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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Project Publications: University of Louisville: Environmental Exposure and Cardiometabolic Disease

Superfund Research Program

Environmental Exposure and Cardiometabolic Disease

Project Leader: Craig J. McClain
Co-Investigators: Matthew C. Cave, Aruni Bhatnagar, Rachel J. Keith
Grant Number: P42ES023716
Funding Period: 2017-2022

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Publications

2022

  • Cave MC, Pinkston CM, Rai SN, Wahlang B, Pavuk M, Head KZ, Carswell GK, Nelson GM, Klinge CM, Bell DA, Birnbaum LS, Chorley BN. 2022. Circulating microRNAs, polychlorinated biphenyls, and environmental liver disease in the Anniston Community Health Survey. Environ Health Perspect 130:doi:10.1289/EHP9467 PMID:34989596 PMCID:PMC8734566
  • Coleman CJ, Yeager R, Pond ZA, Riggs DW, Bhatnagar A, Pope III C. 2022. Mortality risk associated with greenness, air pollution, and physical activity in a representative US cohort. Sci Total Environ 824:doi:10.1016/j.scitotenv.2022.153848 PMID:35176374
  • Heindel JJ, Howard S, Agay-Shay K, Arrebola J, Audouze K, Babin P, Barouki R, Bansal A, Blanc E, Cave MC, Chatterjee S, Chevalier N, Choudhury M, Collier D, Connolly L, Coumoul X, Garruti G, Gilbertson M, Hoepner L, Holloway A, Howell G, Kassotis CD, Kay M, Kim MJ, Lagadic-Gossmann D, Langouet S, Legrand A, Li Z, Mentec H, Lind L, Lind PM, Lustig R, Martin-Chouly C, Kos VM, Podechard N, Roepke T, Sargis R, Starling AP, Tomlinson CR, Touma C, Vondracek J, vom Saal FS, Blumberg B. 2022. Obesity II: Establishing causal links between chemical exposures and obesity. Biochem Pharmacol doi:10.1016/j.bcp.2022.115015 PMID:35395240 PMCID:PMC9124454
  • Lorkiewicz P, Keith RJ, Lynch J, Jin L, Theis W, Krivokhizhina T, Riggs D, Bhatnagar A, Srivastava S, Conklin DJ. 2022. Electronic cigarette solvents, JUUL e-liquids, and biomarkers of exposure: In vivo evidence for acrolein and glycidol in e-cig-derived aerosols. Chem Res Toxicol doi:10.1021/acs.chemrestox.1c00328 PMID:35044764
  • Lustig R, Collier D, Kassotis CD, Roepke T, Kim MJ, Blanc E, Barouki R, Bansal A, Cave MC, Chatterjee S, Choudhury M, Gilbertson M, Lagadic-Gossmann D, Howard S, Lind L, Tomlinson CR, Vondracek J, Heindel JJ. 2022. Obesity I: Overview and molecular and biochemical mechanisms. Biochem Pharmacol 199:doi:10.1016/j.bcp.2022.115012 PMID:35393120 PMCID:PMC9050949
  • Petri BJ, Piell KM, Wahlang B, Head KZ, Andreeva K, Rouchka EC, Pan J, Rai SN, Cave MC, Klinge CM. 2022. Multiomics analysis of the impact of polychlorinated biphenyls on environmental liver disease in a mouse model. Environ Toxicol Pharmacol 94:doi:10.1016/j.etap.2022.103928 PMID:35803474
  • Petriello MC, Mottaleb MA, Serio TC, Balyan B, Cave MC, Birnbaum LS, Morris AJ. 2022. Serum concentrations of legacy and emerging per- and polyfluoroalkyl substances in the Anniston Community Health Surveys (ACHS I and ACHS II). Environ Int 158:106907. doi:10.1016/j.envint.2021.106907 PMID:34763231
  • Riggs DW, Malovichko MV, Gao H, McGraw KE, Taylor BS, Krivokhizhina T, Rai SN, Keith RJ, Bhatnagar A, Srivastava S. 2022. Environmental exposure to volatile organic compounds is associated with endothelial injury. Toxicol Appl Pharmacol 437:115877. doi:10.1016/j.taap.2022.115877 PMID:35045333
  • Wahlang B, Gripshover T, Gao H, Krivokhizhina T, Keith RJ, Sithu ID, Rai SN, Bhatnagar A, McClain CJ, Srivastava S, Cave MC. 2022. Associations between residential exposure to volatile organic compounds and liver injury markers. Toxicol Sci 185(1):doi:10.1093/toxsci/kfab119 PMID:34668566 PMCID:PMC8714366
  • Young JL, Cave MC, Xu Q, Kong M, Xu J, Lin Q, Tan Y, Cai L. 2022. Whole life exposure to low dose cadmium alters diet-induced NAFLD. Toxicol Appl Pharmacol 436:doi:10.1016/j.taap.2021.115855 PMID:34990729 PMCID:PMC8796138

