Superfund Research Program

Analytical Chemistry Core

Project Leader: Jun Yang
Co-Investigators: Bruce D. Hammock, Bruce A. Buchholz (Lawrence Livermore National Laboratory)
Grant Number: P42ES004699
Funding Period: 1995-2023

Project-Specific Links

News Items List

• Enzyme plays key role in Parkinson's disease
  Paper of the Month - July 2018
  New research by NIEHS grantees and colleagues suggested an enzyme in the brain plays a key role in Parkinson's disease (PD). Scientists demonstrated that inhibiting the enzyme soluble epoxide hydrolase (sEH) in mice helped curb the inflammation associated with the development and progression of PD.
  

• Enzyme plays key role in Parkinson's disease and inflammation
  Environmental Factor - June 2018
  New research partially funded by NIEHS suggests an enzyme in the brain plays a key role in Parkinson's disease (PD). Scientists demonstrated that inhibiting an enzyme known as soluble epoxide hydrolase (sEH) can help curb the inflammation associated with the development and progression of PD.
  

• Possible explanation for male and female cardiovascular differences
  Paper of the Month - March 2018
  NIEHS grantees discovered that estrogen can block the function of soluble epoxide hydrolase (sEH), an enzyme in cells that degrades chemically stable fatty acid metabolites. Because inhibition of sEH can be cardioprotective, this finding may help explain why women generally have a lower incidence of cardiovascular disease than men.