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Project Publications: Boston University: Developmental Toxicity of non-Dioxin-like PCBs and Chemical Mixtures

Superfund Research Program

Developmental Toxicity of non-Dioxin-like PCBs and Chemical Mixtures

Project Leader: John J. Stegeman (Woods Hole Oceanographic Institution)
Co-Investigator: Jared V. Goldstone (Woods Hole Oceanographic Institution)
Grant Number: P42ES007381
Funding Period: 2000-2017
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  • Celander MC, Goldstone JV, Brun NR, Clark BW, Jayaraman S, Nacci DE, Stegeman JJ. 2021. Resistance to Cyp3a induction by polychlorinated biphenyls, including non-dioxin-like PCB153, in gills of killifish (Fundulus heteroclitus) from New Bedford Harbor. Environ Toxicol Pharmacol 83:103580. doi:10.1016/j.etap.2020.103580 PMID:33429071


  • Holland EB, Goldstone JV, Pessah IN, Whitehead A, Reid NM, Karchner SI, Hahn ME, Nacci DE, Clark BW, Stegeman JJ. 2017. Ryanodine receptor and FK506 binding protein 1 in the Atlantic killifish (Fundulus heteroclitus): a phylogenetic and population-based comparison. Aquat Toxicol 192:105-115. doi:10.1016/j.aquatox.2017.09.002 PMID:28942070 PMCID:PMC5662517


  • Goldstone JV, Sundaramoorthy M, Zhao B, Waterman MR, Stegeman JJ, Lamb DC. 2016. Genetic and structural analyses of cytochrome P450 hydroxylases in sex hormone biosynthesis: Sequential origin and subsequent coevolution. Mol Phylogenet Evol 94(PtB):676-687. doi:10.1016/j.ympev.2015.09.012 PMID:26432395 PMCID:PMC4801120
  • Lemaire B, Kubota A, O'Meara CM, Lamb DC, Tanguay RL, Goldstone JV, Stegeman JJ. 2016. Cytochrome P450 20A1 in zebrafish: Cloning, regulation and potential involvement in hyperactivity disorders. Toxicol Appl Pharmacol 296:73-84. doi:10.1016/j.taap.2016.02.001 PMID:26853319 PMCID:PMC4807407
  • Maldonado A, Lavodo R, Knuston S, Slattery M, Ankisetty S, Goldstone JV, Watanabe K, Hoh E, Gadepalli RS, Rimoldi JM, Ostrander GK, Schlenk D. 2016. Biochemical mechanisms for geographical adaptations to novel toxin exposures in butterflyfish. PLoS One 11(5):e0154208. doi:10.1371/journal.pone.0154208 PMID:27136924 PMCID:PMC4854401
  • Tokunaga S, Woodin BR, Stegeman JJ. 2016. Plant lignan secoisolariciresinol suppresses pericardial edema caused by dioxin-like compounds in developing zebrafish: Implications for suppression of morphological abnormalities. Food Chem Toxicol 96:160-166. doi:10.1016/j.fct.2016.07.012 PMID:27427306
  • Wincent E, Kubota A, Timme-Laragy A, Jonsson ME, Hahn ME, Stegeman JJ. 2016. Biological effects of 6-formylindolo[3,2-b]carbazole (FICZ) in vivo are enhanced by loss of CYP1A function in an Ahr2-dependent manner. Biochem Pharmacol 110-111:117-129. doi:10.1016/j.bcp.2016.04.012 PMID:27112072 PMCID:PMC4887394


