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Your Environment. Your Health.

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Superfund Research Program

Analytical Chemistry Core

Project Leader: Jun Yang
Co-Investigators: Bruce D. Hammock, Bruce A. Buchholz (Lawrence Livermore National Laboratory)
Grant Number: P42ES004699
Funding Period: 1995-2023
View this project in the NIH Research Portfolio Online Reporting Tools (RePORT)

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  • Atone J, Wagner KM, Koike S, Yang J, Hwang SH, Hammock BD. 2023. Inhibition of soluble epoxide hydrolase reduces paraquat neurotoxicity in rodents. Environ Toxicol Pharmacol 98:104070. doi:10.1016/j.etap.2023.104070 PMID:36682504 PMCID:PMC9992278
  • Thai PN, Ren L, Xu W, Overton J, Timofeyev V, Nader CE, Haddad MJ, Yang J, Gomes AV, Hammock BD, Chiamvimonvat N, Sirish P. 2023. Chronic diclofenac exposure increases mitochondrial oxidative stress, inflammatory mediators, and cardiac dysfunction. Cardiovasc Drugs Ther 37(1):25-37. doi:10.1007/s10557-021-07253-4 PMID:34499283 PMCID:PMC8904649
  • Wang W, Wagner KM, Wagner YM, Singh N, Yang J, He Q, Morisseau C, Hammock BD. 2023. Soluble epoxide hydrolase contributes to cell senescence and ER stress in aging mice colon. Int J Mol Sci 24(5):4570. doi:10.3390/ijms24054570 PMID:36901999 PMCID:PMC1000356
  • Wang Y, Morisseau C, Takamura A, Wan D, Li D, Sidoli S, Yang J, Wolan DW, Hammock BD, Kitamura S. 2023. PROTAC-mediated selective degradation of cytosolic soluble epoxide hydrolase enhances ER stress reduction. ACS Chem Biol doi:10.1021/acschembio.3c00017 PMID:36947831


  • Gowler PR, Turnbull J, Shahtaheri M, Gohir S, Kelly T, McReynolds C, Yang J, Jha RR, Fernandes GS, Zhang W, Doherty M, Walsh DA, Hammock BD, Valdes AM, Barrett DA, Chapman V. 2022. Clinical and preclinical evidence for roles of soluble epoxide hydrolase in osteoarthritis knee pain. Arthritis Rheumatol 74(4):doi:10.1002/art.42000 PMID:34672113 PMCID:PMC8957539
  • Nguyen N, Morisseau C, Li D, Yang J, Lam E, Woodside DB, Hammock BD, Shih P. 2022. Soluble epoxide hydrolase is associated with postprandial anxiety decrease in healthy adult women. Int J Mol Sci 23(19):11798. doi:10.3390/ijms231911798 PMID:36233100 PMCID:PMC9569757
  • Wan D, Morisseau C, Hammock BD, Yang J. 2022. A fast and selective approach for profiling vicinal diols using liquid chromatography-post column derivatization-double precursor ion scanning mass spectrometry. Molecules 27(1):283. doi:10.3390/molecules27010283 PMID:35011515 PMCID:PMC8747065
  • Xu J, Qiu X, Yu G, Ly M, Yang J, Silva RM, Zhang X, Yu M, Wang Y, Hammock BD, Pinkerton KE, Zhao D. 2022. Soluble epoxide hydrolase inhibitor can protect the femoral head against tobacco smoke exposure-induced osteonecrosis in spontaneously hypertensive rats. Toxicology 465(15):doi:10.1016/j.tox.2021.153045 PMID:34801612
  • Zhang C, Li W, Li X, Wan D, Mack S, Zhang J, Wagner KM, Wang C, Tan B, Chen J, Wu C, Tsuji K, Takeuchi M, Chen Z, Hammock BD, Pinkerton KE, Yang J. 2022. Novel aerosol treatment of airway hyper-reactivity and inflammation in a murine model of asthma with a soluble epoxide hydrolase inhibitor. PLoS One 17(4):doi:10.1371/journal.pone.0266608 PMID:35443010 PMCID:PMC9020733



  • An G, Lee K, Yang J, Hammock BD. 2020. Target-Mediated Drug Disposition-A Class Effect of Soluble Epoxide Hydrolase Inhibitors. J Clin Pharmacol doi:10.1002/jcph.1763 PMID:33078430 PMCID:PMC7969377
  • El-Moghazy AY, Huo J, Amaly N, Vasylieva N, Hammock BD, Sun G. 2020. An innovative nanobody-based electrochemical immunosensor using decorated nylon nanofibers for point-of-care monitoring of human exposure to pyrethroid insecticides. ACS Appl Mater Interfaces 12:6159-6168. doi:10.1021/acsami.9b16193
  • Huerta-Yepez S, Tirado-Rodriguez A, Montecillo-Aguado M, Yang J, Hammock BD, Hankinson O. 2020. Aryl Hydrocarbon Receptor-Dependent inductions of omega-3 and omega-6 polyunsaturated fatty acid metabolism act inversely on tumor progression. Sci Rep 10:17. doi:10.1038/s41598-020-64146-6 PMID:32398692 PMCID:PMC7217871
  • Liu G, Wu F, Jiang X, Que Y, Qin Z, Hu P, Lee K, Yang J, Zeng C, Hammock BD, Tong X. 2020. Inactivation of SERCA2 cysteine 674 increases blood pressure by induction of endoplasmic reticulum stress and soluble epoxide hydrolase. Br J Pharmacol 177(8):1793-1805. doi:10.1111/bph.14937
