Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

National Institute of Environmental Health Sciences

Use this QR code to view the newest version of this document
Use this QR code to view the newest version of this document

Your Environment. Your Health.

Project Publications: University of North Carolina-Chapel Hill: Arsenic-Obesity-Diabetes Interactions

Superfund Research Program

Arsenic-Obesity-Diabetes Interactions

Project Leader: Fernando Pardo-Manuel de Villena
Co-Investigators: Miroslav Styblo, Rebecca C. Fry, Fei Zou
Grant Number: P42ES031007
Funding Period: 2020-2025
View this project in the NIH Research Portfolio Online Reporting Tools (RePORT)

Project-Specific Links

Connect with the Grant Recipients

Visit the grantee's eNewsletter page Visit the grantee's eNewsletter page Visit the grantee's Twitter page

Publications

2022

  • Clark J, Bommarito P, Styblo M, Rubio-Andrade M, Garcia-Vargas GG, Gamble MV, Fry RC. 2022. Maternal serum concentrations of one-carbon metabolism factors modify the association between biomarkers of arsenic methylation efficiency and birth weight. Environmental Health 21(1):68. doi:10.1186/s12940-022-00875-7 PMID:35836250 PMCID:PMC9281096
  • Gaines CH, Schoenrock SA, Farrington J, Lee DF, Aponte-Collazo LJ, Shaw GD, Miller DR, Ferris MT, Pardo-Manuel de Villena F, Tarantino LM. 2022. Cocaine-induced locomotor activation differs across inbred mouse substrains. Front Psychiatry 13:800245. doi:10.3389/fpsyt.2022.800245 PMID:35599758 PMCID:PMC9120424
  • Gu B, Levine NG, Xu W, Lynch RM, Pardo-Manuel de Villena F, Philpot BD. 2022. Ictal neural oscillatory alterations precede sudden unexpected death in epilepsy. Brain Commun 4(2):doi:10.1093/braincomms/fcac073 PMID:35474855 PMCID:PMC9035525
  • Mersaoui SY, Guilbert C, Chou H, Douillet C, Bohle DS, Styblo M, Richard S, Mann KK. 2022. Arsenic 3 methyltransferase (AS3MT) automethylates on cysteine residues in vitro. Arch Toxicol 96(5):1371-1386. doi:10.1007/s00204-022-03248-8 PMID:35244730 PMCID:PMC9013690
  • Morgan AP, Hughes JJ, Didion JP, Jolley WJ, Campbell KJ, Threadgill DW, Banhomme F, Searle JB, Pardo-Manuel de Villena F. 2022. Population structure and inbreeding in wild house mice (Mus musculus) at different geographic scales. Heredity (Edinb) 129(3):183-194. doi:10.1038/s41437-022-00551-z PMID:35764696 PMCID:PMC9411160
