Superfund Research Program
Linoleic Acid Diol and Glucuronide Conjugate Levels as Diagnostic Markers of Disorders of Abnormal Regulation of Cytochrome P450 Metabolism of Unsaturated Fatty Acids
Patent Status: Issued
Authors: Hammock, B.D., G. Zurek, S.J. Gee, J.W. Newman, J. Zheng
The invention provides methods of using dihydroxy unsaturated fatty acids as markers for identifying patients with a disorder associated with abnormal regulation of the cytochrome P450 metabolism or oxidation of unsaturated fatty acids. For example, linoleic acid diols, including leukotoxindiol, can be used as a diagnostic tool for identifying patients with pre-eclampsia, eclampsia, and pregnancy-induced hypertension.
- University of California-Davis: Immunoassays for Human and Environmental Health Monitoring