  • Matin N, Fisher C, Lansdell TA, Hammock BD, Yang J, Jackson WF, Dorrance AM. 2020. Soluble epoxide hydrolase inhibition improves cognitive function and parenchymal artery dilation in a hypertensive model of chronic cerebral hypoperfusion. Microcirculation 11:doi:10.1111/micc.12653 PMID:32767848 PMCID:PMC7990111
  • Overby HB, Yang Y, Xu X, Graham K, Hildreth K, Choi S, Wan D, Morisseau C, Zeldin DC, Hammock BD, Wang S, Bettaieb A, Zhao L. 2020. Soluble Epoxide Hydrolase Inhibition by t-TUCB Promotes Brown Adipogenesis and Reduces Serum Triglycerides in Diet-Induced Obesity. Int J Mol Sci 21:doi:10.3390/ijms21197039 PMID:32987880 PMCID:PMC7582898
  • Spath J, Nording M, Lindberg R, Brodin T, Jansson S, Yang J, Wan D, Hammock BD, Fick J. 2020. Novel metabolomic method to assess the effect-based removal efficiency of advanced wastewater treatment techniques. Environ Chem 17:1-5. doi:10.1071/en19270
  • Wagner KM, Atone J, Hammock BD. 2020. Soluble epoxide hydrolase inhibitor mediated analgesia lacks tolerance in rat models. Brain Res 1728:doi:10.1016/j.brainres.2019.146573 PMID:31790682 PMCID:PMC6996511
  • Wang Y, Yang J, Wang W, Sanidad KZ, Cinelli MA, Wan D, Hee-Hwang S, Kim D, Lee KS, Xiao H, Hammock BD, Zhang G. 2020. Soluble epoxide hydrolase is an endogenous regulator of obesity-induced intestinal barrier dysfunction and bacterial translocation. Proc Natl Acad Sci U S A 117:8431-8436. doi:10.1073/pnas.1916189117 PMID:32220957 PMCID:PMC7165420
  • Wu N, Hammock BD, Lee KS, An G. 2020. Simultaneous target-mediated drug disposition model for two small-molecule compounds competing for their pharmacological target: Soluble epoxide hydrolase. J Pharmacol Exp Ther 374:223-232. doi:10.1124/jpet.120.265330 PMID:32238455 PMCID:PMC7318792
  • Xie M, Yang J, Zhang J, Sherman HL, Zhang Z, Minter LM, Hammock BD, Park Y, Zhang G. 2020. Effects of linoleic acid-rich diet on plasma profiles of eicosanoids and development of colitis in Il-10(-/-) mice. J Agric Food Chem 68:7641-7647. doi:10.1021/acs.jafc.0c03024 PMID:32594738


  • Burmistrov V, Morisseau C, DYachenko V, Rybakov V, Butov GM, Hammock BD. 2019. Fluoroaromatic fragments on 1,3-disubstituted ureas enhance soluble epoxide hydrolase inhibition. J Fluor Chem 220:48-53. doi:10.1016/j.jfluchem.2019.02.005 PMID:32132741 PMCID:PMC7055688
  • Codony S, Valverde E, Leiva R, Brea J, Loza I, Morisseau C, Hammock BD, Vazquez S. 2019. Exploring the size of the lipophilic unit of the soluble epoxide hydrolase inhibitors. Bioorg Med Chem 27(20):115078. doi:10.1016/j.bmc.2019.115078 PMID:31488357 PMCID:PMC6892585
  • de Oliveira GS, Adriani PP, Ribeiro JA, Morisseau C, Hammock BD, Dias MV, Chambergo FS. 2019. The molecular structure of an epoxide hydrolase from trichoderma reesei in complex with urea or amide-based inhibitors. Int J Biol Macromol 129:653-658. doi:10.1016/j.ijbiomac.2019.02.070 PMID:30771398 PMCID:PMC6447457
  • Deol P, Yang J, Morisseau C, Hammock BD, Sladek FM. 2019. Dimethyl sulfoxide decreases levels of oxylipin diols in mouse liver. Front Pharmacol 10:580. doi:10.3389/fphar.2019.00580 PMID:31191316 PMCID:PMC6548860
  • Dileepan M, Rastle-Simpson S, Greenberg Y, Wijesinghe D, Kumar N, Yang J, Hwang SH, Hammock BD, Sriramarao P, Rao S. 2019. Effect Of Dual sEH/COX-2 Inhibition on Allergen-Induced Airway Inflammation. Front Pharmacol 10:1118. doi:10.3389/fphar.2019.01118 PMID:31611798 PMCID:PMC6777353
  • Ding Y, Hua X, Chen H, Gonazlez-Sapienza GG, Barnych B, Liu F, Wang M, Hammock BD. 2019. A dual signal immunochromatographic strip for the detection of imidaclothiz using a recombinant fluorescent-peptide tracer and gold nanoparticles. Sens Actuators B Chem 297:7. doi:10.1016/j.snb.2019.126714
  • Duflot T, Moreau-Grange L, Roche C, Lacob M, Wils J, Remy-Jouet I, Cailleux A, Leuillier M, Renet S, Li D, Morisseau C, Lamoureux F, Richard V, Prevost G, Joannides R, Bellien J. 2019. Altered bioavailability of epoxyeicosatrienoic acids is associated with conduit artery endothelial dysfunction in type 2 diabetic patients. Cardiovasc Diabetol 18:35. doi:10.1186/s12933-019-0843-z PMID:30885203 PMCID:PMC6423843
  • Gartung A, Yang J, Sukhatme VP, Bielenberg DR, Fernandes D, Chang J, Schmidt BA, Hee-Hwang S, Zurakowski D, Huang S, Kieran MW, Hammock BD, Panigrahy D. 2019. Suppression of chemotherapy-induced cytokine/lipid mediator surge and ovarian cancer by a dual COX-2/sEH inhibitor. Proc Natl Acad Sci U S A 116:1698-1703. doi:10.1073/pnas.1803999116 PMID:30647111 PMCID:PMC6358686
