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Your Environment. Your Health.

Program Publications: Texas A&M University: Comprehensive Tools and Models for Addressing Exposure to Mixtures During Environmental Emergency-Related Contamination Events

Superfund Research Program

Comprehensive Tools and Models for Addressing Exposure to Mixtures During Environmental Emergency-Related Contamination Events

Center Director: Ivan Rusyn
Grant Number: P42ES027704
Funding Period: 2017-2022
View this project in the NIH Research Portfolio Online Reporting Tools (RePORT)

Learn More About the Grantee

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Publications

  • Newman G, Li D. Environmental and social resilience by design in Houston, TX. In: International Geodesign Collaboration: Changing Geography by Design. Environmental Systems Research Institute Press, Redlands, CA.

2020

  • Beykal B, Avraamidou S, Pistikopoulos IP, Onel M, Pistikopoulos EN. 2020. DOMINO: Data driven optimization of bi level mixed integer nonlinear problems. J Glob Optim doi:10.1007/s10898-020-00890-3
  • Bhandari S, Lewis PT, Craft ES, Marvel S, Reif DM, Chiu WA. 2020. HGBEnviroScreen: Enabling community action through data integration in the Houston-Galveston-Brazoria region. Int J Environ Res Public Health 17:doi:10.3390/ijerph17041130 PMID:32053902
  • Chen C, Yang S, Liu Y, Jamieson P, Shan L, Chu K. 2020. Accumulation and phytotoxicity of perfluorooctanoic acid and 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoate in Arabidopsis thaliana and Nicotiana benthamiana. Environ Pollut 259(9):doi:10.1016/j.envpol.2019.113817
  • Chen Z, Liu Y, Wright FA, Chiu WA, Rusyn I. 2020. Rapid hazard characterization of environmental chemicals using a compendium of human cell lines from different organs. ALTEX doi:10.14573/altex.2002291 PMID:32521033 (ahead of print)
  • Dalaijamts C, Cichocki JA, Luo Y, Rusyn I, Chiu WA. 2020. PBPK modeling of impact of nonalcoholic fatty liver disease on toxicokinetics of perchloroethylene in mice. Toxicol Appl Pharmacol 400:115069. doi:10.1016/j.taap.2020.115069 PMID:32445755
  • Danforth C, Chiu WA, Rusyn I, Schultz K, Bolden A, Kwiatkowski C, Craft ES. 2020. An integrative method for identification and prioritization of constituents of concern in produced water from onshore oil and gas extraction. Environ Int 134:105280. doi:10.1016/j.envint.2019.105280 PMID:31704566
  • de Conti A, Tryndyak VP, Willett RA, Borowa-Mazgaj B, Watson A, Patton R, Khare S, Muskhelishvili L, Olsen GR, Avigan MI, Cerniglia CE, Ross SA, Sanyal AJ, Beland FA, Rusyn I, Pogribny IP. 2020. Characterization of the variability in the extent of nonalcoholic fatty liver induced by a high-fat diet in the genetically diverse collaborative cross mouse model. FASEB J doi:10.1096/fj.202000194R PMID:32304142 (ahead of print)
  • Dodds J, Hopkins ZR, Knappe D, Baker ES. 2020. Rapid characterization of per- and polyfluoroalkyl substances (PFAS) by ion mobility spectrometry-mass spectrometry (IMS-MS). Anal Chem doi:10.1021/acs.analchem.9b05364 PMID:32011866
  • Horney JA, Dwyer C, Vendrell-Velez B, Newman G. 2020. Validating a comprehensive plan scoring system for healthy community design in League City, Texas. J Urban Des 25:2013-217. doi:10.1080/13574809.2019.1572453 PMID:32132860 PMCID:PMC7055687
  • House JS, Bouzos E, Fahy K, Francisco VM, Lloyd D, Wright FA, Motsinger-Reif A, Asuri P, Wheeler K. 2020. Low dose silver nanoparticle surface chemistry and temporal effects on gene expression in human liver cells. Wiley Interdiscip Rev Nanomed Nanobiotechnol doi:10.1002/smll.202000299 PMID:32227433
  • Kim G, Newman G, Jiang B. 2020. Urban regeneration: Community engagement process for vacant land in declining cities. Cities 102:12. doi:10.1016/j.cities.2020.102730
  • Kim Y, Newman G. 2020. Advancing scenario planning through integrating urban growth prediction with future flood risk model. Comput Environ Urban Syst 82:14. doi:10.1016/j.compenvurbsys.2020.101498 PMID:32431469 PMCID:PMC7236661
  • Luo Y, Ferguson K, Rusyn I, Chiu WA. 2020. In Vitro Bioavailability of the Hydrocarbon Fractions of Dimethyl Sulfoxide Extracts of Petroleum Substances. Toxicol Sci doi:10.1093/toxsci/kfaa007 PMID:32040194
  • Newman G, Kim Y, Joshi K, Liu J. 2020. Integrating prediction and performance models into scenario-based resilient community design. JoDLA 510-520. doi:10.14627/537690052
  • Newman G, Kim Y, Kim G, Lee R, Gu D, Forghanparast K, Goldberg D. 2020. A python script for longitudinally measuring the duration of vacant land uses. J of Spa Sci 13:doi:10.1080/14498596.2020.1721344
  • Newman G, Shi T, Yao Z, Li D, Sansom G, Kirsch KR, Casillas GA, Horney JA. 2020. Citizen science-informed community master planning: land use and built environment changes to increase flood resilience and decrease contaminant exposure. Int J Environ Res Public Health 17:doi:10.3390/ijerph17020486 PMID:31940904
  • Onel M, Burnak B, Pistikopoulos EN. 2020. Integrated Data-Driven Process Monitoring and Explicit Fault-Tolerant Multiparametric Control. Ind Eng Chem Res 59(6):2291-2306. doi:10.1021/acs.iecr.9b04226
  • Sakolish C, Chen Z, Dalaijamts C, Mitra K, Liu Y, Fulton T, Wade TL, Kelly EJ, Rusyn I, Chiu WA. 2020. Predicting tubular reabsorption with a human kidney proximal tubule tissue-on-a-chip and physiologically-based modeling. Toxicol In Vitro 63:doi:10.1016/j.tiv.2019.104752 PMID:31857146
  • Sansom G, Kirsch KR, Horney JA. 2020. Using the 12-item short form health survey (SF-12) to assess self rated health of an engaged population impacted by Hurricane Harvey, Houston, TX. BMC Public Health 20:doi:10.1186/s12889-020-8349-x PMID:32075614 PMCID:PMC7031970
  • Stossi F, Dandekar RD, Mancini MG, Gu G, Fuqua SA, Nardone A, De Angelis C, Fu X, Schiff R, Bedford MT, Xu W, Johansson HE, Stephan C, Mancini MA. 2020. Estrogen-induced transcription at individual alleles is independent of receptor level and active conformation but can be modulated by coactivators activity. Nucleic Acids Res 48:1800-1810. doi:10.1093/nar/gkz1172 PMID:31930333
  • Stossi F, Mistry R, Singh PK, Johnson H, Mancini MG, Szafran AT, Mancini MA. 2020. Single cell distribution analysis of AR levels by high throughput microscopy in cell models: Application for testing endocrine disrupting chemicals. SLAS Discov 11:doi:10.1177/2472555220934420 PMID:32552291
  • Szafran AT, Bolt MJ, Obkirchner CE, Mancini MG, Helsen C, Claessens F, Stossi F, Mancini MA. 2020. A mechanistic high-content analysis assay using a chimeric androgen receptor that rapidly characterizes androgenic chemicals. SLAS Discov 14:doi:10.1177/2472555220922917 PMID:32392092
  • Van Zandt S, Masterson J, Newman G, Meyer M. 2020. Engaged Research for Community Resilience to Climate Change. Elsevier, Cambridge, MA.

