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University of California-San Diego: Dataset Details, ID=GSE86996

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Superfund Research Program

Detection and Models of Toxicant Exposure

Center Director: Robert H. Tukey
Grant Number: P42ES010337
Funding Period: 2000-2023
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Title: Histone modifications in primary intestinal epithelial cells from wild type (F/FUN) and intesinal NCoR1 deletion (ΔIECUN) neonates.

Accession Number: GSE86996

Link to Dataset: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE86996

Repository: Gene Expression Omnibus (GEO)

Data Type(s): Gene Expression

Experiment Type(s): Genome binding/occupancy profiling by high throughput sequencing

Organism(s): Mus musculus

Summary: ChIP-seq analyses were carried out in intestinanl epithelial cells (IECs) isolated from F/FUN and ΔIECUN mice to assess histone modifications across the genome, an event that links the actions of corepressors with molecular insight towards a mechanism.

Publication(s) associated with this dataset:
  • Chen S, Lu W, Yueh MF, Rettenmeier E, Liu M, Auwerx J, Yu RT, Evans RM, Wang K, Karin M, Tukey RH. 2017. Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia. Proc Natl Acad Sci U S A 114(8):E1432-E1440. doi:10.1073/pnas.1700232114 PMID:28167773 PMCID:PMC5338369
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