  • Fritsch EB, Stegeman JJ, Goldstone JV, Nacci DE, Champlin D, Jayaraman S, Connon RE, Pessah IN. 2015. Expression and function of ryanodine receptor related pathways in PCB tolerant Atlantic killifish (Fundulus heteroclitus) from New Bedford Harbor, MA, USA. Aquat Toxicol 159:156-166. doi:10.1016/j.aquatox.2014.12.017 PMID:25546006 PMCID:PMC4300256
  • Grans J, Wassmur B, Fernandez-Santoscoy M, Zanette J, Woodin BR, Karchner SI, Nacci DE, Champlin D, Jayaraman S, Hahn ME, Stegeman JJ, Celander MC. 2015. Regulation of pregnane-X-receptor, CYP3A and P-glycoprotein genes in the PCB-resistant killifish (Fundulus heteroclitus) population from New Bedford Harbor. Aquat Toxicol 159:198-207. doi:10.1016/j.aquatox.2014.12.010 PMID:25553538 PMCID:PMC4311260
  • Hahn ME, Timme-Laragy AR, Karchner SI, Stegeman JJ. 2015. Nrf2 and Nrf2-related proteins in development and developmental toxicity: Insights from studies in zebrafish (Danio rerio). Free Radic Biol Med 88(PtB):275-289. doi:10.1016/j.freeradbiomed.2015.06.022 PMID:26130508 PMCID:PMC4698826
  • Kubota A, Goldstone JV, Lemaire B, Takata M, Woodin BR, Stegeman JJ. 2015. Role of pregnane X receptor and aryl hydrocarbon receptor in transcriptional regulation of pxr, CYP2, and CYP3 genes in developing zebrafish. Toxicol Sci 143(2):398-407. doi:10.1093/toxsci/kfu240 PMID:25424564 PMCID:PMC4306721
  • Lille-Langoy R, Goldstone JV, Rusten M, Milnes MR, Male R, Stegeman JJ, Blumberg B, Goksoyr A. 2015. Environmental contaminants activate human and polar bear (Ursus maritimus) pregnane X receptors (PXR, NR1I2) differently. Toxicol Appl Pharmacol 284(1):54-64. doi:10.1016/j.taap.2015.02.001 PMID:25680588 PMCID:PMC4387200
  • Stegeman JJ, Behrendt L, Woodin BR, Kubota A, Lemaire B, Pompon D, Goldstone JV, Urban P. 2015. Functional characterization of zebrafish cytochrome P450 1 family proteins expressed in yeast. Biochim Biophys Acta 1850(11):2340-2352. doi:10.1016/j.bbagen.2015.07.010 PMID:26231923 PMCID:PMC4587093
  • Wincent E, Stegeman JJ, Jonsson ME. 2015. Combination effects of AHR agonists and Wnt/β-catenin modulators in zebrafish embryos: implications for physiological and toxicological AHR functions. Toxicol Appl Pharmacol 284(2):163-179. doi:10.1016/j.taap.2015.02.014 PMID:25711857 PMCID:PMC4747639


  • Hahn ME, McArthur AG, Karchner SI, Franks DG, Jenny MJ, Timme-Laragy AR, Stegeman JJ, Woodin BR, Cipriano MJ, Linney EA. 2014. The transcriptional response to oxidative stress during vertebrate development: effects of tert-butylhydroquinone and 2,3,7,8-tetrachlorodibenzo-p-dioxin. PLoS One 9(11):e113158. doi:10.1371/journal.pone.0113158 PMID:25402455 PMCID:PMC4234671
  • Morrison AM, Goldstone JV, Lamb DC, Kubota A, Lemaire B, Stegeman JJ. 2014. Identification, modeling and ligand affinity of early deuterostome CYP51s, and functional characterization of recombinant zebrafish sterol 14α-demethylase. Biochim Biophys Acta 1840(6):1825-1836. doi:10.1016/j.bbagen.2013.12.009 PMID:24361620 PMCID:PMC4118742
  • Teraoka H, Okuno Y, Nijoukubo D, Yamakoshi A, Peterson RE, Stegeman JJ, Kitazawa T, Hiraga T, Kubota A. 2014. Involvement of COX2-thromboxane pathway in TCDD-induced precardiac edema in developing zebrafish. Aquat Toxicol 154:19-26. doi:10.1016/j.aquatox.2014.04.025 PMID:24858302 PMCID:PMC4326229
  • Tokunaga S, Stegeman JJ. 2014. Elimination of nonspecific bands in non-radioactive electrophoretic mobility shift assays using the digoxigenin system. Anal Biochem 465:70-72. doi:10.1016/j.ab.2014.06.020 PMID:25004462 PMCID:PMC4318779