2019

  • Alves VM, Borba J, Capuzzi SJ, Muratov EN, Andrade CH, Rusyn I, Tropsha A. 2019. Oy vey! A comment on machine learning of toxicological big data enables read-across structure activity relationships outperforming animal test reproducibility. Toxicol Sci 167:3-4. doi:10.1093/toxsci/kfy286 PMID:30500930 PMCID:PMC6317419
  • Bera G, Camargo K, Sericano JL, Liu Y, Sweet S, Horney JA, Jun M, Chiu WA, Rusyn I, Wade TL, Knap A. 2019. Baseline data for distribution of contaminants by natural disasters: Results from a residential Houston neighborhood during Hurricane Harvey flooding. Heliyon 5:e02860. doi:10.1016/j.heliyon.2019.e02860 PMID:31763489 PMCID:PMC6861583
  • Blanchette A, Grimm FA, Dalaijamts C, Hsieh N, Ferguson K, Luo Y, Rusyn I, Chiu WA. 2019. Thorough QT/QTc in a dish: An In Vitro human model that accurately predicts clinical concentration-QTc relationships. Clin Pharmacol Ther 105:1175-1186. doi:10.1002/cpt.1259 PMID:30346629 PMCID:PMC6465173
  • Burnett SD, Blanchette A, Grimm FA, House JS, Reif DM, Wright FA, Chiu WA, Rusyn I. 2019. Population-based toxicity screening in human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol 381:114711. doi:10.1016/j.taap.2019.114711 PMID:31425687 PMCID:PMC6745256
  • Burnum-Johnson KE, Zheng X, Dodds J, Ash J, Fourches D, Nicora CD, Wendler J, Metz TO, Waters KM, Jansson J, Smith RD, Baker ES. 2019. Ion mobility spectrometry and the omics: Distinguishing isomers, isobars, molecular classes and contaminant ions in complex samples. Trends in Analytical Chemistry 116:292-299. doi:10.1016/j.trac.2019.04.022 PMID:31798197 PMCID:PMC6887105
  • Di Bona M, Mancini MA, Mazza D, Vicidomini G, Diaspro A, Lanzano L. 2019. Measuring Mobility in Chromatin by Intensity-Sorted FCS. Biophys J 116(6):P987-999. doi:10.1016/j.bpj.2019.02.003 PMID:30819566 PMCID:PMC6428914
  • Dodds J, Baker ES. 2019. Ion mobility spectrometry: fundamental concepts, instrumentation, applications, and the road ahead. J Am Soc Mass Spectrom doi:10.1007/s13361-019-02288-2 PMID:31493234 PMCID:PMC6832852
  • Englehardt JD, Chiu WA. 2019. A general dose-response relationship for chronic chemical and other health stressors and mixtures based on an emergent illness severity model. PLoS One 14(2):e0211780. doi:10.1371/journal.pone.0211780 PMID:30768598 PMCID:PMC6377108
  • Ferguson K, Luo Y, Rusyn I, Chiu WA. 2019. Comparative analysis of Rapid Equilibrium Dialysis (RED) and solid phase micro-extraction (SPME) methods for In Vitro-In Vivo extrapolation of environmental chemicals. Toxicol In Vitro 60:245-251. doi:10.1016/j.tiv.2019.06.006 PMID:31195086 PMCID:PMC6717004
  • Grimm FA, House JS, Wilson MR, Sirenko O, Iwata Y, Wright FA, Ball N, Rusyn I. 2019. Multi-dimensional in vitro bioactivity profiling for grouping of glycol ethers. Regul Toxicol Pharmacol 101:91-102. PMID:30471335 PMCID:PMC6333527
  • Gu D, Newman G, Kim J, Park Y, Lee J. 2019. Neighborhood decline and sustainable urbanism: Mitigating housing abandonment in shrinking cities. Land Use Policy 37:doi:10.1016/j.landusepol.2019.02.033 PMCID:PMC6818744
  • Hearon S, Wang M, Phillips TD. 2019. Strong adsorption of dieldrin by parent and processed montmorillonite clays. Environ Toxicol Chem doi:10.1002/etc.4642 PMID:31756776 PMCID:PMC7047628
  • Horney JA, Casillas GA, Miller A, Craft ES, Burdette K, Ferguson PL, Knap A, Baker ES, McDonald TJ, Bhandari S, Chiu WA, Rusyn I. 2019. Conducting environmental health research after disaster: Disaster research response to Hurricane Florence. Environmental Health
  • Horney JA, Rios J, Cantu A, Ramsey S, Montemayor L, Raun L, Miller A. 2019. Improving Hurricane Harvey disaster research response through academic practice partnerships. Am J Public Health 109(9):1198-1201. doi:10.2105/AJPH.2019.305166 PMID:31318601 PMCID:PMC6687265
  • Jun M, Ding Y. 2019. Spatio-temporal short-term wind forecast: a calibrated regime-switching method. Annals of Applied Statistics doi:10.1214/19-AOAS1243 (in press)
  • Jun M, Schumacher C, Saravanan R. 2019. Global multivariate point pattern models for rain type occurrence. Spat Stat 31:100355. doi:10.1016/j.spasta.2019.04.003 PMID:31886123 PMCID:PMC6934176
  • Karaye I, Stone KW, Casillas GA, Newman G, Horney JA. 2019. A spatial analysis of possible environmental exposures in recreational areas impacted by Hurricane Harvey flooding, Harris County, Texas. Environ Manage doi:10.1007/s00267-019-01204-4 PMID:31515572 PMCID:PMC6790291
  • Kim Y, Newman G. 2019. Climate change preparedness: comparing future urban growth and flood risk in Amsterdam and Houston. Sustainability 11:1048. doi:10.3390/su11041048 PMID:30809384 PMCID:PMC6387741
  • Kirsch J, Elizondo J, De Hoyos Salazar D, Washington S, Burdick T, Alvarez P, Horney JA. 2019. An engaged environmental science curriculum for underserved youth. Environ Education Res 25:doi:10.1080/13504622.2019.1637822 PMCID:PMC6897383
  • Kuthurua S, Szafran AT, Stossi F, Mancini MA, Rao A. 2019. Leveraging image-derived phenotypic measurements for drug-target interaction predictions. Cancer Inform doi:10.1177/1176935119856595 PMID:31217689 PMCID:PMC6563400
