2017. Estrogenic activity measurements in water using diffusive gradients in thin-film coupled with an estrogen bioassay. Anal Chem 89:13357-13364. doi:10.1021/acs.analchem.7b03537 PMID:29151339
  • Holland EB, Feng W, Zheng J, Dong Y, Li X, Lehmler H, Pessah IN. 2017. An extended structure-activity relationship of nondioxin-like PCBs evaluates and supports modeling predictions and identifies picomolar potency of PCB 202 towards ryanodine receptors. Toxicol Sci 155(1):170-181. doi:10.1093/toxsci/kfw189 PMID:27655348 PMCID:PMC5216651
  • Khedidji S, Croes K, Yassaa N, Ladji R, Denison MS, Baeyens W, Elskens M. 2017. Assessment of dioxin-like activity in PM10 air samples from an industrial location in Algeria, using the DRE-CALUX bioassay. Environ Sci Pollut Res Int 24(13):11868–11877. doi:10.1007/s11356-015-5841-4 PMID:26611627
  • Mehinto AC, VanDervort DR, Lao W, He G, Denison MS, Vliet SM, Volz DC, Mazor RD, Maruya KA. 2017. High throughput in vitro and in vivo screening of inland waters of Southern California. Environ Sci Process Impacts 19:1142-1149. doi:10.1039/c7em00170c PMID:28612856


  • Ahn K, Ranganathan A, Bever C, Hwang SH, Holland EB, Morisseau K, Pessah IN, Hammock BD, Gee SJ. 2016. Detection of the antimicrobial triclosan in environmental samples by immunoassay. Environ Sci Technol 50(7):3754-3761. doi:10.1021/acs.est.5b05357 PMID:26937944 PMCID:PMC4821808
  • Cole BJ, Brander SM, Jeffries KM, Hasenbein S, He G, Denison MS, Fangue NA, Connon RE. 2016. Changes in Menidia beryllina gene expression and in vitro hormone-receptor activation after exposure to estuarine waters near treated wastewater outfalls. Arch Environ Contam Toxicol 71(2):210-223. doi:10.1007/s00244-016-0282-8 PMID:27155869 PMCID:PMC4772679
  • Denison MS, Croes K, Van den Heuvel R, Van den Bril B, Van Langenhove K, Staelens J, Vandermarken T, Elskens M. 2016. Assessment of estrogenic and androgenic activity in PM10 air samples from an urban, industrial and rural area in Flanders (Belgium) using the CALUX bioassay. Environ Res 150:66-72. doi:10.1016/j.envres.2016.05.044 PMID:27257826
  • Joshi G, Schmidt R, Denison MS, Hristova KR. 2016. Effect of benzene and ethylbenzene on the transcription of methyl-tert-butyl ether degradation genes of Methylibium petroleiphilum PM1. Microbiology 162(9):1563-1571. doi:10.1099/mic.0.000338 PMID:27450417 PMCID:PMC4459789
  • Ronjat M, Feng W, Dardevet L, Dong Y, Khoury SA, Chatelain F, Vialla V, Chahboun S, Lesage F, Darbon H, Pessah IN, De Waard M. 2016. In cellulo phosphorylation induces pharmacological reprogramming of maurocalcin, a cell-penetrating venom peptide. Proc Natl Acad Sci U S A 113(17):E2460-E2468. doi:10.1073/pnas.1517342113 PMID:27071086 PMCID:PMC4855579
  • Simon C, Onghena M, Covaci A, Hoeck EV, Loco JV, Vandermarken T, Langenhove KV, Demaegdt H, Mertens B, Vandermeiren K, Scippo M, Elskens M. 2016. Screening of endocrine activity of compounds migrating from plastic baby bottles using a multi-receptor panel of in vitro bioassays. Toxicol In Vitro 37:121-133. doi:10.1016/j.tiv.2016.09.008 PMID:27633901
  • Vandermarken T, de Galan S, Croes K, Van Langenhove K, Vercammen J, Sanctorum H, Denison MS, Goeyens L, Elskens M, Baeyens W. 2016. Characterisation and implementation of the ERE-CALUX bioassay on indoor dust samples of kindergartens to assess estrogenic potencies. Psychiatr Pol 155(PtB):182-189. doi:10.1016/j.jsbmb.2015.01.005 PMID:25595043


  • Bittner GD, Denison MS, Yang CZ, Stoner MA, He G. 2015. Chemicals having estrogenic activity can be released from some bisphenol A-free, hard and clear, thermoplastic resins. Environ Health 13:103. doi:10.1186/1476-069X-13-103 PMID:25477047 PMCID:PMC4298073
  • Cao Z, Zou X, Cui Y, Hulsizer S, Lein PJ, Wulff H, Pessah IN. 2015. Rapid throughput analysis demonstrates that chemicals with distinct seizurogenic mechanisms differentially alter Ca2+ dynamics in networks formed by hippocampal neurons in culture. Mol Pharmacol 87(4):595-605. doi:10.1124/mol.114.096701 PMID:25583085 PMCID:PMC4366799
  • DeGroot DE, Franks DG, Higa T, Tanaka J, Hahn ME, Denison MS. 2015. Naturally occurring marine brominated indoles are aryl hydrocarbon receptor ligands/agonists. Chem Res Toxicol 28(6):1176-1185. doi:10.1021/acs.chemrestox.5b00003 PMID:26001051 PMCID:PMC4469569
  • Flannery BM, Silverman JL, Bruun DA, Puhger KR, McCoy MR, Hammock BD, Crawley JN, Lein PJ. 2015. Behavioral assessment of NIH Swiss mice acutely intoxicated with tetramethylenedisulfotetramine. Neurotoxicol Teratol 47:36-45. doi:10.1016/ PMID:25446016 PMCID:PMC4291292
  • Fritsch EB, Stegeman JJ, Goldstone JV, Nacci DE, Champlin D, Jayaraman S, Connon RE, Pessah IN. 2015. Expression and function of ryanodine receptor related pathways in PCB tolerant Atlantic killifish (Fundulus heteroclitus) from New Bedford Harbor, MA, USA. Aquat Toxicol 159:156-166. doi:10.1016/j.aquatox.2014.12.017 PMID:25546006 PMCID:PMC4300256
  • Joshi G, Schmidt R, Scow KM, Denison MS, Hristova KR. 2015. Gene mdpC plays a regulatory role in the methyl-tert-butyl ether degradation pathway of Methylibium petroleiphilum strain PM1. FEMS Microbiol Lett 362(7):doi:10.1093/femsle/fnv029 PMID:25724531 PMCID:PMC4459789
  • Samokhvalov V, Zlobine I, Jamieson KL, Jurasz P, Chen C, Lee KS, Hammock BD, Seubert JM. 2015. PPARδ signaling mediates the cytotoxicity of DHA in H9c2 cells. Toxicol Lett 232(1):10-20. doi:10.1016/j.toxlet.2014.09.029 PMID:25300478 PMCID:PMC4486642
  • Yang J, Bratt J, Franzi L, Liu J, Zhang G, Zeki AA, Vogel CF, Williams K, Dong H, Lin Y, Hwang SH, Kenyon NJ, Hammock BD. 2015. Soluble epoxide hydrolase inhibitor attenuates inflammation and airway hyperresponsiveness in mice. Am J Respir Cell Mol Biol 52(1):46-55. doi:10.1165/rcmb.2013-0440OC PMID:24922186 PMCID:PMC4370250


