Superfund Research Program

NDMA and DNA Alkylation Repair in the Liver: Impact of Gene-Environment Interactions on Cellular Responses, Mutations and Cancer

Project Leader: Bevin P. Engelward
Co-Investigator: Leona D. Samson
Grant Number: P42ES027707
Funding Period: 2017-2022

Project-Specific Links

Publications

2022

• Hrdina AI, Kohale I, Kaushal S, Kelly J, Selin NE, Engelward BP, Kroll JH. 2022. The parallel transformations of polycyclic aromatic hydrocarbons in the body and in the atmosphere. Environ Health Perspect 130(2):doi:10.1289/EHP9984 PMID:35225689 PMCID:PMC8884122
• Pradhan D, Ding H, Zhu J, Engelward BP, Levine SS. 2022. NExtSEEK: Extending SEEK for active management of interoperable metadata. J Biomol Tech 33(1):doi:10.7171/3fc1f5fe.db404124 PMID:35836998 PMCID:PMC9258913

2021

• Buick JK, Williams A, Meier MJ, Swartz C, Recio L, Gagne R, Ferguson SS, Engelward BP, Yauk C. 2021. A modern genotoxicity testing paradigm: Integration of the high-throughput CometChip and the TGx-DDI transcriptomic biomarker in human HepaRG cell cultures. Front Public Health 9:doi:10.3389/fpubh.2021.694834 PMID:34485225 PMCID:PMC8416458
• Engelward BP. 2021. Implications of an epidemiological study showing an association between in utero NDMA exposure and childhood cancer. Environ Mol Mutagen 62:288-292. doi:10.1002/em.22434 PMID:33963777
• Ge J, Ngo LP, Kaushal S, Tay IJ, Thadhani E, Kay J, Mazzucato P, Chow DN, Fessler JL, Weingeist DM, Sobol RW, Samson LD, Floyd SR, Engelward BP. 2021. CometChip enables parallel analysis of multiple DNA repair activities. DNA Repair (Amst) 106(11):doi:10.1016/j.dnarep.2021.103176 PMID:34365116 PMCID:PMC8439179
• Kay J, Corrigan JJ, Armijo AL, Nazari IS, Kohale I, Torous DK, Avlasevich SL, Croy RG, Wadduwage DN, Carrasco SE, Dertinger SD, White FM, Essigmann JM, Samson LD, Engelward BP. 2021. Excision of mutagenic replication-blocking lesions suppresses cancer but promotes cytotoxicity and lethality in nitrosamine-exposed mice. Cell Rep 34(11):108864. doi:10.1016/j.celrep.2021.108864 PMID:33730582
• Kelly JM, Ivatt PD, Evans MJ, Kroll JH, Hrdina AI, Kohale I, White FM, Engelward BP, Selin NE. 2021. Global cancer risk from unregulated polycyclic aromatic hydrocarbons. Geohealth 5(9):doi:10.1029/2021GH000401 PMID:34589640 PMCID:PMC8460132
• Owiti NA, Nagel Z, Engelward BP. 2021. Fluorescence sheds light on DNA damage, DNA repair, and mutations. Trends Cancer 7(3):240-248. doi:10.1016/j.trecan.2020.10.006 PMID:33203608 PMCID:PMC7889721

2020

• Chao C, Engelward BP. 2020. Applications of CometChip for environmental health studies. Chem Res Toxicol 33:1528-1538. doi:10.1021/acs.chemrestox.9b00393 PMID:32519858
• Chao C, Ngo LP, Engelward BP. 2020. SpheroidChip: patterned agarose microwell compartments harboring HepG2 spheroids are compatible with genotoxicity testing. ACS Biomater Sci Eng 6:2427-2439. doi:10.1021/acsbiomaterials.9b01951
• Ngo LP, Owiti NA, Swartz C, Winters J, Su Y, Ge J, Xiong A, Han J, Recio L, Samson LD, Engelward BP. 2020. Sensitive CometChip assay for screening potentially carcinogenic DNA adducts by trapping DNA repair intermediates. Nucleic Acids Res 48(3):e13. doi:10.1093/nar/gkz1077 PMID:31822921 PMCID:PMC7026589

2019

• Kay J, Thadhani E, Samson LD, Engelward BP. 2019. Inflammation-induced DNA damage, mutations and cancer. DNA Repair (Amst) 83:doi:10.1016/j.dnarep.2019.102673 PMID:31387777 PMCID:PMC6801086
• Ngo LP, Chan TK, Ge J, Samson LD, Engelward BP. 2019. Microcolony Size Distribution Assay Enables High-Throughput Cell Survival Quantitation. Cell Rep 26:1668-1678. doi:10.1016/j.celrep.2019.01.053 PMID:30726746 PMCID:PMC6431241