  • Kvasnicka J, Stylianou KS, Nguyen VK, Huang L, Chiu WA, Burton AG, Semrau J, Jolliet O. 2019. Human Health Benefits from Fish Consumption vs. Risks from Inhalation Exposures Associated with Contaminated Sediment Remediation: Dredging of the Hudson River. Environ Health Perspect 127:doi:10.1289/EHP5034 PMID:31834828
  • Lee R, Newman G. 2019. A classification scheme for vacant urban lands: integrating duration, land characteristics, and survival rates. J of Land Use Sci doi:10.1080/1747423X.2019.1706655
  • Lewis L, Borowa-Mazgaj B, de Conti A, Chappell G, Luo Y, Bodnar WM, Konganti K, Wright FA, Threadgill DW, Chiu WA, Pogribny IP, Rusyn I. 2019. Population-based analysis of DNA damage and epigenetic effects of 1,3-butadiene in the mouse. Chem Res Toxicol doi:10.1021/acs.chemrestox.9b00035 PMID:30990016 (ahead of print)
  • Li D, Zhai Y, Xiao Y, Newman G, Wang D. 2019. Subtypes of park use and self-reported psychological benefits among older adults: A multilevel latent class analysis approach. Landsc Urban Plan 190:doi:10.1016/j.landurbplan.2019.103605 PMID:31341342 PMCID:PMC6656528
  • Luo Y, Cichocki JA, Hsieh N, Lewis L, Wright FA, Threadgill DW, Chiu WA, Rusyn I. 2019. Using Collaborative Cross mouse population to fill data gaps in risk assessment: A case study of population-based analysis of toxicokinetics and kidney toxicodynamics of tetrachloroethylene. Environ Health Perspect 127(6):67011. doi:10.1289/EHP5105 PMID:31246107 PMCID:PMC6792382
  • Masterson J, Meyer M, Ghariabeh N, Hendricks M, Lee R, Musharrat S, Newman G, Sansom G, Van Zandt S. 2019. Interdisciplinary citizen science and design projects for hazard and disaster education. Int J Mass Emergencies Disasters 37:PMCID:PMC6594559
  • Monge ME, Dodds J, Baker ES, Edison AS, Fernandez FM. 2019. Challenges in Identifying the Dark Molecules of Life. Annu Rev Anal Chem 12:177-199. doi:10.1146/annurev-anchem-061318-114959 PMID:30883183 PMCID:PMC6716371
  • Mukherjee R, Onel M, Beykal B, Szafran AT, Stossi F, Mancini MA, Zhou L, Wright FA, Pistikopoulos EN. 2019. Development of the Texas A&M Superfund Research Program computational platform for data integration, visualization, and analysis. Computer Aided Chemical Engineering 46:967-972. doi:10.1016/B978-0-12-818634-3.50162-4 PMID:31612156 PMCID:PMC6791821
  • Newman G, Dongying L, Rui Z, Dingding R. 2019. Resilience through regeneration: the economics of repurposing vacant land with green infrastructure. Landsc Archit Front 6:10-23. doi:10.15302/J-LAF-20180602 PMID:30761217 PMCID:PMC637032
  • Newman G, Lee R, Gu D, Park Y, Saginor J, Van Zandt S, Li W. 2019. Evaluating drivers of housing vacancy a longitudinal analysis of large U.S. cities from 1960 to 2010. J Hous Built Environ 34:807-827. doi:10.1007/s10901-019-09684-w PMID:31857804 PMCID:PMC6920573 (accepted for publication)
  • Newman G, Malecha M, Yu S, Qiao Z, Horney JA, Lee J, Kim Y, Lee R, Berke P. 2019. Integrating a resilience scorecard and landscape performance tools into a Geodesign process. Landscape Research doi:10.1080/01426397.2019.1569219
  • Newman G, Qiao Z. 2019. Climate change armor. Cheng Shi She Ji 19(5):50-63. PMID:30680250 PMCID:PMC6342505
  • Onel M, Beykal B, Ferguson K, Chiu WA, McDonald TJ, Zhou L, House JS, Wright FA, Sheen D, Rusyn I, Pistikopoulos EN. 2019. Grouping of complex substances using analytical chemistry data: A framework for quantitative evaluation and visualization. PLoS One 14(10):e0223517. doi:10.1371/journal.pone.0223517 PMID:31600275 PMCID:PMC6786635
  • Onel M, Kieslich CA, Pistikopoulos EN. 2019. A nonlinear support vector machine based feature selection approach for fault detection and diagnosis: application to the Tennessee Eastman process. AIChE Journal 65(3):992-1005. doi:10.1002/aic.16497
  • Perry A, Lynch RM, Rusyn I, Threadgill DW. 2019. Long-term combinatorial exposure to trichloroethylene and inorganic arsenic in genetically heterogeneous mice results in renal tubular damage and cancer-associated molecular changes. G3 (Bethesda) 9(5):1729-1737. doi:10.1534/g3.119.400161 PMID:30898898
  • Plante P, Francovic-Fontaine E, May J, McLean JA, Baker ES, Laviolette F, Marchand M, Corbeil J. 2019. Predicting Ion Mobility Collision Cross-Sections Using a Deep Neural Network: DeepCCS. Anal Chem 91:5191-5199. doi:10.1021/acs.analchem.8b05821 PMID:30932474 PMCID:PMC6628689
  • Potter H, DiMarco S, Knap A. 2019. Tropical cyclone heat potential and the rapid intensification of Hurricane Harvey in the Texas Bight. J Geophys Res Oceans 124:doi:10.1029/2018JC014776
  • Sansom G, Berke P, McDonald TJ, Shipp E, Horney JA. 2019. Evaluating the impact of race and gender on environmental risk perceptions in the Houston neighborhood of Manchester. Environ Justice 12(3):doi:10.1089/env.2018.0028 PMID:31871531 PMCID:PMC6927678
  • Sansom G, Cizmas LH, Aarvig K, Dixon B, Kirsch KR, Katare A, Sansom L. 2019. Vulnerable populations exposed to lead-contaminated drinking water within Houston Ship Channel communities. Int J Environ Res Public Health 16(15):E2745. doi:10.3390/ijerph16152745 PMID:31374814
