Superfund Research Program

Oxidative Stress and PCB Exposure in Mammalian Cells

Project Leader: Prabhat C. Goswami
Co-Investigators: Douglas R. Spitz, Frederick E. Domann
Grant Number: P42ES013661
Funding Period: 2006 - 2015

Project-Specific Links

Publications

2016

• Xiao W, Sarsour EH, Wagner BA, Doskey CM, Buettner GR, Domann FE, Goswami PC. 2016. Succinate dehydrogenase activity regulates PCB3-quinone-induced metabolic oxidative stress and toxicity in HaCaT human keratinocytes. Arch Toxicol 90(2):319-332. doi:10.1007/s00204-014-1407-3 PMID:25417049 PMCID:PMC4441874

2015

• Xiao W, Goswami PC. 2015. Down-regulation of peroxisome proliferator activated receptor γ coactivator 1α induces oxidative stress and toxicity of 1-(4-Chlorophenyl)-benzo-2,5-quinone in HaCaT human keratinocytes. Toxicol In Vitro 29(7):1332-1338. doi:10.1016/j.tiv.2015.05.009 PMID:26004620 PMCID:PMC4553100
• Xiao W, Son J, Vorrink SU, Domann FE, Goswami PC. 2015. Ligand-independent activation of aryl hydrocarbon receptor signaling in PCB3-quinone treated HaCaT human keratinocytes. Toxicol Lett 233(3):258-266. doi:10.1016/j.toxlet.2015.02.005 PMID:25668756 PMCID:PMC4341842

2014

• Hallberg AR, Vorrink SU, Hudachek DR, Cramer-Morales K, Milhem MM, Cornell RA, Domann FE. 2014. Aberrant CpG methylation of the TFAP2A gene constitutes a mechanism for loss of TFAP2A expression in human metastatic melanoma. Epigenetics 9(12):1641-1647. doi:10.4161/15592294.2014.988062 PMID:25625848 PMCID:PMC4622677
• Sarsour EH, Kalen AL, Goswami PC. 2014. Manganese superoxide dismutase regulates a redox cycle within the cell cycle. Antioxid Redox Signal 20(10):1618-1627. doi:10.1089/ars.2013.5303 PMID:23590434 PMCID:PMC3942678
• Vorrink SU, Domann FE. 2014. Regulatory crosstalk and interference between the xenobiotic and hypoxia sensing pathways at the AhR-ARNT-HIF1α signaling node. Chem Biol Interact 218:82-88. doi:10.1016/j.cbi.2014.05.001 PMID:24824450 PMCID:PMC4091760
• Vorrink SU, Hudachek DR, Domann FE. 2014. Epigenetic determinants of CYP1A1 induction by the aryl hydrocarbon receptor agonist 3,3',4,4',5-pentachlorobiphenyl (PCB 126). Int J Mol Sci 15(8):13916-13931. doi:10.3390/ijms150813916 PMID:25116688 PMCID:PMC4159831
• Vorrink SU, Sarsour EH, Olivier AK, Robertson LW, Goswami PC, Domann FE. 2014. PCB 126 perturbs hypoxia-induced HIF-1α activity and glucose consumption in human HepG2 cells. Exp Toxicol Pathol 66(8):377-382. doi:10.1016/j.etp.2014.05.005 PMID:24916446 PMCID:PMC4143452
• Vorrink SU, Severson PL, Kulak MV, Futscher BW, Domann FE. 2014. Hypoxia perturbs aryl hydrocarbon receptor signaling and CYP1A1 expression induced by PCB 126 in human skin and liver-derived cell lines. Toxicol Appl Pharmacol 274(3):408-416. doi:10.1016/j.taap.2013.12.002 PMID:24355420 PMCID:PMC3919493

