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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Project Publications: Texas A&M University: Inter-Tissue and -Individual Variability in Response to Mixtures

Superfund Research Program

Inter-Tissue and -Individual Variability in Response to Mixtures

Project Leader: Ivan Rusyn
Co-Investigator: David W. Threadgill
Grant Number: P42ES027704
Funding Period: 2017-2022

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Publications

2023

2022

  • Aeppli C, Mitchell DA, Keyes P, Beirne EC, McFarlin KM, Roman-Hubers AT, Rusyn I, Prince RC, Zhao L, Parkerton TF, Nedwed T. 2022. Oil irradiation experiments document changes in oil properties, molecular composition, and dispersant effectiveness associated with oil photo-oxidation. Environ Sci Technol 56:doi:10.1021/acs.est.1c06149 PMID:35605020
  • Bhandari S, Casillas GA, Aly NA, Zhu R, Newman G, Wright FA, Miller A, Adler G, Rusyn I, Chiu WA. 2022. Spatial and temporal analysis of impacts of Hurricane Florence on criteria air pollutants and air toxics in eastern North Carolina. Int J Environ Res Public Health 19(3):doi:10.3390/ijerph19031757 PMID:35162780 PMCID:PMC8835244
  • Blanchette A, Burnett SD, Rusyn I, Chiu WA. 2022. A tiered approach to population-based in vitro testing for cardiotoxicity: Balancing estimates of potency and variability. J Pharmacol Toxicol Methods 114:doi:10.1016/j.vascn.2022.107154 PMID:34999233 PMCID:PMC8930538
  • Boysen G, Rusyn I, Chiu WA, Wright FA. 2022. Characterization of population variability of 1,3-butadiene derived protein adducts in humans and mice. Regul Toxicol Pharmacol doi:10.1016/j.yrtph.2022.105171 PMID:35469930
  • Ford L, Jang S, Chen Z, Zhou Y, Gallins P, Wright FA, Chiu WA, Rusyn I. 2022. A population-based human in vitro approach to quantify inter-individual variability in responses to chemical mixtures. Toxics 10(8):441. doi:10.3390/toxics10080441 PMID:36006120
  • House JS, Dalzell A, Kuchi S, Zhang S, Lenz K, Boogard PJ, Ketelslegers HB, Gant TW, Rusyn I, Wright FA, Grimm FA, Klaren WD. 2022. Grouping of UVCB substances with dose-response transcriptomics data from human cell-based assays. ALTEX doi:10.14573/altex.2107051 PMID:35288757
  • Kowalczewski A, Sakolish C, Hoang P, Liu X, Jacquir S, Rusyn I, Ma Z. 2022. Integrating nonlinear analysis and machine learning for human induced pluripotent stem cell-based drug cardiotoxicity testing. J Tissue Eng Regen Med doi:10.1002/term.3325 PMID:35621199
  • Roman-Hubers AT, Cordova AC, Rohde A, Chiu WA, McDonald TJ, Wright FA, Dodds J, Baker ES, Rusyn I. 2022. Characterization of compositional variability in petroleum substances. Fuel 317:doi:10.1016/j.fuel.2022.123547 PMID:35250041 PMCID:PMC8896784
  • Rusyn I, Chiu WA. 2022. Decision-Making with New Approach Methodologies: Time to Replace Default Uncertainty Factors with Data. Toxicol Sci doi:10.1093/toxsci/kfac033 PMID:35404442
  • Rusyn I, Chiu WA, Wright FA. 2022. Model systems and organisms for addressing inter- and intra-species variability in risk assessment. Regul Toxicol Pharmacol 132:105197. doi:10.1016/j.yrtph.2022.105197 PMID:35636685
  • Sakolish C, Georgescu A, Huh DD, Rusyn I. 2022. A model of human small airway on a chip for studies of subacute effects of inhalation toxicants. Toxicol Sci 187(2):267-278. doi:10.1093/toxsci/kfac036 PMID:35357501

