Superfund Research Program
Biomarkers of Exposure to Hazardous Substances
Center Director: Bruce D. Hammock
Grant Number: P42ES004699
Funding Period: 1987-2022
News Items List
Enzyme may play key role in obesity-related leaky gut
Environmental Factor - May 2020
A new NIEHS-funded study suggests that intestinal problems connected to obesity are associated with an enzyme known as soluble epoxide hydrolase (sEH).
Early SRP Collaboration Guides Potential Treatment Options for Disorders of the Eye
SRP News Page - August 2018
Researchers are one step closer to determining how to prevent blindness from occurring in mice with macular degeneration and diabetic retinopathy, two diseases that affect the eye. This work stems from a collaboration dating back nearly 20 years between SRP-funded researchers Bruce Hammock, Ph.D., from the University of California, Davis, and Bernhard Hennig, Ph.D., from the University of Kentucky.
Researchers Identify Compounds that Reduce Abnormal Blood Vessel Growth in the Eye
Research Brief - July 2018
Scientists have identified key compounds produced when the body metabolizes omega fatty acids that can reduce the severity of age-related macular degeneration (AMD) in mice. By increasing these lipid metabolites and preventing them from degrading, the researchers reduced abnormal blood vessel growth, in part by regulating the movement of inflammatory immune cells into the retina.
Millions of dollars saved by NIEHS-funded technologies
Environmental Factor - July 2018
More than $100 million was saved through the adoption of tools supported by the Superfund Research Program (SRP), according to a commentary published June 15 in the journal Environmental Health Perspectives. The tools also led to additional benefits to society, including hazardous substance remediation and site monitoring.
Enzyme plays key role in Parkinson's disease
Paper of the Month - July 2018
New research by NIEHS grantees and colleagues suggested an enzyme in the brain plays a key role in Parkinson's disease (PD). Scientists demonstrated that inhibiting the enzyme soluble epoxide hydrolase (sEH) in mice helped curb the inflammation associated with the development and progression of PD.
Enzyme plays key role in Parkinson's disease and inflammation
Environmental Factor - June 2018
New research partially funded by NIEHS suggests an enzyme in the brain plays a key role in Parkinson's disease (PD). Scientists demonstrated that inhibiting an enzyme known as soluble epoxide hydrolase (sEH) can help curb the inflammation associated with the development and progression of PD.
SRP Grantee Presents NIEHS Seminar on Clinical Intervention for Pain
SRP News Page - April 2018
Renowned scientist and Superfund Research Program (SRP) grantee Bruce Hammock, Ph.D., was invited to present the Immunity, Inflammation, and Disease Laboratory Special Seminar at NIEHS on March 28, 2018. Hammock's talk focused on neuropathic pain, which is caused by damage or disease affecting the body's sensory system, and how findings from his lab are being translated into clinical interventions.
Possible explanation for male and female cardiovascular differences
Paper of the Month - March 2018
NIEHS grantees discovered that estrogen can block the function of soluble epoxide hydrolase (sEH), an enzyme in cells that degrades chemically stable fatty acid metabolites. Because inhibition of sEH can be cardioprotective, this finding may help explain why women generally have a lower incidence of cardiovascular disease than men.
Risk e-Learning Web Seminar Series on Analytical Tools and Methods a Big Success
SRP News Page - July 2017
In a spring 2017 three-part Risk e-Learning Web seminar series titled 'Analytical Tools and Methods,' the Superfund Research Program (SRP) highlighted groundbreaking chemical detection, measurement, and fate and transport modeling techniques developed by grantees. In total, this series attracted 1,209 live participants, 6,543 online archive views, 1,419 audio podcast downloads, and 14,596 video podcast downloads.
Survival of the resilient: rapid killifish evolution evades pollution
Environmental Factor - January 2017
A study published Dec. 9 in the journal Science and funded in part by NIEHS sheds light on genetic variability that may explain the survival of killifish in four polluted environments on the U.S. eastern seaboard. A team led by Andrew Whitehead, Ph.D., an NIEHS grantee at the University of California at Davis (UCD), sequenced the entire genome of nearly 400 killifish from eight sites along the Atlantic coast and reported that changes in genes in the aryl hydrocarbon receptor (AHR) pathway might hold the key to adaptation.