2021

  • Coleman CJ, Yeager R, Riggs DW, Coleman NC, Garcia GR, Bhatnagar A, Pope CA. 2021. Greenness, air pollution, and mortality risk: A US cohort study of cancer patients and survivors. Environ Int 157:106797. doi:10.1016/j.envint.2021.106797 PMID:34332301
  • Das S, Rai A, Merchant ML, Cave MC, Rai SN. 2021. A comprehensive survey of statistical approaches for differential expression analysis in single-cell RNA sequencing studies. Genes (Basel) 12(12):1947. doi:10.3390/genes12121947 PMID:34946896 PMCID:PMC8701051
  • Guardiola JJ, Hardesty JE, Beier JI, Prough RA, McClain CJ, Cave MC. 2021. Plasma metabolomics analysis of polyvinyl chloride workers identifies altered processes and candidate biomarkers for hepatic hemangiosarcoma and its development. Int J Mol Sci 22:doi:10.3390/ijms22105093 PMID:34065028 PMCID:PMC8150673
  • Hardesty JE, Wahlang B, Prough RA, Head KZ, Wilkey D, Merchant ML, Shi H, Jin J, Cave MC. 2021. Effect of epidermal growth factor treatment and polychlorinated biphenyl exposure in a dietary-exposure mouse model of steatohepatitis. Environ Health Perspect 129:37010. doi:10.1289/EHP8222 PMID:33788613 PMCID:PMC8011667
  • Jin J, Wahlang B, Thapa M, Head KZ, Hardesty JE, Srivastava S, Merchant ML, Rai SN, Prough RA, Cave MC. 2021. Proteomics and metabolic phenotyping define principal roles for the aryl hydrocarbon receptor in mouse liver. Acta Pharm Sin B 11:3806-3819. doi:10.1016/j.apsb.2021.10.014 PMID:35024308 PMCID:PMC8727924
  • Jin L, Lorkiewicz P, Xie Z, Bhatnagar A, Srivastava S, Conklin DJ. 2021. Acrolein but not its metabolite, 3-Hydroxypropylmercapturic acid (3HPMA), activates vascular transient receptor potential Ankyrin-1 (TRPA1): Physiological to toxicological implications. Toxicol Appl Pharmacol 426:115647. doi:10.1016/j.taap.2021.115647 PMID:34271065 PMCID:PMC8343963
  • Klinge CM, Piell KM, Petri BJ, He L, Zhang X, Pan J, Rai SN, Andreeva K, Rouchka EC, Wahlang B, Beier JI, Cave MC. 2021. Combined exposure to polychlorinated biphenyls and high-fat diet modifies the global epitranscriptomic landscape in mouse liver. Environ Epigenet 7:doi:10.1093/eep/dvab008 PMID:34548932 PMCID:PMC8448424
  • Malovichko MV, Abplanalp WT, McFall SA, Taylor BS, Wickramasinghe NS, Sithu ID, Zelko I, Uchida S, Hill BG, Sutaria S, Nantz MH, Bhatnagar A, Conklin DJ, O'Toole TE, Srivastava S. 2021. Subclinical markers of cardiovascular toxicity of benzene inhalation in mice. Toxicol Appl Pharmacol 431(9):115742. doi:10.1016/j.taap.2021.115742 PMID:34624356 PMCID:PMC8647905
  • McGraw KE, Riggs DW, Rai SN, Navas-Acien A, Xie Z, Lorkiewicz P, Lynch J, Zafar N, Krishnasamy SS, Taylor KC, Conklin DJ, DeFilippis A, Srivastava S, Bhatnagar A. 2021. Exposure to volatile organic compounds - acrolein, 1,3-butadiene, and crotonaldehyde - is associated with vascular dysfunction. Environ Res 196:110903. doi:10.1016/j.envres.2021.110903 PMID:33636185 PMCID:PMC8119348
  • Riggs DW, Yeager R, Conklin DJ, DeJarnett N, Keith RJ, DeFilippis A, Rai SN, Bhatnagar A. 2021. Residential proximity to greenness mitigates the hemodynamic effects of ambient air pollution. Am J Physiol Heart Circ Physiol 320(3):doi:10.1152/ajpheart.00689.2020 PMID:33416460 (ahead of print)
  • Tevis DS, Flores SR, Kenwood BM, Bhandari D, Jacob P, Liu J, Lorkiewicz P, Conklin DJ, Hecht SS, Goniewicz ML, Blount BC, De Jesus VR. 2021. Harmonization of acronyms for volatile organic compound metabolites using a standardized naming system. Int J Hyg Environ Health 235:113749. doi:10.1016/j.ijheh.2021.113749 PMID:33962120
  • Wahlang B, Alexander II NC, Li X, Rouchka EC, Kirpich IA, Cave MC. 2021. Polychlorinated biphenyls altered gut microbiome in CAR and PXR knockout mice exhibiting toxicant-associated steatohepatitis. Toxicol Rep 8:doi:10.1016/j.toxrep.2021.03.010 PMID:33777700 PMCID:PMC7985695
  • Zelko I, Taylor BS, Das TP, Watson WH, Sithu ID, Wahlang B, Malovichko MV, Cave MC, Srivastava S. 2021. Effect of vinyl chloride exposure on cardiometabolic toxicity. Environ Toxicol 37(2):245-255. doi:10.1002/tox.23394 PMID:34717031 PMCID:PMC8724461

