Superfund Research Program

Role of NRF2 in the Pulmonary Response to Inhaled Mine Tailing Dust

Project Leader: Donna D. Zhang
Co-Investigators: Scott Boitano, Robert Clark Lantz
Grant Number: P42ES004940
Funding Period: 2017-2020

Project-Specific Links

Publications

2021

• Chau BT, Witten M, Cromey DW, Chen Y, Lantz RC. 2021. Lung developmental is altered after inhalation exposure to various concentrations of calcium arsenate. Toxicol Appl Pharmacol 432:115754. doi:10.1016/j.taap.2021.115754 PMID:34634286 PMCID:PMC8572171
• Liu P, Luo G, Dodson M, Schmidlin C, Wei Y, Kerimoglu B, Ooi A, Chapman E, Garcia JG, Zhang DD. 2021. The NRF2-LOC344887 signaling axis suppresses pulmonary fibrosis. Redox Biol 38:101766. doi:10.1016/j.redox.2020.101766 PMID:33126057 PMCID:PMC7573654
• Schmidlin C, Shakya A, Dodson M, Chapman E, Zhang DD. 2021. The intricacies of NRF2 regulation in cancer. Semin Cancer Biol 76:110-119. doi:10.1016/j.semcancer.2021.05.016 PMID:34020028 PMCID:PMC8599504

2020

• Liu P, Dodson M, Fang D, Chapman E, Zhang DD. 2020. NRF2 negatively regulates primary ciliogenesis and hedgehog signaling. PLoS Biol 18(2):doi:10.1371/journal.pbio.3000620 PMID:32053600 PMCID:PMC7043785

2019

• Dodson M, Castro-Portuguez R, Zhang DD. 2019. NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis. Redox Biol 23:101107. doi:10.1016/j.redox.2019.101107 PMID:30692038 PMCID:PMC6859567
• Dodson M, de la Vega MR, Cholanians AB, Schmidlin CJ, Chapman E, Zhang DD. 2019. Modulating NRF2 in disease: timing is everything. Annu Rev Pharmacol Toxicol 59:555-575. doi:10.1146/annurev-pharmtox-010818-021856 PMID:30256716 PMCID:PMC6538038
• Liu P, de la Vega MR, Dodson M, Yue F, Shi B, Fang D, Chapman E, Liu L, Zhang DD. 2019. Spermidine confers liver protection by enhancing NRF2 signaling through a MAP1S-mediated noncanonical mechanism. Hepatology 70(1):372-388. doi:10.1002/hep.30616 PMID:30873635 PMCID:PMC6597327
• Pengfei L, Kerins M, Tian W, Neupane D, Zhang DD, Ooi A. 2019. Differential and overlapping targets of the transcriptional regulators NRF1, NRF2, and NRF3 in human cells. J Biol Chem 294:18131-18149. doi:10.1074/jbc.RA119.009591 PMID:31628195 PMCID:PMC6885608
• Schmidlin C, Dodson M, Zhang DD. 2019. Filtering through the role of NRF2 in kidney disease. Archives of Pharmacal Research doi:10.1007/s12272-019-01177-2 PMID:31372933
• Schmidlin CJ, Dodson M, Madhavan L, Zhang DD. 2019. Redox regulation by NRF2 in aging and disease. Free Radic Biol Med 134:702-707. doi:10.1016/j.freeradbiomed.2019.01.016 PMID:30654017 PMCID:PMC6588470

2018

• Dodson M, de la Vega MR, Harder B, Castro-Portuguez R, Rodrigues SD, Wong PK, Chapman E, Zhang DD. 2018. Low-level arsenic causes proteotoxic stress and not oxidative stress. Toxicol Appl Pharmacol 341:106-113. doi:10.1016/j.taap.2018.01.014 PMID:29408041 PMCID:PMC5929483
• Dodson M, Liu P, Jiang T, Ambrose AJ, Luo G, de la Vega MR, Cholanians AB, Wong PK, Chapman E, Zhang DD. 2018. Increased O-GlcNAcylation of SNAP29 drives arsenic-induced autophagic dysfunction. Mol Cell Biol 38(11):e00595-17. doi:10.1128/MCB.00595-17 PMID:29507186 PMCID:PMC5954189
• Liu P, de la Vega MR, Sammani S, Mascarenhas JB, Kerins M, Dodson M, Sun X, Wang T, Ooi A, Garcia JG, Zhang DD. 2018. RPA1 binding to NRF2 switches ARE-dependent transcriptional activation to ARE-NRE-dependent repression. Proc Natl Acad Sci U S A 115(44):E10352-E10361. doi:10.1073/pnas.1812125115 PMID:30309964 PMCID:PMC6217430