Superfund Research Program

Molecular and Microbial Mechanisms Leading to Triclosan Induced Liver Fibrosis

Project Leader: Robert H. Tukey
Grant Number: P42ES010337
Funding Period: 2017-2023

Project-Specific Links

Publications

2024

• Rabin B, Cain KL, Ayers LO, Lomeli A, Escoto AA, Burola M, Aguilar M, Tinoco-Calvillo S, Reyes B, Salgin L, Tukey RH, Laurent LC, Stadnick NA. 2024. Adaptation of the brainwriting premortem technique to inform the co-creation of COVID-19 testing strategies in underserved communities in South San Diego. BM Health Serv Res 24(1):12. doi:10.1186/s12913-023-10341-w PMID:38172787 PMCID:PMC10765849

2023

• Rabin B, Cain KL, Salgin L, Watson P, Oswald W, Kaiser BN, Ayers LO, Yi C, Alegre A, Ni J, Reyes A, Yu KE, Broyles SL, Tukey RH, Laurent LC, Stadnick NA. 2023. Using ethnographic approaches to document, evaluate, and facilitate virtual community-engaged implementation research. BMC Public Health 23(1):409. doi:10.1186/s12889-023-15299-2 PMID:36855118 PMCID:PMC9974043
• Salgin L, Ayers LO, Burola M, Engler A, Osuna A, Gay L, Cain KL, Stadnick NA, Rabin AB, Zaslavsky I, Laurent LC, Tukey RH, Seifert M. 2023. Perceived COVID-19 risk and testing experiences in the San Ysidro U.S./Mexico border region. Transl Behav Med doi:10.1093/tbm/ibac120 PMID:36999822 PMCID:PMC10314726
• Yang X, Weber AA, Mennillo E, Paszek M, Wong S, Le S, Teo JY, Chang M, Benner CW, Tukey RH, Chen S. 2023. Oral arsenic administration to humanizedUDP-glucuronosyltransferase1 neonatal mice induces UGT1A1 through a dependence on Nrf2 and PXR. J Biol Chem 299(3):102955. doi:10.1016/j.jbc.2023.102955 PMID:36720308 PMCID:PMC9996368
• Yang X, Weber AA, Mennillo E, Secrest P, Chang M, Wong S, Le S, Liu J, Benner CW, Karin M, Gordts P, Tukey RH, Chen S. 2023. Effects of early life oral arsenic exposure on intestinal tract development and lipid homeostasis in neonatal mice: Implications for NAFLD development. Environ Health Perspect 131(9):doi:10.1289/ehp12381 PMID:37668303 PMCID:10478510

2022

• Mennillo E, Yang X, Weber AA, Maruo Y, Verreault M, Barbier O, Chen S, Tukey RH. 2022. Intestinal UDP-glucuronosyltransferase 1A1 and protection against irinotecan-induced toxicity in a novel UDP-glucuronosyltransferase 1A1 tissue-specific humanized mouse model. Drug Metab Dispos 50:33-42. doi:10.1124/dmd.121.000644 PMID:34697081
• Weber AA, Yang X, Mennillo E, Ding J, Watrous JD, Jain M, Chen S, Karin M, Tukey RH. 2022. Lactational delivery of Triclosan promotes non-alcoholic fatty liver disease in newborn mice. Nat Commun 13(1):4346. doi:10.1038/s41467-022-31947-4 PMID:35896521 PMCID:PMC9329322

2021

• Weber AA, Mennillo E, Yang X, van der Schoor LW, Jonker JW, Chen S, Tukey RH. 2021. Regulation of Intestinal UDP-Glucuronosyltransferase 1A1 by the Farnesoid X Receptor Agonist Obeticholic Acid Is Controlled by Constitutive Androstane Receptor through Intestinal Maturation. Drug Metab Dispos 49:12-19. doi:10.1124/dmd.120.000240 PMID:33154041 PMCID:PMC7745083

2020

• Hansmann E, Mennillo E, Yoda E, Verreault M, Barbier O, Chen S, Tukey RH. 2020. Differential role of LXRa and LXRy in the regulation of UDP-glucuronosyltransferase 1A1 in humanized UGT1 mice. Drug Metab Dispos 48:255-263. doi:10.1124/dmd.119.090068 PMID:31980500 PMCID:PMC7065491
• Mennillo E, Yang X, Paszek M, Auwerx J, Benner CW, Chen S. 2020. NCoR1 protects mice from dextran sodium sulfate-induced colitis by guarding colonic crypt cells from luminal insult. Cell Mol Gastroenterol Hepatol 10:133-147. doi:10.1016/j.jcmgh.2020.01.014 PMID:32044398 PMCID:PMC7229481
• Paszek M, Tukey RH. 2020. NRF2-Independent regulation of intestinal constitutive androstane receptor by the pro-oxidants cadmium and isothiocyanate in hUGT1 mice. Drug Metab Dispos 48:25-30. doi:10.1124/dmd.119.089508 PMID:31704714 PMCID:PMC6904881
• Yueh MF, He F, Chen C, Vu C, Tripathi A, Knight R, Karin M, Chen S, Tukey RH. 2020. Triclosan leads to dysregulation of the metabolic regulator FGF21 exacerbating high fat diet-induced nonalcoholic fatty liver disease. Proc Natl Acad Sci U S A 117:31259-31266. doi:10.1073/pnas.2017129117 PMID:33229553 PMCID:PMC7733785

2018

• Chen S, Tukey RH. 2018. Humanized UGT1 mice, regulation of UGT1A1, and the role of the intestinal tract in neonatal hyperbilirubinemia and breast milk-induced jaundice. Drug Metab Dispos 46(11):1745-1755. doi:10.1124/dmd.118.083212 PMID:30093417 PMCID:PMC6199628
• Gonzalez FJ, Coughtrie MW, Tukey RH. 2018. Drug Metabolism. Chapter 6 in: The Pharmacological Basis of Therapeutics. McGraw Hill Education,

2017

• Fujiwara R, Mitsugi R, Uemura A, Itoh T, Tukey RH. 2017. Severe neonatal hyperbilirubinemia in Crigler-Najjar Syndrome model mice can be reversed with zinc protoporphyrin. Hepatol Commun 1(8):792-802. doi:10.1002/hep4.1082 PMID:29399656 PMCID:PMC567892
• Fujiwara R, Yoda E, Tukey RH. 2017. Species differences in drug glucuronidation: humanized UDP-glucuronosyltransferase 1 mice and their application for predicting drug glucuronidation and drug-induced toxicity in humans. Drug Metab Pharmacokinet 33(1):9-16. doi:10.1016/j.dmpk.2017.10.002 PMID:29079228 PMCID:PMC5809266
• Gasser E, Moutos CP, Downes M, Evans RM. 2017. FGF1-a new weapon to control type 2 diabetes mellitus. Nat Rev Endocrinol 13(10):599-609. doi:10.1038/nrendo.2017.78 PMID:28664920 PMCID:PMC5839646
• Lu W, Rettenmeier E, Paszek M, Yueh MF, Tukey RH, Trottier J, Barbier O, Chen S. 2017. Crypt organoid culture as an in vitro model in drug metabolism and cytotoxicity studies. Drug Metab Dispos 45:748-754. doi:10.1124/dmd.117.075945 PMID:28468837 PMCID:PMC5478905