  • Sharma VK, Yu X, McDonald TJ, Jinadatha C, Dionysiou DD, Feng M. 2019. Elimination of antibiotic resistance genes and control of horizontal transfer risk by UV-based treatment of drinking water: A mini review. Frontiers of Environmental Science & Engineering 13:37. doi:10.1007/s11783-019-1122-7 PMID:32133212 PMCID:PMC7055709
  • Stermer A, Klein D, Wilson S, Dalaijamts C, Bai CY, Hall SJ, Madnick SJ, Bianchi E, Chiu WA, Boekelheide K. 2019. Differential toxicity of water versus gavage exposure to trichloroethylene in rats. Environ Toxicol Pharmacol 68:1-3. doi:10.1016/j.etap.2019.02.003 PMID:30836291 PMCID:PMC6594756
  • Stone KW, Casillas GA, Karaye I, Camargo K, McDonald TJ, Horney JA. 2019. Using spatial analysis to examine potential sources of polycyclic aromatic hydrocarbons in an environmental justice community after Hurricane Harvey. Environ Justice doi:10.1089/env.2019.0007
  • Stossi F, Dandekar RD, Johnson H, Lavere P, Foulds CE, Mancini MG, Mancini MA. 2019. Tributyltin chloride (TBT) induces RXRA down-regulation and lipid accumulation in human liver cells. PLoS One 14:13. doi:10.1371/journal.pone.0224405 PMID:31710612 PMCID:PMC6844554
  • Stossi F, Dandekar RD, Mancini MG, Gu G, Fuqua SA, Nardone A, De Angelis C, Fu X, Schiff R, Bedford MT, Xu W, Johansson HE, Stephan C, Mancini MA. 2019. Methyltransferases buffer E2-induced transcription at individual alleles. Nucleic Acids Res
  • Tao Z, Newman G, Arnold M, Li M, Kim J. 2019. The living green infrastructure lab: Advancing interdisciplinary teaching and experiential learning in landscape architecture pedagogy. Landsc Res Rec 8:75-86. PMID:31891111 PMCID:PMC6936730
  • Trueblood A, Ross J, Shipp E, McDonald TJ. 2019. Feasibility of Portable Fingerstick Cholinesterase Testing in Adolescents in South Texas. J Prim Care Community Health doi:10.1177/2150132719838716 PMID:30929548
  • Wang M, Hearon S, Johnson N, Phillips TD. 2019. Development of broad-acting clays for the tight adsorption of benzo[a]pyrene and aldicarb. Appl Clay Sci 168:196-202. doi:10.1016/j.clay.2018.11.010 PMID:31435120 PMCID:PMC6703832
  • Wang M, Hearon S, Phillips TD. 2019. A high capacity bentonite clay for the sorption of aflatoxins. Food Addit Contam Part A Chem Anal Control Expo Risk Assess 37(25):doi:10.1080/19440049.2019.1662493 PMID:31790632 PMCID:PMC6989347
  • Wang M, Hearon S, Phillips TD. 2019. Development of enterosorbents that can be added to food and water to reduce toxin exposures during disasters. J Environ Sci Health B 54:514-524. doi:10.1080/03601234.2019.1604039 PMID:31014207 PMCID:PMC6681816
  • Wang M, Orr AA, He S, Dalaijamts C, Chiu WA, Tamamis P, Phillips TD. 2019. Montmorillonite clays can tightly sorb glyphosate and paraquat onto interlamellar surfaces and protect against exposure and toxicity. ACS Omega 4:
  • Wang M, Orr AA, He S, Dalaijamts C, Chiu WA, Tamamis P, Phillips TD. 2019. Montmorillonites can tightly bind glyphosate and paraquat reducing toxin exposures and toxicity. ACS Omega 4:17702-17713. doi:10.1021/acsomega.9b02051 PMID:31681876 PMCID:PMC6822125
  • Wang M, Phillips TD. 2019. Potential applications of clay-based therapy for the reduction of pesticide exposures in humans and animals. Appl. Sci 9:5325. doi:10.3390/app9245325
  • Wang M, Safe SH, Hearon S, Phillips TD. 2019. Strong adsorption of Polychlorinated Biphenyls by processed montmorillonite clays: Potential applications as toxin enterosorbents during disasters and floods. Environ Pollut 255:doi:10.1016/j.envpol.2019.113210 PMID:31542671 PMCID:PMC6878994
  • Wang P, Wang Y, Langley SA, Zhou Y, Jen K, Sun Q, Brislawn C, Rojas CM, Wahl KL, Wang T, Fan X, Jansson J, Celniker SE, Zou X, Threadgill DW, Snijders AM, Mao J. 2019. Diverse tumour susceptibility in Collaborative Cross mice: Identification of a new mouse model for human gastric tumourigenesis. Gut doi:10.1136/gutjnl-2018-316691 PMID:30842212
  • Xia J, Chiu L, Nehring R, Bravo Nunez M, Mei Q, Perez M, Zhai Y, Fitzgerald D, Pribis J, Wang Y, Hu C, Powell R, LaBonte S, Jalali A, Matadamas Guzman M, Lentzsch A, Szafran AT, Joshi M, Richters M, Gibson J, Frisch R, Hastings P, Bates D, Queitsch C, Hilsenbeck SG, Coarfa C, Hu JC, Siegele DA, Scott KL, Liang H, Mancini MA, Herman C, Miller KM, Rosenberg SM. 2019. Bacteria-to-human protein networks reveal origins of endogenous DNA damage. Cell 176(1-2):127-143. doi:10.1016/j.cell.2018.12.008 PMID:30633903 PMCID:PMC6344048
  • Yang J, Jun M, Schumacher C, Saravanan R. 2019. Predictive statistical representations of observed and simulated rainfall using generalized linear models. journal of climate 32:3409-3427. doi:10.1175/jcli-d-18-0527.1
  • Zheng X, Smith FB, Aly NA, Cai J, Patterson A, Baker ES. 2019. Evaluating the structural complexity of isomeric bile acids with ion mobility spectrometry. Anal Bioanal Chem 411:4673-4682. doi:10.1007/s00216-019-01869-0 PMID:31098744 PMCID:PMC6612315

