Superfund Research Program

Biomarkers of Exposure to Hazardous Substances

Center Director: Bruce D. Hammock
Grant Number: P42ES004699
Funding Period: 1987-2023

Program Links

Grant Recipient Patent List

Patents

• Acyl Piperidine Inhibitors of Soluble Epoxide Hydrolase

  Number: US 2010-299495P
  Year: 2012
  Patent Status: Issued
  Authors: Hammock, B.D., C. Morisseau, K. Lee, T.E. Rose

• Bioassay for Detecting 2,3,7,8-tetrachlorodibenzo-para-dioxin and TCDD-like Compounds and Novel Recombinant Cell Line Useful Therefore

  Number: 5,854,010
  Year: 1998
  Patent Status: Issued
  Authors: Denison, M.S., A. Brouwer, G.C. Clark

• Compact Assay System with Digital Information

  Number: 6,342,395
  Year: 2002
  Patent Status: Issued
  Authors: Hammock, B.D., H. Kido, A. Maquieira

• Compounds and Methods for Inhibiting Cif Virulence Factor

  Number: 10,332,118
  Year: 2019
  Patent Status: Issued
  Authors: Madden, D.R., B.D. Hammock, C. Morisseau, C.D. Bahl

• Cyanohydrin Ethers and Esters as High-Sensitivity Enzyme Substrates

  Number: 6,710,200
  Year: 2004
  Patent Status: Issued
  Authors: Hammock, B.D., G. Shan, R. Zhang

• Diagnostic Microarray Apparatus

  Number: 6,395,562
  Year: 2002
  Patent Status: Issued
  Authors: Hammock, B.D., H. Kido, A. Maquieira

• Digital Microfluidic Meter-on-Chip

  Number: 62/939, 503
  Year: 2019
  Patent Status: Pending
  Authors: Pan, T.

• Enzyme Amplified, Complex Linked, Competitive and Non-Competitive Assays for the Detection of Metal Ions

  Number: 5,459,040
  Year: 1995
  Patent Status: Issued
  Authors: Hammock, B.D., F. Szurdoki, H. Kido

• Epoxide Hydrolase Complexes and Methods Therewith

  Number: 6,150,415
  Year: 2000
  Patent Status: Issued
  Authors: Hammock, B.D., C. Morisseau, J. Zheng, M.H. Goodrow, T. Severson, J.R. Sanborn

• Epoxide Hydrolase Inhibitor Methods

  Number: 6,174,695
  Year: 2001
  Patent Status: Issued
  Authors: Hammock, B.D., M.F. Moghaddam, J.M. Cheek, B. Borhan, J. Fergusson, D.F. Grant, J.F. Greene, K. Matoba, J. Zheng, M.F. Sisemore

• Gold Coating of Rare Earth Nano-Phosphors and Uses Thereof

  Number: 2010-181-3
  Year: 2010
  Patent Status: Pending
  Authors: Kennedy, I.M.

• Inhibition of Glutathione Transferase by Haloenol Lactones

  Number: 6,103,665
  Year: 2000
  Patent Status: Issued
  Authors: Jones, A.D., A.E. Mitchell, B.D. Hammock, J. Zheng

• Inhibition of Glutathione Transferase by Haloenol Lactones

  Number: 5,767,147
  Year: 1998
  Patent Status: Issued
  Authors: Jones, A.D., A.E. Mitchell, B.D. Hammock, J. Zheng

• Inhibitor of Apoptosis Proteins and Nucleic Acids and Methods for Making and Using Them

  Number: 8,119,404
  Year: 2012
  Patent Status: Issued
  Authors: Huang, Q., J. Reed, B.D. Hammock, Q.L. Deveraux, S. Maeda

• Inhibitors for Soluble Epoxide Hydrolase (SHE) and Fatty Acid Amide Hydrolase (FAAH)

  Number: 10,858,338
  Year: 2020
  Patent Status: Issued
  Authors: Hammock, B.D., S.D. Kodani

• Inhibitors of Epoxide Hydrolases for the Treatment of Hypertension

  Number: 6,693,130
  Year: 2004
  Patent Status: Issued
  Authors: Kroetz, D.L., D.C. Zeldin, B.D. Hammock, C. Morisseau

• Linoleic Acid Diol and Glucuronide Conjugate Levels as Diagnostic Markers of Disorders of Abnormal Regulation of Cytochrome P450 Metabolism of Unsaturated Fatty Acids

  Number: 6,756,210
  Year: 2004
  Patent Status: Issued
  Authors: Hammock, B.D., G. Zurek, S.J. Gee, J.W. Newman, J. Zheng

• Metal Coating of Rare Earth Nano-Phosphors and Uses Thereof

  Number: 2010-181-4
  Year: 2010
  Patent Status: Pending
  Authors: Kennedy, I.M., S. Lakshmana

• Methods of Improving Cell-based Therapy

  Number: 10,369,141
  Year: 2019
  Patent Status: Issued
  Authors: Chiamvimonvat, N.