  • Addeck A, Croes K, Van Langenhove K, Denison MS, Afify AS, Gao Y, Elskens M, Baeyens W. 2014. Time-integrated monitoring of dioxin-like polychlorinated biphenyls (dl-PCBs) in aquatic environments using the ceramic toximeter and the CALUX bioassay. Talanta 120:413-418. doi:10.1016/j.talanta.2013.12.017 PMID:24468390 PMCID:PMC4379351
  • Addeck A, Croes K, Van Langenhove K, Denison MS, Elhamalawy A, Elskens M, Baeyens W. 2014. Time-integrated monitoring of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans (PCDD/Fs) in urban and industrial wastewaters using a ceramic toximeter and the CALUX bioassay. Chemosphere 94:27-35. doi:10.1016/j.chemosphere.2013.08.075 PMID:24075528 PMCID:PMC4308619
  • Altamirano F, Eltit JM, Robin G, Linares N, Ding X, Pessah IN, Allen PD, Lopez JR. 2014. Ca2+ Influx via the Na+/Ca2+ exchanger is enhanced in malignant hyperthermia skeletal muscle. J Biol Chem 289:19180-19190. doi:10.1074/jbc.M114.550764 PMID:24847052 PMCID:PMC4081953
  • Bettaieb A, Chahed S, Tabet G, Yang J, Morisseau C, Griffey S, Hammock BD, Haj FG. 2014. Effects of soluble epoxide hydrolase deficiency on acute pancreatitis in mice. PLoS One 9(11):e113019. doi:10.1371/journal.pone.0113019 PMID:25402489 PMCID:PMC4234494
  • Burmistrov V, Morisseau C, Lee KS, Shihadih DS, Harris TR, Butov GM, Hammock BD. 2014. Symmetric adamantyl-diureas as soluble epoxide hydrolase inhibitors. Bioorg Med Chem Lett 24(9):2193-2197. doi:10.1016/j.bmcl.2014.03.016 PMID:24685540 PMCID:PMC4019751
  • Cao Z, Cui Y, Nguyen HM, Jenkins D, Wulff H, Pessah IN. 2014. Nanomolar bifenthrin alters synchronous Ca2+ oscillations and cortical neuron development independent of sodium channel activity. Mol Pharmacol 85(4):630-639. doi:10.1124/mol.113.090076 PMID:24482397 PMCID:PMC3965893
  • Charles RL, Rudyk O, Prysyazhna O, Kamynina A, Yang J, Morisseau C, Hammock BD, Freeman BA, Eaton P. 2014. Protection from hypertension in mice by the Mediterranean diet is mediated by nitro fatty acid inhibition of soluble epoxide hydrolase. Proc Natl Acad Sci U S A 111(22):8167-8172. doi:10.1073/pnas.1402965111 PMID:24843165 PMCID:PMC4050620
  • DeGroot DE, Denison MS. 2014. Nucleotide specificity of DNA binding of the aryl hydrocarbon receptor: ARNT complex is unaffected by Ligand structure. Toxicol Sci 137(1):102-113. doi:10.1093/toxsci/kft234 PMID:24136190 PMCID:PMC3924043
  • DeGroot DE, Hayashi A, Denison MS. 2014. Lack of ligand-selective binding of the aryl hydrocarbon receptor to putative DNA binding sites regulating expression of Bax and paraoxonase 1 genes. Arch Biochem Biophys 541:13-20. doi:10.1016/ PMID:24200861 PMCID:PMC3875388
  • Despa S, Sharma S, Harris TR, Dong H, Li N, Chiamvimonvat N, Taegtmeyer H, Margulies KB, Hammock BD, Despa F. 2014. Cardioprotection by controlling hyperamylinemia in a "humanized" diabetic rat model. J Am Heart Assoc 3(4):doi:10.1161/JAHA.114.001015 PMID:25146704 PMCID:PMC4310392
  • Gardell AM, Qin Q, Rice RH, Li J, Kültz D. 2014. Derivation and osmotolerance characterization of three immortalized tilapia (Oreochromis mossambicus) cell lines. PLoS One 9(5):e95919. doi:10.1371/journal.pone.0095919 PMID:24797371 PMCID:PMC4010420
  • Kim J, Imig JD, Yang J, Hammock BD, Padanilam BJ. 2014. Inhibition of soluble epoxide hydrolase prevents renal interstitial fibrosis and inflammation. Am J Physiol Renal Physiol 307(8):F971-F980. doi:10.1152/ajprenal.00256.2014 PMID:25164080 PMCID:PMC4200297
  • Kujal P, Chabova VC, Skaroupkova P, Huskova Z, Vernerova Z, Kramer HJ, Walkowska A, Kompanowska-Jezierska E, Sadowski J, Kitada K, Nishiyama A, Hwang SH, Hammock BD, Imig JD, Cervenka L. 2014. Inhibition of soluble epoxide hydrolase is renoprotective in 5/6 nephrectomized Ren-2 transgenic hypertensive rats. Clin Exp Pharmacol Physiol 41(3):227-237. doi:10.1111/1440-1681.12204 PMID:24471737 PMCID:PMC4038339
  • Laatsch CN, Durbin-Johnson BP, Rocke DM, Mukwana S, Newland AB, Flagler MJ, Davis MG, Eigenheer RA, Phinney BS, Rice RH. 2014. Human hair shaft proteomic profiling: individual differences, site specificity and cuticle analysis. PeerJ 2:e506. doi:10.7717/peerj.506 PMID:25165623 PMCID:PMC4137660
  • Lee KS, Liu J, Wagner KM, Pakhomova S, Dong H, Morisseau C, Fu SH, Yang J, Wang P, Ulu A, Mate CA, Nguyen LV, Hwang SH, Edin ML, Mara AA, Wulff H, Newcomer ME, Zeldin DC, Hammock BD. 2014. Optimized inhibitors of soluble epoxide hydrolase improve in vitro target residence time and in vivo efficacy. J Med Chem 57(16):7016-7030. doi:10.1021/jm500694p PMID:25079952 PMCID:PMC4148150
  • Lesiak A, Zhu M, Chen H, Appleyard SM, Impey S, Lein PJ, Wayman GA. 2014. The environmental neurotoxicant PCB 95 promotes synaptogenesis via ryanodine receptor-dependent miR132 upregulation. J Neurosci 34(3):717-725. doi:10.1523/jneurosci.2884-13.2014 PMID:24431430 PMCID:PMC3891953
  • Morisseau C, Wecksler AT, Deng C, Dong H, Yang J, Lee KS, Kodani SD, Hammock BD. 2014. Effect of soluble epoxide hydrolase polymorphism on substrate and inhibitor selectivity and dimer formation. J Lipid Res 55(6):1131-1138. doi:10.1194/jlr.M049718 PMID:24771868 PMCID:PMC4031944
  • Ono E, Dutile S, Kazani S, Weschsler ME, Yang J, Hammock BD, Douda DN, Tabet Y, Khaddaj-Mallat R, Sirois M, Sirois C, Rizcallah E, Rousseau E, Martin R, Sutherland E, Castro M, Jarjour NN, Israel E, Levy BD. 2014. Lipoxin generation is related to soluble epoxide hydrolase activity in severe asthma. Am J Respir Crit Care Med 190(8):886-897. doi:10.1164/rccm.201403-0544OC PMID:25162465 PMCID:PMC4299578
  • Schebb N, Muvvala JB, Morin D, Buckpitt AR, Hammock BD, Rice RH. 2014. Metabolic activation of the antibacterial agent triclocarban by cytochrome P450 1A1 yielding glutathione adducts. Drug Metab Dispos 42(7):1098-1102. doi:10.1124/dmd.114.058206 PMID:24733789 PMCID:PMC4170114
  • Schebb N, Ostermann AI, Yang J, Hammock BD, Hahn A, Schuchardt J. 2014. Comparison of the effects of long-chain omega-3 fatty acid supplementation on plasma levels of free and esterified oxylipins. Prostaglandins Other Lipid Mediat 113-115:21-29. doi:10.1016/j.prostaglandins.2014.05.002 PMID:24880049 PMCID:PMC4247815
  • Soshilov AA, Denison MS. 2014. Ligand promiscuity of aryl hydrocarbon receptor agonists and antagonists revealed by site-directed mutagenesis. Mol Cell Biol 34(9):1707-1719. doi:10.1128/MCB.01183-13 PMID:24591650 PMCID:PMC3993610
  • Sporkova A, Jichova S, Huskova Z, Kopkan L, Nishiyama A, Hwang SH, Hammock BD, Imig JD, Kompanowska-Jezierska E, Sadowski J, Kramer HJ, Cervenka L. 2014. Different mechanisms of acute versus long-term antihypertensive effects of soluble epoxide hydrolase inhibition: studies in Cyp1a1-Ren-2 transgenic rats. Clin Exp Pharmacol Physiol 41(12):1003-1013. doi:10.1111/1440-1681.12310 PMID:25224811 PMCID:PMC4347520
  • Sundberg JP, Awgulewitsch A, Pruett ND, Potter CS, Silva KA, Stearns TM, Sundberg BA, Munoz MW, Cuasnicu PS, King LE, Rice RH. 2014. Crisp1 and alopecia areata in C3H/HeJ mice. Exp Mol Pathol 97(3):525-528. doi:10.1016/j.yexmp.2014.10.010 PMID:25446841 PMCID:PMC4262666
  • Ulu A, Lee S, Miyabe C, Yang J, Hammock BG, Dong H, Hammock BD. 2014. An omega-3 epoxide of docosahexaenoic acid lowers blood pressure in angiotensin-II-dependent hypertension. J Cardiovasc Pharmacol 64(1):87-99. doi:10.1097/FJC.0000000000000094 PMID:24691274 PMCID:PMC4092041
  • Wagner KM, Vito S, Inceoglu B, Hammock BD. 2014. The role of long chain fatty acids and their epoxide metabolites in nociceptive signaling. Prostaglandins Other Lipid Mediat 113-115:2-12. doi:10.1016/j.prostaglandins.2014.09.001 PMID:25240260 PMCID:PMC4254344
  • Wagner KM, Yang J, Inceoglu B, Hammock BD. 2014. Soluble epoxide hydrolase inhibition is antinociceptive in a mouse model of diabetic neuropathy. J Pain 15(9):907-914. doi:10.1016/j.jpain.2014.05.008 PMID:24924124 PMCID:PMC4150748
  • Wang W, Zhu J, Lyu F, Panigrahy D, Ferrara KW, Hammock BD, Zhang G. 2014. ω-3 polyunsaturated fatty acids-derived lipid metabolites on angiogenesis, inflammation and cancer. Prostaglandins Other Lipid Mediat 113-115:13-20. doi:10.1016/j.prostaglandins.2014.07.002 PMID:25019221 PMCID:PMC4306447
  • Wecksler AT, Hwang SH, Wettersten HI, Gilda JE, Patton A, Leon LJ, Carraway KL, Gomes AV, Baar K, Weiss RH, Hammock BD. 2014. Novel sorafenib-based structural analogues: in-vitro anticancer evaluation of t-MTUCB and t-AUCMB. Anticancer Drugs 25(4):433-446. doi:10.1097/CAD.0000000000000079 PMID:24525589 PMCID:PMC3947856
  • Xu J, Morisseau C, Hammock BD. 2014. Expression and characterization of an epoxide hydrolase from Anopheles gambiae with high activity on epoxy fatty acids. Insect Biochem Mol Biol 54:42-52. doi:10.1016/j.ibmb.2014.08.004 PMID:25173592 PMCID:PMC4252830
  • Yang DR, Kania-Korwel I, Ghogha A, Chen H, Stamou M, Bose DD, Pessah IN, Lehmler H, Lein PJ. 2014. PCB 136 atropselectively alters morphometric and functional parameters of neuronal connectivity in cultured rat hippocampal neurons via ryanodine receptor-dependent mechanisms. Toxicol Sci 138(2):379-392. doi:10.1093/toxsci/kft334 PMID:24385416 PMCID:PMC4007107
  • Yueh MF, Taniguchi K, Chen S, Evans RM, Hammock BD, Karin M, Tukey RH. 2014. The commonly used antimicrobial additive triclosan is a liver tumor promoter. Proc Natl Acad Sci U S A 111(48):17200-17205. doi:10.1073/pnas.1419119111 PMID:25404284 PMCID:PMC4260592
  • Zhang G, Kodani SD, Hammock BD. 2014. Stabilized epoxygenated fatty acids regulate inflammation, pain, angiogenesis and cancer. Prog Lipid Res 53:108-123. doi:10.1016/j.plipres.2013.11.003 PMID:24345640 PMCID:PMC3914417
  • Zhang G, Panigrahy D, Hwang SH, Yang J, Mahakian LM, Wettersten HI, Liu J, Wang Y, Ingham ES, Tam S, Kieran MW, Weiss RH, Ferrara KW, Hammock BD. 2014. Dual inhibition of cyclooxygenase-2 and soluble epoxide hydrolase synergistically suppresses primary tumor growth and metastasis. Proc Natl Acad Sci U S A 111(30):11127-11132. doi:10.1073/pnas.1410432111 PMID:25024195 PMCID:PMC4121808