2018

  • Avraamidou S, Beykal B, Pistikopoulos IP, Pistikopoulos EN. 2018. A hierarchical Food-Energy-Water Nexus (FEW-N) decision-making approach for Land Use Optimization. Int Symp Process Syst Eng 44:1885-1890. doi:10.1016/B978-0-444-64241-7.50309-8 PMID:30397687
  • Avraamidou S, Milhorn A, Sarwar O, Pistikopoulos EN. 2018. Towards a quantitative food-energy-water nexus metric to facilitate decision making in process systems: A case study on a dairy production plant. ESCAPE 43:391-396. doi:10.1016/B978-0-444-64235-6.50071-1 PMID:30320306
  • Bera G, Parkerton TF, Redman A, Turner N, Renegar DA, Sericano JL, Knap A. 2018. Passive dosing yields dissolved aqueous exposures of crude oil comparable to the CROSERF (Chemical Response to Oil Spill: Ecological Effects Research Forum) water accommodated fraction method. Environ Toxicol Chem 37:2810-2819. doi:10.1002/etc.4263
  • Beykal B, Boukouvala F, Floudas CA, Pistikopoulos EN. 2018. Optimal design of energy systems using constrained grey-box multi-objective optimization. Computers & Chemical Engineering 116:488-502. doi:10.1016/j.compchemeng.2018.02.017 PMID:30546167 PMCID:PMC6287910
  • Chiu WA, Axelrad DA, Dalaijamts C, Dockins C, Shao K, Shapiro AJ, Paoli GM. 2018. Beyond the RfD: Broad application of a probabilistic approach to improve chemical dose response assessments for noncancer effects. Environ Health Perspect 126(6):067009. doi:10.1289/EHP3368 PMID:29968566 PMCID:PMC6084844
  • Chiu WA, Guyton KZ, Martin MT, Reif DM, Rusyn I. 2018. Use of high-throughput in vitro toxicity screening data in cancer hazard evaluations by IARC Monograph Working Groups. ALTEX 35(1):51-64. doi:10.14573/altex.1703231 PMID:28738424 PMCID:PMC5783793
  • Chiu WA, Rusyn I. 2018. Advancing chemical risk assessment decision-making with population variability data: challenges and opportunities. Mamm Genome 29(1-2):182-189. doi:10.1007/s00335-017-9731-6 PMID:29299621 PMCID:PMC5849521
  • Chowdhury P, Powell R, Stephan C, Uray I, Talley T, Karki M, Tripathi D, Park Y, Mancini MA, Davies P, Dere R. 2018. Bexarotene - a novel modulator of AURKA and the primary cilium in VHL-deficient cells. Journal of Cell Science 131(24):doi:10.1242/jcs.219923 PMID:30518623 PMCID:PMC6307881
  • Cuomo D, Porreca I, Ceccarelli M, Threadgill DW, Barrington WT, Petriella A, D'Angelo F, Cobellis G, De Stefano F, D' Agostino MN, De Felice M, Mallardo M, Ambrosino C. 2018. Transcriptional landscape of mouse-aged ovaries reveals a unique set of non-coding RNAs associated with physiological and environmental ovarian dysfunctions. Cell Death Discov doi:10.1038/s41420-018-0121-y PMID:30534420
  • Dalaijamts C, Cichocki JA, Luo Y, Rusyn I, Chiu WA. 2018. Incorporation of the glutathione conjugation pathway in an updated physiologically-based pharmacokinetic model for perchloroethylene in mice. Toxicol Appl Pharmacol 352:142-152. doi:10.1016/j.taap.2018.05.033 PMID:29857080 PMCID:PMC6051410
  • Ezzat AA, Jun M, Ding Y. 2018. Spatio-temporal asymmetry of local wind fields and its impact on short-term wind forecasting. IEEE Trans Sustain Energy 9:1437-1447. doi:10.1109/TSTE.2018.2789685 PMID:30405893 PMCID:PMC6218160
  • Fantke P, Aylward L, Bare J, Chiu WA, Dodson R, Dwyer R, Ernstoff A, Howard B, Jantunen M, Jolliet O, Judson RR, Kirchhubel N, Li D, Miller A, Paoli GM, Price P, Rhomberg L, Shen B, Shin H, Teeguarden J, Vallero D, Wambaugh J, Wetmore BA, Zaleski R, McKone TE. 2018. Advancements in life cycle human exposure and toxicity characterization. Environ Health Perspect 126:10. doi:10.1289/ehp3871 PMID:30540492
  • Garbutt TA, Konneker TI, Konganti K, Hillhouse AE, Swift-Haire F, Jones A, Phelps D, Aylor DL, Threadgill DW. 2018. Permissiveness to form pluripotent stem cells may be an evolutionarily derived characteristic in Mus musculus. Sci Rep 8(1):14706. doi:10.1038/s41598-018-32116-8 PMID:30279419 PMCID:PMC6168588
  • Grimm FA, Blanchette A, House JS, Ferguson K, Hsieh N, Dalaijamts C, Wright AA, Anson B, Wright FA, Chiu WA, Rusyn I. 2018. A human population-based organotypic in vitro model for cardiotoxicity screening. ALTEX 35:441-452. doi:10.14573/altex.1805301 PMID:29999168 PMCID:PMC6231908
  • Guyton KZ, Rieswijk L, Wang A, Chiu WA, Smith MT. 2018. Key characteristics approach to carcinogenic hazard identification. Chem Res Toxicol 31(12):1290-1292. doi:10.1021/acs.chemrestox.8b00321 PMID:30521319 PMCID:PMC6424613
  • Guyton KZ, Rusyn I, Chiu WA, Corpet DE, van den Berg M, Ross MK, Christiani DC, Beland FA, Smith MT. 2018. Application of the key characteristics of carcinogens in cancer hazard identification. Carcinogenesis 39(4):614-622. doi:10.1093/carcin/bgy031 PMID:29562322 PMCID:PMC5888955
