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University of California-Davis

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Superfund Research Program

Analytical Chemistry

Project Leader: Bruce D. Hammock
Grant Number: P42ES004699
Funding Period: 1995-2023

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Project Summary (2000-2005)

The Analytical Core is a central resource designed to facilitate the development and application of powerful analytical methods to solve key problems encountered by the components of the UC Davis Superfund Program. The goals of the Analytical Core are to facilitate research and develop analytical technologies that address the detection, assessment, evaluation and reduction of hazardous chemical exposure and the associated population health risks. There are three specific aims. Aim (1): Provide analytical support in chromatographic and spectroscopic techniques including enhanced development of biomarkers of chemical exposure through application of immunoaffinity purification and development of HPLC/MS/MS driven multi-dimensional metabolite profiling. Aim (2): Provide high sensitivity analysis of hazardous substances using Accelerator Mass Spectroscopy (AMS) and Nuclear Microscopy. Core personnel are using the attomole (i.e. 10-18) sensitivity of AMS to improve the analyses of risks to human health due to hazardous chemicals in the environment. Chemicals labeled with low levels of 14C, 36Cl, and other long-lived isotopes will be traced quantitatively through ecosystems, animal models, and humans. Nuclear Microprobe analyses is being used to quantify the location, distribution, and amount of heavy metals from the environment on filters or tissues that can similarly lead to diseased states. Aim (3): Provide support in peptide chemistry including gas phase sequencing and LC-MS analysis of peptides to address questions of protein identity and modification associated with hazardous chemical exposure.

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