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University of California-San Diego: Dataset Details, ID=GSE86927

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Superfund Research Program

Detection and Models of Toxicant Exposure

Center Director: Robert H. Tukey
Grant Number: P42ES010337
Funding Period: 2000-2023
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Title: Impact of NCoR1 on global transcriptomic profiling in intestinal epithelial cells during development

Accession Number: GSE86927

Link to Dataset: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE86927

Repository: Gene Expression Omnibus (GEO)

Data Type(s): Gene Expression

Experiment Type(s): Array expression profiling by high throughput sequencing

Organism(s): Mus musculus

Summary: To explore the molecular events engaged following the deletion of NCoR1 in intestinal tissue during development, we performed global transcriptional profiling in wild type (F/FUN) and NCoR1 intestinal deletion (ΔIECUN) mice at neonates (day 12) and adults (week 10) by utilizing RNA-seq technology.

Publication(s) associated with this dataset:
  • Chen S, Lu W, Yueh MF, Rettenmeier E, Liu M, Auwerx J, Yu RT, Evans RM, Wang K, Karin M, Tukey RH. 2017. Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia. Proc Natl Acad Sci U S A 114(8):E1432-E1440. doi:10.1073/pnas.1700232114 PMID:28167773 PMCID:PMC5338369
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