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| Publication Title | Authors | Grant Number(s) | Journal (Pub date) | PubMed Link | Pub Year |
|---|---|---|---|---|---|
| Direct Methane Oxidation by Copper- and Iron-Dependent Methane Monooxygenases. | Tucci, Frank J; Rosenzweig, Amy C | F31ES034283 | Chem Rev (2024 Feb 14) |
38305159
|
2024 |
| Examining Heterodimerization by Aryl C-N Coupling in Dynemicin Biosynthesis. | Pal, Paramita; Alley, Jamie R; Townsend, Craig A | R01ES001670, R01ES001670 | ACS Chem Biol (2023 Feb 17) |
36696117
|
2023 |
| Normal and Aberrant Methyltransferase Activities Give Insights into the Final Steps of Dynemicin A B ... | Pal, Paramita; Wessely, Serena M L; Townsend, Craig A | R01ES001670, R01ES001670 | J Am Chem Soc (2023 Jun 14) |
37276497
|
2023 |
| Product analog binding identifies the copper active site of particulate methane monooxygenase. | Tucci, Frank J; Jodts, Richard J; Hoffman, Brian M; Rosenzweig, Amy C | F31ES034283 | Nat Catal (2023 Dec) |
38187819
|
2023 |
| C-N-Coupled Metabolites Yield Insights into Dynemicin A Biosynthesis. | Cohen, Douglas R; Townsend, Craig A | R01ES001670, R01ES001670 | Chembiochem (2020 08 03) |
32198800
|
2020 |
| A dual role for a polyketide synthase in dynemicin enediyne and anthraquinone biosynthesis. | Cohen, Douglas R; Townsend, Craig A | R01ES001670, R01ES001670 | Nat Chem (2018 Feb) |
29359752
|
2018 |
| Characterization of an Anthracene Intermediate in Dynemicin Biosynthesis. | Cohen, Douglas R; Townsend, Craig A | R01ES001670, R01ES001670 | Angew Chem Int Ed Engl (2018 May 14) |
29512267
|
2018 |
| Chromobacterium spp. mediate their anti-Plasmodium activity through secretion of the histone deacety ... | Saraiva, Raúl G; Huitt-Roehl, Callie R; Tripathi, Abhai; Cheng, Yi-Qiang; Bosch, Jürgen; Townse ... | R01ES001670, R01ES001670 | Sci Rep (2018 Apr 18) |
29670144
|
2018 |
| Exploring Fungal Polyketide C-Methylation through Combinatorial Domain Swaps. | Storm, Philip A; Pal, Paramita; Huitt-Roehl, Callie R; Townsend, Craig A | R01ES001670, R01ES001670 | ACS Chem Biol (2018 11 16) |
30350943
|
2018 |
| Gene cluster conservation provides insight into cercosporin biosynthesis and extends production to t ... | de Jonge, Ronnie; Ebert, Malaika K; Huitt-Roehl, Callie R; Pal, Paramita; Suttle, Jeffrey C; Sp ... | R01ES001670, R01ES001670 | Proc Natl Acad Sci U S A (2018 06 12) |
29844193
|
2018 |
| The architectures of iterative type I PKS and FAS. | Herbst, Dominik A; Townsend, Craig A; Maier, Timm | R01ES001670, R01ES001670 | Nat Prod Rep (2018 Oct 17) |
30137093
|
2018 |
| The structural organization of substrate loading in iterative polyketide synthases. | Herbst, Dominik A; Huitt-Roehl, Callie R; Jakob, Roman P; Kravetz, Jacob M; Storm, Philip A; Al ... | R01ES001670, R01ES001670 | Nat Chem Biol (2018 05) |
29610486
|
2018 |
| Functional and Structural Analysis of Programmed C-Methylation in the Biosynthesis of the Fungal Pol ... | Storm, Philip A; Herbst, Dominik A; Maier, Timm; Townsend, Craig A | R01ES001670, R01ES001670 | Cell Chem Biol (2017 Mar 16) |
28238725
|
2017 |
| In trans hydrolysis of carrier protein-bound acyl intermediates by CitA during citrinin biosynthesis ... | Storm, Philip A; Townsend, Craig A | R01ES001670, R01ES001670 | Chem Commun (Camb) (2017 Dec 19) |
29189834
|
2017 |
| Polyketide mimetics yield structural and mechanistic insights into product template domain function ... | Barajas, Jesus F; Shakya, Gaurav; Moreno, Gabriel; Rivera Jr, Heriberto; Jackson, David R; Topp ... | R01ES001670, R01ES001670 | Proc Natl Acad Sci U S A (2017 May 23) |
