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Progress Reports: University of California-Davis: Analytical Chemistry Core

Superfund Research Program

Analytical Chemistry Core

Project Leader: Jun Yang
Co-Investigators: Bruce D. Hammock, Bruce A. Buchholz (Lawrence Livermore National Laboratory)
Grant Number: P42ES004699
Funding Period: 1995-2022
View this project in the NIH Research Portfolio Online Reporting Tools (RePORT)

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Progress Reports

Year:   2019  2018  2017  2016  2014  2013  2012  2011  2010  2009  2008  2007  2006  2005  2004 

The focus of University of California, Davis (UC Davis) Superfund Research Program (SRP) Center is on biomarkers of exposure to hazardous substances. As integral part of the UC Davis SRP Center, the Analytical Chemistry Core provides the analytical support to research Projects and Cores including developing analytical methods for biomarkers measurement; validating novel immunoassays (for the Immunoassays for Human and Environmental Health Monitoring Project) or biosensors (for the Field-Deployable Lab-on-a-Chip Nanosensing Platforms for Health and Environmental Monitoring Project) with the classical instrumentation methods; and providing metabolomics supports for the mechanistic Projects (Critical Role of Mitochondrial Oxidative Stress (MOS) in Chemical Induced Cardiac Toxicity and Monitoring Endoplasmic Reticulum Stress Caused by Chronic Exposure to Chemicals Projects). Last year, the Analytical Chemistry Core made significant achievements on most of the directions mentioned above. For example, working with researchers involved in the Immunoassays for Human and Environmental Health Monitoring project, the Core continued to improve the novel methods for fipronil detection (the toxic compound in European “egg scandal”) (Wang K 2019). On the metabolomics arm, Analytical Core researchers characterized the regiotempral changes in lipid mediators in rats intoxicated by an organic phosphate pesticide (diisopropylfluorophosphate) (Yang J 2019). This metabolomics approach monitoring lipid mediators-biomarkers for exposure of environmental toxicants could identify potential targets for treatment as shown in colon study (Wang W 2019). Based on the metabolomic profiles, preoperative stimulation of some lipid mediators eliminated micrometastases and reduced tumor recurrence (Panigraphy 2019). All of the Core’s achievements greatly helped the UC Davis SRP Center reach its goals by identifying and quantifying biomarkers of exposure to various hazardous substances.

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