Superfund Research Program
Analytical Chemistry Core
Project Leader: Jun Yang
Co-Investigators: Bruce D. Hammock, Bruce A. Buchholz (Lawrence Livermore National Laboratory)
Grant Number: P42ES004699
Funding Period: 1995-2022
News Items List
Researchers Identify Compounds that Reduce Abnormal Blood Vessel Growth in the Eye
Research Brief - July 2018
Scientists have identified key compounds produced when the body metabolizes omega fatty acids that can reduce the severity of age-related macular degeneration (AMD) in mice. By increasing these lipid metabolites and preventing them from degrading, the researchers reduced abnormal blood vessel growth, in part by regulating the movement of inflammatory immune cells into the retina.
Enzyme plays key role in Parkinson's disease
Paper of the Month - July 2018
New research by NIEHS grantees and colleagues suggested an enzyme in the brain plays a key role in Parkinson's disease (PD). Scientists demonstrated that inhibiting the enzyme soluble epoxide hydrolase (sEH) in mice helped curb the inflammation associated with the development and progression of PD.
Enzyme plays key role in Parkinson's disease and inflammation
Environmental Factor - June 2018
New research partially funded by NIEHS suggests an enzyme in the brain plays a key role in Parkinson's disease (PD). Scientists demonstrated that inhibiting an enzyme known as soluble epoxide hydrolase (sEH) can help curb the inflammation associated with the development and progression of PD.
Possible explanation for male and female cardiovascular differences
Paper of the Month - March 2018
NIEHS grantees discovered that estrogen can block the function of soluble epoxide hydrolase (sEH), an enzyme in cells that degrades chemically stable fatty acid metabolites. Because inhibition of sEH can be cardioprotective, this finding may help explain why women generally have a lower incidence of cardiovascular disease than men.
FDA ban on antibacterials in soaps informed by SRP research
Environmental Factor - October 2016
The U.S. Food and Drug Administration (FDA) issued a rule Sept. 2 banning 19 antibacterial chemicals as ingredients in over-the-counter (OTC) antibacterial hand and body washes. Development of the final rule was informed by research that included several studies from scientists supported by the NIEHS Superfund Research Program (SRP).
Anti-inflammatory chemical may offer new tool for depression treatment
Paper of the Month - May 2016
An NIEHS grantee and colleagues discovered that a chemical inhibitor of the soluble epoxide hydrolase (sEH) enzyme may be a new tool to treat depression. The enzyme plays a key role in inflammation, which is involved in depression.
Hammock recognized with first McGiff Memorial Award
Environmental Factor - April 2016
NIEHS grantee Bruce Hammock, Ph.D., a toxicologist and entomologist at the University of California, Davis (UCD), is the first recipient of the John C. McGiff Memorial Award for Contributions to Eicosanoid Research.
Chemical Discovered at UC Davis May Be New Tool for Depression Therapy
SRP News Page - March 2016
A chemical discovered at the University of California (UC) Davis may be a new, innovative tool to control depression, a severe and chronic psychiatric disease that affects 350 million people worldwide.
UC Davis Researchers Find Key Mechanism that Causes Neuropathic Pain
SRP News Page - July 2015
Scientists at the University of California, Davis (UC Davis) have identified a key mechanism in neuropathic pain. The discovery could eventually benefit millions of patients with chronic pain from trauma, diabetes, shingles, multiple sclerosis, or other conditions that cause nerve damage.
Applying SRP Tools to Detect Environmental Contaminants in California
SRP News Page - August 2014
A Superfund Research Program (SRP) grantee presentation has shown how biochemical tests can be shared. University of California, Davis (UC Davis) SRP project leader Shirley Gee explained how the California Department of Toxic Substances Control (DTSC) can apply UC Davis immunoassay technologies to detect environmental chemicals.
SRP grantee receives prestigious Brodie Award
Environmental Factor - March 2014
Bruce Hammock, Ph.D., a longtime NIEHS Superfund Research Program (SRP) grantee, was honored by the American Society for Pharmacology and Experimental Therapeutics (ASPET) with the biennial Bernard B. Brodie Award in Drug Metabolism.
Research supported by NIEHS informs policy and regulatory discussion
Environmental Factor - February 2014
NIEHS-funded researchers found themselves at center stage in the national discussion concerning policy and regulatory issues related to environmental public health.