2021

  • Alves VM, Auerbach SS, Kleinstreuer N, Rooney JP, Muratov EN, Rusyn I, Tropsha A, Schmitt CJ. 2021. Curated data in - trustworthy in silico models out: The impact of data quality on the reliability of artificial intelligence models as alternatives to animal testing. Altern Lab Anim 49(3):doi:10.1177/02611929211029635 PMID:34233495 (ahead of print)
  • Aly NA, Dodds J, Luo Y, Grimm FA, Foster MR, Rusyn I, Baker ES. 2021. Utilizing ion mobility spectrometry-mass spectrometry for the characterization and detection of persistent organic pollutants and their metabolites. Anal Bioanal Chem 414(3):doi:10.1007/s00216-021-03686-w PMID:34668045 (ahead of print)
  • Anklam E, Bahl MI, Ball R, Beger RD, Cohen J, Fitzpatrick S, Girard P, Halamoda-Kenzaoui B, Hinton D, Hirose A, Hoeveler A, Honma M, Hugas M, Ishida S, Kass GE, Kojima H, Krefting I, Liachenko S, Liu Y, Masters S, Marx U, McCarthy T, Mercer T, Patri A, Pelaez C, Pirmohamed M, Platz S, Ribeiro AJ, Rodricks JV, Rusyn I, Salek RM, Schoonjans R, Silva P, Svendsen CN, Sumner S, Sung K, Tagle DA, Tong L, Tong W, Van den Eijnden-van Raaij J, Vary N, Wang T, Waterton J, Wang M, Wen H, Wishart D, Yuan Y, Slikker W. 2021. Emerging technologies and their impact on regulatory science. Exp Biol Med (Maywood) 75:doi:10.1177/15353702211052280 PMID:34783606
  • Burnett SD, Blanchette A, Chiu WA, Rusyn I. 2021. Cardiotoxicity hazard and risk characterization of ToxCast chemicals using human induced pluripotent stem cell-derived cardiomyocytes from multiple donors. Chem Res Toxicol 34(9):2110-2124. doi:10.1021/acs.chemrestox.1c00203 PMID:34448577
  • Burnett SD, Blanchette A, Chiu WA, Rusyn I. 2021. Human induced pluripotent stem cell (iPSC)-derived cardiomyocytes as an in vitro model in toxicology: Strengths and weaknesses for hazard identification and risk characterization. Expert Opin Drug Metab Toxicol 17(8):1-16. doi:10.1080/17425255.2021.1894122 PMID:33612039 (ahead of print)
  • Burnett SD, Karmakar M, Murphy WJ, Chiu WA, Rusyn I. 2021. A new approach method for characterizing inter-species toxicodynamic variability. J Toxicol Environ Health A 84(24):doi:10.1080/15287394.2021.1966861 PMID:34427174 (ahead of print)
  • Chen Z, Jang S, Kaihatu JM, Zhou Y, Wright FA, Chiu WA, Rusyn I. 2021. Potential human health hazard of post-Hurricane Harvey sediments in Galveston Bay and Houston Ship Channel: A case study of using in vitro bioactivity data to inform risk management decisions. Int J Environ Res Public Health 18:doi:10.3390/ijerph182413378 PMID:34948986 PMCID:PMC8702027
  • Chen Z, Lloyd D, Zhou Y, Chiu WA, Wright FA, Rusyn I. 2021. Risk characterization of environmental samples using in vitro bioactivity and polycyclic aromatic hydrocarbon (PAH) concentrations data. Toxicol Sci 179(1):108-120. doi:10.1093/toxsci/kfaa166 PMID:33165562 PMCID:PMC7797768
  • Dalaijamts C, Cichocki JA, Luo Y, Rusyn I, Chiu WA. 2021. Quantitative characterization of population-wide tissue- and metabolite-specific variability in perchloroethylene toxicokinetics in male mice. Toxicol Sci 182(2):doi:10.1093/toxsci/kfab057 PMID:33988684 (ahead of print)
  • Erber L, Goodman S, Wright FA, Chiu WA, Tretyakova N, Rusyn I. 2021. Intra- and inter-species variability in urinary N7-(1-hydroxy-3-buten-2-yl)guanine adducts following inhalation exposure to 1,3-butadiene. Chem Res Toxicol 34(11):2375-2383. doi:10.1021/acs.chemrestox.1c00291 PMID:34726909 PMCID:PMC8715497
  • House JS, Grimm FA, Klaren WD, Dalzell A, Kuchi S, Zhang S, Lenz K, Boogaard PJ, Ketelslegers HB, Gant TW, Wright FA, Rusyn I. 2021. Grouping of UVCB substances with new approach methodologies (NAMs) data. ALTEX 38:123-137. doi:10.14573/altex.2006262 PMID:33086383 PMCID:PMC7900923
