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Patent Detail: Linoleic Acid Diol and Glucuronide Conjugate Levels as Diagnostic Markers of Disorders of Abnormal Regulation of Cytochrome P450 Metabolism of Unsaturated Fatty Acids

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Patent Detail

Superfund Research Program

Linoleic Acid Diol and Glucuronide Conjugate Levels as Diagnostic Markers of Disorders of Abnormal Regulation of Cytochrome P450 Metabolism of Unsaturated Fatty Acids

Number: 6,756,210
Year: 2004
Patent Status: Issued
Authors: Hammock, B.D., G. Zurek, S.J. Gee, J.W. Newman, J. Zheng

The invention provides methods of using dihydroxy unsaturated fatty acids as markers for identifying patients with a disorder associated with abnormal regulation of the cytochrome P450 metabolism or oxidation of unsaturated fatty acids. For example, linoleic acid diols, including leukotoxindiol, can be used as a diagnostic tool for identifying patients with pre-eclampsia, eclampsia, and pregnancy-induced hypertension.

Associated Projects:

  • University of California-Davis: Immunoassays for Human and Environmental Health Monitoring
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