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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Patent Detail: Inhibition of Glutathione Transferase by Haloenol Lactones

Patent Detail

Superfund Research Program

Inhibition of Glutathione Transferase by Haloenol Lactones

Number: 5,767,147
Year: 1998
Patent Status: Issued
Authors: Jones, A.D., A.E. Mitchell, B.D. Hammock, J. Zheng

This invention relates to novel haloenol lactone compounds. These compounds have the following general structure: ##STR1## in which Ar is an aryl group and Y is a haloenol lactone moiety. The compounds of the invention are useful for the specific measurement of particular isoenzymes of glutathione S-transferase. Measurement of glutathione S-transferase isoenzymes has importance in diagnostic medicine. The compounds of the invention are also useful for treatment of drug resistance in cancer and for preventing herbicide resistance in plants.

Associated Projects:

  • University of California-Davis: Immunoassays for Human and Environmental Health Monitoring
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