  • He J, Tao X, Wang K, Ding G, Li J, Li QX, Gee SJ, Hammock BD, Xu T. 2019. One-step immunoassay for the insecticide carbaryl using a chicken single-chain variable fragment (scFv) fused to alkaline phosphatase. Anal Biochem 572:9-15. doi:10.1016/j.ab.2019.02.022 PMID:30831096
  • Hiesinger K, Kramer JS, Achenbach J, Moser D, Weber J, Wittmann SK, Morisseau C, Angioni C, Geisslinger G, Kahnt AS, Kaiser A, Proschak A, Steinhilber D, Pogoryelov D, Wagner KM, Hammock BD, Proschak E. 2019. Computer-aided selective optimization of side activities of talinolol. ACS Med Chem Lett 10(6):899-903. doi:10.1021/acsmedchemlett.9b00075 PMID:31223445 PMCID:PMC6580380
  • Hongsibsong S, Prapamontol T, Dong J, Bever C, Xu Z, Gee SJ, Hammock BD. 2019. Exposure of consumers and farmers to organophosphate and synthetic pyrethroid insecticides in Northern Thailand. J Verbrauch Lebensm 14(1):17-23. doi:10.1007/s00003-019-01207-7
  • Hrdlicka J, Neckar J, Papousek F, Huskova Z, Kikerlova S, Vanourkova Z, Vernerova Z, Akat F, Vasinova J, Hammock BD, Hwang SH, Imig JD, Falck JR, Cervenka L, Kolar F. 2019. Epoxyeicosatrienoic acid-based therapy attenuates the progression of postischemic heart failure in normotensive Sprague-Dawley but not in hypertensive Ren-2 transgenic rats. Front Pharmacol 10:12. doi:10.3389/fphar.2019.00159 PMID:30881303 PMCID:PMC6406051
  • Huo J, Barnych B, Li Z, Wan D, Li D, Vasylieva N, Knezevic SZ, Osipitan OA, Scott JE, Zhang J, Hammock BD. 2019. Hapten synthesis, antibody development, and a highly sensitive indirect competitive chemiluminescent enzyme immunoassay for detection of dicamba. J Agric Food Chem 67:5711-5719. doi:10.1021/acs.jafc.8b07134 PMID:31042038 PMCID:PMC6873229
  • Hye Khan A, Kolb L, Skibba M, Yeboah MM, Chesnik MA, Hwang SH, Hammock BD, Imig JD. 2019. A novel dual soluble epoxide hydrolase inhibitor/cyclooxygenase-2 inhibitor treats Type 2 Diabetic complications in complications in obese ZSF1 rats. FASEB J 33:
  • Klocke J, Ulu A, Wu K, Rudolph B, Dragun D, Gollasch M, Schunck W, Hammock BD, Riemekasten G, Enghard P. 2019. Prophylactic inhibition of soluble epoxide hydrolase delays onset of nephritis and ameliorates kidney damage in NZB/W F1 mice. Sci Rep 9(1):8993. doi:10.1038/s41598-019-45299-5 PMID:31222024 PMCID:PMC6586931
  • Kodani SD, Morisseau C. 2019. Role of epoxy-fatty acids and epoxide hydrolases in the pathology of neuro-inflammation. Biochimie 159:59-65. doi:10.1016/j.biochi.2019.01.020 PMID:30716359 PMCID:PMC6431267
  • Lee KS, Yang J, Niu J, Ng CJ, Wagner KM, Dong H, Kodani SD, Wan D, Morisseau C, Hammock BD. 2019. Drug-target residence time affects in vivo target occupancy through multiple pathways. ACS Cent Sci 5:1614-1624. doi:10.1021/acscentsci.9b00770 PMID:31572788 PMCID:PMC6764161
  • Li Q, Kailemia M, Merleev A, Xu G, Serie D, Danan L, Haj FG, Maverakis E, Lebrilla CB. 2019. Site-Specific Glycosylation Quantitation of 50 Serum Glycoproteins Enhanced by Predictive Glycopeptidomics for Improved Disease Biomarker Discovery. Anal Chem 91:5433-5445. doi:10.1021/acs.analchem.9b00776
  • Liang Z, Zhang B, Xu M, Morisseau C, Hwang SH, Hammock BD, Li QX. 2019. 1-Trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea, a selective and potent dual inhibitor of soluble epoxide hydrolase and p38 kinase intervenes in Alzheimer's signaling in human nerve cells. ACS Chem Neurosci 10:4018-4030. doi:10.1021/acschemneuro.9b00271 PMID:31378059 PMCID:PMC7028313
  • Liu Z, Wang K, Wang Z, Ding G, Hao X, Li QX, Li J, Gee SJ, Hammock BD, Xu T. 2019. Development of an immunoassay for the detection of carbaryl in cereals based on a camelid variable heavy-chain antibody domain. Journal of the Science of Food and Agriculture 99(9):4383-4390. doi:10.1002/jsfa.9672 PMID:30851058 PMCID:PMC7061733
  • Luo L, Wei X, Jia B, Yang J, Shen Y, Hammock BD, Dong J, Wang H, Lei H, Xu Z. 2019. Modulating linker composition of haptens resulted in improved immunoassay for histamine. Biomolecules 9:10. doi:10.3390/biom9100597 PMID:31614550 PMCID:PMC6843301
  • Luo Y, Wu M, Deng B, Huang J, Hwang SH, Li M, Zhou C, Zhang Q, Yu H, Zhao D, Zhang G, Qin L, Peng A, Hammock BD, Liu J. 2019. Inhibition of soluble epoxide hydrolase attenuates a high-fat diet-mediated renal injury by activating PAX2 and AMPK. Proc Natl Acad Sci U S A 116(11):5154-5159. doi:10.1073/pnas.1815746116 PMID:30804206 PMCID:PMC6421466
