Superfund Research Program

Research Experience and Training Coordination Core

Project Leader: David W. Hein
Co-Investigator: Daniel J. Conklin
Grant Number: P42ES023716
Funding Period: 2022-2027

Project-Specific Links

Publications

2023

• Agbonlahor O, DeJarnett N, Hart J, Bhatnagar A, McLeish AC, Walker KL. 2023. Racial/ethnic discrimination and cardiometabolic diseases: A systematic review. J Racial Ethn Health Disparities 1-25. doi:10.1007/s40615-023-01561-1 PMID:36976513 PMCID:PMC1004413
• Bolatimi OE, Head KZ, Luo J, Gripshover T, Lin Q, Adiele NV, Watson WH, Wilkerson C, Cai L, Cave MC, Young JL. 2023. Can zinc supplementation attenuate high fat diet-induced non-alcoholic fatty liver disease?. Int J Mol Sci 24(2):1763. doi:10.3390/ijms24021763 PMID:36675277 PMCID:PMC9864360
• Habil MR, Hein DW. 2023. Effects of dose and human N-acetyltransferase 1 genetic polymorphism in benzidine metabolism and genotoxicity. Arch Toxicol doi:10.1007/s00204-023-03497-1 PMID:37097310 PMCID:PMC10192036
• Habil MR, Salazar-Gonzalez R, Doll MA, Hein DW. 2023. Effect of N-acetyltransferase 2 genetic polymorphism on 4,4'-methylenebis(2-chloroaniline)-induced genotoxicity and oxidative stress. Arch Toxicol 97(6):1773-1781. doi:10.1007/s00204-023-03508-1 PMID:37142755 PMCID:PMC10259506
• Hein DW, Salazar-Gonzalez R, Doll MA, Zang Y. 2023. The effect of the rs1799931 G857A (G286E) polymorphism on N-acetyltransferase 2-mediated carcinogen metabolism and genotoxicity differs with heterocyclic amine exposure. Arch Toxicol 97(10):2697-2705. doi:10.1007/s00204-023-03577-2 PMID:37592049
• Hong KU, Hein DW. 2023. N-acetyltransferase 2 haplotype modifies risks for both dyslipidemia and urinary bladder cancer. Pharmacogenet Genomics doi:10.1097/FPC.0000000000000500 PMID:37306342
• Walls KM, Hong KU, Hein DW. 2023. Heterocyclic amines reduce insulin-induced AKT phosphorylation and induce gluconeogenic gene expression in human hepatocytes. Arch Toxicol doi:10.1007/s00204-023-03488-2 PMID:37005939 PMCID:PMC10192068
• Walls KM, Hong KU, Hein DW. 2023. Induction of glucose production by heterocyclic amines is dependent on N-acetyltransferase 2 genetic polymorphism in cryopreserved human hepatocytes. Toxicol Lett 383:192-195. doi:10.1016/j.toxlet.2023.07.002 PMID:37423373
• Wise JT, Yin X, Ma X, Zhang X, Hein DW. 2023. Stable isotope tracing reveals an altered fate of glucose in n-acetyltransferase 1 knockout breast cancer cells. Genes (Basel) 14(4):843. doi:10.3390/genes14040843 PMID:37107601 PMCID:PMC1013786

2022

• Gripshover T, Wahlang B, Head KZ, Young JL, Luo J, Mustafa mT, Kirpich IA, Cave MC. 2022. The environmental pollutant, polychlorinated biphenyl 126, alters liver function in a rodent model of alcohol-associated liver disease. Alcohol Clin Exp Res doi:10.1111/acer.14976 PMID:36377258
• Habil MR, Doll MA, Hein DW. 2022. Acetyl coenzyme A kinetic studies on N-acetylation of environmental carcinogens by human N-acetyltransferase 1 and its NAT1*14B variant. Front Pharmacol 13:931323. doi:10.3389/fphar.2022.931323 PMID:36386142 PMCID:PMC9650386
• Habil MR, Salazar-Gonzalez R, Doll MA, Hein DW. 2022. Differences in beta-naphthylamine metabolism and toxicity in Chinese hamster ovary cell lines transfected with human CYP1A2 and NAT2*4, NAT2*5B or NAT2*7B N-acetyltransferase 2 haplotypes. Arch Toxicol doi:10.1007/s00204-022-03367-2 PMID:36040704
• Habil MR, Salazar-Gonzalez R, Doll MA, Hein DW. 2022. N-acetyltransferase 2 acetylator genotype-dependent N-acetylation and toxicity of the arylamine carcinogen beta-naphthylamine in cryopreserved human hepatocytes. Arch Toxicol doi:10.1007/s00204-022-03381-4 PMID:36112171