• Methods of Inhibiting Pain

  Number: 10,813,894
  Year: 2020
  Patent Status: Issued
  Authors: Hammock, B.D., A.B. Inceoglu, F.G. Haj, A. Bettaieb

• Microchannel Magneeto-Immunoassay

  Number: 20090227044
  Year: 2009
  Patent Status: Pending
  Authors: Kennedy, I.M.

• Microfluidic-Robotic Interface for Automated High-Precision Liquid Handling

  Number: 62/898, 139
  Year: 2019
  Patent Status: Pending
  Authors: Pan, T.

• Modeling Combinatorial Interventions for Protecting Against Threat Agents

  Number: 2012-035-0
  Year: 2012
  Patent Status: Issued
  Authors: Pessah, I.N.

• Modulation of Bioactive Epoxy-Fatty Acid Levels by Phosphodiesterase Inhibitors

  Number: PCT/US2011/036511
  Year: 2011
  Patent Status: Pending
  Authors: Hammock, B.D., A.B. Inceoglu, K.M. Wagner, N. Schebb

• Nanophotonic Device Employing Nanowell-housed Nanoparticles for Ultrasensitive Bioassays

  Number: WO 2013/103997 A1
  Year: 2013
  Patent Status: Pending
  Authors: Kennedy, I.M., J. Han, S. Lakshmana

• Non-Competitive Immunoassays to Detect Small Molecules Using Nanopeptamers

  Number: 10,101,324
  Year: 2018
  Patent Status: Issued
  Authors: Gonzalez-Sapienza, G.G., B.D. Hammock, A. Gonzalez-Techera, L. Vanrelle, G. Lassabe

• Novel methods for treating and preventing obesity

  Number: 62595226
  Year: 2017
  Patent Status: Pending
  Authors: Zhao, L., C. Morisseau, A. Bettaieb, B.D. Hammock

• Preparation of Novel 1,3-Substituted Ureas as Inhibitors of Soluble Epoxide Hydrolase

  Number: 2007-549-2
  Year: 2009
  Patent Status: Pending
  Authors: Sanborn, J.R., B.D. Hammock, S.H. Hwang, P.D. Jones, C. Morisseau

• Recombinant nanobodies (VHHs) deactivating Pseudomonas aeruginosa virulence factor Cif – tools for drug development, application in diagnostics and clinical treatment

  Number: 62/512,711
  Year: 2017
  Patent Status: Pending
  Authors: Hammock, B.D., N. Vasylieva, J. Dong, C. Morisseau, D.R. Madden

• Recombinant Soluble Epoxide Hydrolase

  Number: 5,445,956
  Year: 1995
  Patent Status: Issued
  Authors: Hammock, B.D., D.F. Grant, J.K. Beetham

• Sorafenib Derivatives as P21 Inhibitors

  Number: 10,449,1882
  Year: 2019
  Patent Status: Issued
  Authors: Weiss, R.H., B.D. Hammock, H. Inoue, S.H. Hwang

• Sorafenib Derivatives as sEH Inhibitors

  Number: PCT/US2012/025074
  Year: 2012
  Patent Status: Pending
  Authors: Weiss, R.H., B.D. Hammock, H. Inoue, S.H. Hwang

• Stable Analogs of CYP450 Lipid Metabolies and Inhibitors of Soluble Epoxide Hydrolase

  Number: 10,758,511
  Year: 2020
  Patent Status: Issued
  Authors: Connor, K.M., E. Hasegawa, B.D. Hammock, K.S. Lee

• Subsituted Piperidines as Soluble Epoxide Hydrolase Inhibitors

  Number: 9,850,207
  Year: 2017
  Patent Status: Issued
  Authors: Hammock, B.D., K.S. Lee, B. Inceoglu, K.M. Wagner

• Synthesis and Use of Omega-Hydroxylated Polyunsaturated Fatty Acids

  Number: 10,689,595
  Year: 2020
  Patent Status: Issued
  Authors: Zhang, G., B.D. Hammock, S.H. Hwang, W. Wang

• Treatment of Inflammatory Disorders in Non-Human Mammals

  Number: 10,383,835
  Year: 2019
  Patent Status: Issued
  Authors: Guedes, A.P., B.D. Hammock, C. Morisseau

• Ultrasensitive Assays with a Nanoparticle-Based Photonic Crystal

  Number: 61/584,230 and 61/730,951
  Year: 2012
  Patent Status: Issued
  Authors: Kennedy, I.M.

• Use of Inhibitors of Soluble Expoxide Hydrolase to Synergize Activity of COX and 5-LOX Inhibitors

  Number: 20100286222
  Year: 2010
  Patent Status: Issued
  Authors: Hammock, B.D.