28484029
|
2017 |
| Molecular Characterization of the Cercosporin Biosynthetic Pathway in the Fungal Plant Pathogen Cerc ... | Newman, Adam G; Townsend, Craig A | R01ES001670, R01ES001670 | J Am Chem Soc (2016 Mar 30) |
26938470
|
2016 |
| Quenching of pH-Responsive Luminescence of a Benzoindolizine Sensor by an Ultrafast Hydrogen Shift. | Zhou, Jiawang; Outlaw, Victor K; Townsend, Craig A; Bragg, Arthur E | R01ES001670, R01ES001670 | Chemistry (2016 Oct 17) |
27549912
|
2016 |
| Structural and Biochemical Analysis of Protein-Protein Interactions Between the Acyl-Carrier Protein ... | Barajas, Jesus F; Finzel, Kara; Valentic, Timothy R; Shakya, Gaurav; Gamarra, Nathan; Martinez, ... | R01ES001670, R01ES001670 | Angew Chem Int Ed Engl (2016 Oct 10) |
27653519
|
2016 |
| Unusual Blue-Shifted Acid-Responsive Photoluminescence Behavior in 6-Amino-8-cyanobenzo[1,2-b]indoli ... | Outlaw, Victor K; Zhou, Jiawang; Bragg, Arthur E; Townsend, Craig A | R01ES001670, R01ES001670 | RSC Adv (2016 Jul 08) |
28580137
|
2016 |
| New Insights into the Conversion of Versicolorin A in the Biosynthesis of Aflatoxin B1. | Conradt, David; Schätzle, Michael A; Haas, Julian; Townsend, Craig A; Müller, Michael | R01ES001670, R01ES001670 | J Am Chem Soc (2015 Sep 02) |
26266881
|
2015 |
| One-pot synthesis of highly substituted N-fused heteroaromatic bicycles from azole aldehydes. | Outlaw, Victor K; d'Andrea, Felipe B; Townsend, Craig A | R01ES001670, R01ES001670 | Org Lett (2015 Apr 17) |
25815402
|
2015 |
| Starter unit flexibility for engineered product synthesis by the nonreducing polyketide synthase Pks ... | Huitt-Roehl, Callie R; Hill, Eric A; Adams, Martina M; Vagstad, Anna L; Li, Jesse W; Townsend, ... | R01ES001670, R01ES001670 | ACS Chem Biol (2015 Jun 19) |
25714897
|
2015 |
| A practical route to substituted 7-aminoindoles from pyrrole-3-carboxaldehydes. | Outlaw, Victor K; Townsend, Craig A | R01ES001670, R01ES001670 | Org Lett (2014 Dec 19) |
25479249
|
2014 |
| Aflatoxin and deconstruction of type I, iterative polyketide synthase function. | Townsend, Craig A | R01ES001670, R01ES001670 | Nat Prod Rep (2014 Oct) |
25079257
|
2014 |
| Systematic domain swaps of iterative, nonreducing polyketide synthases provide a mechanistic underst ... | Newman, Adam G; Vagstad, Anna L; Storm, Philip A; Townsend, Craig A | R01ES001670, R01ES001670 | J Am Chem Soc (2014 May 21) |
24815013
|
2014 |
| Active site comparisons and catalytic mechanisms of the hot dog superfamily. | Labonte, Jason W; Townsend, Craig A | R01ES001670, R01ES001670 | Chem Rev (2013 Mar 13) |
23205964
|
2013 |
| Biochemical determination of enzyme-bound metabolites: preferential accumulation of a programmed oct ... | Belecki, Katherine; Townsend, Craig A | R01ES001670, R01ES001670 | J Am Chem Soc (2013 Sep 25) |
24041368
|
2013 |
| Combinatorial domain swaps provide insights into the rules of fungal polyketide synthase programming ... | Vagstad, Anna L; Newman, Adam G; Storm, Philip A; Belecki, Katherine; Crawford, Jason M; Townse ... | R01ES001670, R01ES001670 | Angew Chem Int Ed Engl (2013 Feb 04) |
23283670
|
2013 |
| Enzymology: Modular biosynthesis branches out. | Townsend, Craig A | R01ES001670, R01ES001670 | Nature (2013 Oct 03) |
24048474
|
2013 |
| Probing the selectivity and protein·protein interactions of a nonreducing fungal polyketide synthase ... | Bruegger, Joel; Haushalter, Robert W; Haushalter, Bob; Vagstad, Anna L; Vagstad, Anna; Shakya, ... | R01ES001670, R01ES001670 | Chem Biol (2013 Sep 19) |