  • Schafer A, Leist SR, Gralinski L, Martinez DR, Winkler ES, Okuda K, Hawkins PE, Gully KL, Graham RL, Scobey DT, Bell TA, Hock P, Shaw GD, Loome JF, Madden EA, Anderson E, Baxter VK, Taft-Benz SA, Zweigart MR, May SR, Dong S, Clark M, Miller DR, Lynch RM, Heise MT, Tisch R, Bouchard RC, Pardo-Manuel de Villena F, Montgomery SA, Diamond MS, Ferris MT, Baric RS. 2022. A multitrait locus regulates sarbecovirus pathogenesis. MBio 13(4):e0145422. doi:10.1128/mbio.01454-22 PMID:35862771 PMCID:PMC9426612
  • Searle JB, Pardo-Manuel de Villena F. 2022. The evolutionary significance of meiotic drive. Heredity (Edinb) 129(1):44-47. doi:10.1038/s41437-022-00534-0 PMID:35468941 PMCID:PMC9273639
  • Shang B, Venkatratnam A, Hartwell HJ, Douillet C, Cable P, Liu T, Zou F, Ideraabdullah FY, Fry RC, Styblo M. 2022. Ex vivo exposures to arsenite and its methylated trivalent metabolites alter gene transcription in mouse sperm cells. Toxicol Appl Pharmacol 455:116266. doi:10.1016/j.taap.2022.116266 PMID:36209798
  • Smith CM, Baker RE, Proulx MK, Mishra BB, Park SW, Lee H, Kiritsy MC, Bellerose MM, Olive AJ, Murphy KC, Papavinasasundaram K, Boehm FJ, Reames CJ, Meade RK, Hampton BK, Linnertz C, Shaw GD, Hock P, Bell TA, Ehrt S, Schnappinger D, Pardo-Manuel de Villena F, Ferris MT, Loerger TR, Sassetti CM. 2022. Host-pathogen genetic interactions underlie tuberculosis susceptibility in genetically diverse mice. Elife 11:doi:10.7554/eLife.74419 PMID:35112666 PMCID:PMC8846590
  • Todero JE, Koch-Laskowski K, Shi Q, Kanke M, Hung Y, Beck R, Styblo M, Sethupathy P. 2022. Candidate master microRNA regulator of arsenic-induced pancreatic beta cell impairment revealed by multi-omics analysis. Arch Toxicol 96(6):1685-1699. doi:10.1007/s00204-022-03263-9 PMID:35314868 PMCID:PMC9095563
  • Xenakis JG, Douillet C, Bell TA, Hock P, Farrington J, Liu T, Murphy C, Saraswatula A, Shaw GD, Nativio G, Shi Q, Venkatratnam A, Zou F, Fry RC, Styblo M, Pardo-Manuel de Villena F. 2022. An interaction of inorganic arsenic exposure with body weight and composition on type 2 diabetes indicators in Diversity Outbred mice. Mamm Genome doi:10.1007/s00335-022-09957-w PMID:35819478
  • Yam P, VerHague M, Albright J, Gertz E, Pardo-Manuel de Villena F, Bennett BJ. 2022. Altered macronutrient composition and genetics influence the complex transcriptional network associated with adiposity in the Collaborative Cross. Genes Nutr 17(1):13. doi:10.1186/s12263-022-00714-x PMID:35945490 PMCID:PMC9364539
  • Zhabotynsky V, Huang L, Little P, Hu Y, Pardo-Manuel de Villena F, Zou F, Sun W. 2022. eQTL mapping using allele-specific count data is computationally feasible, powerful, and provides individual-specific estimates of genetic effects. PLoS Genet 18:doi:10.1371/journal.pgen.1010076 PMID:35286297 PMCID:PMC8947591

