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Your Environment. Your Health.

Project Publications: University of Louisville: Environmental Exposure and Cardiometabolic Disease

Superfund Research Program

Environmental Exposure and Cardiometabolic Disease

Project Leader: Craig J. McClain
Co-Investigators: Matthew C. Cave, Aruni Bhatnagar, Rachel J. Keith
Grant Number: P42ES023716
Funding Period: 2017-2022
View this project in the NIH Research Portfolio Online Reporting Tools (RePORT)

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Publications

2020

  • Donde H, Ghare S, Joshi-Barve S, Zhang J, Vadhanam MV, Gobejishvili L, Lorkiewicz P, Srivastava S, McClain CJ, Barve S. 2020. Tributyrin Inhibits Ethanol-Induced Epigenetic Repression of CPT-1A and Attenuates Hepatic Steatosis and Injury. Cell Mol Gastroenterol Hepatol 9:569-585. doi:10.1016/j.jcmgh.2019.10.005 PMID:31654770 PMCID:PMC7078548
  • Jin J, Wahlang B, Shi H, Hardesty JE, Falkner KC, Head KZ, Srivastava S, Merchant ML, Rai SN, Cave MC, Prough RA. 2020. Dioxin-like and non-dioxin-like PCBs differentially regulate the hepatic proteome and modify diet-induced nonalcoholic fatty liver disease severity. Med Chem Res 29:1247-1263. doi:10.1007/s00044-020-02581-w
  • Keith RJ, Fetterman JL, Orimoloye OA, Dardari Z, Lorkiewicz P, Hamburg NM, DeFilippis A, Blaha MJ, Bhatnagar A. 2020. Characterization of volatile organic compound metabolites in cigarette smokers, electronic nicotine device users, dual users, and nonusers of tobacco. Nicotine Tob Res 22:264-272. doi:10.1093/ntr/ntz021 PMID:30759242 PMCID:PMC7297089
  • Konkle S, Zierold K, Taylor KC, Riggs DW, Bhatnagar A. 2020. National secular trends in ambient air volatile organic compound levels and biomarkers of exposure in the United States. Environ Res 182:10. doi:10.1016/j.envres.2019.108991 PMID:31835113
  • Rai SN, Qian C, Pan J, McClain CJ, McClain M, Eichenberger MR, Galandiuk S. 2020. Statistical issues and group classification in plasma microRNA studies with data application. Evol Bioinform 16:9. doi:10.1177/1176934320913338 PMID:32313420 PMCID:PMC7157974
  • Riggs DW, Zafar N, Krishnasamy SS, Yeager R, Rai SN, Bhatnagar A, O'Toole TE. 2020. Exposure to airborne fine particulate matter is associated with impaired endothelial function and biomarkers of oxidative stress and inflammation. Environ Res 180:doi:10.1016/j.envres.2019.108890 PMID:31718786 PMCID:PMC6899204
  • Yeager R, Riggs DW, DeJarnett N, Srivastava S, Lorkiewicz P, Xie Z, Krivokhizhina T, Keith RJ, Srivastava S, Browning MH, Zafar N, Krishnasamy SS, DeFilippis A, Turner JR, Rai SN, Bhatnagar A. 2020. Association between residential greenness and exposure to volatile organic compounds. Sci Total Environ 707:doi:10.1016/j.scitotenv.2019.135435 PMID:31865083