  • Hsieh N, Chen Z, Rusyn I, Chiu WA. 2021. Risk Characterization and Probabilistic Concentration Response Modeling of Complex Environmental Mixtures Using New Approach Methodologies (NAMs) Data from Organotypic in Vitro Human Stem Cell Assays. Environ Health Perspect 129:doi:10.1289/EHP7600 PMID:33395322 PMCID:PMC7781439
  • Jang S, McDonald TJ, Bhandari S, Rusyn I, Chiu WA. 2021. Spatial and temporal distribution of surface water contaminants in the Houston Ship Channel after the Intercontinental Terminal Company Fire. J Expo Sci Environ Epidemiol 31(5):doi:10.1038/s41370-021-00343-3 PMID:34079063 (ahead of print)
  • Kim S, Richardson L, Radnaa E, Chen Z, Rusyn I, Menon R, Han A. 2021. Molecular mechanisms of environmental toxin cadmium at the feto-maternal interface investigated using an organ-on-chip (FMi-OOC) model. J Hazard Mater 422:126759. doi:10.1016/j.jhazmat.2021.126759 PMID:34391970 (ahead of print)
  • Luo Y, Chen Z, Blanchette A, Zhou Y, Wright FA, Baker ES, Chiu WA, Rusyn I. 2021. Relationships between constituents of energy drinks and beating parameters in human induced pluripotent stem cell (iPSC)-derived cardiomyocytes. Food Chem Toxicol doi:10.1016/j.fct.2021.111979 PMID:33450301
  • Marvel S, House JS, Wheeler M, Song K, Zhou Y, Wright FA, Chiu WA, Rusyn I, Motsinger-Reif A, Reif DM. 2021. The COVID-19 Pandemic Vulnerability Index (PVI) dashboard: Monitoring county-level vulnerability using visualization, statistical modeling, and machine learning. Environ Health Perspect 129:17701. doi:10.1289/EHP8690 PMID:33400596 PMCID:PMC7785295
  • Roman-Hubers AT, Cordova AC, Aly NA, McDonald TJ, Lloyd D, Wright FA, Baker ES, Chiu WA, Rusyn I. 2021. Data processing workflow to identify structurally related compounds in petroleum substances using ion mobility spectrometry-mass spectrometry. Energy Fuels 35:10529-10539. doi:10.1021/acs.energyfuels.1c00892 PMID:34366560 PMCID:PMC8341389
  • Rusyn I, Arzuaga X, Cattley RC, Corton JC, Ferguson SS, Godoy P, Guyton KZ, Kaplowitz N, Khetani SR, Roberts RA, Roth RA, Smith MT. 2021. Key characteristics of human hepatotoxicants as a basis for identification and characterization of the causes of liver toxicity. Hepatology 74(6):doi:10.1002/hep.31999 PMID:34105804 (ahead of print)
  • Sakolish C, Luo Y, Chiu WA, Rusyn I, Reese CE, Valdiviezo A, Schurdak ME, Gough A, Taylor DL, Vernetti LA. 2021. Analysis of reproducibility and robustness of a human microfluidic four-cell liver acinus microphysiology system (LAMPS). Toxicology 448:doi:10.1016/j.tox.2020.152651 PMID:33307106 PMCID:PMC7785655
  • Sakolish C, Luo Y, Valdiviezo A, Vernetti LA, Rusyn I, Chiu WA. 2021. Prediction of hepatic drug clearance with a human microfluidic four-cell liver acinus microphysiology system. Toxicology 463:152954. doi:10.1016/j.tox.2021.152954 PMID:34543702 PMCID:PMC8585690
  • Valdiviezo A, Aly NA, Luo Y, Cordova AC, Casillas GA, Foster MR, Baker ES, Rusyn I. 2021. Analysis of per- and polyfluoroalkyl substances in Houston Ship Channel and Galveston Bay following a large-scale industrial fire using ion-mobility-spectrometry-mass spectrometry. J Environ Sci (China) 115:350-362. doi:10.1016/j.jes.2021.08.004 PMID:34969462 PMCID:PMC8724578
  • Valdiviezo A, Luo Y, Chen Z, Chiu WA, Rusyn I. 2021. Quantitative in vitro-to-in vivo extrapolation for mixtures: A case study of Superfund priority list pesticides. Toxicol Sci 183(1):doi:10.1093/toxsci/kfab076 PMID:34142158 (ahead of print)
  • Wang M, Chen Z, Rusyn I, Phillips TD. 2021. Testing the efficacy of broad-acting sorbents for environmental mixtures using isothermal analysis, mammalian cells, and H. vulgaris. J Hazard Mater 408:124425. doi:10.1016/j.jhazmat.2020.124425 PMID:33162237 PMCID:PMC7904642