2020

  • Cave MC. 2020. Environmental Pollution and the Developmental Origins of Childhood Liver Disease. Hepatology 72:1518-1521. doi:10.1002/hep.31549 PMID:32910501
  • Donde H, Ghare S, Joshi-Barve S, Zhang J, Vadhanam MV, Gobejishvili L, Lorkiewicz P, Srivastava S, McClain CJ, Barve S. 2020. Tributyrin Inhibits Ethanol-Induced Epigenetic Repression of CPT-1A and Attenuates Hepatic Steatosis and Injury. Cell Mol Gastroenterol Hepatol 9:569-585. doi:10.1016/j.jcmgh.2019.10.005 PMID:31654770 PMCID:PMC7078548
  • Jin J, Wahlang B, Shi H, Hardesty JE, Falkner KC, Head KZ, Srivastava S, Merchant ML, Rai SN, Cave MC, Prough RA. 2020. Dioxin-like and non-dioxin-like PCBs differentially regulate the hepatic proteome and modify diet-induced nonalcoholic fatty liver disease severity. Med Chem Res 29:1247-1263. doi:10.1007/s00044-020-02581-w
  • Keith RJ, Fetterman JL, Orimoloye OA, Dardari Z, Lorkiewicz P, Hamburg NM, DeFilippis A, Blaha MJ, Bhatnagar A. 2020. Characterization of volatile organic compound metabolites in cigarette smokers, electronic nicotine device users, dual users, and nonusers of tobacco. Nicotine Tob Res 22:264-272. doi:10.1093/ntr/ntz021 PMID:30759242 PMCID:PMC7297089
  • Konkle S, Zierold K, Taylor KC, Riggs DW, Bhatnagar A. 2020. National secular trends in ambient air volatile organic compound levels and biomarkers of exposure in the United States. Environ Res 182:10. doi:10.1016/j.envres.2019.108991 PMID:31835113
  • Rai SN, Qian C, Pan J, McClain CJ, McClain M, Eichenberger MR, Galandiuk S. 2020. Statistical issues and group classification in plasma microRNA studies with data application. Evol Bioinform 16:9. doi:10.1177/1176934320913338 PMID:32313420 PMCID:PMC7157974
  • Riggs DW, Zafar N, Krishnasamy SS, Yeager R, Rai SN, Bhatnagar A, O'Toole TE. 2020. Exposure to airborne fine particulate matter is associated with impaired endothelial function and biomarkers of oxidative stress and inflammation. Environ Res 180:doi:10.1016/j.envres.2019.108890 PMID:31718786 PMCID:PMC6899204
  • Yeager R, Riggs DW, DeJarnett N, Srivastava S, Lorkiewicz P, Xie Z, Krivokhizhina T, Keith RJ, Srivastava S, Browning MH, Zafar N, Krishnasamy SS, DeFilippis A, Turner JR, Rai SN, Bhatnagar A. 2020. Association between residential greenness and exposure to volatile organic compounds. Sci Total Environ 707:doi:10.1016/j.scitotenv.2019.135435 PMID:31865083