23993461
|
2013 |
| Analysis of the cercosporin polyketide synthase CTB1 reveals a new fungal thioesterase function. | Newman, Adam G; Vagstad, Anna L; Belecki, Katherine; Scheerer, Jonathan R; Townsend, Craig A | R01ES001670, R01ES001670 | Chem Commun (Camb) (2012 Dec 14) |
23108075
|
2012 |
| Characterization of a fungal thioesterase having Claisen cyclase and deacetylase activities in melan ... | Vagstad, Anna L; Hill, Eric A; Labonte, Jason W; Townsend, Craig A | R01ES001670, R01ES001670 | Chem Biol (2012 Dec 21) |
23261597
|
2012 |
| Demonstration of starter unit interprotein transfer from a fatty acid synthase to a multidomain, non ... | Foulke-Abel, Jennifer; Townsend, Craig A | R01ES001670, R01ES001670 | Chembiochem (2012 Sep 03) |
22807303
|
2012 |
| Environmental control of the calicheamicin polyketide synthase leads to detection of a programmed oc ... | Belecki, Katherine; Townsend, Craig A | R01ES001670, R01ES001670 | Angew Chem Int Ed Engl (2012 Nov 5) |
23042574
|
2012 |
| Interrogation of global active site occupancy of a fungal iterative polyketide synthase reveals stra ... | Vagstad, Anna L; Bumpus, Stefanie B; Belecki, Katherine; Kelleher, Neil L; Townsend, Craig A | R01ES001670, R01ES001670 | J Am Chem Soc (2012 Apr 18) |
22452347
|
2012 |
| Polyketide proofreading by an acyltransferase-like enzyme. | Jensen, Katja; Niederkrüger, Holger; Zimmermann, Katrin; Vagstad, Anna L; Moldenhauer, Jana; Br ... | R01ES001670, R01ES001670 | Chem Biol (2012 Mar 23) |
22444588
|
2012 |
| A "diels-alderase" at last. | Townsend, Craig A | R01ES001670, R01ES001670 | Chembiochem (2011 Oct 17) |
21796752
|
2011 |
| Absence of the aflatoxin biosynthesis gene, norA, allows accumulation of deoxyaflatoxin B1 in Asperg ... | Ehrlich, Kenneth C; Chang, Perng-Kuang; Scharfenstein Jr, Leslie L; Cary, Jeffrey W; Crawford, ... | R01ES001670, R01ES001670 | FEMS Microbiol Lett (2010 Apr) |
20158523
|
2010 |
| New insights into the formation of fungal aromatic polyketides. | Crawford, Jason M; Townsend, Craig A | R01ES001670, R01ES001670 | Nat Rev Microbiol (2010 Dec) |
21079635
|
2010 |
| Structure and function of an iterative polyketide synthase thioesterase domain catalyzing Claisen cy ... | Korman, Tyler Paz; Crawford, Jason M; Labonte, Jason W; Newman, Adam G; Wong, Justin; Townsend, ... | R01ES001670, R01ES001670 | Proc Natl Acad Sci U S A (2010 Apr 06) |
20332208
|
2010 |
| Production of octaketide polyenes by the calicheamicin polyketide synthase CalE8: implications for t ... | Belecki, Katherine; Crawford, Jason M; Townsend, Craig A | R01ES001670, R01ES001670 | J Am Chem Soc (2009 Sep 9) |
19689130
|
2009 |
| Structural basis for biosynthetic programming of fungal aromatic polyketide cyclization. | Crawford, Jason M; Korman, Tyler P; Labonte, Jason W; Vagstad, Anna L; Hill, Eric A; Kamari-Bid ... | R01ES001670, R01ES001670 | Nature (2009 Oct 22) |
19847268
|
2009 |
| Acyl-carrier protein-phosphopantetheinyltransferase partnerships in fungal fatty acid synthases. | Crawford, Jason M; Vagstad, Anna L; Ehrlich, Kenneth C; Udwary, Daniel W; Townsend, Craig A | R01ES001670, R01ES001670 | Chembiochem (2008 Jul 02) |
18551496
|
2008 |
| Deconstruction of iterative multidomain polyketide synthase function. | Crawford, Jason M; Thomas, Paul M; Scheerer, Jonathan R; Vagstad, Anna L; Kelleher, Neil L; Tow ... | R01ES001670, R01ES001670 | Science (2008 Apr 11) |
18403714
|
2008 |