  • Bettaieb A, Nagata N, AbouBechara D, Chahed S, Morisseau C, Hammock BD, Haj FG. 2013. Soluble epoxide hydrolase deficiency or inhibition attenuates diet-induced endoplasmic reticulum stress in liver and adipose tissue. J Biol Chem 288:14189-14199. doi:10.1074/jbc.M113.458414 PMID:23576437 PMCID:PMC3656275
  • Brander SM, Connon RE, He G, Hobbs JA, Smalling KL, Teh SJ, White JW, Werner I, Denison MS, Cherr GN. 2013. From 'omics to otoliths: responses of an estuarine fish to endocrine disrupting compounds across biological scales. PLoS One 8(9):e74251. doi:10.1371/journal.pone.0074251 PMID:24086325 PMCID:PMC3783432
  • Brennan JC, Denison MS, Holstege DM, Magiatis P, Dallas JL, Gutierrez EG, Soshilov AA, Millam JR. 2013. 2,3-cis-2R, 3R-(-)-epiafzelechin-3-O-p-coumarate, a novel flavan-3-ol isolated from Fallopia convolvulus seed, is an estrogen receptor agonist in human cell lines. BMC Complement Altern Med 13:133. doi:10.1186/1472-6882-13-133 PMID:23768005 PMCID:PMC3695784
  • Chen T, Takrouri K, Hee-Hwang S, Rana S, Yefidoff-Freedman R, Halperin J, Natarajan A, Morisseau C, Hammock BD, Chorev M, Aktas BH. 2013. Explorations of substituted urea functionality for the discovery of new activators of the heme-regulated inhibitor kinase. J Med Chem 56(23):9457-9470. doi:10.1021/jm400793v PMID:24261904 PMCID:PMC3938169
  • Croes K, Colles A, Koppen G, de Galan S, Vandermarken T, Govarts E, Bruckers L, Nelen V, Schoeters G, Van Larebeke N, Denison MS, Mampaey M, Baeyens W. 2013. Determination of PCDD/Fs, PBDD/Fs and dioxin-like PCBs in human milk from mothers residing in the rural areas in Flanders, using the CALUX bioassay and GC-HRMS. Talanta 113:99-105. doi:10.1016/j.talanta.2013.03.086 PMID:23708629 PMCID:PMC3690775
  • Fraccalvieri D, Soshilov AA, Karchner SI, Franks DG, Pandini A, Bonati L, Hahn ME, Denison MS. 2013. Comparative analysis of homology models of the AH receptor ligand binding domain: verification of structure-function predictions by site-directed mutagenesis of a nonfunctional receptor. Biochemistry 52:714-725. doi:10.1021/bi301457f PMID:23286227 PMCID:PMC3568667
  • Fritsch EB, Connon RE, Werner I, Davies RE, Beggel S, Feng W, Pessah IN. 2013. Triclosan impairs swimming behavior and alters expression of excitation-contraction coupling proteins in Fathead Minnow (Pimephales promelas). Environ Sci Technol 47(4):2008-2017. doi:10.1021/es303790b PMID:23305567 PMCID:PMC3640625
  • Fritsch EB, Pessah IN. 2013. Structure-activity relationship of non-coplanar polychlorinated biphenyls toward skeletal muscle ryanodine receptors in rainbow trout (Oncorhynchus mykiss). Aquat Toxicol 140-141C:204-212. doi:10.1016/j.aquatox.2013.06.003 PMID:23827775 PMCID:PMC3813431
  • Guedes AP, Morisseau C, Sole A, Soares JN, Ulu A, Dong H, Hammock BD. 2013. Use of a soluble epoxide hydrolase inhibitor as an adjunctive analgesic in a horse with laminitis. Vet Anaesth Analg 40(4):440-448. doi:10.1111/vaa.12030 PMID:23463912 PMCID:PMC3956586
  • He G, Zhao J, Brennan JC, Affatato AA, Zhao B, Rice RH, Denison MS. 2013. Cell-based assays for identification of aryl hydrocarbon (Ah) receptor activators. In: Optimization of Drug Discovery: In Vitro Methods (2E). Humana Press, New York, NY. pp.221-235.
  • He G, Zhao J, Brennan JC, Affatato AA, Zhao B, Rice RH, Denison MS. 2013. Cell-based assays for identification of aryl hydrocarbon (AhR) receptor activators. Chapter 13 in: Optimization of Drug Discovery: In Vitro Methods (2E). Humana Press, New York, NY. pp.221-235.
  • Hu Q, He G, Zhao J, Soshilov AA, Denison MS, Zhang A, Yin H, Fraccalvieri D, Bonati L, Xie Q, Zhao B. 2013. Ginsenosides are novel naturally-occurring aryl hydrocarbon receptor ligands. PLoS One 8:e66258. doi:10.1371/journal.pone.0066258 PMID:23776647 PMCID:PMC3679084
  • Hu Q, Rice RH, Qin Q, Phinney BS, Eigenheer RA, Bao W, Zhao B. 2013. Proteomic analysis of human keratinocyte response to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure. J Proteome Res 12(11):5340-5347. doi:10.1021/pr4006266 PMID:23991859 PMCID:PMC4026210
  • Hwang SH, Wecksler AT, Zhang G, Morisseau C, Nguyen LV, Fu SH, Hammock BD. 2013. Synthesis and biological evaluation of sorafenib- and regorafenib- like sEH inhibitors. Bioorg Med Chem Lett 23(13):3732-3737. doi:10.1016/j.bmcl.2013.05.011 PMID:23726028 PMCID:PMC3744640
  • Inceoglu B, Zolkowska D, Yoo H, Wagner KM, Yang J, Hackett E, Hwang SH, Lee KS, Rogawski MA, Morisseau C, Hammock BD. 2013. Epoxy fatty acids and inhibition of the soluble epoxide hydrolase selectively modulate GABA mediated neurotransmission to delay onset of seizures. PLoS One 8(12):doi:10.1371/journal.pone.0080922 PMID:24349022 PMCID:PMC3862847
  • Kamenickova A, Anzenbacherova E, Pavek P, Soshilov AA, Denison MS, Anzenbacher P, Dvorak Z. 2013. Pelargonidin activates the AhR and induces CYP1A1 in primary human hepatocytes and human cancer cell lines HepG2 and LS174T. Toxicol Lett 218(3):253-259. doi:10.1016/j.toxlet.2013.01.020 PMID:23419638 PMCID:PMC3644221
  • Kamenickova A, Anzenbacherova E, Pavek P, Soshilov AA, Denison MS, Zapletalova M, Anzenbacher P, Dvorak Z. 2013. Effects of anthocyanins on the AhR-CYP1A1 signaling pathway in human hepatocytes and human cancer cell lines. Toxicol Lett 221(1):1-8. doi:10.1016/j.toxlet.2013.05.007 PMID:23735880 PMCID:PMC3759295
  • Kamita SG, Oshita GH, Wang P, Morisseau C, Hammock BD, Nandety R, Falk BW. 2013. Characterization of HOVI-MEH1, a microsomal epoxide hydrolase from the Glassy-Winged Sharpshooter Homalodisca vitripennis. Arch Insect Biochem Physiol 83(4):171-179. doi:10.1002/arch.21100 PMID:23704009 PMCID:PMC3846607
  • Kamita SG, Yamamoto K, Dadala MM, Pha K, Morisseau C, Escaich A, Hammock BD. 2013. Cloning and characterization of a microsomal epoxide hydrolase from Heliothis virescens. Insect Biochem Mol Biol 43(3):219-228. doi:10.1016/j.ibmb.2012.12.002 PMID:23276675 PMCID:PMC3577957
  • Lee KS, Morisseau C, Yang J, Wang P, Hwang SH, Hammock BD. 2013. Forster resonance energy transfer competitive displacement assay for human soluble epoxide hydrolase. Anal Biochem 434(2):259-268. doi:10.1016/j.ab.2012.11.015 PMID:23219719 PMCID:PMC3632402
  • Lin Y, Pessah IN, Puschner B. 2013. Simultaneous determination of polybrominated diphenyl ethers and polychlorinated biphenyls by gas chromatography-tandem mass spectrometry in human serum and plasma. Talanta 113:41-48. doi:10.1016/j.talanta.2013.04.001 PMID:23708622 PMCID:PMC3698050
  • Liu J, Lin Y, Qiu H, Morisseau C, Rose TE, Hwang SH, Chiamvimonvat N, Hammock BD. 2013. Substituted phenyl groups improve the pharmacokinetic profile and anti-inflammatory effect of urea-based soluble epoxide hydrolase inhibitors in murine models. European Journal of Pharmaceutical Sciences 48(4-5):619-627. doi:10.1016/j.ejps.2012.12.013 PMID:23291046 PMCID:PMC3596469
  • Magiatis P, Pappas P, Gaitanis G, Mexia N, Melliou E, Galanou M, Vlachos C, Stathopoulou K, Skaltsounis AL, Marselos M, Velegraki A, Denison MS, Bassukas ID. 2013. Malassezia yeasts produce a collection of exceptionally potent activators of the Ah (dioxin) receptor detected in diseased human skin. Journal of Investigative Dermatology 133(8):2023-2030. doi:10.1038/jid.2013.92 PMID:23448877 PMCID:PMC3714356
  • Morisseau C, Hammock BD. 2013. Impact of soluble epoxide hydrolase and epoxyeicosanoids on human health. Annu Rev Pharmacol Toxicol 53:37-58. doi:10.1146/annurev-pharmtox-011112-140244 PMID:23020295 PMCID:PMC3578707
  • Morisseau C, Pakhomova S, Hwang SH, Newcomer ME, Hammock BD. 2013. Inhibition of soluble epoxide hydrolase by fulvestrant and sulfoxides. Bioorg Med Chem Lett 23(13):3818-3821. doi:10.1016/j.bmcl.2013.04.083 PMID:23684894 PMCID:PMC3703951
  • Morisseau C, Sahdeo S, Cortopassi GA, Hammock BD. 2013. Development of an HTS assay for EPHX2 phosphatase activity and screening of nontargeted libraries. Anal Biochem 434(1):105-111. doi:10.1016/j.ab.2012.11.017 PMID:23219563 PMCID:PMC3557602
  • Niknam Y, Feng W, Cherednichenko G, Dong Y, Joshi SN, Vyas SM, Lehmler H, Pessah IN. 2013. Structure-activity relationship of selected meta- and para-hydroxylated non-dioxin like polychlorinated biphenyls: from single RyR1 channels to muscle dysfunction. Toxicol Sci 136(2):500-513. doi:10.1093/toxsci/kft202 PMID:24014653 PMCID:PMC3858193
  • Phillips MA, Qin Q, Hu Q, Zhao B, Rice RH. 2013. Arsenite suppression of BMP signaling in human keratinocytes. Toxicol Appl Pharmacol 269(3):290-296. doi:10.1016/j.taap.2013.02.017 PMID:23566955 PMCID:PMC3759367
  • Rice RH, Bradshaw KM, Durbin-Johnson BP, Rocke DM, Eigenheer RA, Phinney BS, Schmuth M, Gruber R. 2013. Distinguishing ichthyoses by protein profiling. PLoS One 8(10):e75355. doi:10.1371/journal.pone.0075355 PMID:24130705 PMCID:PMC3793978
  • Rice RH, Winters BR, Durbin-Johnson BP, Rocke DM. 2013. Chicken corneocyte cross-linked proteome. J Proteome Res 12(2):771-776. doi:10.1021/pr301036k PMID:23256538 PMCID:PMC3569041
  • Sirish P, Li N, Liu J, Lee KS, Hwang SH, Qiu H, Zhao C, Ma S, Lopez JE, Hammock BD, Chiamvimonvat N. 2013. Unique mechanistic insights into the beneficial effects of soluble epoxide hydrolase inhibitors in the prevention of cardiac fibrosis. Proc Natl Acad Sci U S A 110(14):5618-5623. doi:10.1073/pnas.1221972110 PMID:23493561 PMCID:PMC3619365
  • Stamou M, Streifel KM, Goines PE, Lein PJ. 2013. Neuronal connectivity as a convergent target of gene X environment interactions that confer risk for Autism Spectrum Disorders. Neurotoxicol Teratol 36:3-16. doi:10.1016/ PMID:23269408 PMCID:PMC3610799
  • Ulu A, Harris TR, Morisseau C, Miyabe C, Inoue H, Schuster G, Dong H, Iosif A, Liu J, Weiss RH, Chiamvimonvat N, Imig JD, Hammock BD. 2013. Anti-inflammatory effects of omega-3 polyunsaturated fatty acids and soluble epoxide hydrolase inhibitors in angiotensin-II dependent hypertension. J Cardiovasc Pharmacol 62(3):285-297. doi:10.1097/FJC.0b013e318298e460 PMID:23676336 PMCID:PMC3773051
  • Wagner KM, Inceoglu B, Dong H, Yang J, Hwang SH, Jones PD, Morisseau C, Hammock BD. 2013. Comparative efficacy of 3 soluble epoxide hydrolase inhibitors in rat neuropathic and inflammatory pain models. Eur J Pharmacol 700(1-3):93-101. doi:10.1016/j.ejphar.2012.12.015 PMID:23276668 PMCID:PMC3578047
  • Wu X, Kania-Korwel I, Chen H, Stamou M, Dammanahalli KJ, Duffel MW, Lein PJ, Lehmler H. 2013. Metabolism of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) atropisomers in tissue slices from phenobarbital or dexamethasone-induced rats is sex-dependent. Xenobiotica 43(11):933-947. doi:10.3109/00498254.2013.785626 PMID:23581876 PMCID:PMC3878182
  • Zhang G, Panigrahy D, Mahakian LM, Yang J, Liu J, Lee KS, Wettersten HI, Ulu A, Hu X, Tam S, Hwang SH, Ingham ES, Kieran MW, Weiss RH, Ferrara KW, Hammock BD. 2013. Epoxy metabolites of docosahexaenoic acid (DHA) inhibit angiogenesis, tumor growth, and metastasis. Proc Natl Acad Sci U S A 110(16):6530-6535. doi:10.1073/pnas.1304321110 PMID:23553837 PMCID:PMC3631682
  • Zhang W, Li H, Dong H, Liao J, Hammock BD, Yang G. 2013. Soluble epoxide hydrolase deficiency inhibits dextran sulfate sodium-induced colitis and carcinogenesis in mice. Anticancer Res 33(12):5261-5271. PMID:24324059 PMCID:PMC4076172
  • Zhao B, Bohonowych JE, Timme-Laragy AR, Jung D, Affatato AA, Rice RH, Di Giulio RT, Denison MS. 2013. Common commercial and consumer products contain activators of the aryl hydrocarbon (dioxin) receptor. PLoS One 8(2):e56860. doi:10.1371/journal.pone.0056860 PMID:23441220 PMCID:PMC3575475


  • Addeck A, Croes K, Van Langenhove K, Denison MS, Elskens M, Baeyens W. 2012. Dioxin analysis in water by using a passive sampler and CALUX bioassay. Talanta 88:73-78. doi:10.1016/j.talanta.2011.10.009 PMID:22265472
  • Brander SM, He G, Smalling KL, Denison MS, Cherr GN. 2012. The in vivo estrogenic and in vitro anti-estrogenic activity of permethrin and bifenthrin. Environ Toxicol Chem 31(12):2848-2855. doi:10.1002/etc.2019 PMID:23007834 PMCID:PMC3529915
  • Cao Z, Hammock BD, McCoy MR, Rogawski MA, Lein PJ, Pessah IN. 2012. Tetramethylenedisulfotetramine alters Ca2+ dynamics in cultured hippocampal neurons: mitigation by NMDA receptor blockade and GABA(A) receptor-positive modulation. Toxicol Sci 130(2):362-372. doi:10.1093/toxsci/kfs244 PMID:22889812 PMCID:PMC3529644
  • Cherednichenko G, Zhang R, Bannister RA, Timofeyev V, Li N, Fritsch EB, Feng W, Barrientos G, Schebb N, Hammock BD, Beam KG, Chiamvimonvat N, Pessah IN. 2012. Triclosan impairs excitation-contraction coupling and Ca2+ dynamics in striated muscle. Proc Natl Acad Sci U S A 109(35):14158-14163. doi:10.1073/pnas.1211314109 PMID:22891308 PMCID:PMC3435154
  • Kania-Korwel I, Barnhart CD, Stamou M, Truong KM, El-Komy MH, Lein PJ, Veng-Pedersen P, Lehmler H. 2012. 2,2',3,5',6-Pentachlorobiphenyl (PCB 95) and its hydroxylated metabolites are enantiomerically enriched in female mice. Environ Sci Technol 46(20):11393-11401. doi:10.1021/es302810t PMID:22974126 PMCID:PMC3475189
  • Kaplan ES, Cao Z, Hulsizer S, Tassone F, Berman RF, Hagerman PJ, Pessah IN. 2012. Early mitochondrial abnormailities in hippocampal neurons cultured from Fmr I pre-mutation mouse model. J Neurochem 123(4):613-621. doi:10.1111/j.1471-4159.2012.07936.x PMID:22924671 PMCID:PMC3564636
  • Koenig CM, Lango J, Pessah IN, Berman RF. 2012. Maternal transfer of BDE-47 to offspring and neurobehavioral development in C57BL/6J mice. Neurotoxicol Teratol 34(6):571-580. doi:10.1016/ PMID:23022914 PMCID:PMC3501584
  • Wayman GA, Bose DD, Yang DR, Lesiak A, Bruun DA, Impey S, Ledoux V, Pessah IN, Lein PJ. 2012. PCB-95 modulates the calcium-dependent signaling pathway responsible for activity-dependent dendritic growth. Environ Health Perspect 120:1003-1009. doi:10.1289/ehp.1104833 PMID:22534176 PMCID:PMC3404671
  • Wayman GA, Yang DR, Bose DD, Lesiak A, Ledoux V, Bruun DA, Pessah IN, Lein PJ. 2012. PCB-95 promotes dendritic growth via ryanodine receptor-dependent mechanisms. Environ Health Perspect 120:997-1002. doi:10.1289/ehp.1104832 PMID:22534141 PMCID:PMC3404670