  • Amemiya CT, Alfoldi J. 2013. The African coelacanth genome provides insights into tetrapod evolution. Nature 496:311–316. doi:10.1038/nature12027 PMID:23598338 PMCID:PMC3633110
  • Bainy AC, Kubota A, Goldstone JV, Lille-Langoy R, Karchner SI, Celander MC, Hahn ME, Goksoyr A, Stegeman JJ. 2013. Functional characterization of a full length pregnane X receptor, expression in vivo, and identification of PXR alleles, in Zebrafish (Danio rerio). Aquat Toxicol 142-143:447-457. doi:10.1016/j.aquatox.2013.09.014 PMID:24121122 PMCID:PMC3873750
  • Kubota A, Bainy AC, Woodin BR, Goldstone JV, Stegeman JJ. 2013. The cytochrome P450 2AA gene cluster in zebrafish (Danio rerio): expression of CYP2AA1 and CYP2AA2 and response to phenobarbital-type inducers. Toxicol Appl Pharmacol 272(1):172–179. doi:10.1016/j.taap.2013.05.017 PMID:23726801 PMCID:PMC3846545
  • Nelson DR, Goldstone JV, Stegeman JJ. 2013. The cytochrome P450 genesis locus: the origin and evolution of animal cytochrome P450s. Philos Trans R Soc Lond B Biol Sci 368:20120474. doi:10.1098/rstb.2012.0474 PMID:23297357 PMCID:PMC3538424
  • Timme-Laragy AR, Goldstone JV, Imhoff BR, Stegeman JJ, Hahn ME, Hansen JM. 2013. Glutathione redox dynamics and expression of glutathione-related genes in the developing embryo. Free Radic Biol Med 65:89-101. doi:10.1016/j.freeradbiomed.2013.06.011 PMID:23770340 PMCID:PMC3823629
  • Williams LM, Timme-Laragy AR, Goldstone JV, McArthur AG, Stegeman JJ, Smolowitz RM, Hahn ME. 2013. Developmental expression of the Nfe2-related factor (Nrf) transcription factor family in the zebrafish, Danio rerio. PLoS One doi:10.1371/journal.pone.0079574 PMID:24298298 PMCID:PMC3840143
  • Wolenski FS, Bradham CA, Finnerty JR, Gilmore TD. 2013. NF-kappa B is required for cnidocyte development in the sea anemone Nematostella vectensis. Dev Biol 373(1):205-215. doi:10.1016/j.ydbio.2012.10.004 PMID:23063796
  • Zanette J, Jenny MJ, Goldstone JV, Parente T, Woodin BR, Bainy AC, Stegeman JJ. 2013. Identification and expression of multiple CYP1-like and CYP3-like genes in the bivalve mollusk Mytilus edulis. Aquat Toxicol 128-129:101-112. doi:10.1016/j.aquatox.2012.11.017 PMID:23277104 PMCID:PMC3846546
  • Zanette J, Stegeman JJ. 2013. The members of cytochrome P450 family 1 and new perspectives in aquatic pollution. In: Exploring Themes on Aquatic Toxicology. pp.89-101.



  • Gao K, Brandt I, Goldstone JV, Jonsson ME. 2011. Cytochrome P450 1A, 1B, and 1C mRNA induction patterns in three-spined stickleback exposed to a transient and a persistent inducer. Comp Biochem Physiol 154:42-55. doi:10.1016/j.cbpc.2011.02.005 PMID:21354474 PMCID:PMC3560405
  • Godard-Codding CJ, Clark R, Fossi MC, Marsili L, Maltese S, West AG, Valenzuela L, Rowntree V, Polyak I, Cannon JC, Pinkerton K, Rubio-Cisneros N, Mesnick SL, Cox SB, Kerr I, Payne R, Stegeman JJ. 2011. Pacific ocean-wide profile of CYP1A1 expression, stable carbon and nitrogen isotope ratios, and organic contaminant burden in Sperm Whale skin biopsies. Environ Health Perspect 119:337-343. doi:10.1289/ehp.0901809 PMID:21134820 PMCID:PMC3059996
  • Jonsson ME, Berg C, Goldstone JV, Stegeman JJ. 2011. New CYP1 genes in the frog Xenopus (Silurana) tropicalis: induction patterns and effects of AHR agonists during development. Toxicol Appl Pharmacol 250:170-183. doi:10.1016/j.taap.2010.10.010 PMID:20965207 PMCID:PMC3014448
  • Jonsson ME, Woodin BR, Stegeman JJ, Brunstrom B. 2011. Cytochrome P450 1 genes in birds: evolutionary relationships and transcription profiles in chicken and Japanese quail embryos. PLoS One 6(12):e28257. doi:10.1371/journal.pone.0028257 PMID:22164255 PMCID:PMC3229566
  • Kubota A, Stegeman JJ, Goldstone JV, Nelson DR, Kim EY, Tanabe S, Iwata H. 2011. Cytochrome P450 CYP2 genes in the common cormorant: Evolutionary relationships with 130 diapsid CYP2 clan sequences and chemical effects on their expression. Comp Biochem Physiol C Toxicol Pharmacol 153:280-289. doi:10.1016/j.cbpc.2010.11.006 PMID:21130899 PMCID:PMC3560406
  • Parente T, Rebelo MF, da-Silva ML, Woodin BR, Goldstone JV, Bisch PM, Paumgartten FJ, Stegeman JJ. 2011. Structural features of cytochrome P450 1A associated with the absence of EROD activity in liver of the loricariid catfish Pterygoplichthys sp. Gene 489:111-118. doi:10.1016/j.gene.2011.07.023 PMID:21840383 PMCID:PMC3200446
  • Whitehead A, Galvez F, Zhang S, Williams LM, Oleksiak MF. 2011. Functional genomics of physiological plasticity and local adaptation in Killifish. J Hered 102:499-511. doi:10.1093/jhered/esq077 PMID:20581107 PMCID:PMC3156563