  • Ma M, Ren Q, Yang J, Zhang K, Xiong Z, Ishima T, Pu Y, Hwang SH, Toyoshima M, Iwayama Y, Hisano Y, Yoshikawa T, Hammock BD, Hashimoto K. 2019. Key role of soluble epoxide hydrolase in the neurodevelopmental disorders of offspring after maternal immune activation. Proc Natl Acad Sci U S A 116(14):7083-7088. doi:10.1073/pnas.1819234116 PMID:30890645 PMCID:PMC6452650
  • McReynolds C, Hee-Hwang S, Yang J, Wan D, Wagner KM, Morisseau C, Li D, Schmidt WK, Hammock BD. 2019. Pharmaceutical effects of inhibiting the soluble epoxide hydrolase in canine osteoarthritis. Front Pharmacol 10:12. doi:10.3389/fphar.2019.00533 PMID:31214021 PMCID:PMC6554663
  • Minaz N, Razdan R, Hammock BD, Mujwar S, Goswami SK. 2019. Impact of diabetes on male sexual function in streptozotocin-induced diabetic rats: Protective role of soluble epoxide hydrolase inhibitor. Biomed Pharmacother 115:108897. doi:10.1016/j.biopha.2019.108897 PMID:31102913 PMCID:PMC6893866
  • Mishra M, Tiwari S, Gunaseelan A, Li D, Hammock BD, Gomes AV. 2019. Improving the sensitivity of traditional Western blotting via Streptavidin containing Poly-horseradish peroxidase (PolyHRP). Electrophoresis 40:1731-1739. doi:10.1002/elps.201900059 PMID:31021001 PMCID:PMC7036291
  • Otoki Y, Metherel AH, Pedersen TL, Yang J, Hammock BD, Bazinet RP, Newman JW, Taha AY. 2019. Acute hypercapnia/ischemia alters the esterification of arachidonic acid and docosahexaenoic acid epoxide metabolites in rat brain neutral lipids. Lipids 55(1):7-22. doi:10.1002/lipd.12197
  • Panigrahy D, Gartung A, Yang J, Yang H, Gilligan MM, Sulciner ML, Bhasin SS, Bielenberg DR, Chang J, Schmidt BA, Piwowarski J, Fishbein A, Soler-Ferran D, Sparks MA, Staffa SJ, Sukhatme V, Hammock BD, Kieran MW, Huang S, Bhasin M, Serhan CN, Sukhatme VP. 2019. Preoperative stimulation of resolution and inflammation blockade eradicates micrometastases. J Clin Invest 129(7):2964-2979. doi:10.1172/JCI127282 PMID:31205032 PMCID:PMC6597207
  • Pardeshi R, Bolshette N, Gadhave K, Arfeen M, Ahmed S, Jamwal R, Hammock BD, Lahkar M, Goswami SK. 2019. Docosahexaenoic Acid Increases the Potency of Soluble Epoxide Hydrolase Inhibitor in Alleviating Streptozotocin-Induced Alzheimers Disease-Like Complications of Diabetes. Front Pharmacol 10:288. doi:10.3389/fphar.2019.00288 PMID:31068802 PMCID:PMC6491817
  • Qiu Y, Li P, Liu B, Liu Y, Wang Y, Tao T, Xu J, Hammock BD, Liu X, Guan R, Zhang C. 2019. Phage-displayed nanobody based double antibody sandwich chemiluminescent immunoassay for the detection of Cry2A toxin in cereals. Food Agric Immunol 30:924-936. doi:10.1080/09540105.2019.1642307
  • Ren W, Li Z, Xu Y, Wan D, Barnych B, Li Y, Tu Z, He Q, Fu J, Hammock BD. 2019. One-Step Ultrasensitive Bioluminescent Enzyme Immunoassay Based on Nanobody/Nanoluciferase Fusion for Detection of Aflatoxin B1 in Cereal. J Agric Food Chem 67:5221-5229. doi:10.1021/acs.jafc.9b00688
  • Riangrungroj P, Bever C, Hammock BD, Polizzi K. 2019. A label-free optical whole-cell Escherichia coli biosensor for the detection of pyrethroid insecticide exposure. Sci Rep doi:10.1038/s41598-019-48907-6 PMID:31462650 PMCID:PMC6713742
  • Sander H, Wallace S, Plouse R, Tiwari S, Gomes AV. 2019. Ponceau S waste: Ponceau S staining for total protein normalization. Anal Biochem 575:44-53. doi:10.1016/j.ab.2019.03.010 PMID:30914243 PMCID:PMC6954006
  • Shen Y, Peng W, Chen Q, Hammock BD, Liu J, Li D, Yang J, Ding J, Wang X. 2019. Anti-inflammatory treatment with a soluble epoxide hydrolase inhibitor attenuates seizures and epilepsy-associated depression in the LiCl-pilocarpine post-status epilepticus rat model. Brain Behav Immun 81:535-544. doi:10.1016/j.bbi.2019.07.014 PMID:31306773 PMCID:PMC6873816
  • Shin H, Moschet C, Young TM, Bennett DH. 2019. Measured concentrations of consumer product chemicals in California house dust: Implications for sources, exposure, and toxicity potential. Indoor Air 30(1):60-75. doi:10.1111/ina.12607 PMID:31587372 PMCID:PMC6917863
  • Tang Z, Liu X, Wang Y, Chen Q, Hammock BD, Xu Y. 2019. Nanobody-based fluorescence resonance energy transfer immunoassay for noncompetitive and simultaneous detection of ochratoxin a and ochratoxin B. Environ Pollut 251:238-245. doi:10.1016/j.envpol.2019.04.135
