Superfund Research Program
Inter-Tissue and -Individual Variability in Response to Mixtures
- Project Summary
- 298 - Collaborative Cross Mice Can Fill Data Gaps in Risk Assessment -- Rusyn
Release Date: 10/02/2019
NIEHS Superfund Research Program (SRP) grantees showed how the Collaborative Cross (CC) mouse model, which uses genetically diverse mice to capture over 90% of known mouse genetic variations, can account for individual differences in susceptibility to environmental chemicals. Led by Ivan Rusyn, M.D., Ph.D., director of the Texas A&M University SRP Center, researchers measured variability in kidney toxicity and metabolism in CC mice after exposing them to tetrachloroethylene (PERC).