FDA ban on antibacterials in soaps informed by SRP research
Environmental Factor - October 2016
The U.S. Food and Drug Administration (FDA) issued a rule Sept. 2 banning 19 antibacterial chemicals as ingredients in over-the-counter (OTC) antibacterial hand and body washes. Development of the final rule was informed by research that included several studies from scientists supported by the NIEHS Superfund Research Program (SRP).
Anti-inflammatory chemical may offer new tool for depression treatment
Paper of the Month - May 2016
An NIEHS grantee and colleagues discovered that a chemical inhibitor of the soluble epoxide hydrolase (sEH) enzyme may be a new tool to treat depression. The enzyme plays a key role in inflammation, which is involved in depression.
A New Dilution Tool to Facilitate High-Throughput Assay Techniques
Research Brief - April 2016
A new tool provides a quick and easy way to dilute samples for biochemical and biological analyses.
Hammock recognized with first McGiff Memorial Award
Environmental Factor - April 2016
NIEHS grantee Bruce Hammock, Ph.D., a toxicologist and entomologist at the University of California, Davis (UCD), is the first recipient of the John C. McGiff Memorial Award for Contributions to Eicosanoid Research.
Chemical Discovered at UC Davis May Be New Tool for Depression Therapy
SRP News Page - March 2016
A chemical discovered at the University of California (UC) Davis may be a new, innovative tool to control depression, a severe and chronic psychiatric disease that affects 350 million people worldwide.
SRP Scientists Cited Among the World's Most Influential Scientific Minds
SRP News Page - February 2016
Eight Superfund Research Program scientists are among the 2015 listing of The World's Most Influential Scientific Minds, an annual compendium of Highly Cited Researchers by Thomson Reuters, a multinational mass-media and information company.
UC Davis Researchers Find Key Mechanism that Causes Neuropathic Pain
SRP News Page - July 2015
Scientists at the University of California, Davis (UC Davis) have identified a key mechanism in neuropathic pain. The discovery could eventually benefit millions of patients with chronic pain from trauma, diabetes, shingles, multiple sclerosis, or other conditions that cause nerve damage.
Detecting Environmental Chemicals with Novel Immunoassay Technology
Research Brief - March 2015
A new low-cost portable device uses a smart phone to detect the presence and concentrations of BDE-47 (2,2’,4,4’-tetrabromodiphenyl ether), a type of flame retardant and widespread environmental contaminant.
If Cells Could Talk, What Would They Tell Us About Environmental Exposures?
SRP News Page - September 2014
In a two-part web-based seminar, researchers from the University of Arizona (UA) and the University of California (UC) Davis Superfund Research Program (SRP) Centers described how they use cell methods to study exposure to toxic chemicals in the environment, including dioxin-like compounds and nanoparticles.
Applying SRP Tools to Detect Environmental Contaminants in California
SRP News Page - August 2014
A Superfund Research Program (SRP) grantee presentation has shown how biochemical tests can be shared. University of California, Davis (UC Davis) SRP project leader Shirley Gee explained how the California Department of Toxic Substances Control (DTSC) can apply UC Davis immunoassay technologies to detect environmental chemicals.
Translating research into products to improve public health
Environmental Factor - June 2014
What do a new eco-friendly cleanup chemical, a mercury-sensing device, and pathogen-detection technology have in common? They are all products of small business startups spun out of NIEHS-funded basic research, recognized for innovation.
Novel Pathway Involved in Neurodevelopmental Toxicity of PCBs
Research Brief - March 2014
Non-dioxin-like (NDL) polychlorinated biphenyls (PCBs) are widespread environmental contaminants previously associated with neurological disorders in children. In a new study funded in part by the University of California UC), researchers demonstrated a novel mechanism of PCB developmental neurotoxicity.
SRP grantee receives prestigious Brodie Award
Environmental Factor - March 2014
Bruce Hammock, Ph.D., a longtime NIEHS Superfund Research Program (SRP) grantee, was honored by the American Society for Pharmacology and Experimental Therapeutics (ASPET) with the biennial Bernard B. Brodie Award in Drug Metabolism.
Research supported by NIEHS informs policy and regulatory discussion
Environmental Factor - February 2014
NIEHS-funded researchers found themselves at center stage in the national discussion concerning policy and regulatory issues related to environmental public health.