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Project Publications: University of Arizona: Toxicological Impact of Mine Tailings Dust on Lung Epithelial Barrier Function

Superfund Research Program

Toxicological Impact of Mine Tailings Dust on Lung Epithelial Barrier Function

Project Leader: Robert Clark Lantz
Co-Investigators: Scott Boitano, Donna D. Zhang
Grant Number: P42ES004940
Funding Period: 2005-2020
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  • Michel-Ramirez G, Recio-Vega R, Lantz RC, Gandolfi A, Olivas-Calderon E, Chau BT, Amistadi M. 2020. Assessment of YAP gene polymorphisms and arsenic interaction in Mexican women with breast cancer. J Appl Toxicol 40(3):342-351. doi:10.1002/jat.3907 PMID:31631368 PMCID:PMC7012748


  • Dadashazar H, Ma L, Sorooshian A. 2019. Sources of pollution and interrelationships between aerosol and precipitation chemistry at a central California site. Sci Total Environ 651:1776-1787. doi:10.1016/j.scitotenv.2018.10.086 PMID:30316095 PMCID:PMC6246821
  • Garcia-Rico L, Meza-Figueroa D, Beamer P, Burgess JL, O'Rourke MK, Lantz C, Furlong M, Martinez-Cinco MA, Mondaca-Fernandez I, Balderas-Cortes JJ, Meza-Montenegro MM. 2019. Serum matrix metalloproteinase-9 in children exposed to arsenic from playground dust at elementary schools in Hermosillo, Sonora, Mexico. Environ Geochem Health 42(2):499-511. doi:10.1007/s10653-019-00384-6 PMID:31372863
  • Witten M, Chau BT, Saez AE, Boitano S, Lantz RC. 2019. Early life inhalation exposure to mine tailings dust affects lung development. Toxicol Appl Pharmacol 365:124-132. doi:10.1016/j.taap.2019.01.009 PMID:30641074 PMCID:PMC6349506



  • Michel-Ramirez G, Recio-Vega R, Ocampo-Gomez G, Palacios-Sanchez E, Delgado-Macias M, Delgado-Gaona M, Lantz RC, Gandolfi A, Gonzalez-Cortes. 2017. Association between YAP expression in neoplastic and non-neoplastic breast tissue with arsenic urinary levels. J Appl Toxicol 37:1195-1202. doi:10.1002/jat.3481 PMID:28524356
  • Moy JK, Khoutorsky A, Asiedu MN, Black BJ, Kuhn JL, Barragan-Iglesias P, Megat S, Burton MD, Burgos-Vega CC, Melemedjian OK, Boitano S, Vagner J, Gkogkas CG, Pancrazio JJ, Mogil JS, Dussor G, Sonenberg N, Price TJ. 2017. The MNK-eIF4E signaling axis contributes to injury-induced Nociceptive plasticity and the development of chronic pain. J Neurosci Res 37:7481-7499. doi:10.1523/JNEUROSCI.0220-17.2017 PMID:28674170 PMCID:PMC5546114 (accepted for publication)
  • Polley DJ, Mihara K, Ramachandran R, Vliagoftis H, Renaux B, Saifeddine M, Daines MO, Boitano S, Hollenberg M. 2017. Cockroach allergen serine proteinases: Isolation, sequencing and signalling via proteinase-activated receptor-2. Clinical and Experimental Allergy 47:946-960. doi:10.1111/cea.12921 PMID:28317204 PMCID:PMC5501740 (accepted for publication)


  • Beamer P, Klimecki WT, Loh M, Van Horne YO, Sugeng AJ, Lothrop N, Billheimer D, Guerra S, Lantz RC, Canales RA, Martinez FD. 2016. Association of children's urinary CC16 levels with arsenic concentrations in multiple environmental media. Int J Environ Res Public Health 13(5):521. doi:10.3390/ijerph13050521 PMID:27223295 PMCID:PMC4881146
  • Recio-Vega R, Gonzalez-Cortes, Olivas-Calderon E, Gandolfi A, Michel-Ramirez G, Lantz RC. 2016. Association between polymorphisms in arsenic metabolism genes and urinary arsenic methylation profiles in girls and boys chronically exposed to arsenic. Environ Mol Mutagen 57(7):516-525. doi:10.1002/em.22026 PMID:27327299 PMCID:PMC4980171
  • Sherwood CL, Boitano S. 2016. Airway epithelial cell exposure to distinct e-cigarette liquid flavorings reveals toxicity thresholds and activation of CFTR by the chocolate flavoring 2,5-dimethypyrazine. Respir Res 17(1):57. doi:10.1186/s12931-016-0369-9 PMID:27184162 PMCID:PMC4869201