  • Baston DS, Denison MS. 2011. Considerations for potency equivalent calculations in the Ah receptor-based CALUX bioassay: normalization of superinduction results for improved sample potency estimation. Talanta 83(5):1415-1421. doi:10.1016/j.talanta.2010.11.035 PMID:21238730 PMCID:PMC3036574
  • Charles RL, Burgoyne JR, Mayr M, Weldon SM, Hubner N, Dong H, Morisseau C, Hammock BD, Landar A, Eaton P. 2011. Redox regulation of soluble epoxide hydrolase by 15-Deoxy-AProstaglandin J2 controls coronary hypoxic vasodilation. Circ. Res. Circ Res 108:324-334. doi:10.1161/CIRCRESAHA.110.235879 PMID:21164107 PMCID:PMC3259859
  • Croes K, Van Langenhove K, Den Hond E, Bruckers L, Colles A, Koppen G, Loots I, Nelen V, Schoeters G, Nawrot T, Van Larebeke N, Denison MS, Vandermarken T, Elskens M, Baeyens W. 2011. Quantification of PCDD/Fs and dioxin-like PCBs in small amounts of human serum using the sensitive H1L75c1 mouse hepatoma cell line: optimization and analysis of human serum samples from adolescents of the Flemish human biomonitoring program FLEHS II. Talanta 85(5):2484-2491. doi:10.1016/j.talanta.2011.07.103 PMID:21962672 PMCID:PMC3523230
  • Denison MS, Soshilov AA, He G, DeGroot DE, Zhao B. 2011. Exactly the same but different: promiscuity and diversity in the molecular mechanisms of action of the aryl hydrocarbon (dioxin) receptor. Toxicol Sci 124:1-22. doi:10.1093/toxsci/kfr218 PMID:21908767 PMCID:PMC3196658
  • Feng W, Barrientos G, Cherednichenko G, Padilla I, Truong KM, Allen PD, Lopez J, Pessah IN. 2011. Functional and biochemical properties of ryanodine receptor type 1 channels from heterozygous R163C malignant hyperthermia-susceptible mice. Mol Pharmacol 79(3):420-431. doi:10.1124/mol.110.067959 PMID:21156754 PMCID:PMC3061367
  • He G, Tsutsumi T, Baston DS, Zhao B, Zhao J, Heath-Pagliuso S, Denison MS. 2011. Third-generation Ah receptor-responsive luciferase reporter plasmids: amplification of dioxin-responsive elements dramatically increases CALUX bioassay sensitivity and responsiveness. Toxicol Sci 123:511-522. doi:10.1093/toxsci/kfr189 PMID:21775728 PMCID:PMC3179681
  • He G, Zhao B, Denison MS. 2011. Identification of benzothiazole derivatives and polycyclic aromatic hydrocarbons as aryl hydrocarbon receptor agonists present in tire extracts. Environ Toxicol Chem 30:1915-1925. doi:10.1002/etc.581 PMID:21590714 PMCID:PMC3263332
  • Hwang SH, Wagner KM, Morisseau C, Liu J, Dong H, Wecksler AT, Hammock BD. 2011. Synthesis and structure-activity relationship studies of urea-containing pyrazoles as dual inhibitors of cyclooxygenase-2 and soluble epoxide hydrolase. J Med Chem 54:3037-3050. doi:10.1021/jm2001376 PMID:21434686 PMCID:PMC3281519
  • Kim K, Bose DD, Ghogha A, Riehl J, Zhang R, Barnhart CD, Lein PJ, Pessah IN. 2011. Para- and ortho-substitutions are key determinants of polybrominated diphenyl ether activity toward Ryanodine receptors and neurotoxicity. Environ Health Perspect 119:519-526. doi:10.1289/ehp.1002728 PMID:21106467 PMCID:PMC3080935
  • Kim K, Pessah IN. 2011. Perinatal exposure to environmental polychlorinated biphenyls sensitizes hippocampus to excitotoxicity ex vivo. Neurotoxicology 32:98-985. doi:10.1016/j.neuro.2011.04.004 PMID:21571002 PMCID:PMC3181005
  • Koeners MP, Wesseling S, Ulu A, Sepulveda R, Morisseau C, Braam B, Hammock BD, Joles JA. 2011. Soluble epoxide hydrolase in the generation and maintenance of high blood pressure in spontaneously hypertensive rats. Am J Physiol Endocrinol Metab 300:E691-698. doi:10.1152/ajpendo.00710.2010 PMID:21266668 PMCID:PMC3074945
  • Liu J, Qiu H, Moisseau C, Hwang SH, Tsai H, Ulu A, Chiamvimonvat N, Hammock BD. 2011. Inhibition of soluble epoxide hydrolase contributes to the anti-inflammatory effect of antimicrobial triclocarban in a murine model. Toxicol Appl Pharmacol 255:200-206. doi:10.1016/j.taap.2011.06.017 PMID:21741984 PMCID:PMC3156297
  • Magby JP, Neal AP, Atchison WD, Pessah IN, Shafer TJ. 2011. Channelopathies: Summary of the hot topic keynotes session. Neurotoxicology 32(5):661-665. doi:10.1016/j.neuro.2011.06.002 PMID:21756936 PMCID:PMC3200451
  • Morisseau C, Bernay M, Escaich A, Sanborn JR, Lango J, Hammock BD. 2011. Development of fluorescent substrates for microsomal epoxide hydrolase and application to inhibition studies. Anal Biochem 414(1):154-162. doi:10.1016/j.ab.2011.02.038 PMID:21371418 PMCID:PMC3090455
  • Motto I, Bordogna A, Soshilov AA, Denison MS, Bonati L. 2011. New aryl hydrocarbon receptor homology model targeted to improve docking reliability. J Chem Inf Model 51(11):2868-2881. doi:10.1021/ci2001617 PMID:21981577 PMCID:PMC3263330
  • Rice RH. 2011. Proteomic analysis of hair shaft and nail plate. Biol Res 62:222-236. PMID:21635850 PMCID:PMC3227502
  • Rice RH, Phillips MA, Sundberg JP. 2011. Localization of hair shaft protein VSIG8 in the hair follicle, nail unit, and oral cavity. Journal of Investigative Dermatology 131:1936-1938. doi:10.1038/jid.2011.133 PMID:21614015 PMCID:PMC3156960
  • Ta TA, Koenig CM, Golub MS, Pessah IN, Qi L, Aronov PA, Berman RF. 2011. Bioaccumulation and behavioral effects of 2.2',4,4'-tetrabromodiphenyl ether (BDE-47) in perinatally exposed mice. Neurotoxicol Teratol 33:393-404. doi:10.1016/ PMID:21334437 PMCID:PMC3543834


  • Boitano A, Wang J, Romeo R, Bouchez L, Parker A, Sutton SE, Walker J, Flaveny C, Perdew GH, Denison MS, Schultz P, Cooke M. 2010. Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells. Science 329(5997):1345-1348. doi:10.1126/science.1191536 PMID:20688981 PMCID:PMC3033342
  • Feng W, Cherednichenko G, Ward C, Padilla I, Cabrales E, Lopez JR, Eltit JM, Allen PD, Pessah IN. 2010. Green tea catechins are potent sensitizers of ryanodine receptor type 1 (RyR1). Biochem Pharmacol 80(4):512-521. doi:10.1016/j.bcp.2010.05.004 PMID:20471964 PMCID:PMC2907350
  • Kennedy K, Macova M, Bartkow ME, Hawker DW, Zhao B, Denison MS, Mueller JF. 2010. Effect based monitoring of seasonal ambient air exposures in Australia sampled by PUF passive air samplers. Atmos Pollut Res 1(1):50-58. doi:10.5094/APR.2010.008 PMID:21552507 PMCID:PMC3087176
  • Morisseau C, Inceoglu B, Schmelzer KR, Tsai H, Jinks SL, Hegedus CM, Hammock BD. 2010. Naturally occurring monoepoxides of eicosapentaenoic acid and docosahexaenoic acid are bioactive antihyperalgesic lipids. J Lipid Res 51:3481-3490. doi:10.1194/jlr.M006007 PMID:20664072 PMCID:PMC2975720
  • Reznikova TV, Phillips MA, Patterson TP, Rice RH. 2010. Opposing actions of insulin and arsenite converge on PKCS to alter keratinocyte proliferative potential and differentiation. Mol Carcinog 49:398-409.
  • Rice RH, Xia Y, Alvarado RJ, Phinney BS. 2010. Proteomic analysis of human nail plate. J Proteome Res 9(12):67526758. doi:10.1021/pr1009349 PMID:20939611 PMCID:PMC3007598
  • Rose TE, Morisseau C, Liu J, Inceoglu B, Jones PD, Sanborn JR, Hammock BD. 2010. 1-Aryl-3-(1-acylpiperidin-4-yl)urea inhibitors of human and murine soluble epoxide hydrolase: structure-activity relationships, pharmacokinetics, and reduction of inflammatory pain. J Med Chem 53(19):7067-7075. doi:10.1021/jm100691c PMID:20812725 PMCID:PMC3285450
  • Sinitsyna NN, Reznikova TV, Qin Q, Song H, Phillips MA, Rice RH. 2010. Arsenite suppression of involucrin transcription through AP1 promoter sites in cultured human keratinocytes. Toxicol Appl Pharmacol 243(3):275-282. doi:10.1016/j.taap.2009.12.006 PMID:20006635 PMCID:PMC2830317
  • Tsai H, Hwang SH, Morisseau C, Yang J, Jones PD, Kasagami T, Kim I, Hammock BD. 2010. Pharmacokinetic screening of soluble epoxide hydrolase inhibitors in dogs. European Journal of Pharmaceutical Sciences 40(3):222-238. doi:10.1016/j.ejps.2010.03.018 PMID:20359531 PMCID:PMC3285443
  • Zhao B, Baston DS, Khan EM, Sorrentino C, Denison MS. 2010. Enhancing the response of CALUX and CAFLUX cell bioassays for quantitative detection of dioxin-like compounds. Sci China Chem 53(5):1010-1016. doi:10.1007/s11426-010-0142-8 PMID:21394221 PMCID:PMC3049243
  • Zhao B, DeGroot DE, Hayashi A, He G, Denison MS. 2010. CH223191 is a ligand-selective antagonist of the Ah (Dioxin) receptor. Toxicol Sci 117(2):393-403. doi:10.1093/toxsci/kfq217 PMID:20634293 PMCID:PMC2940411



  • Berman RF, Pessah IN, Mouton PR, Mav D, Harry J. 2008. Low-level neonatal thimerosal exposure: further evaluation of altered neurotoxic potential in SJL mice. Toxicol Sci 101(2):294-309. PMID:17977901
  • Chen J, Ahn K, Zhao B, Denison MS, Lasley BL, Pessah IN, Kültz D, Chang DP, Gee SJ, Hammock BD, Cherednichenko G. 2008. In vitro biologic activities of the antimicrobials triclocarban, its analogs, and triclosan in bioassay screens: receptor-based bioassay screens. Environ Health Perspect 116:1203-1210. doi:10.1289/ehp.11200 PMID:18795164 PMCID:PMC2535623
  • Pessah IN, Seegal R, Lein PJ, LaSalle J, Yee BK, van de Water JG, Berman RF. 2008. Immunologic and neurodevelopmental susceptibilities of autism. Neurotoxicology 29(3):532-545. doi:10.1016/j.neuro.2008.02.006 PMID:18394707 PMCID:PMC2475601


  • Brown DJ, Orelien J, Gordon JD, Chu AC, Chu MD, Nakamura M, Handa H, Kayama F, Denison MS, Clark GC. 2007. Mathematical model developed for environmental samples: prediction of GC/MS dioxin TEQ from XDS-CALUX bioassay data. Environ Sci Technol 41(12):4354-4360. PMID:17626436 PMCID:PMC2877589
  • Inceoglu B, Schmelzer KR, Morisseau C, Jinks SL, Hammock BD. 2007. Soluble epoxide hydrolase inhibition reveals novel biological functions of epoxyeicosatrienoic acids (EETs). Prostaglandins Other Lipid Mediat 82(1-4):42-49. PMID:17164131
  • Ngo MA, Sinitsyna NN, Qin Q, Rice RH. 2007. Oxygen-dependent differentiation of human keratinocytes. Journal of Investigative Dermatology 127(2):354-61. PMID:16977326
  • Nording M, Denison MS, Baston DS, Persson Y, Spinnel E, Haglund P. 2007. Analysis of dioxins in contaminated soils with the calux and caflux bioassays, an immunoassay, and gas chromatography/high-resolution mass spectrometry. Environ Toxicol Chem 26(6):1122-9. PMID:17571676
  • Phimister AJ, Lango J, Lee EH, Ernst-Russell M, Takeshima H, Ma J, Allen PD, Pessah IN. 2007. Conformation-dependent stability of junctophilin 1 (JP1) and ryanodine receptor type 1 (RyR1) channel complex is mediated by their hyper-reactive thiols. J Biol Chem 282(12):8667-8677. doi:10.1074/jbc.M609936200 PMID:17237236
  • Ta TA, Pessah IN. 2007. Ryanodine receptor type 1 (RyR1) possessing malignant hyperthermia mutation R615C exhibits heightened sensitivity to dysregulation by non-coplanar 2,22,3,52,6-pentachlorobiphenyl (PCB 95). Neurotoxicology 28(4):770-9.


