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Your Environment. Your Health.

Project Publications: Texas A&M University: Genotoxicity of Complex Mixtures

Superfund Research Program

Genotoxicity of Complex Mixtures

Project Leader: Kirby C. Donnelly
Grant Number: P42ES004917
Funding Period: 2000-2008

Project-Specific Links



  • Phillips TD, Richardson MB, Cheng YL, He L, McDonald TJ, Cizmas LH, Safe SH, Donnelly KC, Wang F, Moorthy B, Zhou GD. 2015. Mechanistic relationships between hepatic genotoxicity and carcinogenicity in male B6C3F1 mice treated with polycyclic aromatic hydrocarbon mixtures. Arch Toxicol 89(6):967-977. doi:10.1007/s00204-014-1285-8 PMID:24888377 PMCID:PMC4254891


  • Theodorakis CW, Bickham JW, Donnelly KC, McDonald TJ, Willink PW. 2012. DNA damage in cichlids from an oil production facility in Guatemala. Ecotoxicology 21:496-511. doi:10.1007/s10646-011-0811-1 PMID:22080433



  • Barbee GC, Barich J, Duncan B, Bickham JW, Matson CW, Hintze CJ, Autenrieth RL, Zhou GD, McDonald TJ, Cizmas LH, Norton D, Donnelly KC. 2008. In situ biomonitoring of PAH-contaminated sediments using juvenile coho salmon (Oncorhynchus kisutch). Ecotoxicol Environ Saf 71(2):454-464. doi:10.1016/j.ecoenv.2008.01.001 PMID:18304636
  • Zhou GD, Donnelly KC, Tian Y, Naspinski C, Gu X, Mertens-Talcott SU. 2008. Pregnane X receptor protects HepG2 cells from BaP-induced DNA damage. Toxicol Sci 104(1):67-73. doi:10.1093/toxsci/kfn058 PMID:18381355


  • Custer CM, Drummer P, Li A, Warburton DH, Melancon MJ, Hoffman DJ, Matson CW, Bickham JW, Custer TW. 2007. Water level management and contaminant exposure to tree swallows nesting on the Upper Mississippi River. Environ Monit Assess 133(1-3):335-345. doi:10.1007/s10661-006-9588-8 PMID:17286172
  • Nwaneshiudu OC, Autenrieth RL, McDonald TJ, Donnelly KC, Degollado ED, Abusalih AA. 2007. Risk of polycyclic aromatic hydrocarbon (PAH) exposure from ingested food: The Azerbaijan case study. J Environ Sci Health B 42(2):201-209. PMID:17365335


  • Cho T, Wild JR, Donnelly KC, Tiffany-Castiglioni E. 2006. Degradation of organophosphorus neurotoxicity in SY5Y neuroblastoma cells by organophosphorus hydrolase (OPH). J Toxicol Environ Health A 69(15):1413-1429. PMID:16766477
  • Matson CW, Lambert MM, McDonald TJ, Autenrieth RL, Donnelly KC, Islamzadeh A, Politov DI, Bickham JW. 2006. Evolutionary toxicology: population-level effects of chronic contaminant exposure on the marsh frogs (Rana ridibunda) of Azerbaijan. Environ Health Perspect 114(4):547-552. PMID:16581544
  • Tiffany-Castiglioni E, Hong SJ, Qian Y, Tang Y, Donnelly KC. 2006. In vitro models for assessing neurotoxicity of mixtures. Neurotoxicology 27(5):835-839. PMID:16843529


  • Donnelly KC, Huebner HJ, Claxton LD, Calvin J, Vos GA, Cizmas LH, He L. 2005. Biodegradation of simple chemical mixtures in soil. Environ Toxicol Chem 24(11):2839-2845. PMID:16398121
  • Matson CW, Palatnikov GM, Islamzadeh A, McDonald TJ, Autenrieth RL, Donnelly KC, Bickham JW. 2005. Chromosomal Damage in two species of aquatic turtles (Emys orbicularis and Mauremys caspica) inhabiting contaminated sites in Azerbaijan. Ecotoxicology 14(5):513-525. PMID:16220359
  • Matson CW, Palatnikov GM, McDonald TJ, Autenrieth RL, Donnelly KC, Anderson TA, Canas JE, Islamzadeh A, Bickham JW. 2005. Patterns of genotoxicity and contaminant exposure: evidence of genomic instability in the marsh frog (Rana Ridibunda) of Sumgayit, Azerbaijan. Environ Toxicol Chem 24:2055-2064. PMID:16152979