  • Boitano S, Hoffman J, Flynn AN, Asiedu MN, Tillu DV, Zhang Z, Sherwood CL, Rivas CM, DeFea KA, Vagner J, Price TJ. 2015. The novel PAR2 ligand C391 blocks multiple PAR2 signalling pathways in vitro and in vivo. Br J Pharmacol 172(18):4535-4545. doi:10.1111/bph.13238 PMID:26140338 PMCID:PMC4562513
  • Olivas-Calderon E, Recio-Vega R, Gandolfi A, Lantz RC, Gonzalez-Cortes, Gonzalez-De Alba C, Froines JR, Espinosa-Fematt JA. 2015. Lung inflammation biomarkers and lung function in children chronically exposed to arsenic. Toxicol Appl Pharmacol 287(2):161-167. doi:10.1016/j.taap.2015.06.001 PMID:26048584 PMCID:PMC4751871
  • Recio-Vega R, Dena-Cazares JA, Ramirez-de la Pena JL, Jacobo-Avila A, Portales-Castanedo A, Gallegos-Arreola MP, Ocampo-Gomez G, Michel-Ramirez G. 2015. MRP1 expression in bronchoalveolar lavage cells in subjects with lung cancer who were chronically exposed to arsenic. Environ Mol Mutagen 56(9):759-766. doi:10.1002/em.21960 PMID:26031227
  • Recio-Vega R, Gonzalez-Cortes, Olivas-Calderon E, Lantz RC, Gandolfi A, Gonzalez-De Alba C. 2015. In utero and early childhood exposure to arsenic decreases lung function in children. J Appl Toxicol 35(4):358-366. doi:10.1002/jat.3023 PMID:25131850 PMCID:PMC4750377
  • Sherwood CL, Lantz RC. 2015. Lung cancer and other pulmonary diseases. Chapter 9 in: Arsenic: Exposure Sources, Health Risks, and Mechanisms of Toxicity. John Wiley & Sons, Hoboken, NJ. pp.342-386.
  • Stanton BA, Caldwell KL, Congdon CB, Disney J, Donahue M, Ferguson E, Flemings E, Golden M, Guerinot ML, Highman J, James K, Kim C, Lantz RC, Marvinney RG, Miller D, Navas-Acien A, Nordstrom D, Postema S, Rardin LR, Rosen BP, Sengupta A, Shaw JR, Stanton E, Susca P. 2015. MDI biological laboratory arsenic summit: approaches to limiting human exposure to arsenic. Curr Environ Health Rep 2(3):329-337. doi:10.1007/s40572-015-0057-9 PMID:26231509 PMCID:PMC4522277


  • Boitano S, Hoffman J, Tillu DV, Asiedu MN, Zhang Z, Sherwood CL, Wang Y, Dong X, Price TJ, Vagner J. 2014. Development and evaluation of small peptidomimetic ligands to protease-activated receptor-2 (PAR2) through the use of lipid tethering. PLoS One 9(6):e99140. doi:10.1371/journal.pone.0099140 PMID:24927179 PMCID:PMC4057235
  • Burgess JL, Kurzius-Spencer M, Poplin GS, Littau S, Kopplin MJ, Sturup S, Boitano S, Lantz RC. 2014. Environmental arsenic exposure, selenium and sputum alpha-1 antitrypsin. J Expo Sci Environ Epidemiol 24(2):150-155. doi:10.1038/jes.2013.35 PMID:23838883 PMCID:PMC4019207
  • Sherwood CL, Daines MO, Price TJ, Vagner J, Boitano S. 2014. A highly potent agonist to protease-activated receptor-2 reveals apical activation of the airway epithelium resulting in Ca2+-regulated ion conductance. Am J Physiol Cell Physiol 307(8):C718-C726. doi:10.1152/ajpcell.00257.2014 PMID:25143347 PMCID:PMC4199996


  • Flynn AN, Hoffman J, Tillu DV, Sherwood CL, Zhang Z, Patek R, Asiedu MN, Vagner J, Price TJ, Boitano S. 2013. Development of highly potent protease-activated receptor 2 agonists via synthetic lipid tethering. FASEB J 27(4):1498-1510. doi:10.1096/fj.12-217323 PMID:23292071 PMCID:PMC3606532
  • Sherwood CL, Lantz RC, Boitano S. 2013. Chronic arsenic exposure in nanomolar concentrations compromises wound response and intercellular signaling in airway epithelial cells. Toxicol Sci 132:222-234. doi:10.1093/toxsci/kfs331 PMID:23204110 PMCID:PMC3576008
  • Sherwood CL, Liguori AE, Olsen CE, Lantz RC, Burgess JL, Boitano S. 2013. Arsenic compromises conducting airway epithelial barrier properties in primary mouse and immortalized human cell cultures. PLoS One 8(12):e82970. doi:10.1371/journal.pone.0082970 PMID:24349408 PMCID:PMC3857810
  • Tao S, Zheng Y, Lau A, Jaramillo MC, Chau BT, Lantz RC, Wong PK, Wondrak GT, Zhang DD. 2013. Tanshinone I activates the Nrf2-dependent antioxidant response and protects against As(III)-induced lung inflammation in vitro and in vivo. Antioxid Redox Signal 19(14):1647-1661. doi:10.1089/ars.2012.5117 PMID:23394605 PMCID:PMC3809600