  • Truong KM, Pessah IN. 2019. Comparison of chlorantraniliprole and flubendiamide activity toward wild-type and malignant hyperthermia-susceptible ryanodine receptors and heat stress intolerance. Toxicol Sci 167(2):509-523. doi:10.1093/toxsci/kfy256 PMID:30329129 PMCID:PMC6358238
  • Vackova S, Kopkan L, Kikerlova S, Huskova Z, Sadowski J, Kompanowska-Jezierska E, Hammock BD, Imig JD, Taborsky M, Melenovsky V, Cervenka L. 2019. Pharmacological blockade of soluble epoxide hydrolase attenuates the progression of congestive heart failure combined with chronic kidney disease: insights from studies with fawn-hooded hypertensive rats. Front Pharmacol 10:16. doi:10.3389/fphar.2019.00018 PMID:30728778 PMCID:PMC6351500
  • Vasquez S, Codony S, Pizarro J, Loza MI, Brea J, Morisseau C, Hammock BD, Vasquez-Carrera M. 2019. Synthesis of a new family soluble epoxid hydrolase inhibitors, in vitro profiling and in vivo evaluation in a murine model of acute pancreatitis. FASEB J 33:
  • Vasylieva N, Kitamura S, Dong J, Barnych B, Hvorecny KL, Madden DR, Gee SJ, Wolan DW, Morisseau C, Hammock BD. 2019. Nanobody-based binding assay for the discovery of potent inhibitors of CFTR inhibitory factor (Cif). Anal Chim Acta 1057:106-113. doi:10.1016/j.aca.2018.12.060 PMID:30832908 PMCID:PMC6426448
  • Wan D, Yang J, McReynolds C, Barnych B, Wagner KM, Morisseau C, Hee-Hwang S, Sun J, Blocher R, Hammock BD. 2019. In vitro and in vivo metabolism of a potent inhibitor of soluble epoxide hydrolase, 1-(1-Propionylpiperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea. Front Pharmacol 10:464. doi:10.3389/fphar.2019.00464 PMID:31143115 PMCID:PMC6520522
  • Wang K, Liu Z, Ding G, Li J, Vasylieva N, Li QX, Li D, Gee SJ, Hammock BD, Xu T. 2019. Development of a one-step immunoassay for triazophos using camel single-domain antibody-alkaline phosphatase fusion protein. Anal Bioanal Chem 411(6):1287-1295. doi:10.1007/s00216-018-01563-7
  • Wang K, Vasylieva N, Wan D, Eads DA, Yang J, Tretten T, Barnych B, Li J, Li QX, Gee SJ, Hammock BD, Xu T. 2019. Quantitative detection of fipronil and fipronil-sulfone in sera of black-tailed prairie dogs and rats after oral exposure to fipronil by camel single-domain antibody-based immunoassays. Anal Chem 91:1532-1540. doi:10.1021/acs.analchem.8b04653
  • Wang W, Yang J, Edin ML, Wang Y, Luo Y, Wan D, Yang H, Song C, Xue W, Sanidad KZ, Song M, Bisbee HA, Bradbury JA, Nan G, Zhang J, Shih P, Sing K, Lee S, Minter LM, Kim D, Xiao H, Liu J, Hammock BD, Zeldin DC, Zhang G. 2019. Targeted Metabolomics identifies the cytochrome P450 monooxygenase eicosanoid pathway as a novel therapeutic target of colon tumorigenesis. Cancer Res 79:1822-1830. doi:10.1158/0008-5472.CAN-18-3221 PMID:30803995 PMCID:PMC6467714
  • Wang Y, Li Z, Barnych B, Huo J, Wan D, Vasylieva N, Xu J, Li P, Liu B, Zhang C, Hammock BD. 2019. Investigation of the small size of nanobodies for a sensitive fluorescence polarization immunoassay for small molecules: 3-phenoxybenzoic acid, an exposure biomarker of pyrethroid insecticides as a model. J Agric Food Chem 67(41):11536-11541. doi:10.1021/acs.jafc.9b04621
  • Wang Y, Xu J, Qiu Y, Li P, Liu B, Yang L, Barnych B, Hammock BD, Zhang C. 2019. Highly specific monoclonal antibody and sensitive quantum dot beads-based fluorescence immunochromatographic test strip for tebuconazole assay in agricultural products. J Agric Food Chem 67:9096-9103. doi:10.1021/acs.jafc.9b02832 PMID:31356079 PMCID:PMC7069222
  • Xia R, Sun L, Liao J, Li H, You X, Xu D, Yang J, Hee-Hwang S, Jones R, Hammock BD, Yang G. 2019. Inhibition of Pancreatic Carcinoma Growth Through Enhancing omega-3 Epoxy Polyunsaturated Fatty Acid Profile by Inhibition of Soluble Epoxide Hydrolase. Anticancer Res 39(7):3651-3660. doi:10.21873/anticanres.13513
  • Yang J, Bruun DA, Wang C, Wan D, McReynolds C, Phu K, Inceoglu B, Lein PJ, Hammock BD. 2019. Lipidomes of brain from rats acutely intoxicated with diisopropylfluorophosphate identifies potential therapeutic targets. Toxicol Appl Pharmacol 382:114749. doi:10.1016/j.taap.2019.114749 PMID:31521729 PMCID:PMC6957308
  • Yu Y, Tang P, Barnych B, Zhao C, Sun G, Ge M. 2019. Design and synthesis of core-shell carbon polymer dots with highly stable fluorescence in polymeric materials. ACS Appl Nano Mater 2:6503-6512. doi:10.1021/acsanm.9b01446