  • Guyton KZ, Rusyn I, Chiu WA, Corpet DE, van den Berg M, Ross MK, Christiani DC, Beland FA, Smith MT. 2018. Re: Application of the key characteristics of carcinogens in cancer hazard evaluation : response to Goodman, Lynch and Rhomberg. Carcinogenesis 39(8):1091-1093. doi:10.1093/carcin/bgy082 PMID:29982359 PMCID:PMC6067125
  • Hendricks M, Meyer MA, Gharaibeh N, Van Zandt S, Masterson J, Cooper JT, Horney JA, Berke P. 2018. The development of a participatory assessment technique for infrastructure: Neighborhood-level monitoring towards sustainable infrastructure systems. Sustain Cities Soc 38:265-274. doi:10.1016/j.scs.2017.12.039 PMID:30370207 PMCID:PMC6200349
  • Horney JA, Casillas GA, Baker ES, Stone KW, Kirsch KR, Camargo K, Wade TL, McDonald TJ. 2018. Comparing residential contamination in a Houston environmental justice neighborhood before and after Hurricane Harvey. PLoS One 13(2):e0192660. doi:10.1371/journal.pone.0192660 PMID:29420658 PMCID:PMC5805347
  • Huang P, Hwangbo M, Chen Z, Liu Y, Kameoka J, Chu K. 2018. Reusable functionalized hydrogel sorbents for removing long- and short-chain perfluoroalkyl acids (PFAAs) and GenX from aqueous solution. ACS Omega 3(12):17447-17455. doi:10.1021/acsomega.8b02279
  • Hwang H, Fiala M, Wade TL, Park D. 2018. Review of pollutants in urban road dust: Part II. Organic contaminants from vehicles and road management. International Journal of Urban Sciences doi:10.1080/12265934.2018.1538811
  • Kim J, Li W, Newman G, Kil S, Park S. 2018. The influence of urban landscape spatial patterns on single-family housing prices. Environ Plan B Urban Anal City Sci 45(1):26-43. doi:10.1177/0265813516663932 PMID:30345396
  • Klaren WD, Rusyn I. 2018. High-content assay multiplexing for muscle toxicity screening in human-induced pluripotent stem cell-derived skeletal myoblasts. Assay Drug Dev Technol 16(6):333-342. doi:10.1089/adt.2018.860 PMID:30070899 PMCID:PMC6114077
  • Lee J, Newman G, Park Y. 2018. A Comparison of Vacancy Dynamics between Growing and Shrinking Cities Using the Land Transformation Model. Sustainability 10(5):1513. doi:10.3390/su10051513 PMID:30687533
  • Li G, Shabalin AA, Rusyn I, Wright FA, Nobel AB. 2018. An empirical Bayes approach for multiple tissue eQTL analysis. Biostatistics 19(3):391-406. doi:10.1093/biostatistics/kxx048 PMID:29029013 PMCID:PMC6366007
  • Low Y, Alves VM, Fourches D, Sedykh A, Andrade CH, Muratov EN, Rusyn I, Tropsha A. 2018. Chemistry-wide association studies (CWAS): a novel framework for identifying and interpreting structure-activity relationships. J Chem Inf Model 58(11):2203-2213. doi:10.1021/acs.jcim.8b00450 PMID:30376324
  • Luo Y, Hsieh N, Soldatow VY, Chiu WA, Rusyn I. 2018. Comparative analysis of metabolism of trichloroethylene and tetrachloroethylene among mouse tissues and strains. Toxicology 409:33-43. doi:10.1016/j.tox.2018.07.012 PMID:30053492 PMCID:PMC6186498
  • MacLean BX, Prat BS, Egertson JD, MacCoss MJ, Smith RD, Baker ES. 2018. Using skyline to analyze data-containing liquid chromatography, ion mobility spectrometry, and mass spectrometry dimensions. J Am Soc Mass Spectrom 1-7. doi:10.1007/s13361-018-2028-5 PMID:30047074 PMCID:PMC6191345
  • Marvel S, To K, Grimm FA, Wright FA, Rusyn I, Reif DM. 2018. ToxPi Graphical User Interface 2.0: dynamic exploration, visualization, and sharing of integrated data models. BMC Bioinformatics 19(1):80. doi:10.1186/s12859-018-2089-2 PMID:29506467 PMCID:PMC5838926
  • Mendoza-Sanchez I, Autenrieth RL, McDonald TJ, Cunningham JA. 2018. Biological limitations of dechlorination of cis-Dichloroethene during transport in porous media. Environ Sci Technol 52(2):684-691. doi:10.1021/acs.est.7b04426 PMID:29236483 (ahead of print)
  • Meyer MA, Hendricks M, Newman G, Masterson J, Cooper JT, Sansom G, Gharaibeh N, Horney JA, Berke P, Van Zandt S, Cousins T. 2018. Participatory action research: tools for disaster resilience education. Int J Disaster Resil Built Environ 9:402-419. doi:10.1108/ijdrbe-02-2017-0015 PMID:30519288 PMCID:PMC6277034
  • Newman G, Brody SD, Smith AL. 2018. Repurposing vacant land through landscape connectivity. Landsc J 36(1):37-57. doi:10.3368/lj.36.1.37 PMID:30034076 PMCID:PMC6053283 (in press)
  • Nicora CD, Burnum-Johnson KE, Nakayasu ES, Casey CP, White RA, Chowdhury TR, Kyle JE, Kim Y, Smith RD, Metz TO, Jansson J, Baker ES. 2018. The MPLEx protocol for multi-omic analyses of soil samples. J Vis Exp 135:e57343. doi:10.3791/57343 PMID:29912205 PMCID:PMC6101435