  • Cizmas LH, Zhou GD, Safe SH, McDonald TJ, Zhu L, Donnelly KC. 2004. Comparative in vitro and in vivo genotoxicities of 7H-benzo[c]fluorene, manufactured gas plant residue (MGP), and MGP fractions. Environ Mol Mutagen 43(3):159-168. doi:10.1002/em.20011 PMID:15065203
  • Donnelly KC, Lingenfelter R, Cizmas LH, Falahatpisheh MH, Qian Y, Tang Y, Garcia SS, Ramos KS, Tiffany-Castiglioni E, Mumtaz MM. 2004. Toxicity assessment of complex mixtures remains a goal. Environ Toxicol Pharmacol 18(2):135-141. doi:10.1016/j.etap.2004.03.013 PMID:21782742
  • Falahatpisheh MH, Kerzee JK, Metz RP, Donnelly KC, Ramos KS. 2004. Inducible cytochrome P450 activities in renal glomerular mesangial cells: biochemical basis for antagonistic interactions among nephrocarcinogenic polycyclic aromatic hydrocarbons. J Carcinog 3(1):12. doi:10.1186/1477-3163-3-12 PMID:15315710 PMCID:PMC516019
  • Zhou GD, Randerath K, Donnelly KC, Jaiswal AK. 2004. Effects of NQO1 deficiency on levels of cyclopurines and other oxidative DNA lesions in liver and kidney of young mice. Int J Cancer 112(5):877-883. PMID:15386390


  • Bickham JW, Matson CW, Islamzadeh A, Rowe GT, Donnelly KC, Swartz CD, Autenrieth RL, McDonald TJ, Politov DI, Wickliffe JK, Palatnikov GM, Mekhtiev AA, Kasimov R, Rogers WJ. 2003. Editorial: the unknown environmental tragedy in Sumgayit, Azerbaijan. Ecotoxicology 12(6):505-508. PMID:14680331
  • Cizmas LH, Barhoumi R, Burghardt RC, Reeves WR, He L, McDonald TJ, Donnelly KC. 2003. A comparison of two methods for fractionating complex mixtures in preparation for toxicity analysis. J Toxicol Environ Health A 66(14):1351-1370. PMID:12851116
  • Hong MS, Hong SJ, Barhoumi R, Burghardt RC, Donnelly KC, Wild JR, Venkatraj V, Tiffany-Castiglioni E. 2003. Neurotoxicity induced in differentiated SK-N-SH-SY5Y human neuroblastoma cells by organophosphorus compounds. Toxicol Appl Pharmacol 186(2):110-118. PMID:12639502
  • Kuliev G, Bickham JW. 2003. Karyotypes of four species of rodents. Tex J Sci 55:271-277.
  • Mueller DC, Bonner JS, McDonald SJ, Autenrieth RL, Donnelly KC, Lee K, Doe K, Anderson J. 2003. The use of toxicity bioassays to monitor the recovery of oiled wetland sediments. Environ Toxicol Chem 22(9):1945-1955. PMID:12959519
  • Swartz CD, Donnelly KC, Islamzadeh A, Rowe GT, Rogers WJ, Palatnikov GM, Mekhtiev AA, Kasimov R, McDonald TJ, Wickliffe JK, Presley BJ, Bickham JW. 2003. Chemical contaminants and their effects in fish and wildlife from the industrial zone of Sumgayit, Republic of Azerbaijan. Ecotoxicology 12(6):509-521. PMID:14680332
  • Tang Y, Donnelly KC, Tiffany-Castiglioni E, Mumtaz MM. 2003. Neurotoxicity of polycyclic aromatic hydrocarbons and simple chemical mixtures. J Toxicol Environ Health A 66(10):919-940. PMID:12825237