  • Burnett KG, Bain LJ, Baldwin WS, Callard GV, Cohen S, Di Giulio RT, Evans DH, Gomez-Chiarri M, Hahn ME, Hoover CA, Karchner SI, Katoh F, MacLatchy DL, Marshall WS, Meyer JN, Nacci DE, Rees BB, Singer TD, Stegeman JJ, Towle DW, van Veld PA, Vogelbein WK, Whitehead A, Winn RN, Crawford DL, Oleksiak MF. 2007. Fundulus as the premier teleost model in environmental biology: opportunities for new insights using genomics. Comp Biochem Physiol Part D Genomics Proteomics 2(4):257-286. doi:10.1016/j.cbd.2007.09.001 PMID:18071578 PMCID:PMC2128618
  • Goldstone JV, Handley-Goldstone HM, Morrison AM, Tarrant AM, Kern SE, Woodin BR, Stegeman JJ. 2007. Cytochrome P450 1 genes in early deuterostomes (tunicates and sea urchins) and vertebrates (chicken and frog): origin and diversification of the CYP1 gene family. Mol Biol Evol 24(12):2619-31. doi:10.1093/molbev/msm200 PMID:17916789
  • Goldstone JV, Stegeman JJ. 2007. Gene structure of the novel cytochrome P4501D1 genes in stickleback (Gasterosteus aculeatus) and medaka (Oryzias latipes). Mar Environ Res 66(1):19--20. PMID:18400289
  • Jonsson ME, Jenny MJ, Woodin BR, Hahn ME, Stegeman JJ. 2007. Role of AHR2 in the expression of novel cytochrome P450 1 family genes, cell cycle genes, and morphological defects in developing zebra fish exposed to 3,3',4,4',5-pentachlorobiphenyl or 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Sci 100(1):180-93. PMID:17686920
  • Jonsson ME, Orrego R, Woodin BR, Goldstone JV, Stegeman JJ. 2007. Basal and 3,3',4,4',5-pentachlorobiphenyl-induced expression of cytochrome P450 1A, 1B and 1C genes in zebrafish. Toxicol Appl Pharmacol 221(1):29-41. PMID:17445853
  • Prasad JC, Goldstone JV, Camacho CJ, Vajda S, Stegeman JJ. 2007. Ensemble modeling of substrate binding to cytochromes P450: Analysis of catalytic differences between CYP1A orthologues. Biochemistry 46(10):2640-2654. PMID:17300179
  • Wilson JY, Wells R, Aguilar AA, Borrell A, Tornero V, Reijnders P, Moore M, Stegeman JJ. 2007. Correlates of cytochrome P450 1A1 expression in bottlenose dolphin (Tursiops truncatus) integument biopsies. Toxicol Sci 97(1):111-9. PMID:17324949