2021

  • Clark J, Avula V, Ring C, Eaves LA, Howard T, Santos HP, Smeester L, Bangma J, O'Shea TM, Fry RC, Rager JE. 2021. Comparing the predictivity of human placental gene, microRNA, and CpG methylation signatures in relation to perinatal outcomes. Toxicol Sci 183(2):269-284. doi:10.1093/toxsci/kfab089 PMID:34255065 PMCID:PMC8478332
  • Douillet C, Ji J, Meenakshi IL, Lu K, Pardo-Manuel de Villena F, Fry RC, Styblo M. 2021. Diverse genetic backgrounds play a prominent role in the metabolic phenotype of CC021/Unc and CC027/GeniUNC mice exposed to inorganic arsenic. Toxicology 452:152696. doi:10.1016/j.tox.2021.152696 PMID:33524430 PMCID:PMC7914223
  • Ghiuzeli CM, Styblo M, Saunders RJ, Calabro A, Budman D, Allen S, Devoe C, Dhingra R. 2021. The pharmacokinetics of therapeutic arsenic trioxide in acute promyelocytic leukemia patients. Leuk Lymphoma 63:653-663. doi:10.1080/10428194.2021.1978084 PMID:34689693 PMCID:PMC8891048
  • Graham JB, Swarts JL, Edwards KR, Voss KM, Green R, Jeng S, Miller DR, Mooney MA, McWeeney SK, Ferris MT, Pardo-Manuel de Villena F, Gale M, Lund JM. 2021. Correlation of regulatory T cell numbers with disease tolerance upon virus infection. Immunohorizons 5(4):157-169. doi:10.4049/immunohorizons.2100009 PMID:33893179 PMCID:PMC8281504
  • Graham JB, Swarts JL, Leist SR, Schafer A, Menachery VD, Gralinski L, Jeng S, Miller DR, Mooney MA, McWeeney SK, Ferris MT, Pardo-Manuel de Villena F, Heise MT, Baric RS, Lund JM. 2021. Baseline T cell immune phenotypes predict virologic and disease control upon SARS-CoV infection in Collaborative Cross mice. PLoS Pathog 17(1):e1009287. doi:10.1371/journal.ppat.1009287 PMID:33513210 PMCID:PMC7875398
  • Keele GR, Zhang T, Pham DT, Vincenti MP, Bell TA, Hock P, Shaw GD, Paulo JA, Munger SC, Pardo-Manuel de Villena F, Ferris MT, Gygi SP, Churchill GA. 2021. Regulation of protein abundance in genetically diverse mouse populations. Cell Genom 1(1):100003. doi:10.1016/j.xgen.2021.100003 PMID:36212994 PMCID:PMC9536773
  • Ryan NM, Hess JA, Pardo-Manuel de Villena F, Leiby BE, Shimada A, Yu L, Yarmahmoodi A, Petrovsky N, Zhan B, Bottazzi ME, Makepeace BL, Lustigman S, Abraham D. 2021. Onchocerca volvulus bivalent subunit vaccine induces protective immunity in genetically diverse collaborative cross recombinant inbred intercross mice. NPJ Vaccines 6(1):17. doi:10.1038/s41541-020-00276-2 PMID:33500417 PMCID:PMC7838260
  • Styblo M, Venkatratnam A, Fry RC, Thomas DJ. 2021. Origins, fate, and actions of methylated trivalent metabolites of inorganic arsenic: progress and prospects. Arch Toxicol 95(5):doi:10.1007/s00204-021-03028-w PMID:33768354 (ahead of print)
  • Sun KY, Oreper D, Schoenrock SA, McMullan R, Giusti-Rodriguez P, Zhabotynsky V, Miller DR, Tarantino LM, Pardo-Manuel de Villena F, Valdar W. 2021. Bayesian modeling of skewed X inactivation in genetically diverse mice identifies a novel Xce allele associated with copy number changes. Genetics 218(1):iyab034. doi:10.1093/genetics/iyab034 PMID:33693696 PMCID:PMC8128399

