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Patent Detail: Epoxide Hydrolase Complexes and Methods Therewith

Patent Detail

Superfund Research Program

Epoxide Hydrolase Complexes and Methods Therewith

Number: 6,150,415
Year: 2000
Patent Status: Issued
Authors: Hammock, B.D., C. Morisseau, J. Zheng, M.H. Goodrow, T. Severson, J.R. Sanborn

Biologically stable inhibitors of soluble epoxide hydrolases are provided. The inhibitors can be used, for example, to selectively inhibit epoxide hydrolase in therapeutic applications such as treating inflammation, for use in affinity separations of the epoxide hydrolases, and in agricultural applications. A preferred class of compounds for practicing the invention have the structure shown by Formula 1 ##STR1## wherein X and Y is each independently nitrogen, oxygen, or sulfur, and X can further be carbon, at least one of R.sub.1 -R.sub.4 is hydrogen, R.sub.2 is hydrogen when X is nitrogen but is not present when X is sulfur or oxygen, R.sub.4 is hydrogen when Y is nitrogen but is not present when Y is sulfur or oxygen, R.sub.1 and R.sub.3 are each independently a substituted or unsubstituted alkyl, haloalkyl, cycloalkyl, aryl, acyl, or heterocyclic, or being a metabolite or degradation product thereof.

Associated Projects:

  • University of California-Davis: Immunoassays for Human and Environmental Health Monitoring
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