  • Davis BB, Morisseau C, Newman JW, Pedersen TL, Hammock BD, Weiss RH. 2006. Attenuation of vascular smooth muscle cell proliferation by 1-cyclohexyl-3-dodecyl urea is independent of soluble epoxide hydrolase inhibition. J Pharmacol Exp Ther 316(2):815-821. PMID:16221742
  • Denison MS, Han D, Nagy SR, Zhao B, Baston DS, Hayashi A, Knockaert M, Meijer L. 2006. Indirubins as activators of the aryl hydrocarbon receptor signal transduction pathways. Chapter 16 in: Indirubin, The Red Shade of Indigo. Roscoff, France. pp.157-167.
  • Denison MS, Khan EM, Sorrentino C, Zhao B. 2006. Enhanced CALUX and CAFLUX cell bioassay responses through intracellular signaling pathways and incubation temperature. Organohalogen Compounds 68:1265-1268.
  • Gomez GA, Morisseau C, Hammock BD, Christianson DW. 2006. Human soluble epoxide hydrolase: structural basis of inhibition by 4-(3-cyclohexylureido)-carboxylic acids. Protein Sci 15(1):58-64. doi:10.1110/ps.051720206 PMID:16322563 PMCID:PMC1762130
  • Gordon JD, Denison MS, Chu AC, Chu MD, Matherly C, Kayama F, Clark GC. 2006. Proposed classification system for tier-1 screening of estrogenic EDC using the Lumi-Cell ER bioassay. Organohalogen Compounds 68:1273-1276.
  • Harris TR, Morisseau C, Walzem RL, Ma S, Hammock BD. 2006. The cloning and characterization of a soluble epoxide hydrolase in chicken. Poultry Science 82(2):278-287. PMID:16523628
  • Huang H, Nishi K, Gee SJ, Hammock BD. 2006. Evaluation of chiral alpha-cyanoesters as general fluorescent substrates for screening enantioselective esterases. J Agric Food Chem 54(3):694-699. doi:10.1021/jf0526083 PMID:16448170 PMCID:PMC1444886
  • Hwang SH, Morisseau C, Do ZN, Hammock BD. 2006. Solid-phase combinatorial approach for the optimization of soluble epoxide hydrolase inhibitors. Bioorg Med Chem Lett 16(22):5773-7. PMID:16949285
  • Inceoglu B, Lango J, Whetstone P, Hammock BD. 2006. The neutralizing effect of a polyclonal antibody raised against the N-terminal eighteen-aminoacid residues of birtoxin towards the whole venom of Parabuthus transvaalicus. Toxicology 47(2):144-149. PMID:16356521
  • Jones PD, Tsai H, Do ZN, Morisseau C, Hammock BD. 2006. Synthesis and SAR of conformationally restricted inhibitors of soluble epoxide hydrolase. Bioorg Med Chem Lett 16(19):5212-5216. PMID:16870439
  • Klein GP, Hodge EM, Diamond ML, Yip A, Dann T, Stern G, Denison MS, Harper PA. 2006. Gas-phase ambient air contaminants exhibit significant dioxin-like and estrogen-like activity In vitro. Environ Health Perspect 114(5):697-703. PMID:16675423
  • Larsen BT, Miura H, Hatoum OA, Campbell WB, Hammock BD, Zeldin DC, Falck JR, Gutterman DD. 2006. Epoxyeicosatrienoic and dihydroxyeicosatrienoic acids dilate human coronary arterioles via BKCa channels: implications for soluble epoxide hydrolase inhibition. Am J Pathol 290(2):H491-H499. PMID:16258029
  • Lee CR, North KE, Bray MS, Fornage M, Seubert JM, Newman JW, Hammock BD, Couper DJ, Heiss G, Zeldin DC. 2006. Genetic variation in soluble epoxide hydrolase (EPHX2) and risk of coronary heart disease: The Atherosclerosis Risk in Communities (ARIC) study. Hum Mol Genet 15(10):1640-1649. PMID:16595607
  • Lee YJ, Rice RH, Lee YM. 2006. Proteome analysis of human hair shaft: from protein identification to posttranslational modification. Mol Cell Proteomics 5(5):789-800. doi:10.1074/mcp.M500278-MCP200 PMID:16446289
  • Ng VY, Morisseau C, Falck JR, Hammock BD, Kroetz DL. 2006. Inhibition of smooth muscle proliferation by urea-based alkanoic acids via peroxisome proliferator-activated receptor alpha-dependent repression of cyclin D1. Arterioscler Thromb Vasc Biol 26(11):4262. PMID:16917105
  • Nishi K, Huang H, Kamita SG, Kim I, Morisseau C, Hammock BD. 2006. Characterization of pyrethroid hydrolysis by the human liver carboxylesterases hCE-1 and hCE-2. Arch Biochem Biophys 445(1):115-123. PMID:16359636
  • Olearczyk JJ, Field MB, Kim I, Morisseau C, Hammock BD, Imig JD. 2006. Substituted adamantyl-urea inhibitors of the soluble epoxide hydrolase dilate mesenteric resistance vessels. J Pharmacol Exp Ther 318(3):1307-1314. PMID:16772540
  • Pessah IN, Hansen LG, Albertson TE, Garner CE, Ta TA, Do ZN, Kim K, Wong PW. 2006. Structure-activity relationship for noncoplanar polychlorinated biphenyl congeners toward the ryanodine receptor-Ca2+ channel complex type 1 (RyR1). Chem Res Toxicol 19(1):92-101. doi:10.1021/tx050196m PMID:16411661
  • Peters AK, Leonards PE, Zhao B, Bergman A, Denison MS, van den Berg M. 2006. Determination of in vitro relative potency (REP) values for mono-ortho polychlorinated biphenyls after purification with active charcoal. Toxicol Lett 165(3):230-241. PMID:16750337
  • Peters AK, Nijmeijer S, Gradin K, Backlund M, Bergman A, Poellinger L, Denison MS, van den Berg M. 2006. Interactions of polybrominated diphenyl ethers with the aryl hydrocarbon receptor pathway. Toxicol Sci 92(1):133-142. PMID:16601081
  • Pokreisz P, Fleming I, Kiss L, Barbosa-Sicard E, Fisslthaler B, Falck JR, Hammock BD, Kim I, Szelid Z, Vermeersch P, Gillijns H, Pellens M, Grimminger F, van Zonneveld A, Collen D, Busse R, Janssens S. 2006. Cytochrome P450 epoxygenase gene function in hypoxic pulmonary vasoconstriction and pulmonary vascular remodeling. Hypertension 47(4):762-770. PMID:16505204
  • Schmelzer KR, Inceoglu B, Kubala L, Kim I, Jinks SL, Eiserich JP, Hammock BD. 2006. Enhancement of antinociception by coadministration of nonsteroidal anti-inflammatory drugs and soluble epoxide hydrolase inhibitors. Proc Natl Acad Sci U S A 103(37):13646-13651. PMID:16950874
  • Seubert JM, Sinal CJ, Graves J, Degraff LM, Bradbury JA, Lee CR, Goralski K, Carey MA, Luria A, Newman JW, Hammock BD, Falck JR, Roberts H, Rockman HA, Murphy E, Zeldin DC. 2006. Role of soluble epoxide hydrolase in postischemic recovery of heart contractile function. Circ Res 99(4):442-450. doi:10.1161/01.RES.0000237390.92932.37 PMID:16857962 PMCID:PMC2072806
  • Ta TA, Feng W, Molinski TF, Pessah IN. 2006. Hydroxylated xestospongins block inositol-1,4,5-trisphosphate-induced Ca2+ release and sensitize Ca2+-induced Ca2+ release mediated by ryanodine receptors. Mol Pharmacol 69(2):532-538. doi:10.1124/mol.105.019125 PMID:16249374
  • Wheelock AM, Miller JL, Miller MJ, Phillips BM, Huntley SA, Gee SJ, Tjeerdema RS, Hammock BD. 2006. Use of carboxylesterase activity to remove pyrethroid-associated toxicity to Ceriodaphnia dubia and Hyalella azteca in toxicity identification evaluations. Environ Toxicol Chem 25(4):973-984. PMID:16629136 PMCID:PMC1456014
  • Wolf NM, Morisseau C, Jones PD, Hock B, Hammock BD. 2006. Development of a high-throughput screen for soluble epoxide hydrolase inhibition. Anal Biochem 355(1):71-80. PMID:16729954
  • Xu D, Li N, He Y, Timofeyev V, Lu L, Tsai H, Kim I, Tuteja D, Mateo RP, Singapuri A, Davis BB, Low R, Hammock BD, Chiamvimonvat N. 2006. Prevention and reversal of cardiac hypertrophy by soluble epoxide hydrolase inhibitors. Proc Natl Acad Sci U S A 103(49):18733-18738. PMID:17130447
  • Zhao B, Baston DS, Hammock BD, Denison MS. 2006. Interaction of diuron and related substituted phenylureas with the Ah receptor pathway. J Biochem Mol Toxicol 20(3):103-113. PMID:16788953
  • Zhao B, Bohonowych JE, Denison MS. 2006. Differential responsiveness of the Ah receptor dependent gene expression induced by HAHs and PAHs. Organohalogen Compounds 68:1745-1748.


  • Clark GC, Orelien J, Gordon JD, Chu AC, Chu MD, Denison MS. 2005. Mathematical model predictions of GC/MS data for dioxin contaminated environmental samples using CALUX® by XDS. Organohalogen Compounds 67:50-53.
  • Dorrance AM, Rupp N, Pollock DM, Newman JW, Hammock BD, Imig JD. 2005. An epoxide hydrolase inhibitor, 12-(3-adamantan-1-yl-ureido)dodecanoic acid (AUDA), reduces ischemic cerebral infarct size in stroke-prone spontaneously hypertensive rats. J Cardiovasc Pharmacol 46(6):842-848. PMID:16306811 PMCID:PMC1444897
  • Fang X, Hu S, Watanabe T, Weintraub NL, Snyder GD, Yao J, Liu Y, Shyy JY, Hammock BD, Spector AA. 2005. Activation of peroxisome proliferator-activated receptor alpha by substituted urea-derived soluble epoxide hydrolase inhibitors. J Pharmacol Exp Ther 314(1):260-270. doi:10.1124/jpet.105.085605 PMID:15798002
  • German JB, Hammock BD, Watkins SM. 2005. Metabolomics: building on a century of biochemistry to guide human health. Metabolomics 1(1):3-9. PMID:16680201
  • Gordon JD, Chu AC, Chu MD, Matherly C, Denison MS, Grune G, Clark GC. 2005. Estrogenic potency of many popular suncreens and it's "non-active" components detected using the LUMI-cell" ER bioassay. Organohalogen Compounds 67:
  • Imig JD, Zhao X, Zaharis CZ, Olearczyk JJ, Pollock DM, Newman JW, Kim I, Watanabe T, Hammock BD. 2005. An orally active epoxide hydrolase inhibitor lowers blood pressure and provides renal protection in salt-sensitive hypertension. Hypertension 46(4):975-981. doi:10.1161/01.HYP.0000176237.74820.75 PMID:16157792 PMCID:PMC1444888
  • Inceoglu B, Lango J, Pessah IN, Hammock BD. 2005. Three structurally related, highly potent, peptides from the venom of Parabuthus transvaalicus possess divergent biological activity. Toxicon 45(6):727-733. PMID:15804521
  • Jones PD, Wolf NM, Morisseau C, Whetstone P, Hock B, Hammock BD. 2005. Fluorescent substrates for soluble epoxide hydrolase and application to inhibition studies. Anal Biochem 343(1):66-75. PMID:15963942
  • Jung O, Brandes RP, Kim I, Schweda F, Schmidt R, Hammock BD, Busse R, Fleming I. 2005. Soluble epoxide hydrolase is a main effector of angiotensin II-induced hypertension. Hypertension 45(4):759-765. doi:10.1161/01.HYP.0000153792.29478.1d PMID:15699457
  • Kang K, Jones PD, Huang H, Zhang R, Mostovich LA, Wheelock CE, Watanabe T, Gulyaeva LF, Hammock BD. 2005. Evaluation of a-cyano ethers as fluorescent substrates for assay of cytochrome P450 enyzme activity. Anal Biochem 344(2):183-192. PMID:16083846
  • Kim I, Heirtzler FR, Morisseau C, Nishi K, Tsai H, Hammock BD. 2005. Optimization of amide-based inhibitors of soluble epoxide hydrolase with improved water solubility. J Med Chem 48(10):3621-3629. doi:10.1021/jm0500929 PMID:15887969 PMCID:PMC1450255
  • Liu Y, Zhang Y, Schmelzer KR, Lee T, Fang X, Zhu Y, Spector AA, Gill S, Morisseau C, Hammock BD, Shyy JY. 2005. The antiinflammatory effect of laminar flow: the role of PPAR, epoxyeicosatrienoic acids, and soluble epoxide hydrolase. Proc Natl Acad Sci U S A 102(46):16747-16752. PMID:16267130
  • Lohstroh PN, Overstreet JW, Stewart DR, Nakajima ST, Cragun JR, Boyers SP, Lasley BL. 2005. Secretion and excretion of human chorionic gonadotropin during early pregnancy. Fertil Steril 83(4):1000-1011. PMID:15820813
  • Morisseau C, Hammock BD. 2005. Epoxide hydrolases: mechanisms, inhibitor designs, and biological roles. Annu Rev Pharmacol Toxicol 45:311-333. doi:10.1146/annurev.pharmtox.45.120403.095920 PMID:15822179
  • Newman JW, Morisseau C, Hammock BD. 2005. Epoxide hydrolases: their roles and interactions with lipid metabolism. Prog Lipid Res 44(1):1-50. PMID:15748653
  • Nithipatikom K, Endsley MP, Isbell MA, Wheelock CE, Hammock BD, Campbell WB. 2005. A new class of inhibitors of 2-arachidonoylglycerol hydrolysis and invasion of prostate cancer cells. Biochem Biophys Res Commun 332(4):1028-1033. PMID:15919052
  • Patterson TP, Reznikova TV, Phillips MA, Rice RH. 2005. Arsenite maintains germinative state in cultured human epidermal cells. Toxicol Appl Pharmacol 207(1):69-77. PMID:16054901
  • Peters AK, Nijmeijer S, Zhao B, Denison MS, Bergman A, Sanderson J, van den Berg M. 2005. Polybrominated diphenyl ethers (PBDEs) antagonize or inhibit TCDD induced CYP1A1 activity in various in vitro systems. Organohalogen Compounds 67:2290-2293.
  • Rice RH, Crumrine D, Uchida Y, Gruber R, Elias PM. 2005. Structural changes in epidermal scale and appendages as indicators of defective TGM1 activity. Arch Dermatol Res 297(3):127-133. PMID:16133457
  • Schmelzer KR, Kubala L, Newman JW, Kim I, Eiserich JP, Hammock BD. 2005. Soluble epoxide hydrolase is a therapeutic target for acute inflammation. Proc Natl Acad Sci U S A 102(28):9772-9777. PMID:15994227
  • Sellers KW, Sun C, Diez-Freire C, Waki H, Morisseau C, Falck JR, Hammock BD, Paton JF, Raizada MK. 2005. Novel mechanism of brain soluble epoxide hydrolase-mediated blood pressure regulation in the spontaneously hypertensive rat. FASEB J 19:626-628. PMID:15659536
  • Shearer GC, Newman JW, Hammock BD, Kaysen GA. 2005. Graded effects of proteinuria on HDL structure in nephrotic rats. J Am Soc Nephrol 16(5):1309-1319. PMID:15788471
  • Smith KR, Pinkerton KE, Watanabe T, Pedersen TL, Ma S, Hammock BD. 2005. Attenuation of tobacco smoke-induced lung inflammation by treatment with a soluble epoxide hydrolase inhibitor. Proc Natl Acad Sci U S A 102(6):2186-2191. PMID:15684051
  • Tran KL, Aronov PA, Tanaka H, Newman JW, Hammock BD, Morisseau C. 2005. Lipid sulfates and sulfonates are allosteric competitive inhibitors of the N-terminal phosphatase activity of the mammalian soluble epoxide hydrolase. Biochemistry 44(36):12179-12187. PMID:16142916
  • Wheelock CE, Eder KJ, Werner I, Huang H, Jones PD, Brammell BF, Elskus AA, Hammock BD. 2005. Individual variability in esterase activity and CYP1A levels in Chinook salmon (Oncorhynchus tshawytscha) exposed to esfenvalerate and chlorpyrifos. Aquat Toxicol 74(2):172-192. doi:10.1016/j.aquatox.2005.05.009 PMID:16011852 PMCID:PMC1444896
  • Windal I, Denison MS, Birnbaum LS, Van Wouwe N, Baeyens W, Goeyens L. 2005. Chemically activated luciferase gene expression (CALUX) cell bioassay analysis for the estimation of dioxin-like activity: critical parameters of the CALUX procedure that impact assay results. Environ Sci Technol 39(19):7357-7364. PMID:16245802