  • Onel M, Beykal B, Wang M, Grimm FA, Zhou L, Wright FA, Phillips TD, Rusyn I, Pistikopoulos EN. 2018. Optimal chemical grouping and sorbent material design by data analysis, modeling and dimensionality reduction techniques. Computer Aided Chemical Engineering 43:421-426. doi:10.1016/B978-0-444-64235-6.50076-0 PMID:30534632
  • Onel M, Kieslich CA, Guzman YA, Floudas CA, Pistikopoulos EN. 2018. Big data approach to batch process monitoring: simultaneous fault detection and diagnosis using nonlinear support vector machine-based feature selection. Computers & Chemical Engineering 115:46-63. doi:10.1016/j.compchemeng.2018.03.025 PMID:30386002 PMCID:PMC6205516
  • Onel M, Kieslich CA, Guzman YA, Floudas CA, Pistikopoulos EN. 2018. Reprint of: Big data approach to batch process monitoring: simultaneous fault detection and diagnosis using nonlinear support vector machine-based feature selection. Computers & Chemical Engineering 116:503-520. doi:10.1016/j.compchemeng.2018.10.016
  • Onel M, Kieslich CA, Guzman YA, Pistikopoulos EN. 2018. Simultaneous fault detection and identification in continuous processes via nonlinear Support Vector Machine based feature selection. Int Symp Process Syst Eng 44:2077-2082. doi:10.1016/B978-0-444-64241-7.50341-4 PMID:30534633
  • Orton DJ, Tfaily MM, Moore RJ, LaMarche BL, Zheng X, Fillmore TL, Chu RK, Weitz KK, Monroe ME, Kelly RT, Smith RD, Baker ES. 2018. A customizable flow injection system for automated, high throughput, and time sensitive ion mobility spectrometry and mass spectrometry measurements. Anal Chem 90(1):737-744. doi:10.1021/acs.analchem.7b02986 PMID:29161511 PMCID:PMC5764703
  • Phillips TD, Wang M, Elmore SE, Hearon S, Wang J. 2018. NovaSil clay for the protection of humans and animals from aflatoxins and other contaminants. Clays and Clay Minerals 67(1):99-110. doi:10.1007/s42860-019-0008-x
  • Rusyn I, Greene N. 2018. The impact of novel assessment methodologies in toxicology on green chemistry and chemical alternatives. Toxicol Sci 161:276-284. doi:10.1093/toxsci/kfx196 PMID:29378069
  • Rusyn I, Kleeberger SR, McAllister KA, French JE, Svenson KL. 2018. Introduction to mammalian genome special issue: the combined role of genetics and environment relevant to human disease outcomes. Mamm Genome 29(1-2):1-4. doi:10.1007/s00335-018-9740-0 PMID:29460122 PMCID:PMC5849569
  • Sansom G, Kirsch KR, Stone KW, McDonald TJ, Horney JA. 2018. Domestic exposures to polycyclic aromatic hydrocarbons in a Houston, Texas, environmental justice neighborhood. Environ Justice 11(5):183-191. doi:10.1089/env.2018.0004 PMID:30464781 PMCID:PMC6241524
  • Shapiro AJ, Antoni S, Guyton KZ, Lunn RM, Loomis D, Rusyn I, Jahnke GD, Schwingl PJ, Mehta SS, Addington J, Guha N. 2018. Software Tools to Facilitate Systematic Review Used for Cancer Hazard Identification. Environ Health Perspect 126:104501. doi:10.1289/EHP4224 PMID:30392397 PMCID:PMC6371692
  • Thiagarajan M, Newman G, Van Zandt S. 2018. The projected impact of a neighborhood-scaled green-infrastructure retrofit. Sustainability 10(10):3665. doi:10.3390/su10103665 PMID:30473873 PMCID:PMC6247782 (in press)
  • Tolgyesi A, Giri A, Barta E, McDonald TJ, Sharma VK. 2018. Determination of thyreostats in urine using supported liquid extraction and mixed-mode cation-exchange solid-phase extraction: Screening and confirmatory methods. Journal of Chromatographic Science 56(9):858-866. doi:10.1093/chromsci/bmy054 PMID:29878072 PMCID:PMC6454509
  • Venkatratnam A, House JS, Konganti K, McKenney C, Threadgill DW, Chiu WA, Aylor DL, Wright FA, Rusyn I. 2018. Population-based dose-response analysis of liver transcriptional response to trichloroethylene in mouse. Mamm Genome 29:168-181. doi:10.1007/s00335-018-9734-y PMID:29353386 PMCID:PMC6094947
  • Wignall JA, Muratov EN, Sedykh A, Guyton KZ, Tropsha A, Rusyn I, Chiu WA. 2018. Conditional toxicity value (CTV) predictor: an in silico approach for generating quantitative risk estimates for chemicals. Environ Health Perspect 126(5):057008. doi:10.1289/EHP2998 PMID:29847084 PMCID:PMC6071978
  • Zheng X, Dupuis KT, Aly NA, Zhou Y, Smith FB, Tang K, Smith RD, Baker ES. 2018. Utilizing ion mobility spectrometry and mass spectrometry for the analysis of polycyclic aromatic hydrocarbons, polychlorinated biphenyls, polybrominated diphenyl ethers and their metabolites. Anal Chim Acta 1037:265-273. doi:10.1016/j.aca.2018.02.054 PMID:30292301 PMCID:PMC6223027
  • Zheng X, Smith RD, Baker ES. 2018. Recent advances in lipid separations and structural elucidation using mass spectrometry combined with ion mobility spectrometry, ion-molecule reactions and fragmentation approaches. Curr Opin Chem Biol 42:111-118. doi:10.1016/j.cbpa.2017.11.009 PMID:29223060 PMCID:PMC5828972