2020

2019

  • Alves VM, Borba J, Capuzzi SJ, Muratov EN, Andrade CH, Rusyn I, Tropsha A. 2019. Oy vey! A comment on machine learning of toxicological big data enables read-across structure activity relationships outperforming animal test reproducibility. Toxicol Sci 167:3-4. doi:10.1093/toxsci/kfy286 PMID:30500930 PMCID:PMC6317419
  • Bera G, Camargo K, Sericano JL, Liu Y, Sweet S, Horney JA, Jun M, Chiu WA, Rusyn I, Wade TL, Knap A. 2019. Baseline data for distribution of contaminants by natural disasters: Results from a residential Houston neighborhood during Hurricane Harvey flooding. Heliyon 5:e02860. doi:10.1016/j.heliyon.2019.e02860 PMID:31763489 PMCID:PMC6861583
  • Blanchette A, Grimm FA, Dalaijamts C, Hsieh N, Ferguson K, Luo Y, Rusyn I, Chiu WA. 2019. Thorough QT/QTc in a dish: An In Vitro human model that accurately predicts clinical concentration-QTc relationships. Clin Pharmacol Ther 105:1175-1186. doi:10.1002/cpt.1259 PMID:30346629 PMCID:PMC6465173
  • Burnett SD, Blanchette A, Grimm FA, House JS, Reif DM, Wright FA, Chiu WA, Rusyn I. 2019. Population-based toxicity screening in human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol 381:114711. doi:10.1016/j.taap.2019.114711 PMID:31425687 PMCID:PMC6745256
  • Ferguson K, Luo Y, Rusyn I, Chiu WA. 2019. Comparative analysis of Rapid Equilibrium Dialysis (RED) and solid phase micro-extraction (SPME) methods for In Vitro-In Vivo extrapolation of environmental chemicals. Toxicol In Vitro 60:245-251. doi:10.1016/j.tiv.2019.06.006 PMID:31195086 PMCID:PMC6717004
  • Grimm FA, House JS, Wilson MR, Sirenko O, Iwata Y, Wright FA, Ball N, Rusyn I. 2019. Multi-dimensional in vitro bioactivity profiling for grouping of glycol ethers. Regul Toxicol Pharmacol 101:91-102. doi:10.1016/j.yrtph.2018.11.011 PMID:30471335 PMCID:PMC6333527
  • Luo Y, Cichocki JA, Hsieh N, Lewis L, Wright FA, Threadgill DW, Chiu WA, Rusyn I. 2019. Using Collaborative Cross mouse population to fill data gaps in risk assessment: A case study of population-based analysis of toxicokinetics and kidney toxicodynamics of tetrachloroethylene. Environ Health Perspect 127(6):67011. doi:10.1289/EHP5105 PMID:31246107 PMCID:PMC6792382
  • Onel M, Beykal B, Ferguson K, Chiu WA, McDonald TJ, Zhou L, House JS, Wright FA, Sheen D, Rusyn I, Pistikopoulos EN. 2019. Grouping of complex substances using analytical chemistry data: A framework for quantitative evaluation and visualization. PLoS One 14(10):e0223517. doi:10.1371/journal.pone.0223517 PMID:31600275 PMCID:PMC6786635
  • Perry A, Lynch RM, Rusyn I, Threadgill DW. 2019. Long-term combinatorial exposure to trichloroethylene and inorganic arsenic in genetically heterogeneous mice results in renal tubular damage and cancer-associated molecular changes. G3 (Bethesda) 9(5):1729-1737. doi:10.1534/g3.119.400161 PMID:30898898 PMCID:PMC6505147
  • Wang P, Wang Y, Langley SA, Zhou Y, Jen K, Sun Q, Brislawn C, Rojas CM, Wahl KL, Wang T, Fan X, Jansson J, Celniker SE, Zou X, Threadgill DW, Snijders AM, Mao J. 2019. Diverse tumour susceptibility in Collaborative Cross mice: Identification of a new mouse model for human gastric tumourigenesis. Gut doi:10.1136/gutjnl-2018-316691 PMID:30842212
  • Zheng X, Smith FB, Aly NA, Cai J, Patterson A, Baker ES. 2019. Evaluating the structural complexity of isomeric bile acids with ion mobility spectrometry. Anal Bioanal Chem 411:4673-4682. doi:10.1007/s00216-019-01869-0 PMID:31098744 PMCID:PMC6612315