2019

  • Bassler J, Ducatman A, Elliott M, Wen S, Wahlang B, Barnett J, Cave MC. 2019. Environmental perfluoroalkyl acid exposures are associated with liver disease characterized by apoptosis and altered serum adipocytokines. Environ Pollut 247:1055-1063. doi:10.1016/j.envpol.2019.01.064 PMID:30823334 PMCID:PMC6404528
  • Conklin DJ, Guo Y, Nystoriak M, Jagatheesan G, Obal D, Kilfoil PJ, Hoetker JD, Guo L, Bolli R, Bhatnagar A. 2019. TRPA1 channel contributes to myocardial ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol 316:H889-H899. doi:10.1152/ajpheart.00106.2018 PMID:30735434 PMCID:PMC6483018
  • Conklin DJ, Schick SF, Blaha MJ, Carll AP, DeFilippis A, Ganz P, Hall MN, Hamburg NM, O'Toole TE, Reynolds LM, Srivastava S, Bhatnagar A. 2019. Cardiovascular injury induced by tobacco products: Assessment of risk factors and biomarkers of harm A Tobacco Center of Regulatory Science (TCORS) Compilation. Am J Physiol Heart Circ Physiol 316(4):H801-H827. doi:10.1152/ajpheart.00591.2018 PMID:30707616
  • Hardesty JE, Wahlang B, Falkner KC, Shi H, Jin J, Wilkey D, Merchant ML, Watson C, Prough RA, Cave MC. 2019. Hepatic signalling disruption by pollutant polychlorinated biphenyls in steatohepatitis. Cell Signal 53:132-139. doi:10.1016/j.cellsig.2018.10.004 PMID:30300668 PMCID:PMC6289731
  • Hardesty JE, Wahlang B, Falkner KC, Shi H, Jin J, Zhou Y, Wilkey D, Merchant ML, Watson C, Feng W, Morris AJ, Hennig B, Prough RA, Cave MC. 2019. Proteomic analysis reveals novel mechanisms by which polychlorinated biphenyls compromise the liver promoting diet-induced steatohepatitis. J Proteome Res 18(4):1582-1594. doi:10.1021/acs.jproteome.8b00886 PMID:30807179 PMCID:PMC7059562
  • Shi H, Hardesty JE, Jin J, Head KZ, Cave MC, Prough RA. 2019. Concentration dependence of human and mouse aryl hydrocarbon receptor responsiveness to polychlorinated biphenyl exposures: Implications for aroclor mixtures. Xenobiotica 1-9. doi:10.1080/00498254.2019.1566582 PMID:30991879
  • Shi H, Jan J, Hardesty JE, Falkner KC, Prough RA, Balamurugan AN, Mokshagundam S, Chari ST, Cave MC. 2019. Polychlorinated biphenyl exposures differentially regulate hepatic metabolism and pancreatic function: Implications for nonalcoholic steatohepatitis and diabetes. Toxicol Appl Pharmacol 363:22-33. doi:10.1016/j.taap.2018.10.011 PMID:30312631
  • Vatsalya V, Kong M, Gobejishvili L, Chen W, Srivastava S, Barve S, McClain CJ, Joshi-Barve S. 2019. Urinary acrolein metabolite levels in severe acute alcoholic hepatitis patients. Am J Physiol Gastrointest Liver Physiol 316(1):G115-G122. doi:10.1152/ajpgi.00209.2018 PMID:30234998
  • Wahlang B, Appana S, Falkner KC, McClain CJ, Brock GN, Cave MC. 2019. Insecticide and metal exposures are associated with a surrogate biomarker for non-alcoholic fatty liver disease in the National Health and Nutritional Examination Survey 2003-2004. Environ Sci Pollut Res Int 6(4):265-276. doi:10.1007/s11356-019-07066-x PMID:31873887
  • Wahlang B, Jin J, Beier JI, Hardesty JE, Daly EF, Schnegelberger RD, Falkner KC, Prough RA, Kirpich IA, Cave MC. 2019. Mechanisms of environmental contributions to fatty liver disease. Curr Environ Health Rep 6:80-94. doi:10.1007/s40572-019-00232-w PMID:31134516 PMCID:PMC6698418
  • Wahlang B, Jin J, Hardesty JE, Head KZ, Shi H, Falkner KC, Prough RA, Klinge CM, Cave MC. 2019. Identifying sex differences arising from polychlorinated biphenyl exposures in toxicant-associated liver disease. Food Chem Toxicol 129:64-76. doi:10.1016/j.fct.2019.04.007 PMID:31026535 PMCID:PMC6555661

2018

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