Superfund Research Program
Bioinformatics and Molecular Modeling Core
Project Leader: Stefano Monti
Co-Investigator: Sandor Vajda
Grant Number: P42ES007381
Funding Period: 2000-2021
Project-Specific Links
Research Briefs
- 294 - New Method Quickly Screens Chemicals for Cancer Risk -- Monti
Release Date: 06/05/2019Boston University (BU) researchers, in collaboration with researchers at the National Toxicology Program (NTP) and the Broad Institute, have developed and evaluated a new approach to assess whether exposure to a chemical increases a person’s long-term cancer risk. The fast, cost-effective method uses gene expression profiling, which measures the activity of a thousand or more genes to capture what is happening in a cell. Based on gene expression profiling data, the researchers were able to infer specific biological changes at the cellular level and predict potential carcinogenicity of chemicals, or the ability of chemicals to cause cancer.