Superfund Research Program
Role of Cytochrome P450 (CYP)1A/1B1 Enzymes in the Potentiation of Neonatal Lung Injury in Newborn Mice Exposed Prenatally to PAHs and Increased Risk of Premature Infants to Chronic Lung Disease
Project Leader: Bhagavatula Moorthy
Co-Investigators: Xanthi I. Couroucli, Joseph Hagan, Krithika Lingappan (University of Pennsylvania)
Grant Number: P42ES027725
Funding Period: 2020-2025
Project-Specific Links
- Project Summary
Publications
2024
- Stading R, Swanson L, Xia G, Jiang W, Wang L, Couroucli XI, Lingappan K, Moorthy B. 2024. Prenatal exposure to polycyclic aromatic hydrocarbons (PAHs) augments neonatal hyperoxic lung injury: Role of cytochrome P450 (CYP)1A1, 1A2, and 1B1. Free Radic Biol Med 211:35-46. doi:10.1016/j.freeradbiomed.2023.12.001 PMID:38081439
2023
- Denison SB, Jin P, Dias Da Silva P, Chu C, Moorthy B, Senftle TP, Zygourakis K, Alvarez PJ. 2023. Pyro-catalytic degradation of pyrene by bentonite-supported transition metals: Mechanistic insights and trade-offs with low pyrolysis temperature. Environ Sci Technol 57(38):14373-14383. doi:10.1021/acs.est.3c04487 PMID:37683087
- Grimm SL, Reddick S, Dong X, Leek C, Wang AX, Gutierrez MC, Hartig SM, Moorthy B, Coarfa C, Lingappan K. 2023. Loss of microRNA-30a and sex-specific effects on the neonatal hyperoxic lung injury. Biol Sex Differ 14(1):50. doi:10.1186/s13293-023-00535-6 PMID:37553579 PMCID:PMC10408139
- Suh J, Heo MJ, Lee SH, Poulsen KL, An YA, Moorthy B, Hartig SM, Moore DD, Kim K. 2023. Aryl hydrocarbon receptor maintains hepatic mitochondrial homeostasis in mice. Mol Metab 72:101717. doi:10.1016/j.molmet.2023.101717 PMID:37004989 PMCID:PMC1010651
2022
- Almudares F, Hagan J, Chen X, Devaraj S, Moorthy B, Lingappan K. 2022. Growth and differentiation factor 15 (GDF15) levels predict adverse respiratory outcomes in premature neonates. Pediatr Pulmonol doi:10.1002/ppul.26197 PMID:36205439
- Ghosh S, Moorthy B, Haribabu B, Jala VR. 2022. Cytochrome P450 1A1 is essential for the microbial metabolite, Urolithin A-mediated protection against colitis. Front Immunol 13:doi:10.3389/fimmu.2022.1004603 PMID:36159798 PMCID:PMC9493474
2021
- Burke R, Chu C, Zhou G, Putluri V, Putluri N, Stading R, Couroucli XI, Lingappan K, Moorthy B. 2021. Role of human NADPH quinone oxidoreductase (NQO1) in oxygen-mediated cellular injury and oxidative DNA damage in human pulmonary cells. Oxid Med Cell Longev 2021:5544600. doi:10.1155/2021/5544600 PMID:34691356 PMCID:PMC8536466
- Grimm SL, Dong X, Zhang Y, Carisey AF, Arnold AP, Moorthy B, Coarfa C, Lingappan K. 2021. Effect of sex chromosomes versus hormones in neonatal lung injury. JCI Insight 6(13):e146863. doi:10.1172/jci.insight.146863 PMID:34061778 PMCID:PMC8410054
- Stading R, Gastelum G, Chu C, Jiang W, Moorthy B. 2021. Molecular mechanisms of pulmonary carcinogenesis by polycyclic aromatic hydrocarbons (PAHs): Implications for human lung cancer. Semin Cancer Biol 76:3-16. doi:10.1016/j.semcancer.2021.07.001 PMID:34242741
2020
- Callaway DA, Jiang W, Wang L, Lingappan K, Moorthy B. 2020. Oxygen-mediated lung injury in mice lacking the gene for NRF2: Rescue with the cytochrome P4501A-inducer, beta-naphthoflavone (BNF), and differential sex-specific effects. Free Radic Biol Med 160:208-218. doi:10.1016/j.freeradbiomed.2020.07.027 PMID:32791187 PMCID:PMC7704914
- Coarfa C, Grimm SL, Katz T, Zhang Y, Jangid RK, Walker C, Moorthy B, Lingappan K. 2020. Epigenetic response to hyperoxia in the neonatal lung is sexually dimorphic. Redox Biol 37:101718. doi:10.1016/j.redox.2020.101718 PMID:32961439 PMCID:PMC7509469
- Flores-Villanueva P, Sobhani N, Wang X, Li Y. 2020. MR1-restricted T Cells in cancer immunotherapy. Cancers (Basel) 12:doi:10.3390/cancers12082145 PMID:32756356
- Gastelum G, Jiang W, Wang L, Zhou G, Borkar R, Putluri N, Moorthy B. 2020. Polycyclic aromatic hydrocarbon-induced pulmonary carcinogenesis in cytochrome P450 (CYP)1A1-and 1A2-null mice: roles of CYP1A1 and CYP1A2. Toxicol Sci 177:347-361. doi:10.1093/toxsci/kfaa107 PMID:32726451
- Liu M, Wang X, Li W, Yu X, Flores-Villanueva P, Xu-Monette ZY, Li L, Zhang M, Young KH, Ma X, Li Y. 2020. Targeting PD-L1 in non-small cell lung cancer using CAR T cells. Oncogenesis 9:72. doi:10.1038/s41389-020-00257-z PMID:32792499 PMCID:PMC7426958
- Stading R, Chu C, Couroucli XI, Lingappan K, Moorthy B. 2020. Molecular role of cytochrome P4501A enzymes in oxidative stress. Curr Opin Toxicol 20-21:77-84. doi:10.1016/j.cotox.2020.07.001 PMID:33283080 PMCID:PMC7709944
- Stading R, Couroucli XI, Lingappan K, Moorthy B. 2020. The role of cytochrome P450 (CYP) enzymes in hyperoxic lung injury. Expert Opin Drug Metab Toxicol 8:doi:10.1080/17425255.2021.1853705 PMID:33215946
- Tao G, Huang J, Moorthy B, Wang C, Hu M, Gao S, Ghose R. 2020. Potential role of drug metabolizing enzymes in chemotherapy-induced gastrointestinal toxicity and hepatotoxicity. Expert Opin Drug Metab Toxicol 16:doi:10.1080/17425255.2020.1815705 PMID:32841068
2019
- Hassanin AA, Tavera-Garcia MA, Moorthy B, Zhou GD, Ramos KS. 2019. Lung genotoxicity of benzo(a)pyrene in vivo involves reactivation of LINE-1 retrotransposon and early reprogramming of oncogenic regulatory networks. Am J Physiol Lung Cell Mol Physiol 317:L816-L822. doi:10.1152/ajplung.00304.2019 PMID:31596105 PMCID:PMC6962597 (accepted for publication)