Superfund Research Program
Research Experience & Training Coordination Core
Project Leader: James Ankrum
Co-Investigators: Jonathan A. Doorn, Gregory LeFevre, Rachel F. Marek, Brian Westra
Grant Number: P42ES013661
Funding Period: 2006-2025
Project-Specific Links
Publications
2023
- Nault R, Cave MC, Ludewig G, Moseley HN, Pennell KG, Zacharewski TR. 2023. A case for accelerating standards to achieve the FAIR principles of environmental health research experimental data. Environ Health Perspect 131(6):65001. doi:10.1289/EHP11484 PMID:37352010 PMCID:PMC10289218
- Roh T, Knappett PS, Han D, Ludewig G, Kelly KM, Wang K, Weyer P. 2023. Characterization of arsenic and atrazine contaminations in drinking water in Iowa: a public health concern. Int J Environ Res Public Health 20(7):5397. doi:10.3390/ijerph20075397 PMID:37048011 PMCID:PMC1009410
2022
- Eti N, Flor S, Iqbal K, Scott RL, Klenov V, Gibson-Corley KN, Soares M, Ludewig G, Robertson LW. 2022. PCB126 induced toxic actions on liver energy metabolism is mediated by AhR in rats. Toxicology 466:153054. doi:10.1016/j.tox.2021.153054 PMID:34848246 PMCID:PMC8748418
- Zhang C, Li X, Flor S, Ruiz P, Kruve A, Ludewig G, Lehmler H. 2022. Metabolism of 3-chlorobiphenyl (PCB 2) in a human-relevant cell line: evidence of dechlorinated metabolites. Environ Sci Technol 56(17):12460-12472. doi:10.1021/acs.est.2c03687 PMID:35994059 PMCID:PMC9573771
2021
- Klenov V, Flor S, Ganesan S, Adur M, Eti N, Iqbal K, Soares M, Ludewig G, Ross J, Robertson LW, Keating A. 2021. The aryl hydrocarbon receptor mediates reproductive toxicity of polychlorinated biphenyl congener 126 in rats. Toxicol Appl Pharmacol 426:115639. doi:10.1016/j.taap.2021.115639 PMID:34256052 PMCID:PMC8500329
- Lan T, Liu B, Bao W, Thorne PS. 2021. BMI modifies the association between dietary intake and serum levels of PCBs. Environ Int 156:106626. doi:10.1016/j.envint.2021.106626 PMID:34034117
2020
- Deng P, Hoffman JB, Petriello MC, Wang C, Li X, Kraemer MP, Morris AJ, Hennig B. 2020. Dietary inulin decreases circulating ceramides by suppressing neutral sphingomyelinase expression and activity in mice. J Lipid Res 61:45-53. doi:10.1194/jlr.RA119000346 PMID:31604806 PMCID:PMC6939596
- Deng P, Wang C, Wahlang B, Sexton T, Morris AJ, Hennig B. 2020. Co-exposure to PCB126 and PFOS increases biomarkers associated with cardiovascular disease risk and liver injury in mice. Toxicol Appl Pharmacol 409:115301. doi:10.1016/j.taap.2020.115301 PMID:33096110 PMCID:PMC7725976
- Grimm FA, Klaren WD, Li X, Lehmler H, Karmakar M, Robertson LW, Chiu WA, Rusyn I. 2020. Cardiovascular effects of polychlorinated biphenyls and their major metabolites. Environ Health Perspect 128:77008. doi:10.1289/EHP7030 PMID:32701041 PMCID:PMC7377239
- Hennig B, Deng P. 2020. Healthful nutrition as a prevention and intervention paradigm to decrease the vulnerability to environmental toxicity or stressors and associated inflammatory disease risks. Food Front 1:13-14. doi:10.1002/fft2.6 PMID:33073239 PMCID:PMC7566652
- Stolwijk J, Falls-Hubert KC, Searby CC, Wagner BA, Buettner GR. 2020. Simultaneous detection of the enzyme activities of GPx1 and GPx4 guide optimization of selenium in cell biological experiments. Redox Biol 32:15. doi:10.1016/j.redox.2020.101518 PMID:32278283 PMCID:PMC7150527
- Stolwijk J, Garje R, Sieren JC, Buettner GR, Zakharia Y. 2020. Understanding the redox biology of selenium in the search of targeted cancer therapies. Antioxidants (Basel) 9:doi:10.3390/antiox9050420 PMID:32414091 PMCID:PMC7278812
- Williams AE, Watt J, Robertson LW, Gadupudi GS, Osborn ML, Soares M, Iqbal K, Pedersen KB, Shankar K, Littleton S, Maimone C, Eti N, Suva LJ, Ronis M. 2020. Skeletal toxicity of coplanar polychlorinated biphenyl congener 126 in the rat is aryl hydrocarbon receptor dependent. Toxicol Sci 175:113-125. doi:10.1093/toxsci/kfaa030 PMID:32119087 PMCID:PMC7197949
- Zhang C, Flor S, Ludewig G, Lehmler H. 2020. Atropselective partitioning of polychlorinated biphenyls in a HepG2 cell culture system: Experimental and modeling results. Environ Sci Technol 54:13817-13827. doi:10.1021/acs.est.0c02508 PMID:33059451 PMCID:PMC7642102
2019
- Buranasudja V, Doskey CM, Gibson AR, Wagner BA, Du J, Gordon DJ, Koppenhafer S, Cullen JJ, Buettner GR. 2019. Pharmacologic ascorbate primes pancreatic cancer cells for death by rewiring cellular energetics and inducing DNA damage. Mol Cancer Res 17:2102-14. doi:10.1158/1541-7786.MCR-19-0381 PMID:31337671 PMCID:PMC6774825
- Deng P, Li X, Petriello MC, Wang C, Morris AJ, Hennig B. 2019. Application of metabolomics to characterize environmental pollutant toxicity and disease risks. Rev Environ Health 34(3):251-259. doi:10.1515/reveh-2019-0030 PMID:31408434 PMCID:PMC6915040
- Janechek N, Marek RF, Bryngelson N, Singh A, Bullard RL, Brune WH, Stanier CO. 2019. Physical properties of secondary photochemical aerosol from OH oxidation of a cyclic siloxane. Atmos Chem Phys 19:1649-1664. doi:10.5194/acp-19-1649-2019 PMID:31889955 PMCID:PMC6936766