  • Hoffman J, Flynn AN, Tillu DV, Zhang Z, Patek R, Price TJ, Vagner J, Boitano S. 2012. Lanthanide labeling of a potent protease activated receptor-2 agonist for time-resolved fluorescence analysis. Bioconjug Chem 23(10):2098-2104. doi:10.1021/bc300300q PMID:22994402 PMCID:PMC3556274
  • Zheng Y, Tao S, Lian F, Chau BT, Chen J, Sun G, Fang D, Lantz RC, Zhang DD. 2012. Sulforaphane prevents pulmonary damage in response to inhaled arsenic by activating the Nrf2-defense response. Toxicol Appl Pharmacol 265(3):292-299. doi:10.1016/j.taap.2012.08.028 PMID:22975029 PMCID:PMC3725323


  • Boitano S, Flynn AN, Schulz SM, Hoffman J, Price TJ, Vagner J. 2011. Potent agonists of the protease activated receptor 2 (PAR(2)). J Med Chem 54(5):1308-1313. doi:10.1021/jm1013049 PMID:21294569 PMCID:PMC3069554
  • Flynn AN, Tillu DV, Asiedu MN, Hoffman J, Vagner J, Price TJ, Boitano S. 2011. The protease-activated receptor-2-specific agonists 2-aminothiazol-4-yl-LIGRL-NH2 and 6-aminonicotinyl-LIGRL-NH2 stimulate multiple signaling pathways to induce physiological responses in vitro and in vivo. J Biol Chem 286:19076-19088. doi:10.1074/jbc.M110.185264 PMID:21467041 PMCID:PMC3099721
  • Ramanathan S, Mazzalupo S, Boitano S, Montfort WR. 2011. Thrombospondin-1 and angiotensin II inhibit soluble guanylyl cyclase through an increase in intracellular calcium concentration. Biochemistry 50:7787-7799. doi:10.1021/bi201060c PMID:21823650 PMCID:PMC3168727
  • Sherwood CL, Lantz RC, Burgess JL, Boitano S. 2011. Arsenic alters ATP-dependent Ca2+ signaling in human airway epithelial cell wound response. Toxicol Sci 121:191-206. doi:10.1093/toxsci/kfr044 PMID:21357385 PMCID:PMC3080191
  • States JC, Barchowsky A, Cartwright IL, Reichard JF, Futscher BW, Lantz RC. 2011. Arsenic toxicology: translating between experimental models and human pathology. Environ Health Perspect 119:1356-1363. doi:10.1289/ehp.1103441 PMID:21684831 PMCID:PMC3230447



  • Andrew AS, Lantz RC, Rodgers, LS, Vaillancourt RR, Camenisch TD, Hays AM, Sollome JJ, Hamilton JW. 2008. Arsenic-induced decreases in the vascular matrix. Toxicol Pathol 36(6):805-817. doi:10.1177/0192623308323919 PMID:18812580 PMCID:PMC2875876
  • Petrick JS, Blachere FM, Selmin O, Lantz RC. 2008. Inorganic arsenic as a developmental toxicant: in utero exposure and alterations in the developing rat lungs. Mol Nutr Food Res 53(5):583-591. PMID:19072884


  • Burgess JL, Montenegro M, Josyula AB, Poplin GS, Kopplin MJ, Rowland H, Sturup S, Lantz RC. 2007. Environmental arsenic exposure and urinary 8-OHdG in Arizona and Sonora. Clinical Toxicology 45(5):490-8. PMID:17503254
  • Lantz RC, Lynch BJ, Boitano S, Poplin GS, Littau S, Tsaprailis G, Burgess JL. 2007. Pulmonary biomarkers based on alterations in protein expression after exposure to arsenic. Environ Health Perspect 115(4):586-91. PMID:17450228


  • Josyula AB, Poplin GS, Kurzius-Spencer M, McClellen HE, Kopplin MJ, Sturup S, Lantz RC, Burgess JL. 2006. Environmental arsenic exposure and sputum metalloproteinase concentrations. Environ Res 102(3):283-290. doi:10.1016/j.envres.2006.01.003 PMID:16487958
  • Lantz RC, Hays AM. 2006. Role of oxidative stress in arsenic-induced toxicity. J Mol Biol 38(4):791-804. PMID:17145702
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