  • Dong W, Muramoto W, Nagai Y, Takehana K, Stegeman JJ, Teraoka H, Hiraga T. 2006. Retinal neuronal cell is a toxicological target of tributyltin in developing zebrafish. J Vet Med Sci 68(6):573-9. PMID:16820714
  • Dong W, Muramoto W, Takehana K, Stegeman JJ, Teraoka H, Hiraga T. 2006. Oxidative stress and apoptosis induced by tributyltin in retinal neuronal cells of developing zebrafish. Nihon Juigaku Zasshi
  • Garrick RA, Woodin BR, Wilson JY, Middlebrooks BL, Stegeman JJ. 2006. Cytochrome P4501A is induced in endothelial cell lines from the kidney and lung of the bottlenose dolphin, Tursiops truncatus. Aquat Toxicol 76(3-4):295-305. PMID:16290286
  • Goldstone JV, Hamdoun A, Cole BJ, Howard-Ashby M, Nebert DW, Scally M, Dean M, Epel D, Hahn ME, Stegeman JJ. 2006. The chemical defensome: environmental sensing and response genes in the Strongylocentrotus purpuratus genome. Dev Biol 300(1):366-384. doi:10.1016/j.ydbio.2006.08.066 PMID:17097629 PMCID:PMC3166225
  • Handley-Goldstone HM, Stegeman JJ. 2006. A revised evolutionary history of the CYP1A subfamily: gene duplication, gene conversion, and positive selection. J Mol Evol 62(6):708-717. PMID:16752211
  • Handley-Goldstone HM, Stegeman JJ. 2006. Molecular mechanisms of 2,3,7,8-tetrachlorodibenzo-p-dioxin cardiovascular embryotoxicity. J Mol Biol 38(1-2):261-289. PMID:16684661
  • Kubota A, Iwata H, Handley-Goldstone HM, Kim EY, Stegeman JJ, Tanabe S. 2006. Cytochrome P450 1A4 and 1A5 in common cormorant (Phalacrocorax carbo): evolutionary relationships and functional implications associated with dioxin and related compounds. Toxicol Sci 92(2):394-408. doi:10.1093/toxsci/kfl001 PMID:16679348
  • Malins DC, Anderson KM, Stegeman JJ, Jaruga P, Green VM, Gilman NK, Dizdaroglu M. 2006. Biomarkers signal contaminant effects on the organs of English sole (Parophrys vetulus) from Puget Sound. Environ Health Perspect 114(6):823-829. PMID:16759979
  • Matsuo AY, Woodin BR, Reddy CM, Val AL, Stegeman JJ. 2006. Humic substances and crude oil induce cytochrome P450 1A expression in the Amazonian fish species Colossoma macropomum (Tambaqui). Environ Sci Technol 40(8):2851-8. PMID:16683634
  • Schlezinger JJ, Struntz WD, Goldstone JV, Stegeman JJ. 2006. Uncoupling of cytochrome P450 1A and stimulation of reactive oxygen species production by co-planar polychlorinated biphenyl congeners. Aquat Toxicol 77(4):422-432. PMID:16500718
  • Sea Urchin Genome Sequencing Consortium, Sodergren E, Weinstock GM, Davidson EH, Cameron RA, Gibbs RA, et al. 2006. The genome of the sea urchin Strongylocentrotus purpuratus. Science 314(5801):941-952. doi:10.1126/science.1133609 PMID:17095691 PMCID:PMC3159423
  • Stuchal L, Kleinow KM, Stegeman JJ, James MO. 2006. Demethylation of the pesticide methoxychlor in liver and intestine from untreated, methoxychlor-treated, and 3-methylcholanthrene-treated channel catfish (Ictalurus punctatus): evidence for roles of CYP1 and CYP3A family isozymes. Drug Metab Dispos 34(6):932-8. PMID:16510540
  • Teraoka H, Urakawa S, Nanba S, Nagai Y, Dong W, Imagawa T, Tanguay RL, Svoboda K, Handley-Goldstone HM, Stegeman JJ, Hiraga T. 2006. Muscular contractions in the zebrafish embryo are necessary to reveal thiuram-induced notochord distortions. Toxicol Appl Pharmacol 212(1):24-34. PMID:16051294
  • Verslycke T, Goldstone JV, Stegeman JJ. 2006. Isolation and phylogeny of novel cytochrome P450 genes from tunicates (Ciona spp): a CYP3 line in early deuterostomes?. Mol Phylogenet Evol 40(3):760-771. doi:10.1016/j.ympev.2006.04.017 PMID:16777437


  • Garrick RA, Woodin BR, Stegeman JJ. 2005. Cytochrome p4501a induced differentially in endothelial cells cultured from different organs of Anguilla rostrata. In Vitro Cell Dev Biol Anim 41(1-2):57-63. doi:10.1290/0409063.1 PMID:15926861
  • Handley-Goldstone HM, Grow MW, Stegeman JJ. 2005. Cardiovascular gene expression profiles of dioxin exposure in zebrafish embryos. Toxicol Sci 85(1):683-693. PMID:15716485
  • Malins DC, Stegeman JJ, Green VM, Gilman NK, Anderson KM. 2005. Spectral Models for Assessing Exposure of Fish to Contaminants. In: Techniques in Aquatic Toxicology. CRC Press, Inc., Boca Raton, FL. pp.537-545.