| Starter unit specificity directs genome mining of polyketide synthase pathways in fungi. | Crawford, Jason M; Vagstad, Anna L; Ehrlich, Kenneth C; Townsend, Craig A | R01ES001670, R01ES001670 | Bioorg Chem (2008 Feb) |
18215412
|
2008 |
| Synthetic strategy of nonreducing iterative polyketide synthases and the origin of the classical "st ... | Crawford, Jason M; Vagstad, Anna L; Whitworth, Karen P; Ehrlich, Kenneth C; Townsend, Craig A | R01ES001670, R01ES001670 | Chembiochem (2008 May 05) |
18338425
|
2008 |
| Identification of a starter unit acyl-carrier protein transacylase domain in an iterative type I pol ... | Crawford, Jason M; Dancy, Blair C R; Hill, Eric A; Udwary, Daniel W; Townsend, Craig A | R01ES001670, R01ES001670 | Proc Natl Acad Sci U S A (2006 Nov 07) |
17071746
|
2006 |
| Ordering the reductive and cytochrome P450 oxidative steps in demethylsterigmatocystin formation yie ... | Henry, Kevin M; Townsend, Craig A | R01ES001670, R01ES001670 | J Am Chem Soc (2005 Mar 23) |
15771506
|
2005 |
| Synthesis and fate of o-carboxybenzophenones in the biosynthesis of aflatoxin. | Henry, Kevin M; Townsend, Craig A | R01ES001670, R01ES001670 | J Am Chem Soc (2005 Mar 16) |
15755146
|
2005 |
| A method for prediction of the locations of linker regions within large multifunctional proteins, an ... | Udwary, Daniel W; Merski, Matthew; Townsend, Craig A | R01ES001670, R01ES001670 | J Mol Biol (2002 Oct 25) |
12381311
|
2002 |
| Initial characterization of a type I fatty acid synthase and polyketide synthase multienzyme complex ... | Watanabe, Coran M H; Townsend, Craig A | R01ES001670, R01ES001670 | Chem Biol (2002 Sep) |
12323372
|
2002 |
| Requirement of monooxygenase-mediated steps for sterigmatocystin biosynthesis by Aspergillus nidulan ... | Keller, N P; Watanabe, C M; Kelkar, H S; Adams, T H; Townsend, C A | R01ES001670, R01ES001670 | Appl Environ Microbiol (2000 Jan) |
10618248
|
2000 |
| Heterologous expression, isolation, and characterization of versicolorin B synthase from Aspergillus ... | Silva, J C; Townsend, C A | R01ES001670, R01ES001670 | J Biol Chem (1997 Jan 10) |
8995367
|
1997 |
| Structural studies of natural product biosynthetic proteins. | Townsend, C A | R01ES001670, R01ES001670 | Chem Biol (1997 Oct) |
9375250
|
1997 |
| Demonstration of the catalytic roles and evidence for the physical association of type I fatty acid ... | Watanabe, C M; Wilson, D; Linz, J E; Townsend, C A | R01ES001670, R01ES001670 | Chem Biol (1996 Jun) |
8807876
|
1996 |
| Isolation and characterization of the versicolorin B synthase gene from Aspergillus parasiticus. Exp ... | Silva, J C; Minto, R E; Barry 3rd, C E; Holland, K A; Townsend, C A | R01ES001670, R01ES001670 | J Biol Chem (1996 Jun 07) |
8662689
|
1996 |
| Purification and characterization of versicolorin B synthase from Aspergillus parasiticus. Catalysis ... | McGuire, S M; Silva, J C; Casillas, E G; Townsend, C A | R01ES001670, R01ES001670 | Biochemistry (1996 Sep 3) |
8784203
|
1996 |
| Sterigmatocystin production on complex and defined substrates. | Bennett, J W; Henderberg, A; Grossman, K | R01ES001670, R01ES001670 | Mycopathologia (1989 Jan) |
2662007
|
1989 |
| Biosynthetic origin of aflatoxin G1: confirmation of sterigmatocystin and lack of confirmation of af ... | Henderberg, A; Bennett, J W; Lee, L S | R01ES001670, R01ES001670 | J Gen Microbiol (1988 Mar) |
3141572
|
1988 |
| New perspectives on aflatoxin biosynthesis. | Bennett, J W; Christensen, S B | R01ES001670, R01ES001670 | Adv Appl Microbiol (1983) |
6650265
|
1983 |