2018

  • Chiu WA, Guyton KZ, Martin MT, Reif DM, Rusyn I. 2018. Use of high-throughput in vitro toxicity screening data in cancer hazard evaluations by IARC Monograph Working Groups. ALTEX 35(1):51-64. doi:10.14573/altex.1703231 PMID:28738424 PMCID:PMC5783793
  • Chiu WA, Rusyn I. 2018. Advancing chemical risk assessment decision-making with population variability data: challenges and opportunities. Mamm Genome 29(1-2):182-189. doi:10.1007/s00335-017-9731-6 PMID:29299621 PMCID:PMC5849521
  • Cuomo D, Porreca I, Ceccarelli M, Threadgill DW, Barrington WT, Petriella A, D'Angelo F, Cobellis G, De Stefano F, D' Agostino MN, De Felice M, Mallardo M, Ambrosino C. 2018. Transcriptional landscape of mouse-aged ovaries reveals a unique set of non-coding RNAs associated with physiological and environmental ovarian dysfunctions. Cell Death Discov doi:10.1038/s41420-018-0121-y PMID:30534420
  • Dalaijamts C, Cichocki JA, Luo Y, Rusyn I, Chiu WA. 2018. Incorporation of the glutathione conjugation pathway in an updated physiologically-based pharmacokinetic model for perchloroethylene in mice. Toxicol Appl Pharmacol 352:142-152. doi:10.1016/j.taap.2018.05.033 PMID:29857080 PMCID:PMC6051410
  • Garbutt TA, Konneker TI, Konganti K, Hillhouse AE, Swift-Haire F, Jones A, Phelps D, Aylor DL, Threadgill DW. 2018. Permissiveness to form pluripotent stem cells may be an evolutionarily derived characteristic in Mus musculus. Sci Rep 8(1):14706. doi:10.1038/s41598-018-32116-8 PMID:30279419 PMCID:PMC6168588
  • Grimm FA, Blanchette A, House JS, Ferguson K, Hsieh N, Dalaijamts C, Wright AA, Anson B, Wright FA, Chiu WA, Rusyn I. 2018. A human population-based organotypic in vitro model for cardiotoxicity screening. ALTEX 35:441-452. doi:10.14573/altex.1805301 PMID:29999168 PMCID:PMC6231908
  • Guyton KZ, Rieswijk L, Wang A, Chiu WA, Smith MT. 2018. Key characteristics approach to carcinogenic hazard identification. Chem Res Toxicol 31(12):1290-1292. doi:10.1021/acs.chemrestox.8b00321 PMID:30521319 PMCID:PMC6424613
  • Guyton KZ, Rusyn I, Chiu WA, Corpet DE, van den Berg M, Ross MK, Christiani DC, Beland FA, Smith MT. 2018. Application of the key characteristics of carcinogens in cancer hazard identification. Carcinogenesis 39(4):614-622. doi:10.1093/carcin/bgy031 PMID:29562322 PMCID:PMC5888955
  • Guyton KZ, Rusyn I, Chiu WA, Corpet DE, van den Berg M, Ross MK, Christiani DC, Beland FA, Smith MT. 2018. Re: Application of the key characteristics of carcinogens in cancer hazard evaluation : response to Goodman, Lynch and Rhomberg. Carcinogenesis 39(8):1091-1093. doi:10.1093/carcin/bgy082 PMID:29982359 PMCID:PMC6067125