  • Bohonowych JE, Denison MS. 2004. Binding of 2,3,7,8-tetrachlorodibehzo-p-dioxin to the AhR from various species is essentially irreversible. Organohalogen Compounds 55:3291-3295.
  • Brown DJ, Van Overmeire I, Goeyens L, Denison MS, De Vito MJ, Clark GC. 2004. Analysis of Ah receptor pathway activation by brominated flame retardants. Organohalogen Compounds 55(11):1509-1518. PMID:15099731
  • Denison MS, Rogers WJ, Bohonowych JE, Zhao B, Dey A, Williams RS, Pollock DM, Stepp DW, Newman JW, Hammock BD, Imig JD. 2004. Promiscuous ligand-dependent activation of the Ah receptor: chemicals in crude extracts from commercial and consumer products bind to and activate the Ah receptor and Ah receptor-dependent gene expression. Organohalogen Compounds 66:2966-2971.
  • Denison MS, Zhao B, Baston DS, Clark GC, Murata H, Han D. 2004. Recombinant cell bioassay systems for the detection and relative quantitation of halogenated dioxins and related chemicals. Talanta 63(5):1123-1133. PMID:18969542
  • Dey A, Williams RS, Pollock DM, Stepp DW, Newman JW, Hammock BD, Imig JD. 2004. Altered kidney CYP2C and cyclooxygenase-2 levels are associated with obesity-related albuminuria. Obes Res 12(8):1278-1289. doi:10.1038/oby.2004.162 PMID:15340111
  • DuTeaux SB, Newman JW, Morisseau C, Fairbairn EA, Jelks K, Hammock BD, Miller MG. 2004. Epoxide hydrolases in the rat epididymis: possible roles in xenobiotic and endogenous fatty acid metabolism. Toxicol Sci 78(2):187-195. PMID:14737000
  • Fang X, Weintraub NL, McCaw RB, Hu S, Harmon S, Rice JB, Hammock BD, Spector AA. 2004. Effect of soluble epoxide hydrolase inhibition on epoxyeicosatrienoic acid metabolism in human blood vessels. Am J Physiol Cell Physiol 287:H2412-H2420. PMID:15284062
  • Gafni J, Wong PW, Pessah IN. 2004. Non-coplanar 2,2 ',3,5 ',6-pentachlorobiphenyl (PCB 95) amplifies ionotropic glutamate receptor signaling in embryonic cerebellar granule neurons by a mechanism involving ryanodine receptors. Toxicol Sci 77(1):72-82. PMID:14600284
  • Gomez GA, Morisseau C, Hammock BD, Christianson DW. 2004. Structure of human epoxide hydrolase reveals mechanistic inferences on bifunctional catalysis in epoxide and phosphate ester hydrolysis. Biochemistry 43(16):4716-4723. doi:10.1021/bi036189j PMID:15096040
  • Gordon JD, Chu AC, Chu MD, Denison MS, Clark GC. 2004. Detection of estrogen receptor endocrine disrupter potency of commonly used organochlorine pesticides using the LUMI-CELL ER" bioassay. Organohalogen Compounds 66:169-174.
  • Han D, Nagy SR, Denison MS. 2004. Comparison of recombinant cell bioassays for the detection of Ah receptor agonists. Biofactors 20(1):11-22. PMID:15096657
  • Kim I, Morisseau C, Watanabe T, Hammock BD. 2004. Design, synthesis, and biological activity of 1,3-disubstituted ureas as potent inhibitors of the soluble epoxide hydrolase of increased water solubility. J Med Chem 47(8):2110-2122. doi:10.1021/jm030514j PMID:15056008
  • Knockaert M, Blondel M, Bach S, Leost M, Elbi C, Hager GL, Nagy SR, Han D, Denison MS, Ffrench M, Ryan XP, Magiatis P, Polychronopoulos P, Greengard P, Skaltsounis L, Meijer L. 2004. Independent actions on cyclin-dependent kinases and aryl hydrocarbon receptor mediate the antiproliferative effects of indirubins. Oncogene 23(25):4400-4412. PMID:15077192
  • Newman JW, Stok JE, Vidal JD, Corbin CJ, Huang Q, Hammock BD, Conley AJ. 2004. Cytochrome P450-dependent lipid metabolism in preovulatory follicles. Endocrinology 145(11):5097-5105. PMID:15308618
  • Phillips MA, Jessen BA, Lu Y, Qin Q, Stevens ME, Rice RH. 2004. A distal region of the human TGM1 promoter is required for expression in transgenic mice and cultured keratinocytes. BMC Dermatol 4:2. doi:10.1186/1471-5945-4-2 PMID:15061870 PMCID:PMC416661
  • Stok JE, Goloshchapov A, Song C, Wheelock CE, Derbel M, Morisseau C, Hammock BD. 2004. Investigation of the role of a second conserved serine in carboxylesterases via site-directed mutagenesis. Arch Biochem Biophys 430(2):247-255. PMID:15369824
  • Stok JE, Huang H, Jones PD, Wheelock CE, Morisseau C, Hammock BD. 2004. Identification, expression, and purification of a pyrethroid-hydrolyzing carboxylesterase from mouse liver microsomes. J Biol Chem 279(28):29863-29869. doi:10.1074/jbc.M403673200 PMID:15123619
  • Voss AA, Lango J, Ernst-Russell M, Morin D, Pessah IN. 2004. Identification of hyperreactive cysteines within ryanodine receptor type 1 by mass spectrometry. J Biol Chem 279(33):34514-34520. PMID:15197184
  • Wheelock CE, Miller JL, Miller MJ, Gee SJ, Shan G, Hammock BD. 2004. Development of toxicity identification evaluation procedures for pyrethroid detection using esterase activity. Environ Toxicol Chem 23(11):2699-2708. PMID:15559286
  • Yu Z, Davis BB, Morisseau C, Hammock BD, Olson JL, Kroetz DL, Weiss RH. 2004. Vascular localization of soluble epoxide hydrolase in the human kidney. Am J Physiol Renal Physiol 286(4):F720-F726. PMID:14665429
  • Zhao B, Denison MS. 2004. Development and characterization of a green fluorescent protein-based rat cell bioassay system for detection of Ah receptor ligands. Organohalogen Compounds 66:3285-3290.
  • Zhao B, Nagy SR, Rogers JM, Nantz MH, Kurth M, Springsteel M, Denison MS. 2004. Identification and analysis of novel flavonoid agonists and antagonists for the Ah and estrogen receptor. Organohalogen Compounds 66:2919-2924.


  • Baston DS, Nagy SR, Nantz MH, Kurth M, Springsteel M, Denison MS. 2003. Identification of novel agonists and antagonists of the Ah receptor signal transduction pathway. Organohalogen Compounds 65:142-145.
  • Crumrine D, Hohl D, Munro CS, Elias PM. 2003. Cross-linked envelopes in nail plate in lamellar ichthyosis. Br J Dermatol 149(5):1050-1054. PMID:14632814
  • Denison MS, Han D, Heath-Pagliuso S, Scovill J, Meijer L, Skaltounis L, Gillam EM, Nagy SR. 2003. Activation of the Ah receptor and Ah receptor signal transduction pathway by tryptophan-derived agonists. Organohalogen Compounds 65:90-93.
  • Denison MS, Nagy SR. 2003. Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals. Annu Rev Pharmacol Toxicol 43:309-334. PMID:12540743
  • Denton DL, Wheelock CE, Murray SA, Deanovic LA, Hammock BD, Hinton DE. 2003. Joint acute toxicity of esfenvalerate and diazinon to fathead minnow (Pimephales promelas) larvae. Environ Toxicol Chem 22(2):336-341. PMID:12558165
  • Gordon JD, Chu AC, Chu MD, Taylor CL, Denison MS, Clark GC. 2003. Validation of the LUMI-CELLTM ER recombinant bioassay for rapid evaluatin of chemicals for potential estrogenic activity. Organohalogen Compounds 65:78-81.
  • Han D, Zhao B, Baston DS, Springsteel M, Kurth M, Nantz MH, Denison MS. 2003. Identification and characterization of novel flavone agonists of th Ah receptor. Organohalogen Compounds 65:126-129.
  • Inceoglu B, Lango J, Jing J, Chen L, Doymaz F, Pessah IN, Hammock BD. 2003. One scorpion, two venoms: prevenom of Parabuthus transvaalicus acts as an alternative type of venom with distinct mechanism of action. Proc Natl Acad Sci U S A 100(3):922-927. PMID:12552107
  • Jeuken A, Keser BJ, Khan EM, Brouwer A, Koeman JH, Denison MS. 2003. Activation of the Ah receptor by extracts of dietary herbal supplements, vegetables, and fruits. J Agric Food Chem 51(18):5478-5487. PMID:12926901
  • Koivunen ME, Morisseau C, Newman JW, Horwath WR, Hammock BD. 2003. Purification and characterization of a methylene urea-hydrolyzing enzyme from Rhizobium radiobacter (Agrobacterium tumefaciens). Soil Biol Biochem 35(11):1433-1442.
  • McElroy NR, Jurs PC, Morisseau C, Hammock BD. 2003. QSAR and classification of murine and human soluble epoxide hydrolase inhibition by urea-like compounds. J Med Chem 46(6):1066-1080. PMID:12620084
  • Monk SA, Denison MS, Rice RH. 2003. Reversible stepwise negative regulation of CYP1A1 in cultured rat epidermal cells. Arch Biochem Biophys 419(12):158-169. PMID:14592459
  • Newman JW, Morisseau C, Harris TR, Hammock BD. 2003. The soluble epoxide hydrolase encoded by EPXH2 is a bifunctional enzyme with novel lipid phosphate phosphatase activity. Proc Natl Acad Sci U S A 100(4):1558-1563. PMID:12574510
  • Patterson TP, Ngo MA, Aronov PA, Reznikova TV, Green PG. 2003. Biological activity of inorganic arsenic and antimony reflects oxidation state in cultured human keratinocytes. Chem Res Toxicol 16(12):1624-1631. PMID:14680377
  • Przybyla-Zawislak BD, Srivastava PK, Vazquez-Matias J, Mohrenweiser HW, Maxwell JE, Hammock BD, Bradbury JA, Enayetallah AE, Zeldin DC, Grant DF. 2003. Polymorphisms in human soluble epoxide hydrolase. Mol Pharmacol 64(2):482-490. PMID:12869654
  • Rea MA, Gregg JP, Qin Q, Phillips MA, Rice RH. 2003. Global alteration of gene expression inhuman keratinocytes by inorganic arsenic. Carcinogenesis 24(4):747-756. PMID:12727804
  • Taniai K, Inceoglu AB, Yukuhiro K, Hammock BD. 2003. Characterization and cDNA cloning of a clofibrate-inducible microsomal epoxide hydrolase in Drosophila melanogaster. FEBS J 270(23):4696-4705. PMID:14622257
  • Watanabe T, Morisseau C, Newman JW, Hammock BD. 2003. In vitro metabolism of the mammalian soluble epoxide hydrolase inhibitor, 1-cyclohexyl-3-dodecyl-urea. Drug Metab Dispos 31(7):846-853. doi:10.1124/dmd.31.7.846 PMID:12814960
  • Wheelock CE, Nakagawa Y, Akamatsu M, Hammock BD. 2003. Use of classical and 3-D QSAR to examine the hydration state of juvenile hormone esterase inhibitors. Bioorg Med Chem 11(23):5101-5116. PMID:14604674
  • Wheelock CE, Wheelock AM, Zhang RH, Stok JE, Morisseau C, Le Valley SE, Green CE, Hammock BD. 2003. Evaluation of alpha-cyanoesters as fluorescent substrates for examining interindividual variation in general and pyrethroid-selective esterases in human liver microsomes. Anal Biochem 315(2):208-222. PMID:12689831
  • Wuilloud JC, Wuilloud RG, Sadi BM, Caruso JA, Denison MS, Nagy SR. 2003. Trace humic and fulvic acid determination in natural water by cloud point extraction/preconcentration using non-ionic and cationic surfactants with FI-UV detection. Analyst 128(5):453-458. PMID:12790196
  • Zhang RH, Kang K, Shan G, Hammock BD. 2003. Design, synthesis and evaluation of novel P450 fluorescent probes bearing -cyanoether. Tetrahedron Lett 44(23):4331-4334.
  • Zhao B, Nagy SR, Baston DS, Han D, Nantz MH, Kurth M, Springsteel M, Denison MS. 2003. Screening and analysis of novel naphthoflavone ligands for the Ah receptor. Organohalogen Compounds 65:102-105.