  • Zarriello S, Tuazon JP, Corey S, Schimmel S, Rajani M, Gorsky A, Incontri D, Hammock BD, Borlongan CV. 2019. Humble beginnings with big goals: small molecule soluble epoxide hydrolase inhibitors for treating CNS disorders. Prog Neurobiol 172:23-39. doi:10.1016/j.pneurobio.2018.11.001 PMID:30447256 PMCID:PMC6993804
  • Zhu M, Wang L, Wu X, Na R, Wang Y, Li QX, Hammock BD. 2019. A novel and simple imidazo[1,2-a]pyridin fluorescent probe for the sensitive and selective imaging of cysteine in living cells and zebrafish. Anal Chim Acta 1058:155-165. doi:10.1016/j.aca.2019.01.023


  • Burmistrov V, Morisseau C, Harris TR, Butov GM, Hammock BD. 2018. Effects of adamantane alterations on soluble epoxide hydrolase inhibition potency, physical properties and metabolic stability. Bioorg Chem 76:510-527. doi:10.1016/j.bioorg.2017.12.024 PMID:29310082 PMCID:PMC5837815
  • Burmistrov V, Morisseau C, Pitushkin D, Karlov D, Fayzullin RR, Butov GM, Hammock BD. 2018. Adamantyl thioureas as soluble epoxide hydrolase inhibitors. Bioorg Med Chem Lett 28:2302-2313. doi:10.1016/j.bmcl.2018.05.024 PMID:29803731
  • Cam M, Durieu E, Bodin M, Manousopoulou A, Koslowski S, Vasylieva N, Barnych B, Hammock BD, Bohl B, Koch P, Omori C, Yamamoto K, Hata S, Suzuki T, Karg F, Gizzi P, Haber V, Mihaljevic VB, Tavcar B, Portelius E, Pannee J, Blennow K, Zetterberg H, Garbis SD, Auvray P, Gerber H, Fraering J, Fraering PC, Meijer L. 2018. Induction of amyloid-beta(42) production by fipronil and other pyrazole insecticides. Journal of Alzheimers Disease 62:1663-1681. doi:10.3233/jad-170875 PMID:29504531
  • Chabova VC, Kujal P, Skaroupkova P, Varnourkova Z, Vackova S, Huskova Z, Kikerlova S, Sadowski J, Kompanowska-Jezierska E, Baranowska I, Hwang SH, Hammock BD, Imig JD, Tesar V, Cervenka L. 2018. Combined inhibition of soluble epoxide hydrolase and renin-angiotensin system exhibits superior renoprotection to renin-angiotensin system blockade in 5/6 nephrectomized Ren-2 transgenic hypertensive rats with established chronic kidney disease. Kidney Blood Press Res 43:329-349. doi:10.1159/000487902 PMID:29529602 PMCID:PMC5985203
  • Chen H, Yang Q, Ding Y, Vasylieva N, Bever C, Hua X, Wang M, Hammock BD. 2018. Competitive and noncompetitive immunoassays for the detection of benzothiostrobin using magnetic nanoparticles and fluorescein isothiocyanate-labeled peptides. Anal Bioanal Chem 1-99. doi:10.1007/s00216-018-1478-8 PMID:30478514
  • Cinelli MA, Yang J, Scharmen A, Woodman J, Karchalla LM, Lee KS. 2018. Enzymatic synthesis and chemical inversion provide both enantiomers of bioactive epoxydocosapentaenoic acids. J Lipid Res 59:2237-2252. doi:10.1194/jlr.D089136 PMID:30209076 PMCID:PMC6210906
  • Cui X, He Q, Shen D, Jiang Z, Chen Y, Zhao S, Hammock BD. 2018. Production and characterization of a single-chain variable fragment-alkaline phosphatase fusion protein for glycocholic acid detection in a one-step enzyme-linked immunosorbent assay. Analytical Methods 10:2629-2635. doi:10.1039/c8ay00848e
  • de Oliveira GS, Adriani PP, Wu H, Morisseau C, Hammock BD, Chambergo FS. 2018. Substrate and inhibitor selectivity, and biological activity of an epoxide hydrolase from Trichoderma reesei. Molecular Biology Reports 46(1):371-9. doi:10.1007/s11033-018-4481-4 PMID:30426381 PMCID:PMC6426676
  • Guedes AP, Aristizabal F, Sole A, Adedeji A, Brosnan R, Knych H, Yang J, Hee-Hwang S, Morisseau C, Hammock BD. 2018. Pharmacokinetics and antinociceptive effects of the soluble epoxide hydrolase inhibitor t-TUCB in horses with experimentally induced radiocarpal synovitis. J Vet Pharmacol Ther 41:230-238. doi:10.1111/jvp.12463 PMID:29067696
  • Harris TR, Kodani SD, Rand AA, Yang J, Imai DM, Hwang SH, Hammock BD. 2018. Celecoxib does not protect against fibrosis and inflammation in a carbon tetrachloride-induced model of liver injury. Mol Pharmacol 94:834-841. doi:10.1124/mol.118.111831 PMID:29844231 PMCID:PMC6022802
  • He J, Tian J, Xu J, Wang K, Li J, Gee SJ, Hammock BD, Li QX, Xu T. 2018. Strong and oriented conjugation of nanobodies onto magnetosomes for the development of a rapid immunomagnetic assay for the environmental detection of tetrabromobisphenol-A. Anal Bioanal Chem 410(25):6633-6642. doi:10.1007/s00216-018-1270-9 PMID:30066195
  • Hennebelle M, Metherel AH, Kitson AP, Otoki Y, Yang J, Lee KS, Hammock BD, Bazinet RP, Taha AY. 2018. Brain oxylipin concentrations following hypercapnia/ischemia: effects of brain dissection and dissection time. J Lipid Res 60:671-682. doi:10.1194/jlr.D084228 PMID:30463986 PMCID:PMC6399504