  • Klaren WD, Rusyn I. 2018. High-content assay multiplexing for muscle toxicity screening in human-induced pluripotent stem cell-derived skeletal myoblasts. Assay Drug Dev Technol 16(6):333-342. doi:10.1089/adt.2018.860 PMID:30070899 PMCID:PMC6114077
  • Li G, Shabalin AA, Rusyn I, Wright FA, Nobel AB. 2018. An empirical Bayes approach for multiple tissue eQTL analysis. Biostatistics 19(3):391-406. doi:10.1093/biostatistics/kxx048 PMID:29029013 PMCID:PMC6366007
  • Low Y, Alves VM, Fourches D, Sedykh A, Andrade CH, Muratov EN, Rusyn I, Tropsha A. 2018. Chemistry-wide association studies (CWAS): a novel framework for identifying and interpreting structure-activity relationships. J Chem Inf Model 58(11):2203-2213. doi:10.1021/acs.jcim.8b00450 PMID:30376324
  • Marvel S, To K, Grimm FA, Wright FA, Rusyn I, Reif DM. 2018. ToxPi Graphical User Interface 2.0: dynamic exploration, visualization, and sharing of integrated data models. BMC Bioinformatics 19(1):80. doi:10.1186/s12859-018-2089-2 PMID:29506467 PMCID:PMC5838926
  • Rusyn I, Greene N. 2018. The impact of novel assessment methodologies in toxicology on green chemistry and chemical alternatives. Toxicol Sci 161:276-284. doi:10.1093/toxsci/kfx196 PMID:29378069
  • Rusyn I, Kleeberger SR, McAllister KA, French JE, Svenson KL. 2018. Introduction to mammalian genome special issue: the combined role of genetics and environment relevant to human disease outcomes. Mamm Genome 29(1-2):1-4. doi:10.1007/s00335-018-9740-0 PMID:29460122 PMCID:PMC5849569
  • Shapiro AJ, Antoni S, Guyton KZ, Lunn RM, Loomis D, Rusyn I, Jahnke GD, Schwingl PJ, Mehta SS, Addington J, Guha N. 2018. Software Tools to Facilitate Systematic Review Used for Cancer Hazard Identification. Environ Health Perspect 126:104501. doi:10.1289/EHP4224 PMID:30392397 PMCID:PMC6371692
  • Venkatratnam A, House JS, Konganti K, McKenney C, Threadgill DW, Chiu WA, Aylor DL, Wright FA, Rusyn I. 2018. Population-based dose-response analysis of liver transcriptional response to trichloroethylene in mouse. Mamm Genome 29:168-181. doi:10.1007/s00335-018-9734-y PMID:29353386 PMCID:PMC6094947
  • Wignall JA, Muratov EN, Sedykh A, Guyton KZ, Tropsha A, Rusyn I, Chiu WA. 2018. Conditional toxicity value (CTV) predictor: an in silico approach for generating quantitative risk estimates for chemicals. Environ Health Perspect 126(5):057008. doi:10.1289/EHP2998 PMID:29847084 PMCID:PMC6071978