2019

  • Bassler J, Ducatman A, Elliott M, Wen S, Wahlang B, Barnett J, Cave MC. 2019. Environmental perfluoroalkyl acid exposures are associated with liver disease characterized by apoptosis and altered serum adipocytokines. Environ Pollut 247:1055-1063. doi:10.1016/j.envpol.2019.01.064 PMID:30823334 PMCID:PMC6404528
  • Conklin D, Guo Y, Nystoriak M, Jagatheesan G, Obal D, Kilfoil PJ, Hoetker JD, Guo L, Bolli R, Bhatnagar A. 2019. TRPA1 channel contributes to myocardial ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol 316:H889-H899. doi:10.1152/ajpheart.00106.2018 PMID:30735434 PMCID:PMC6483018
  • Conklin D, Schick SF, Blaha MJ, Carll AP, DeFilippis A, Ganz P, Hall MN, Hamburg NM, O'Toole TE, Reynolds LM, Srivastava S, Bhatnagar A. 2019. Cardiovascular injury induced by tobacco products: Assessment of risk factors and biomarkers of harm A Tobacco Center of Regulatory Science (TCORS) Compilation. Am J Physiol Heart Circ Physiol 316(4):H801-H827. doi:10.1152/ajpheart.00591.2018 PMID:30707616
  • Hardesty JE, Wahlang B, Falkner KC, Shi H, Jin J, Wilkey D, Merchant ML, Watson C, Prough RA, Cave MC. 2019. Hepatic signalling disruption by pollutant polychlorinated biphenyls in steatohepatitis. Cell Signal 53:132-139. doi:10.1016/j.cellsig.2018.10.004 PMID:30300668 PMCID:PMC6289731
  • Hardesty JE, Wahlang B, Falkner KC, Shi H, Jin J, Zhou Y, Wilkey D, Merchant ML, Watson C, Feng W, Morris AJ, Hennig B, Prough RA, Cave MC. 2019. Proteomic analysis reveals novel mechanisms by which polychlorinated biphenyls compromise the liver promoting diet-induced steatohepatitis. J Proteome Res 18(4):1582-1594. doi:10.1021/acs.jproteome.8b00886 PMID:30807179 PMCID:PMC7059562
  • Shi H, Hardesty JE, Jin J, Head KZ, Cave MC, Prough RA. 2019. Concentration dependence of human and mouse aryl hydrocarbon receptor responsiveness to polychlorinated biphenyl exposures: Implications for aroclor mixtures. Xenobiotica 1-9. doi:10.1080/00498254.2019.1566582 PMID:30991879
  • Shi H, Jan J, Hardesty JE, Falkner KC, Prough RA, Balamurugan AN, Mokshagundam S, Chari ST, Cave MC. 2019. Polychlorinated biphenyl exposures differentially regulate hepatic metabolism and pancreatic function: Implications for nonalcoholic steatohepatitis and diabetes. Toxicol Appl Pharmacol 363:22-33. doi:10.1016/j.taap.2018.10.011 PMID:30312631
  • Vatsalya V, Kong M, Gobejishvili L, Chen W, Srivastava S, Barve S, McClain CJ, Joshi-Barve S. 2019. Urinary acrolein metabolite levels in severe acute alcoholic hepatitis patients. Am J Physiol Gastrointest Liver Physiol 316(1):G115-G122. doi:10.1152/ajpgi.00209.2018 PMID:30234998
  • Wahlang B, Appana S, Falkner KC, McClain CJ, Brock GN, Cave MC. 2019. Insecticide and metal exposures are associated with a surrogate biomarker for non-alcoholic fatty liver disease in the National Health and Nutritional Examination Survey 2003-2004. Environ Sci Pollut Res Int 6(4):265-276. doi:10.1007/s11356-019-07066-x PMID:31873887
  • Wahlang B, Jin J, Beier JI, Hardesty JE, Daly EF, Schnegelberger RD, Falkner KC, Prough RA, Kirpich IA, Cave MC. 2019. Mechanisms of environmental contributions to fatty liver disease. Curr Environ Health Rep 6:80-94. doi:10.1007/s40572-019-00232-w PMID:31134516 PMCID:PMC6698418
  • Wahlang B, Jin J, Hardesty JE, Head KZ, Shi H, Falkner KC, Prough RA, Klinge CM, Cave MC. 2019. Identifying sex differences arising from polychlorinated biphenyl exposures in toxicant-associated liver disease. Food Chem Toxicol 129:64-76. doi:10.1016/j.fct.2019.04.007 PMID:31026535 PMCID:PMC6555661

2018

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