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Your Environment. Your Health.

Research Briefs: Texas A&M University

Superfund Research Program

Inter-Tissue and -Individual Variability in Response to Mixtures

Project Leader: Ivan Rusyn
Co-Investigator: David W. Threadgill
Grant Number: P42ES027704
Funding Period: 2017-2022
View this project in the NIH Research Portfolio Online Reporting Tools (RePORT)

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Research Briefs

  • 298 - Collaborative Cross Mice Can Fill Data Gaps in Risk Assessment -- Rusyn
    Release Date: 10/02/2019

    NIEHS Superfund Research Program (SRP) grantees showed how the Collaborative Cross (CC) mouse model, which uses genetically diverse mice to capture over 90% of known mouse genetic variations, can account for individual differences in susceptibility to environmental chemicals. Led by Ivan Rusyn, M.D., Ph.D., director of the Texas A&M University SRP Center, researchers measured variability in kidney toxicity and metabolism in CC mice after exposing them to tetrachloroethylene (PERC).

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