2017

  • Cichocki JA, Furuya S, Venkatratnam A, McDonald TJ, Knap A, Wade TL, Sweet S, Chiu WA, Threadgill DW, Rusyn I. 2017. Characterization of variability in toxicokinetics and toxicodynamics of tetrachloroethylene using the collaborative cross mouse population. Environ Health Perspect 125(5):057006. doi:10.1289/ehp788 PMID:28572074 PMCID:PMC5726344
  • Grimm FA, Russell WK, Luo Y, Iwata Y, Chiu WA, Roy T, Boogaard PJ, Ketelslegers HB, Rusyn I. 2017. Grouping of petroleum substances as example UVCBs by ion mobility-mass spectrometry to enable chemical composition-based read-across. Environ Sci Technol 51:7197-7207. doi:10.1021/acs.est.6b06413 PMID:28502166 PMCID:PMC5627358
  • House JS, Grimm FA, Jima DD, Zhou Y, Rusyn I, Wright FA. 2017. A pipeline for high-throughput concentration response modeling of gene expression for toxicogenomics. Front Genet 8:168. doi:10.3389/fgene.2017.00168 PMID:29163636 PMCID:PMC5672545
  • Iwata Y, Klaren WD, Lebakken CS, Grimm FA, Rusyn I. 2017. High-content assay multiplexing for vascular toxicity screening in induced pluripotent stem cell-derived endothelial cells and human umbilical vein endothelial cells. Assay Drug Dev Technol 15(6):267-279. doi:10.1089/adt.2017.786 PMID:28771372 PMCID:PMC5576216
  • Sirenko O, Grimm FA, Ryan KR, Iwata Y, Chiu WA, Parham F, Wignall JA, Anson B, Cromwell EF, Behl M, Rusyn I, Tice RR. 2017. In vitro cardiotoxicity assessment of environmental chemicals using an organotypic human induced pluripotent stem cell-derived model. Toxicol Appl Pharmacol 322:60-74. doi:10.1016/j.taap.2017.02.020 PMID:28259702 PMCID:PMC5734940
  • Venkatratnam A, Furuya S, Kosyk O, Gold A, Bodnar WM, Konganti K, Threadgill DW, Gillespie DA, Aylor DL, Wright FA, Chiu WA, Rusyn I. 2017. Editor's Highlight: Collaborative Cross mouse population enables refinements to characterization of the variability in toxicokinetics of trichloroethylene and provides genetic evidence for the role of PPAR pathway in its oxidative metabolism. Toxicol Sci 158(1):48-62. doi:10.1093/toxsci/kfx065 PMID:28369613
  • Zhou Y, Cichocki JA, Soldatow VY, Scholl EH, Gallins P, Jima DD, Yoo HS, Chiu WA, Wright FA, Rusyn I. 2017. Editor's highlight: comparative dose-response analysis of liver and kidney transcriptomic effects of trichloroethylene and tetrachloroethylene in B6C3F1 mouse. Toxicol Sci 160(1):95-110. doi:10.1093/toxsci/kfx165 PMID:28973375 PMCID:PMC5837274
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