2013

• Eckers JC, Kalen AL, Xiao W, Sarsour EH, Goswami PC. 2013. Selenoprotein P inhibits radiation-induced late reactive oxygen species accumulation and normal cell injury. Int J Radiat Oncol Biol Phys 87(3):619-625. doi:10.1016/j.ijrobp.2013.06.2063 PMID:24074935 PMCID:PMC3787541
• Xiao W, Zhu Y, Sarsour EH, Kalen AL, Aykin-Burns N, Spitz DR, Goswami PC. 2013. Selenoprotein P regulates 1-(4-Chlorophenyl)-benzo-2, 5-quinone-induced oxidative stress and toxicity in human keratinocytes. Free Radic Biol Med 65:70-77. doi:10.1016/j.freeradbiomed.2013.06.010 PMID:23770201 PMCID:PMC3830697
• Zhu Y, Mapuskar KA, Marek RF, Xu W, Lehmler H, Robertson LW, Hornbuckle KC, Spitz DR, Aykin-Burns N. 2013. A new player in environmentally induced oxidative stress: polychlorinated biphenyl congener, 3,3'-dichlorobiphenyl (PCB11). Toxicol Sci 136(1):39-50. doi:10.1093/toxsci/kft186 PMID:23997111 PMCID:PMC3829572

2012

• Chaudhuri L, Nicholson AM, Kalen AL, Goswami PC. 2012. Preferential selection of MnSOD transcripts in proliferating normal and cancer cells. Oncogene 31:1207-1216. doi:10.1038/onc.2011.325 PMID:21804600 PMCID:PMC3208126
• Sarsour EH, Kalen AL, Xiao Z, Veenstra TD, Chaudhuri L, Venkataraman S, Reigan P, Buettner GR, Goswami PC. 2012. Manganese superoxide dismutase regulates a metabolic switch during the Mammalian Cell Cycle. Cancer Res 72:3807-3816. doi:10.1158/0008-5472.CAN-11-1063 PMID:22710435 PMCID:PMC3429130

2010

• Chaudhuri L, Sarsour EH, Goswami PC. 2010. 2-(4-chlorophenyl)benzo-1,4-quinone induced ROS-signaling inhibits proliferation in human non-malignant prostate epithelial cells. Environ Int 36(8):924-930. doi:10.1016/j.envint.2010.01.001 PMID:20163859 PMCID:PMC2888671
• Chaudhuri L, Sarsour EH, Kalen AL, Aykin-Burns N, Spitz DR, Goswami PC. 2010. Polychlorinated biphenyl induced ROS signaling delays the entry of quiescent human breast epithelial cells into the proliferative cycle. Free Radic Biol Med 49(1):40-49. doi:10.1016/j.freeradbiomed.2010.03.012 PMID:20307652 PMCID:PMC2875331
• Hadzic T, Aykin-Burns N, Zhu Y, Coleman MC, Leick K, Jacobson GM, Spitz DR. 2010. Paclitaxel combined with inhibitors of glucose and hydroperoxide metabolism enhances breast cancer cell killing via H2O2-mediated oxidative stress. Free Radic Biol Med 48(8):1024-1033. doi:10.1016/j.freeradbiomed.2010.01.018 PMID:20083194 PMCID:PMC2843822
• Venkatesha VA, Kalen AL, Sarsour EH, Goswami PC. 2010. PCB-153 exposure coordinates cell cycle progression and cellular metabolism in human mammary epithelial cells. Toxicol Lett 196(2):110-116. doi:10.1016/j.toxlet.2010.04.005 PMID:20394812 PMCID:PMC2891036