2017

  • Bokkers BG, Mengelers MJ, Bakker MI, Chiu WA, Slob W. 2017. APROBA-Plus: A probabilistic tool to evaluate and express uncertainty in hazard characterization and exposure assessment of substances. Food Chem Toxicol 110:408-417. doi:10.1016/j.fct.2017.10.038 PMID:29074418 PMCID:PMC5793872
  • Cichocki JA, Furuya S, Venkatratnam A, McDonald TJ, Knap A, Wade TL, Sweet S, Chiu WA, Threadgill DW, Rusyn I. 2017. Characterization of variability in toxicokinetics and toxicodynamics of tetrachloroethylene using the collaborative cross mouse population. Environ Health Perspect 125(5):057006. doi:10.1289/ehp788 PMID:28572074 PMCID:PMC5726344
  • Grimm FA, Russell WK, Luo Y, Iwata Y, Chiu WA, Roy T, Boogaard PJ, Ketelslegers HB, Rusyn I. 2017. Grouping of petroleum substances as example UVCBs by ion mobility-mass spectrometry to enable chemical composition-based read-across. Environ Sci Technol 51:7197-7207. doi:10.1021/acs.est.6b06413 PMID:28502166 PMCID:PMC5627358
  • House JS, Grimm FA, Jima DD, Zhou Y, Rusyn I, Wright FA. 2017. A pipeline for high-throughput concentration response modeling of gene expression for toxicogenomics. Front Genet 8:168. doi:10.3389/fgene.2017.00168 PMID:29163636 PMCID:PMC5672545
  • Iwata Y, Klaren WD, Lebakken CS, Grimm FA, Rusyn I. 2017. High-content assay multiplexing for vascular toxicity screening in induced pluripotent stem cell-derived endothelial cells and human umbilical vein endothelial cells. Assay Drug Dev Technol 15(6):267-279. doi:10.1089/adt.2017.786 PMID:28771372 PMCID:PMC5576216
  • Jeong J, Jun M, Genton MG. 2017. Spherical process models for global spatial statistics. Stat Sci 32(4):501-513. doi:10.1214/17-STS620 PMID:30983695 PMCID:PMC6457667
  • Jun M. 2017. Climate model intercomparison. Chance (N Y) 30(4):19-25. doi:10.1080/09332480.2017.1406755 PMID:30976137
  • Kim J, Newman G, Feng H, Merrill J, Park J, Bian J. 2017. Sustainable urbanism for a metropolitan corridor: An evidence-based urban design for Park 10 in Houston, Texas. Landsc Archit Front 5(5):96-109. doi:10.15302/j-laf-20170510 PMID:30386665 PMCID:PMC6207208
  • Meyer M, Hendricks M, Newman G, Horney JA, Berke P, Masterson J, Sansom G, Cousins T, Van Zandt S, Cooper JT. 2017. Urban environmental resiliency: Using participatory methods for hazard adaptation and climate justice in socially vulnerable communities. Int J Disaster Resil Built Environ 9(4):(in press)
  • Reja MY, Brody SD, Highfield WE, Newman G. 2017. Hurricane recovery and ecological resilience: measuring the impacts of wetland alteration post Hurricane Ike on the upper TX coast. Environ Manage 60:1116-1126. doi:10.1007/s00267-017-0943-z PMID:28939984
  • Reja MY, Brody SD, Highfield WE, Newman G. 2017. Understanding the notion between resiliency and recovery through a spatial-temporal analysis of Section 404 wetland alteration permits before and after Hurricane Ike. World Acad Sci Eng Technol 11(4):372-379. PMID:30319740 PMCID:PMC6178950
  • Sharma VK, McDonald TJ, Sohn M, Anquandah GA, Pettine M, Zboril R. 2017. Assessment of toxicity of selenium and cadmium selenium quantum dots: A review. Chemosphere 188:403-413. doi:10.1016/j.chemosphere.2017.08.130 PMID:28892773
  • Sharma VK, Yang X, Cizmas LH, McDonald TJ, Luque R, Sayes CM, Yuan B, Dionysiou DD. 2017. Impact of metal ions, metal oxides, and nanoparticles on the formation of disinfection byproducts during chlorination. Chem Eng J 317:777-792. doi:10.1016/j.cej.2017.02.071
  • Sirenko O, Grimm FA, Ryan KR, Iwata Y, Chiu WA, Parham F, Wignall JA, Anson B, Cromwell EF, Behl M, Rusyn I, Tice RR. 2017. In vitro cardiotoxicity assessment of environmental chemicals using an organotypic human induced pluripotent stem cell-derived model. Toxicol Appl Pharmacol 322:60-74. doi:10.1016/j.taap.2017.02.020 PMID:28259702 PMCID:PMC5734940
  • Szafran AT, Stossi F, Mancini MG, Walker CL, Mancini MA. 2017. Characterizing properties of non-estrogenic substituted bisphenol analogs using high throughput microscopy and image analysis. PLoS One 12(7):e0180141. doi:10.1371/journal.pone.0180141 PMID:28704378 PMCID:PMC5509144
  • Telesford-Checkley J, Mora MA, Gentry TJ, McDonald TJ, Boellstorff DE. 2017. Impacts of heronries on water quality as evaluated through Escherichia coli and fecal sterol analyses. Water Environ Res 89(6):508-518. doi:10.2175/106143017X14902968254430 PMID:28545602
  • Venkatratnam A, Furuya S, Kosyk O, Gold A, Bodnar WM, Konganti K, Threadgill DW, Gillespie DA, Aylor DL, Wright FA, Chiu WA, Rusyn I. 2017. Editor's Highlight: Collaborative Cross mouse population enables refinements to characterization of the variability in toxicokinetics of trichloroethylene and provides genetic evidence for the role of PPAR pathway in its oxidative metabolism. Toxicol Sci 158(1):48-62. doi:10.1093/toxsci/kfx065 PMID:28369613
  • Wang M, Maki CR, Deng Y, Tian Y, Phillips TD. 2017. Development of high capacity enterosorbents for aflatoxin B1 and other hazardous chemicals. Chem Res Toxicol 30(9):1694-1701. doi:10.1021/acs.chemrestox.7b00154 PMID:28768106
  • Zheng X, Aly NA, Zhou Y, Dupuis KT, Bilbao A, Paurus VL, Orton DJ, Wilson R, Payne SH, Smith RD, Baker ES. 2017. A structural examination and collision cross section database for over 500 metabolites and xenobiotics using drift tube ion mobility spectrometry. Chem Sci 8(11):7724-7736. doi:10.1039/c7sc03464d PMID:29568436 PMCID:PMC5853271
  • Zhou Y, Cichocki JA, Soldatow VY, Scholl EH, Gallins P, Jima DD, Yoo HS, Chiu WA, Wright FA, Rusyn I. 2017. Editor's highlight: comparative dose-response analysis of liver and kidney transcriptomic effects of trichloroethylene and tetrachloroethylene in B6C3F1 mouse. Toxicol Sci 160(1):95-110. doi:10.1093/toxsci/kfx165 PMID:28973375 PMCID:PMC5837274
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