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University of California-San Diego: Dataset Details, ID=SRP053799

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Superfund Research Program

Detection and Models of Toxicant Exposure

Center Director: Robert H. Tukey
Grant Number: P42ES010337
Funding Period: 2000-2023
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Title: Fat Regulatory T Cells Drive Age-Associated Insulin Resistance

Accession Number: SRP053799

Link to Dataset:

Repository: Sequence Read Archive (SRA)

Data Type(s): Nucleotide Sequence

Experiment Type(s): Transcriptome analysis

Organism(s): Mus musculus

Summary: We show that fat-resident regulatory T cells, termed fTregs, drive age-associated insulin resistance and can be specifically depleted to increase adipose insulin sensitivity. Comparative AdipoImmune profiling in young, aged, and obese mice reveals that fTregs progressively enrich in adipose as a function of age, but not obesity. fTreg-deficient mice are protected from age-associated insulin resistance and its accompanying physiological hallmarks. In contrast, fTreg-deficiency offers no protection from obesity-associated insulin resistance.

Publication(s) associated with this dataset:
  • Bapat SP, Suh J, Fang S, Liu S, Zhang Y, Cheng A, Zhou C, Liang Y, Leblanc M, Liddle C, Atkins AR, Yu RT, Downes M, Evans RM, Zheng Y. 2015. Depletion of fat-resident Treg cells prevents age-associated insulin resistance. Nature 528(7580):137-141. doi:10.1038/nature16151 PMID:26580014 PMCID:PMC4670283
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