  • Barhoumi R, Mouneimne Y, Awooda I, Safe SH, Donnelly KC, Burghardt RC. 2002. Characterization of calcium oscillations in normal and benzo[a]pyrene-treated clone 9 cells. Toxicol Sci 68(2):444-450. PMID:12151640
  • Reese ED, Harris BC, Dimitriou-Christidis P, Autenrieth RL, Donnelly KC, McDonald TJ. 2002. Applicability of Toxic Equivalency Factors (TEFs) For Risk Assessment of Complex Mixtures. In: Proceedings of the Society of Environmental Toxicology and Chemistry 23rd Annual Meeting in North America. Salt Lake City, UT.
  • Ress NB, Donnelly KC, George S. 2002. The effect of pentachlorophenol on DNA adduct formation in p53 wild-type and knockout mice exposed to benzo[a]pyrene. Cancer Lett 178(1):11-17. PMID:11849736
  • Safe SH, Pallaroni L, Yoon K, Gaido KW, Ross S, McDonnell DP. 2002. Problems for risk assessment of endocrine-active estrogenic compounds. Environ Health Perspect 110(Suppl6):925-929. PMID:12634121


  • Bordelon NR, Donnelly KC, George S. 2001. Pentachlorophenol potentiates benzo[a]pyrene DNA adduct formation in adult but not infant B6C3F1 male mice. Environ Mol Mutagen 37(2):164-172. PMID:11246223
  • Falahatpisheh MH, Donnelly KC, Ramos KS. 2001. Antagonistic interactions among nephrotoxic polycyclic aromatic hydrocarbons. J Toxicol Environ Health A 62(7):543-560. PMID:11289703
  • Reese ED, Harris BC, Dimitriou-Christidis P, Autenrieth RL, Donnelly KC, McDonald TJ. 2001. Risk Assessment of Complex Mixtures: Development of Toxic Equivalency Factors to Improve Toxicity Assessment. In: Proceedings of the Seventh International Congress on Combustion By-Products: Origins, Fate, and Health Effects. Research Triangle Park, NC.
  • Reeves WR, Barhoumi R, Burghardt RC, Lemke SL, Mayura K, McDonald TJ, Phillips TD, Donnelly KC. 2001. Evaluation of methods for predicting the toxicity of polycyclic aromatic hydrocarbon mixtures. Environ Sci Technol 35(8):1630-1636. doi:10.1021/es001689a PMID:11329713
  • Reeves WR, McDonald TJ, Bordelon NR, George S, Donnelly KC. 2001. Impacts of aging on in vivo and in vitro measurements of soil-bound polycyclic aromatic hydrocarbon availability. Environ Sci Technol 35(8):1637-1643. PMID:11329714
  • Washburn KS, Donnelly KC, Huebner HJ, Burghardt RC, Sewall TC, Claxton LD. 2001. A study of 2,4,6-trinitrotoluene inhibition of benzo[a]pyrene uptake and activation in a microbial mutagenicity assay. Chemosphere 44(8):1703-1709. PMID:11534902


  • Bordelon NR, Donnelly KC, King LC, Wolf DC, Reeves WR, George S. 2000. Bioavailability of genotoxic compounds in coal tar contaminated soils in Fisher 344 rats. Toxicol Sci 56(1):37-48. doi:10.1093/toxsci/56.1.37 PMID:10869452
  • Cho T, Wild JR, Donnelly KC. 2000. Utility of organophosphorus hydrolase for the remediation of mutagenicity of methyl parathion. Environ Toxicol Chem 19(8):2022-2028.
  • Zhou GD, Hernandez NS, Randerath E, Randerath K. 2000. Effects of different diets and dietary restriction on perinatal endogenous DNA adducts. Time dependence of oxidative and presumptive nonoxidative lesions. Mutat Res 447:137-147. PMID:10751597
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