  • Dong W, Teraoka H, Tsujimoto Y, Stegeman JJ, Hiraga T. 2004. Role of aryl hydrocarbon receptor in mesencephalic circulation failure and apoptosis in zebrafish embryos exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Sci 77(1):109-116. PMID:14657521
  • Malins DC, Stegeman JJ, Anderson JW, Johnson PM, Gold J, Anderson KM. 2004. Structural changes in gill DNA reveal the effects of contaminants on Puget Sound fish. Environ Health Perspect 112(5):511-515. PMID:15064153
  • Powell WH, Morrison HG, Weil EJ, Karchner SI, Sogin ML, Stegeman JJ, Hahn ME. 2004. Cloning and analysis of the CYP1A promoter from the atlantic killifish (Fundulus heteroclitus). Mar Environ Res 58(2-5):119-124. PMID:15178023
  • Zodrow JM, Stegeman JJ, Tanguay RL. 2004. Histological analysis of acute toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in zebrafish. Aquat Toxicol 66(1):25-38. PMID:14687977


  • Goldstone JV, Stegeman JJ. 2003. Quantification of ROS Production and Enzyme Inactivation of CYP 1A by Polychlorinated Biphenyls and by 2,3,7,8-Tetrachlorodibenzo-P-Dioxin. In: Presented at the International Society for the study of Xenobiotics, October. Providence, RI.
  • Jahnavi C, Prasad JC. 2003. Differences in Substrate Binding Between Mammalian and Fish Cytochrome P450 1As Predicted by Comparative Modeling and Flexible Docking. In: Presented at the International Society for the study of Xenobiotics, October. Providence, RI.
  • McArthur AG, Hegelund T, Cox RL, Stegeman JJ, Liljenberg M, Olsson U, Sundberg P, Celander MC. 2003. Phylogenetic analysis of the cytochrome P450 3 (CYP3) gene family. J Mol Evol 57(2):200-211. doi:10.1007/s00239-003-2466-x PMID:14562963
  • Morrison A, Stegeman JJ. 2003. In Vitro Assessment of CYP51 Azole Sensitivity in Fish: Dos Upregulation of CYP1A Protect the CYP51?. In: Presented at the International Society for the study of Xenobiotics, October. Providence, RI.
  • Oleksiak MF, Wu S, Parker C, Qu W, Cox RL, Zeldin DC, Stegeman JJ. 2003. Identification and regulation of a new vertebrate cytochrome P450 subfamily, the CYP2Ps, and functional characterization of CYP2P3, a conserved arachidonic acid epoxygenase/19-hydroxylase. Arch Biochem Biophys 411(2):223-234. PMID:12623071
  • Prasad JC, Vajda S, Goldstone JV, Camacho CJ, Stegeman JJ. 2003. Differences in Substrate Binding Between Mammalian and Fish Cytochrome P450 1As Predicted by Comparative Modeling and Flexible Docking. In: Presented at the International Society for the study of Xenobiotics, October. Providence, RI.
  • Prasch AL, Teraoka H, Carney SA, Dong W, Hiraga T, Stegeman JJ, Heideman W, Peterson RE. 2003. Aryl hydrocarbon receptor 2 mediates 2,3,7,8-tetrachlorodibenzo-p-dioxin developmental toxicity in zebrafish. Toxicol Sci 76(1):138-150. PMID:12883077
  • Teraoka H, Dong W, Tsujimoto Y, Iwasa H, Endoh D, Ueno N, Stegeman JJ, Peterson RE, Hiraga T. 2003. Induction of cytochrome P450 1A is required for circulation failure and edema by 2,3,7,8-tetrachlorodibenzo-p-dioxin in zebrafish. Biochem Biophys Res Commun 304(2):223-228. PMID:12711302