  • Huo J, Li Z, Wan D, Li D, Qi M, Barnych B, Vasylieva N, Zhang J, Hammock BD. 2018. Development of a highly sensitive direct competitive fluorescence enzyme immunoassay based on a nanobody-alkaline phosphatase fusion protein for detection of 3-phenoxybenzoic acid in urine. J Agric Food Chem 66:11284-11290. doi:10.1021/acs.jafc.8b04521 PMID:30293433
  • Jeon J, Uthaman S, Lee J, Hwang H, Kim G, Yoo PJ, Hammock BD, Kim CS, Park Y, Park I. 2018. In-direct localized surface plasmon resonance (LSPR)-based nanosensors for highly sensitive and rapid detection of cortisol. Sens Actuators B Chem 266:710-716. doi:10.1016/j.snb.2018.03.167
  • Kala P, Sedlakova L, Skaroupkova P, Kopkan L, Vanourkova Z, Taborsky M, Nishiyama A, Hwang SH, Hammock BD, Sadowski J, Melenovsky V, Imig JD, Cervenka L. 2018. Effect of angiotensin-converting enzyme blockade, alone or combined with blockade of soluble epoxide hydrolase, on the course of congestive heart failure and occurrence of renal dysfunction in ren-2 transgenic hypertensive rats with aorto-caval fistula. Physiol Res 67:401-415. PMID:29527914 PMCID:PMC6056335
  • Kodani SD, Bhakta S, Hee-Hwang S, Pakhomova S, Newcomer ME, Morisseau C, Hammock BD. 2018. Identification and optimization of soluble epoxide hydrolase inhibitors with dual potency towards fatty acid amide hydrolase. Bioorg Med Chem 28:762-768. doi:10.1016/j.bmcl.2018.01.003 PMID:29366648 PMCID:PMC5837813
  • Kodani SD, Wan D, Wagner KM, Hwang SH, Morisseau C, Hammock BD. 2018. Design and potency of dual soluble epoxide hydrolase/fatty acid amide hydrolase inhibitors. ACS Omega 3(10):14076-14086. doi:10.1021/acsomega.8b01625 PMID:30411058 PMCID:PMC6210075
  • Lakkappa N, Krishnamurthy PT, Yamjala K, Hwang SH, Hammock BD, Babu B. 2018. Evaluation of anti-Parkinson activity of PTUPB by measuring dopamine and its metabolites in Drosophila melanogaster: LC-MS/MS method development. J Pharm Biomed Anal 149:457-464. doi:10.1016/j.jpba.2017.11.043 PMID:29169114
  • Lassabe G, Kramer K, Hammock BD, Gonzalez-Sapienza GG, Gonzalez-Techera A. 2018. Noncompetitive Homogeneous Detection of Small Molecules Using Synthetic Nanopeptamer-Based Luminescent Oxygen Channeling. Anal Chem 90(10):6187-6192. doi:10.1021/acs.analchem.8b00657 PMID:29694028 PMCID:PMC5963685
  • Minaz N, Razdan R, Hammock BD, Goswami SK. 2018. An inhibitor of soluble epoxide hydrolase ameliorates diabetes-induced learning and memory impairment in rats. Prostaglandins Other Lipid Mediat 136:84-89. doi:10.1016/j.prostaglandins.2018.05.004 PMID:29751149
  • Napimoga MH, Trindade-da-Silva C, Demasi AP, Martinez EF, Macedo CG, Abdalla HB, Bettaieb A, Haj FG, Clemente-Napimoga JT, Hammock BD. 2018. Soluble epoxide hydrolase inhibitor promotes immunomodulation to inhibit bone resorption. J Periodontal Res doi:10.1111/jre.12559 PMID:29851077
  • Pali M, Bever C, Vasylieva N, Hammock BD, Suni II. 2018. Impedance detection of 3-phenoxybenzoic acid with a noncompetitive two-site phage anti-immunocomplex assay. Electroanalysis 30:2653-2659. doi:10.1002/elan.201800457
  • Pecic S, Zeki AA, Xu X, Jin GY, Zhang S, Kodani SD, Halim M, Morisseau C, Hammock BD, Deng S. 2018. Novel piperidine-derived amide sEH inhibitors as mediators of lipid metabolism with improved stability. Prostaglandins Other Lipid Mediat 136:90-95. doi:10.1016/j.prostaglandins.2018.02.004 PMID:29567338 PMCID:PMC5970965
  • Philippa C, Barkoski J, Tancredi DJ, Elms B, Barr DB, Ozonoff S, Bennett DH, Hertz-Picciotto I. 2018. Prenatal exposure to organophosphate pesticides and risk of autism spectrum disorders and other non-typical development at 3 years in a high-risk cohort. Int J Hyg Environ Health 221(3):548-555. doi:10.1016/j.ijheh.2018.02.004 PMID:29478806
  • Qiu Y, Li P, Dong S, Zhang X, Yang Q, Wang Y, Ge J, Hammock BD, Zhang C, Liu X. 2018. Phage-mediated competitive chemiluminescent immunoassay for detecting Cry1Ab toxin by using an anti-idiotypic camel nanobody. J Agric Food Chem 66:950-956. doi:10.1021/acs.jafc.7b04923 PMID:29293334
  • Rand AA, Helmer PO, Inceoglu B, Hammock BD, Morisseau C. 2018. LC-MS/MS analysis of the epoxides and diols derived from the endocannabinoid arachidonoyl ethanolamide. Methods Mol Biol 1730:123-133. doi:10.1007/978-1-4939-7592-1_10 PMID:29363071