  • Davis BB, Thompson DA, Howard LL, Morisseau C, Hammock BD, Weiss RH. 2002. Inhibitors of soluble epoxide hydrolase attenuate vascular smooth muscle cell proliferation. Proc Natl Acad Sci U S A 99(4):2222-2227. PMID:11842228
  • Denison MS, Nagy SR, Ziccardi MH, Clark GC, Chu MD, Brown DJ, Shan G, Sugawara Y, Gee SJ, Sanborn JR, Hammock BD. 2002. Bioanalytical approaches for the detection of dioxin and related halogenated aromatic hydrocarbons. In: Biomarkers of Environmentally Associated Disease: Technologies, Concepts, and Perspectives. CRC Press Company, Boca Raton, FL. pp.483-494.
  • Fang X, Weintraub NL, Oltman CL, Stoll LL, Kaduce TL, Harmon S, Dellsperger KC, Morisseau C, Hammock BD, Spector AA. 2002. Human coronary endothelial cells convert 14,15-EET to a biologically active chain-shortened epoxide. Am J Physiol Heart Circ Physiol 283(6):H2306-H2314. doi:10.1152/ajpheart.00448.2002 PMID:12388281
  • Fornage M, Hinojos CA, Nurowska BW, Boerwinkle E, Hammock BD, Morisseau C, Doris PA. 2002. Polymorphism in soluble epoxide hydrolase and blood pressure in spontaneously hypertensive rats. Hypertension 40(4):485-490. PMID:12364351
  • Han D, Nagy SR, Denison MS. 2002. Recombinant cell lines for the detection of dioxins and Ah receptor ligands - not all assays are created equal. Organohalogen Compounds 58:421-424.
  • Hennig B, Hammock BD, Slim RM, Toborek M, Viswanathan S, Robertson LW. 2002. PCB-induced oxidative stress in endothelial cells: modulation by nutrients. Int J Hyg Environ Health 205(1-2):95-102. PMID:12018021
  • Imig JD, Zhao X, Capdevila JH, Morisseau C, Hammock BD. 2002. Soluble epoxide hydrolase inhibition lowers arterial blood pressure in angiotensin II hypertension. Hypertension 39(2):690-694. PMID:11882632
  • Khan EM, Denison MS. 2002. NF-kB is involved in cross-talk between Ah receptor and signal transduction pathways. Organohalogen Compounds 59:411-414.
  • Krig SR, Chandraratna RA, Chang MM, Wu R, Rice RH. 2002. Gene-specific TCDD suppression of RAR- and RXR-mediated induction of tissue transglutaminase. Toxicol Sci 68(1):102-108. PMID:12075115
  • Lashley MR, Niedzinski EJ, Rogers JM, Denison MS, Nantz MH. 2002. Synthesis and estrogen receptor affinity of a 4-hydroxytamoxifen-labeled ligand for diagnostic imaging. Bioorg Med Chem 10(12):4075-4082. PMID:12413861
  • Morisseau C, Goodrow MH, Newman JW, Wheelock CE, Dowdy DL, Hammock BD. 2002. Structural refinement of inhibitors of urea based soluble epoxide hydrolases. Biochem Pharmacol 63(9):1599-1608. PMID:12007563
  • Morisseau C, Hammock BD. 2002. Epoxide Hydrolases. In: Wiley Encyclopedia of Molecular Medicine. Medicine John Wiley & Sons Inc., New York, NY. pp.1194-1197.
  • Nagy SR, Denison MS. 2002. Specificity of nuclear protein binding to a CYP1A1 negative regulatory element. Biochem Biophys Res Commun 296(4):799-805. PMID:12200118
  • Nagy SR, Liu G, Lam KS, Denison MS. 2002. Identification of novel Ah receptor agonists using a high-throughput green fluorescent protein-based recombinant cell bioassay. Biochemistry 41(3):861-868. PMID:11790108
  • Nagy SR, Sanborn JR, Hammock BD, Denison MS. 2002. Development of a green fluorescent protein based cell bioassay for the rapid and inexpensive detection and characterization of AhR agonists. Toxicol Sci 65(2):200-210. PMID:11812924
  • Natarajan K, Overstreet JW, Rogers JM, Denison MS, Chen J, Lohstroh PN, McConnell DS, Lasley BL. 2002. Detection of xenoestrogens in serum after immunoprecipitation of endogenous steroidal estrogens. Environ Health Perspect 110(8):791-795. PMID:12153760
  • Newman JW, Watanabe T, Hammock BD. 2002. The simultaneous quantification of cytochrome P450 dependent linoleate and arachidonate metabolites in urine by HPLC-MS/MS. J Lipid Res 43(9):1563-1578. PMID:12235189
  • Rea MA, Gregg JP, Rice RH. 2002. Expression profiling of TCDD-treated human epidermal cells in culture. Organohalogen Compounds 55:469-472.
  • Rogers JM, Denison MS. 2002. Analysis of the antiestrogenic activity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in human ovarian carcinoma BG-1 cells. Mol Pharmacol 61(6):1393-1403. PMID:12021401
  • Rushing SR, Denison MS. 2002. The silencing mediator of retinoic acid and thyroid hormone receptors can interact with the aryl hydrocarbon (Ah) receptor but fails to repress Ah receptor-dependent gene expression. Arch Biochem Biophys 403(2):189-201. PMID:12139968
  • Severson T, Goodrow MH, Morisseau C, Dowdy DL, Hammock BD. 2002. Urea and amide-based inhibitors of the juvenile hormone epoxide hydrolase of the tobacco hornworm(Manduca sexta: Sphingidae). Insect Biochem Mol Biol 32:1741-1756. PMID:12429126
  • Wheelock CE, Colvin ME, Uemura I, Olmstead MM, Sanborn JR, Nakagawa Y, Jones AD, Hammock BD. 2002. Use of ab initio calculations to predict the biological potency of carboxylesterase inhibitors. J Med Chem 45(25):5576-5593. PMID:12459025
  • Ziccardi MH, Gardner IA, Denison MS. 2002. Application of the luciferase recombinant cell culture bioassay system for the analysis of polycyclic aromatic hydrocarbons. Environ Toxicol Chem 21(10):2027-2033. PMID:12371477
  • Ziccardi MH, Gardner IA, Mazet JA, Denison MS. 2002. Application of the luciferase cell culture bioassay for the detection of refined petroleum products. Mar Pollut Bull 44(10):983-991. PMID:12474956
  • Zurek G, Gee SJ, Hammock BD. 2002. Development of an enzyme immunoassay for linoleic acid diols in urine. Anal Chim Acta 466(2):247-256.


  • Fang X, Kaduce TL, Weintraub NL, Harmon S, Teesch LM, Morisseau C, Thompson DA, Hammock BD, Spector AA. 2001. Pathways of epoxyeicosatrienoic acid metabolism in endothelial cells: implications for the vascular effects of soluble epoxide hydrolase inhibition. J Biol Chem 276(18):14867-14874. PMID:11278979
  • Huang Q, Deveraux QL, Maeda S, Stennicke HR, Hammock BD, Reed JC. 2001. Cloning and characterization of an inhibitor of apoptosis protein (IAP) from Bombyx mori. Biochim Biophys Acta 1499(3):191-198. PMID:11341966
  • Jessen BA, Qin Q, Phillips MA, Phillips DL, Rice RH. 2001. Keratinocyte differentiation marker suppression by arsenic: mediation by AP1 response elements and antagonism by tetradecanoylphorbol acetate. Toxicol Appl Pharmacol 174(3):302-311. PMID:11485391
  • Matveeva EG, Gribkova EV, Sanborn JR, Gee SJ, Hammock BD, Savitsky AP. 2001. Development of a homogeneous phosphorescent immunoassay for the detection of polychlorinated dibenzo-p-dioxins. Anal Lett 34(13):2311-2320.
  • Mazina OM, Phillips MA, Williams T, Vines CA, Cherr GN, Rice RH. 2001. Redistribution of transcription factor AP-2a in differentiating cultured human epidermal cells. Journal of Investigative Dermatology 117(4):864-870. PMID:11676824
  • Monk SA, Denison MS, Rice RH. 2001. Transient expression of CYP1A1 in rat epithelial cells cultured in suspension. Arch Biochem Biophys 393(1):154-162. PMID:11516172
  • Morisseau C, Newman JW, Dowdy DL, Goodrow MH, Hammock BD. 2001. Inhibition of microsomal epoxide hydrolases by ureas, amides, and amines. Chem Res Toxicol 14(4):409-415. PMID:11304129
  • Newman JW, Denton DL, Morisseau C, Koger CS, Wheelock CE, Hinton DE, Hammock BD. 2001. Evaluation of fish models of soluble epoxide hydrolase inhibition. Environ Health Perspect 109(1):61-66. PMID:11171526 PMCID:PMC1242052
  • Newman JW, Hammock BD. 2001. Optimized thiol derivatizing reagent for the mass spectral analysis of disubstituted epoxy fatty acids. J Chromatogr A 925(1-2):223-240. PMID:11519808
  • Rea MA, Rice RH. 2001. Telomerase deregulation in immortalized human epidermal cells: Modulation by cellular microenvironment. Int J Cancer 94(5):669-673. PMID:11745461
  • Rogers JM, Denison MS. 2001. Analysis of the anti-estrogen effect of TCDD in human ovarian carcinoma (BG-1) cells. Organohalogen Compounds 53:5-9.
  • Seidel SD, Winters GM, Rogers JM, Ziccardi MH, Li V, Keser BJ, Denison MS. 2001. Activation of the Ah receptor signaling pathway by prostaglandins. J Biochem Mol Toxicol 15(4):187-196. PMID:11673847
  • Sisemore MF, Zheng J, Yang JC, Thompson DA, Plopper CG, Cortopassi GA, Hammock BD. 2001. Cellular characterization of leukotoxin diol-induced mitochondrial dysfunction. Arch Biochem Biophys 392(1):32-37. PMID:11469791
  • Slim RM, Hammock BD, Toborek M, Robertson LW, Newman JW, Morisseau C, Watkins BA, Viswanathan S, Hennig B. 2001. The role of methyl-linoleic acid epoxide and diol metabolites in the amplified toxicity of linoleic acid and polychlorinated biphenyls to vascular endothelial cells. Toxicol Appl Pharmacol 171(3):184-193. PMID:11243918
  • Watanabe T, Hammock BD. 2001. Rapid determination of soluble epoxide hydrolase inhibitors in rat hepatic microsomes by high performance liquid chromatography with electrospray tandem mass spectrometry. Anal Biochem 299(2):227-234. PMID:11730347
  • Watkins SM, Hammock BD, Newman JW, German JB. 2001. Individual metabolism should guide agriculture toward foods for improved health and nutrition. Am J Clin Nutr 74(3):283-286. PMID:11522549
  • Wheelock CE, Severson T, Hammock BD. 2001. Synthesis of new carboxylesterase inhibitors and evaluation of potency and water solubility. Chem Res Toxicol 14(12):1563-1572. PMID:11743738
  • Wong PW, Garcia EF, Pessah IN. 2001. ortho-Substituted PCB95 alters intracellular calcium signaling and causes cellular acidification in PC12 cells by an immunophilin-dependent mechanism. J Neurochem 76:450-463. PMID:11208908
  • Zheng J, Plopper CG, Lakritz J, Storms DH, Hammock BD. 2001. Leukotoxin-diol - a putative toxic mediator involved in acute respiratory distress syndrome. Am J Respir Cell Mol Biol 25(4):434-438. PMID:11694448
  • Ziccardi MH, Gardner IA, Denison MS. 2001. Application of the luciferase recombinant cell culture bioassay for detection of dioxin-like activity of PAHs in the serum of wildlife. Organohalogen Compounds 54:73-76.