  • Andreasen EA, Spitsbergen JM, Tanguay RL, Stegeman JJ, Heideman W, Peterson RE. 2002. Tissue-specific expression of AHR2, ARNT2, and CYP1A in zebrafish embryos and larvae: effects of developmental stage and 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure. Toxicol Sci 68(2):403-419. PMID:12151636
  • Baader M, Gnerre C, Stegeman JJ, Meyer UA. 2002. Transcriptional activation of cytochrome P-450 CYP2C45 by drugs is mediated by the chicken xenobiotic receptor CXR interacting with a phenobarbital-response enhancer unit. J Biol Chem 277(18):15647-15653. PMID:11867618
  • Bard SM, Bello SM, Hahn ME, Stegeman JJ. 2002. Expression of P-glycoprotein in killifish (Fundulus heteroclitus) exposed to environmental xenobiotics. Aquat Toxicol 59(3-4):237-251. PMID:12127740
  • Bard SM, Woodin BR, Stegeman JJ. 2002. Expression of P-glycoprotein and cytochrome p450 1A in intertidal fish (Anoplarchus purpurescens) exposed to environmental contaminants. Aquat Toxicol 60(1-2):17-32. PMID:12204584
  • Iwata H, Yoshinari K, Negishi M, Stegeman JJ. 2002. Species-specific responses of constitutively active receptor (CAR)-CYP2B coupling: lack of CYP2B inducer-responsive nuclear translocation of CAR in marine teleost, scup (Stenotomus chrysops). Comp Biochem Physiol C Toxicol Pharmacol 131(4):501-510. PMID:11976065
  • Yamazaki K, Teraoka H, Dong W, Stegeman JJ, Hiraga T. 2002. cDNA cloning and expressions of cytochrome P450 1A in zebrafish embryos. J Vet Med Sci 64(9):829-833. PMID:12399609


  • Bello SM, Franks DG, Stegeman JJ, Hahn ME. 2001. Acquired resistance to Ah receptor agonists in a population of Atlantic killifish (Fundulus heteroclitus) inhabiting a marine superfund site: in vivo and in vitro studies on the inducibility of xenobiotic metabolizing enzymes. Toxicol Sci 60(1):77-91. PMID:11222875
  • Handley H, Grow MW, Fishman MC, Stegeman JJ. 2001. Broad-scale characterization of gene expression patterns associated with embryonic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Sci 60(1):1604S.
  • Huang Y, Stegeman JJ, Woodin BR, Karasov WH. 2001. Immunohistochemical localization of cytochrome P450 1A induced by 3,3',4,4',5-pentachlorobiphenyl (PCB126) in multiple organs of the northern leopard frog Rana pipiens. Environ Toxicol Chem 20(1):191-197.
  • Verbrugge LA, Giesy JP, Verbrugge DA, Woodin BR, Stegeman JJ. 2001. Catalytic and immunochemical properties of hepatic cytochrome P450 1A in three avian species treated with beta-naphthoflavone or isosafrole. Comp Biochem Physiol C Toxicol Pharmacol 130(1):67-83. doi:10.1016/S1532-0456(01)00221-6 PMID:11544144


  • Godard-Codding CJ, Leaver MJ, Said MR, Dickerson RL, George S, Stegeman JJ. 2000. Identification of cytochrome P450 1B-like sequences in two teleost fish species (scup, Stenotomus chrysops and plaice, Pleuronectes platessa) and in a cetacean (striped dolphin, Stenella coeruleoalba). Mar Environ Res 50(1-5):7-10. PMID:11460754
  • Iwata H, Stegeman JJ. 2000. In situ RT-PCR detection of CYP1A mRNA in pharyngeal epithelium and chondroid cells from chemically untreated fish: involvement in vertebrate craniofacial skeletal development?. Biochem Biophys Res Commun 271(1):130-137. doi:10.1006/bbrc.2000.2543 PMID:10777692
  • Oleksiak MF, Wu S, Parker C, Zeldin DC. 2000. Identification, functional characterization, and regulation of a new cytochrome P450 subfamily, the CYP2Ns. J Biol Chem 275(4):2312-2321. PMID:10644680
  • Rie MT, Lendas KA, Woodin BR, Stegeman JJ, Callard IP. 2000. Hepatic biotransformation enzymes in a sentinel species, the painted turtle (Chrysemys picta), from Cape Cod, Massachusetts: seasonal-, sex- and location related differences. Biomarkers 5(5):382-394. doi:10.1080/135475000424384 PMID:23886024
  • Schlezinger JJ, Blickarz CE, Mann KK, Doerre S, Stegeman JJ. 2000. Identification of NF-kB in the marine fish Stenotomus chrysops and examination of its activation by aryl hydrocarbon receptor agonists. Chem Biol Interact 126(2):137-157. PMID:10862814
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