2020

  • Giusti-Rodriguez P, Xenakis JG, Crowley JJ, Nonneman RJ, DeCristo DM, Rogala AR, Quackenbush CR, Miller DR, Shaw GD, Zhabotynsky V, Sullivan PF, Pardo-Manuel de Villena F, Zou F. 2020. Antipsychotic behavioral phenotypes in the mouse Collaborative Cross recombinant inbred inter-crosses (RIX). G3 10:doi:10.1534/g3.120.400975 PMID:32694196 (accepted for publication)
  • Graham JB, Swarts JL, Leist SR, Schafer A, Menachery VD, Gralinski L, Jeng S, Miller DR, Mooney MA, McWeeney SK, Ferris MT, Pardo-Manuel de Villena F, Heise MT, Baric RS, Lund JM. 2020. Baseline T cell immune phenotypes predict virologic and disease control upon SARS-CoV infection. bioRxivorg doi:10.1101/2020.09.21.306837 PMID:32995791 PMCID:PMC7523117 (ahead of print)
  • Gu B, Shorter JR, Williams L, Bell TA, Hock P, Dalton KA, Pan Y, Miller DR, Shaw GD, Philpot BD, Pardo-Manuel de Villena F. 2020. Collaborative Cross mice reveal extreme epilepsy phenotypes and genetic loci for seizure susceptibility. Epilepsia 9:2010-2021. doi:10.1111/epi.16617 PMID:32852103
  • Hillis DA, Yadgary L, Weinstock GM, Pardo-Manuel de Villena F, Pomp D, Fowler AS, Xu S, Chan F, Garland T. 2020. Genetic Basis of Aerobically Supported Voluntary Exercise: Results from a Selection Experiment with House Mice. Genetics 216:781-804. doi:10.1534/genetics.120.303668
  • Huda M, VerHague M, Albright J, Smallwood T, Bell TA, Que E, Miller DR, Roshanravan B, Allayee H, Pardo-Manuel de Villena F, Bennett BJ. 2020. Dissecting the Genetic Architecture of Cystatin C in Diversity Outbred Mice. G3 7:2529-2541. doi:10.1534/g3.120.401275 PMID:32467129
  • Koller BH, Snouwaert JN, Douillet C, Jania LA, El-Masri HA, Thomas DJ, Styblo M. 2020. Arsenic metabolism in mice carrying a BORCS7/AS3MT locus humanized by syntenic replacement. Environ Health Perspect 128(8):87003. doi:10.1289/EHP6943 PMID:32779937 PMCID:PMC7418654
  • Payton A, Clark J, Eaves LA, Santos H, Smeester L, Bangma J, O'Shea TM, Fry RC, Rager JE. 2020. Placental genomic and epigenomic signatures associated with infant birth weight highlight mechanisms involved in collagen and growth factor signaling. Reprod Toxicol 96:221-230. doi:10.1016/j.reprotox.2020.07.007 PMID:32721520 PMCID:PMC7855285
  • Sigmon JS, Blanchard MW, Baric RS, Bell TA, Brennan J, Brockmann GA, Burks AW, Calabrese JM, Caron KM, Cheney RE, Ciavatta D, Conlon F, Darr DB, Faber J, Franklin C, Gershon TR, Gralinski L, Gu B, Gaines CH, Hagan RS, Heimsath EG, Heise MT, Hock P, Ideraabdullah FY, Jennette JC, Kafri T, Kashfeen A, Kulis M, Kumar V, Linnertz C, Livraghi-Butrico A, Lloyd KK, Lutz C, Lynch RM, Magnuson T, Matsushima GK, McMullan R, Miller DR, Mohlke KL, Moy SS, Murphy C, Najarian M, O'Brien L, Palmer AA, Philpot BD, Randell SH, Reinholdt L, Ren Y, Rockwood S, Rogala AR, Saraawatula A, Sassetti CM, Schisler JC, Schoenrock SA, Shaw GD, Shorter JR, Smith CM, St Pierre CL, Tarantino LM, Threadgill DW, Valdar W, Vilen BJ, Wardwell K, Whitmire JL, Williams L, Zylka MJ, Ferris MT, McMillan L, Pardo-Manuel de Villena F. 2020. Content and performance of the MiniMUGA genotyping array, a new tool to improve rigor and reproducibility in mouse research. Genetics 216:905-930. doi:10.1534/genetics.120.303596 PMID:33067325 PMCID:PMC7768238
  • Venkatratnam A, Douillet C, Topping BC, Shi Q, Addo KA, Ideraabdullah FY, Fry RC, Styblo M. 2020. Sex-dependent effects of preconception exposure to arsenite on gene transcription in parental germ cells and on transcriptomic profiles and diabetic phenotype of offspring. Arch Toxicol doi:10.1007/s00204-020-02941-w PMID:33145626
  • Yu W, Hill SF, Xenakis JG, Pardo-Manuel de Villena F, Wagnon JL, Meisler MH. 2020. Gabra2 is a genetic modifier of Scn8a encephalopathy in the mouse. Epilepsia 12:2847-2856. doi:10.1111/epi.16741 PMID:33140451 PMCID:PMC7756374
Back
to Top