  • Argiriadi MA, Morisseau C, Goodrow MH, Dowdy DL, Hammock BD, Christianson DW. 2000. Binding of alkylurea inhibitors to epoxide hydrolase implicates active site tyrosines in substrate activation. J Biol Chem 275(20):15265-15270. PMID:10747889
  • Arrieta DE, Ontiveros C, Denison MS, Washburn BS. 2000. Ah receptor mediated effects of particulate organic extracts from the Paso Del Norte airshed along the U.S.-Mexico border. Organohalogen Compounds 45:212-215. PMID:12896850
  • Bohonowych JE, Rogers JM, Jeuken A, Denison MS. 2000. Activation of Ah and estrogen receptor based cell bioassay systems by extracts of natural dietary herbal supplements. Organohalogen Compounds 45:240-243.
  • Chun H, Kuzmicky A, Rucoba L, Kado NY, Rice RH. 2000. Cytotoxicity and keratinocyte microsome mediated mutagenic activation of carcinogens in cultured epidermal cells. Toxicol Lett 115(2):165-172. PMID:10802392
  • Chun H, Kuzmicky PA, Kado NY, Rice RH. 2000. Toxicity of Trp-P-2 to cultured human and rat keratinocytes. Chem Biol Interact 127(3):237-253. PMID:10967320
  • Draper AJ, Hammock BD. 2000. Identification of CYP2C9 as a human liver microsomal linoleic acid epoxygenase. Arch Biochem Biophys 376(1):199-205. PMID:10729206
  • Fanucchi MV, Buckpitt AR, Murphy M, Storms DH, Hammock BD, Plopper CG. 2000. Development of phase II xenobiotic metabolizing enzymes in differentiating murine Clara cells. Toxicol Appl Pharmacol 168(3):253-267. PMID:11042098
  • Greene JF, Newman JW, Williamson K, Hammock BD. 2000. Toxicity of epoxy fatty acids and related compounds to cells expressing human soluble epoxide hydrolase. Chem Res Toxicol 13(4):217-226. PMID:10775319
  • Greene JF, Williamson K, Newman JW, Morisseau C, Hammock BD. 2000. Metabolism of monoepoxides of methyl linoleate: bioactivation and detoxification. Arch Biochem Biophys 376(2):420-432. PMID:10775430
  • Greene JF, Zheng J, Grant DF, Hammock BD. 2000. Cytotoxicity of 1,2-epoxynaphthalene is correlated with protein binding and in situ glutathione depletion in cytochrome P4501A1 expressing Sf-21 cells. Toxicol Sci 53(2):352-360. PMID:10696783
  • Heath-Pagliuso S, Mui R, Milici A, Giese S, Chin R, Denison MS. 2000. Tryptophan metabolites, indole-3-pyruvic acid, DL-3-indolelactic acid, L-kynurenine, and kynurenic acid activate Ah receptor signal transduction. Organohalogen Compounds 49:289-292.
  • Huang Q, Deveraux QL, Maeda S, Salvesen GS, Stennicke HR, Hammock BD, Reed JC. 2000. Evolutionary conservation of apoptosis mechanisms: lepidopteran and baculoviral inhibitor of apoptosis proteins are inhibitors of mammalian caspase-9. Proc Natl Acad Sci U S A 97(4):1427-1432. PMID:10677478 PMCID:PMC26450
  • Jessen BA, Phillips MA, Hovnanian A, Rice RH. 2000. Role of Sp1 response element in transcription of the human transglutaminase 1 gene. Journal of Investigative Dermatology 115(1):113-117. PMID:10886517
  • Jessen BA, Qin Q, Rice RH. 2000. Functional AP1 and CRE response elements in the human keratinocyte transglutaminase promoter mediating Whn suppression. Gene 254(1-2):77-85. PMID:10974538
  • Krig SR, Rice RH. 2000. TCDD suppression of tissue transglutaminase stimulation by retinoids in malignant human keratinocytes. Toxicol Sci 56(2):357-364. PMID:10910994
  • Lakritz J, Winder BS, Noorouz-Zadeh J, Huang TL, Buckpitt AR, Hammock BD, Plopper CG. 2000. Hepatic and pulmonary enzyme activities in horses. American Journal of Veterinary Research 61(2):152-157. PMID:10685686
  • Morisseau C, Beetham JK, Pinot F, Debernard S, Newman JW, Hammock BD. 2000. Cress and potato soluble epoxide hydrolases: purification, biochemical characterization, and comparison to mammalian enzymes. Arch Biochem Biophys 378(2):321-332. PMID:10860549
  • Nagy SR, Lui G, Lam KS, Denison MS. 2000. A green fluorescent protein based recombinant cell bioassay for the detection of activators of the aryl hydrocarbon receptor: application for screening of a 1,5-dialkylamino-2,4-dinitrobenzene combinatorial chemical library. Organohalogen Compounds 45:232-235.
  • Nakagawa Y, Wheelock CE, Morisseau C, Goodrow MH, Hammock BG, Hammock BD. 2000. 3-D QSAR analysis of inhibition of murine soluble epoxide hydrolase (MsEH) by benzoylureas, arylureas, and their analogues. Bioorg Med Chem 8(11):2663-2673. PMID:11092551
  • Phillips MA, Qin Q, Rice RH. 2000. Identification of an involucrin promoter transcriptional response element with activity restricted to keratinocytes. Biochem J 348(Pt.1):45-53. PMID:10794712
  • Rogers JM, Denison MS. 2000. Application of a human ovarian cell bioassay for the detection and analysis of estrogen-toxicant interaction. Organohalogen Compounds 49:338-341.
  • Rogers JM, Denison MS. 2000. Recombinant cell bioassays for endocrine disruptors: development of a stably transfected human ovarian cell line for the detection of estrogenic and anti-estrogenic chemicals. In Vitr Mol Toxicol 13(1):67-82. PMID:10900408
  • Seidel SD, Li V, Winters GM, Rogers WJ, Martinez EI, Denison MS. 2000. Ah receptor-based chemical screening bioassays: application and limitations for the detection of Ah receptor agonists. Toxicol Sci 55(1):107-115. PMID:10788565
  • Shan G, Sanborn JR, Gilman DS, Nagy SR, Gee SJ, Stoutamire DW, Mercer RS, Jones AD, Stanker LH, Denison MS, Hammock BD. 2000. Surrogates for dioxin analyses: analytical, ELISA and toxicological aspects. Organohalogen Compounds 45:188-191.
  • Williams SN, Shih H, Guenette DK, Brackney W, Denison MS, Pickwell GV, Quattrochi LC. 2000. Comparative studies on the effects of green tea extracts and individual tea catechins on human CYP1A gene expression. Chem Biol Interact 128(3):211-229. PMID:11064004
  • Williamson K, Morisseau C, Maxwell JE, Hammock BD. 2000. Regio- and enantioselective hydrolysis of phenyloxiranes catalyzed by soluble epoxide hydrolase. Tetrahedron: Asymmetry 11:4451-4462.
  • Yamada T, Morisseau C, Maxwell JE, Argiriadi MA, Christianson DW, Hammock BD. 2000. Biochemical evidence for the involvement of tyrosine in epoxide activation during the catalytic cycle of epoxide hydrolase. J Biol Chem 275(30):23082-23088. PMID:10806198
  • Yu Z, Xu F, Huse LM, Morisseau C, Draper AJ, Newman JW, Parker C, Graham L, Engler MM, Hammock BD, Zeldin DC, Kroetz DL. 2000. Soluble epoxide hydrolase regulates hydrolysis of vasoactive epoxyeicosatrienoic acids. Circ Res 87(11):992-998. PMID:11090543
  • Ziccardi MH, Gardner IA, Denison MS. 2000. Development and modification of a recombinant cell bioassay to directly detect halogenated and polycyclic aromatic hydrocarbons in serum. Toxicol Sci 54(1):183-193. PMID:10746945


  • Denison MS, Seidel SD, Ziccardi MH, Rogers WJ, Brown DJ, Clark GC. 1999. Ah receptor-based bioassays for dioxins and related chemicals: applications and limitations. Organohalogen Compounds 40:27-30.
  • Draper AJ, Hammock BD. 1999. Inhibition of soluble and microsomal epoxide hydrolase by zinc and other metals. Toxicol Sci 52:26-32. PMID:10568695
  • Draper AJ, Hammock BD. 1999. Soluble epoxide hydrolase in rat inflammatory cells is indistinguishable from soluble epoxide hydrolase in rat liver. Toxicol Sci 50:30-35. PMID:10445750
  • Levine SL, Oris JT, Denison MS. 1999. Modulation of CYP1A expression in rainbow trout by a technical grade formulation of propriconazole. Environ Toxicol Chem 18(11):2565-2573.
  • Morisseau C, Derbel M, Lane TR, Stoutamire DW, Hammock BD. 1999. Differential induction of hepatic drug-metabolizing enzymes by fenvaleric acid in male rats. Toxicol Sci 52(2):148-153. PMID:10630566
  • Morisseau C, Goodrow MH, Dowdy DL, Zheng J, Greene JF, Sanborn JR, Hammock BD. 1999. Potent urea and carbamate inhibitors of soluble epoxide hydrolases. Proc Natl Acad Sci U S A 96(16):8849-8854. PMID:10430859
  • Morisseau C, Ward BL, Gilchrist DG, Hammock BD. 1999. Multiple epoxide hydrolases in Alternaria alternata f. sp. lycopersici and their relationship to medium composition and host-specific toxin production. Appl Environ Microbiol 65(6):2388-2395. PMID:10347018
  • Mullen RT, Trelease RN, Duerk H, Arand M, Hammock BD, Oesch F, Grant DF. 1999. Differential subcellular localization of endogenous and transfected soluble epoxide hydrolase in mammalian cells: evidence for isozyme variants. FEBS Lett 445(2-3):301-305. PMID:10094477
  • Thomas BA, Church WB, Lane TR, Hammock BD. 1999. Homology model of juvenile hormone esterase from the crop pest, Heliothis virescens. Proteins: Structure, Function, and Genetics 34(2):184-196. PMID:10022354


  • Denison MS, Heath-Pagliuso S. 1998. The Ah receptor: a regulator of the biochemical and toxicological actions of structurally diverse chemicals. Bull Environ Contam Toxicol 61:557-568. PMID:9841714
  • Denison MS, Phelan D, Elferink CJ. 1998. The Ah receptor signal transduction pathway. In: Toxicant-Receptor Interactions. Taylor and Francis, Philadelphia, PA. pp.3-33.
  • Denison MS, Phelan D, Winters GM, Ziccardi MH. 1998. Carbaryl, a carbamate insecticide, is a ligand for the hepatic Ah (dioxin) receptor. Toxicol Appl Pharmacol 152(2):406-414. PMID:9853009
  • Fischer L, Seegal R, Ganey PE, Pessah IN, Kodavanti PR. 1998. Symposium overview: toxicity of non-coplanar PCBs. Toxicol Sci 41(1):49-61. doi:10.1006/toxs.1997.2386 PMID:9520341
  • Heath-Pagliuso S, Rogers WJ, Tullis K, Seidel SD, Cenijn PH, Brouwer A, Denison MS. 1998. Activation of the Ah receptor by tryptophan and tryptophan metabolites. Biochemistry 37(33):11508-11515. PMID:9708986
  • Phelan D, Winters GM, Rogers WJ, Lam JC, Denison MS. 1998. Activation of the Ah receptor signal transduction pathway by bilirubin and biliverdin. Arch Biochem Biophys 357(1):155-163. PMID:9721195
  • Rea MA, Phillips MA, Degraffenried LA, Qin Q, Rice RH. 1998. Modulation of human epidermal cell response to 2,3,7,8-tetrachlorodibenzo-p-dioxin by epidermal growth factor. Carcinogenesis 19(3):479-483. PMID:9525283


  • Kachinskas DJ, Qin Q, Phillips MA, Rice RH. 1997. Arsenate suppression of human keratinocyte programming. Mutat Res Rev Mutat Res 386(3):253-261. PMID:9219563
  • Murk AJ, Leonards PE, Bulder AS, Jonas AS, Rozemeijer MJ, Denison MS, Koeman JH, Brouwer A. 1997. The CALUX (chemical-activated luciferase expression) assay adapted and validated for measuring TCDD equivalents in blood plasma. Environ Toxicol Chem 16(8):1583-1589.
  • Ziccardi MH, Rogers WJ, Schecter AJ, Papke O, Denison MS. 1997. Direct detection of dioxins and related chemicals in small quantities of human serum using a recombinant cell bioassay. Organohalogen Compounds 31:215-218.


  • Denison MS, Rogers WJ, Fair M, Ziccardi MH, Clark GC, Murk AJ, Brouwer A. 1996. Applications of the CALUX bioassay system for the detection of dioxin-like chemicals (Ah receptor ligands) in whole serum samples in extracts from commercial and consumer products. Organohalogen Compounds 27:280-284.
  • Garrison PA, Tullis K, Aarts JM, Brouwer A, Giesy JP, Denison MS. 1996. Species-specific recombinant cell lines as bioassay systems for the detection of 2,3,7,8-tetrachlorodibenzo-p-dioxin-like chemicals. Fundam Appl Toxicol 30(2):194-203. PMID:8812265
  • Gebremichael A, Tullis K, Denison MS, Cheek JM, Pinkerton KE. 1996. Ah-receptor-dependent modulation of gene expression by aged and diluted sidestream cigarette smoke. Toxicol Appl Pharmacol 141(1):76-83. PMID:8917678
  • Murk AJ, Legler J, Denison MS, Giesy JP, van der Guchte CJ, Brouwer A. 1996. Chemical-activated luciferase gene expression (CALUX): a novel in vitro bioassay for Ah receptor active compounds in sediments and pore water. Fundam Appl Toxicol 33(1):149-160. PMID:8812260
  • Rice RH, Mehrpouyan M, Qin Q, Phillips MA, Lee YM. 1996. Identification of phosphorylation sites in keratinocyte transglutaminase. Biochemistry 320(Pt.2):547-550. PMID:8973564
  • Rice RH, Wong VJ, Price VH, Hohl D, Pinkerton KE. 1996. Cuticle cell defects in lamellar ichthyosis hair and anomalous hair shaft syndromes visualized after detergent extraction. The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology 246(4):433-440. PMID:8955782
  • Shi B, Isseroff RR. 1996. Thapsigargin induces phosphorylation of the 27-kDa heat shock protein in human keratinocytes. Journal of Investigative Dermatology 107(5):749-754. PMID:8875961
  • Walsh AA, Tullis K, Rice RH, Denison MS. 1996. Identification of a novel cis-acting negative regulatory element affecting expression of the CYP1A1 gene in rate epidermal cells. J Biol Chem 271(37):22746-22753.


  • Mariniello L, Qin Q, Jessen BA, Rice RH. 1995. Keratinocyte transglutaminase promoter analysis. Identification of a functional response element. J Biol Chem 270(52):31358-31363. PMID:8537408
  • Stewart BE, Rice RH. 1995. Differentiation-associated expression of the proto-oncogene pim-1 in cultured human keratinocytes. Journal of Investigative Dermatology 105(5):699-703. PMID:7594647
  • Walsh AA, Degraffenried LA, Rice RH. 1995. 2,3,7,8-Tetrachlorodibenzo-p dioxin sensitization of cultured human epidermal cells to toxicity from a carcinogenic heterocyclic amine. Carcinogenesis 16(9):2187-2191. PMID:7554073
to Top