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Your Environment. Your Health.

Project Publications: Massachusetts Institute of Technology: NDMA and DNA Alkylation Repair in the Liver: Impact of Gene-Environment Interactions on Cellular Responses, Mutations and Cancer

Superfund Research Program

NDMA and DNA Alkylation Repair in the Liver: Impact of Gene-Environment Interactions on Cellular Responses, Mutations and Cancer

Project Leader: Bevin P. Engelward
Co-Investigator: Leona D. Samson
Grant Number: P42ES027707
Funding Period: 2017-2022
View this project in the NIH Research Portfolio Online Reporting Tools (RePORT)

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Publications

2021

  • Engelward BP. 2021. Implications of an epidemiological study showing an association between in utero NDMA exposure and childhood cancer. Environ Mol Mutagen 62:288-292. doi:10.1002/em.22434 PMID:33963777
  • Kay J, Corrigan JJ, Armijo AL, Nazari IS, Kohale I, Torous DK, Avlasevich SL, Croy RG, Wadduwage DN, Carrasco SE, Dertinger SD, White FM, Essigmann JM, Samson LD, Engelward BP. 2021. Excision of mutagenic replication-blocking lesions suppresses cancer but promotes cytotoxicity and lethality in nitrosamine-exposed mice. Cell Rep 34(11):108864. doi:10.1016/j.celrep.2021.108864 PMID:33730582
  • Owiti NA, Nagel Z, Engelward BP. 2021. Fluorescence sheds light on DNA damage, DNA repair, and mutations. Trends Cancer 7(3):240-248. doi:10.1016/j.trecan.2020.10.006 PMID:33203608 PMCID:PMC7889721

2020

  • Chao C, Engelward BP. 2020. Applications of CometChip for environmental health studies. Chem Res Toxicol 33:1528-1538. doi:10.1021/acs.chemrestox.9b00393 PMID:32519858
  • Chao C, Ngo LP, Engelward BP. 2020. SpheroidChip: patterned agarose microwell compartments harboring HepG2 spheroids are compatible with genotoxicity testing. ACS Biomater Sci Eng 6:2427-2439. doi:10.1021/acsbiomaterials.9b01951
  • Ngo LP, Owiti NA, Swartz C, Winters J, Su Y, Ge J, Xiong A, Han J, Recio L, Samson LD, Engelward BP. 2020. Sensitive CometChip assay for screening potentially carcinogenic DNA adducts by trapping DNA repair intermediates. Nucleic Acids Res 48(3):e13. doi:10.1093/nar/gkz1077 PMID:31822921 PMCID:PMC7026589

2019

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