2008

• Glauert HP, Tharappel JC, Banerjee S, Chan NL, Kania-Korwel I, Lehmler H, Lee EY, Robertson LW, Spear BT. 2008. Inhibition of the promotion of hepatocarcinogenesis by 2,2',4,4',5,5'-hexachlorobiphenyl (PCB-153) by the deletion of the p50 subunit of NF-kappa B in mice. Toxicol Appl Pharmacol 232(2):302-308. doi:10.1016/j.taap.2008.06.013 PMID:18644402 PMCID:PMC2583134
• Glauert HP, Tharappel JC, Lu Z, Stemm DN, Banerjee S, Chan L, Lee EY, Lehmler H, Robertson LW, Spear BT. 2008. Role of oxidative stress in the promoting activities of pcbs. Environ Toxicol Pharmacol 25(2):247-250. doi:10.1016/j.etap.2007.10.025 PMID:19122744 PMCID:PMC2836878
• Jacobus JA, Flor S, Klingelhutz AJ, Robertson LW, Ludewig G. 2008. 2-(4'-Chlorophenyl)-1,4-benxoquinone increases the frequency of micronuclei and shortens telomeres. Environ Toxicol Pharmacol 25(2):267-272. doi:10.1016/j.etap.2007.10.022 PMID:18438462 PMCID:PMC2346440
• Kania-Korwel I, Hornbuckle KC, Robertson LW, Lehmler H. 2008. Dose-dependent enantiomeric enrichment of 2,2',3,3',6,6'-hexachlorobiphenyl in female mice. Environ Toxicol Chem 27(2):299-305. doi:10.1897/07-359R.1 PMID:18348647
• Kania-Korwel I, Hornbuckle KC, Robertson LW, Lehmler H. 2008. Influence of dietary fat on the enantioselective disposition of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) in female mice. Food Chem Toxicol 46(2):637-644. doi:10.1016/j.fct.2007.09.072 PMID:17950514 PMCID:PMC2289907
• Klosener J, Swenson DC, Robertson LW, Luthe G. 2008. Effects of fluoro substitution on 4-bromodiphenyl ether (PBDE 3). Acta Crystallogr B 64(Pt1):108-119. doi:10.1107/S0108768107067079 PMID:18204217 PMCID:PMC3120100
• Ludewig G, Lehmann L, Esch HL, Robertson LW. 2008. Metabolic activation of PCBs to carcinogens in vivo - a review. Environ Toxicol Pharmacol 25(2):241-246. doi:10.1016/j.etap.2007.10.029 PMID:18452002 PMCID:PMC2364599
• Luthe G, Jacobus JA, Robertson LW. 2008. Receptor interactions by polybrominated diphenyl ethers versus polychlorinated biphenyls: a theoretical Structure-activity assessment. Environ Toxicol Pharmacol 25(2):202-210. doi:10.1016/j.etap.2007.10.017 PMID:19768137 PMCID:PMC2746664
• Venkatesha VA, Venkataraman S, Sarsour EH, Kalen AL, Buettner GR, Robertson LW, Lehmler H, Goswami PC. 2008. Catalase ameliorates polychlorinated biphenyl-induced cytotoxicity in nonmalignant human breast epithelial cells. Free Radic Biol Med 45(8):1094-1102. doi:10.1016/j.freeradbiomed.2008.07.007 PMID:18691649 PMCID:PMC2614346

2007

• Bunaciu RP, Tharappel JC, Lehmler H, Kania-Korwel I, Robertson LW, Srinivasan C, Spear BT, Glauert HP. 2007. The effect of dietary glycine on the hepatic tumor promoting activity of polychlorinated biphenyls (PCBs) in rats. Toxicology 239(3):147-55. PMID:17703865
• Luthe G, Swenson DC, Robertson LW. 2007. Influence of fluoro-substitution on the planarity of 4-chlorobiphenyl (PCB 3). Acta Crystallogr B 63:319-327. PMID:17374943
• Sadeghi-aliabadi H, Chan K, Lehmler H, Robertson LW, O-Brian PJ. 2007. Molecular cytotoxic mechanisms of catecholic polychlorinated biphenyl metabolites in isolated rat hepatocytes. Chem Biol Interact 167:184-192. PMID:17408604
• Zettner M, Flor S, Ludewig G, Wagner J, Robertson LW, Lehmann L. 2007. Quinoid metabolites of 4-monochlorobiphenyl (PCB3) induce gene mutations in cultured Chinese hamster V79 Cells. Toxicol Sci 100:88-98. PMID:17686921