  • Ren Q, Ma M, Yang J, Nonaka R, Yamaguchi A, Ishikawa K, Kobayashi K, Murayama S, Hwang SH, Saiki S, Akamatsu W, Hattori N, Hammock BD, Hashimoto K. 2018. Soluble epoxide hydrolase plays a key role in the pathogenesis of Parkinson's disease. Proc Natl Acad Sci U S A 115:E5815-E5823. doi:10.1073/pnas.1802179115 PMID:29735655 PMCID:PMC6016799
  • Taha AY, Hennebelle M, Yang J, Zamora D, Rapoport SI, Hammock BD, Ramsden CE. 2018. Regulation of rat plasma and cerebral cortex oxylipin concentrations with increasing levels of dietary linoleic acid. Prostaglandins Leukot Essent Fatty Acids 138:71-80. doi:10.1016/j.plefa.2016.05.004 PMID:27282298 PMCID:PMC5106341
  • Tu R, Armstrong J, Lee KS, Hammock BD, Sapirstein A, Koehler RC. 2018. Soluble epoxide hydrolase inhibition decreases reperfusion injury after focal cerebral ischemia. Sci Rep 8:5279. doi:10.1038/s41598-018-23504-1 PMID:29588470 PMCID:PMC5869703
  • Wang F, zhang H, Ma A, Yu W, Zimmermann M, Yang J, Hwang SH, Zhu D, Lin T, Malfatti MA, Turteltaub KW, Henderson PT, Airhart S, Hammock BD, Yuan J, de Vere White RW, Pan C. 2018. COX-2/sEH dual inhibitor PTUPB potentiates the antitumor efficacy of cisplatin. Mol Cancer Ther 17:474-483. doi:10.1158/1535-7163.MCT-16-0818 PMID:29284644 PMCID:PMC5824635
  • Wang W, Yang J, Zhang J, Wang Y, Hee-Hwang S, Qi W, Wan D, Kim D, Sun J, Sanidad KZ, Yang H, Park Y, Liu J, Zhao X, Zheng X, Liu Z, Hammock BD, Zhang G. 2018. Lipidomic profiling reveals soluble epoxide hydrolase as a therapeutic target of obesity-induced colonic inflammation. Proc Natl Acad Sci U S A 115:5283-5288. doi:10.1073/pnas.1721711115 PMID:29717038 PMCID:PMC5960306
  • Yamanashi H, Boeglin WE, Morisseau C, Davis RW, Sulikowski GA, Hammock BD, Brash AR. 2018. Catalytic activities of mammalian epoxide hydrolases with cis and trans fatty acid epoxides relevant to skin barrier function. J Lipid Res 59:684-695. doi:10.1194/jlr.M082701 PMID:29459481 PMCID:PMC5880498
  • Yang Y, Sun D, Kandhi S, Froogh G, Zhuge J, Huang W, Hammock BD, Huang A. 2018. Estrogen-dependent epigenetic regulation of soluble epoxide hydrolase via DNA methylation. Proc Natl Acad Sci U S A 115:613-618. doi:10.1073/pnas.1716016115 PMID:29295935 PMCID:PMC5776989
  • Zamuruyev KO, Borras E, Pettit DR, Aksenov AA, Simmons JD, Weimer BC, Schivo M, Kenyon NJ, Delplanque J, Davis CE. 2018. Effect of temperature control on the metabolite content in exhaled breath condensate. Anal Chim Acta 1006:49-60. doi:10.1016/j.aca.2017.12.025 PMID:30016264 PMCID:PMC6050983
  • Zamuruyev KO, Schmidt AJ, Borras E, McCartney MM, Schivo M, Kenyon NJ, Delplanque J, Davis CE. 2018. Power-efficient self-cleaning hydrophilic condenser surface for portable exhaled breath condensate (EBC) metabolomic sampling. J Breath Res 12:16. doi:10.1088/1752-7163/aac5a5 PMID:29771240 PMCID:PMC6015477


  • Aksenov AA, Zamuruyev KO, Pasamontes A, Brown JF, Schivo M, Foutouhi S, Weimer BC, Kenyon NJ, Davis CE. 2017. Analytical methodologies for broad metabolite coverage of exhaled breath condensate. J Chromatogr B Analyt Technol Biomed Life Sci 1061-1062:17-25. doi:10.1016/j.jchromb.2017.06.038 PMID:28697414 PMCID:PMC5573623
  • Barnych B, Rand A, Cajka T, Lee KS, Hammock BD. 2017. Synthesis of cylooxygenase metabolites of 8,9-epoxyeicosatrienoic acid (EET): 11-and 15-hydroxy 8,9-EETs. Org Biomol Chem 15:4308-4313. doi:10.1039/c7ob00789b PMID:28470279
  • Borras E, Aksenov AA, Baird M, Novick B, Schivo M, Zamuruyev KO, Pasamontes A, Parry C, Foutouhi S, Venn-Watson S, Weimer BC, Davis CE. 2017. Exhaled breath condensate methods adapted from human studies using longitudinal metabolomics for predicting early health alterations in dolphins. Anal Bioanal Chem 409:6523-6536. doi:10.1007/s00216-017-0581-6 PMID:29063162
  • Cui X, Vasylieva N, Wu P, Barnych B, Yang J, Shen D, He Q, Gee SJ, Zhao S, Hammock BD. 2017. Development of an indirect competitive enzyme-linked immunosorbent assay for glycocholic acid based on chicken single-chain variable fragment antibodies. Anal Chem 89:11091-11097. doi:10.1021/acs.analchem.7b03190 PMID:28942640
  • Deng B, Luo Y, Kang X, Li C, Morisseau C, Yang J, Lee KS, Huang J, Hu D, Wu M, Peng A, Hammock BD, Liu J. 2017. Epoxide metabolites of arachidonate and docosahexaenoate function conversely in acute kidney injury involved in GSK3 beta signaling. Proc Natl Acad Sci U S A 114:12608-12613. doi:10.1073/pnas.1705615114 PMID:29109264 PMCID:PMC5703276
  • Fischer GJ, Bacon W, Yang J, Palmer JM, Dagenais T, Hammock BD, Keller NP. 2017. Lipoxygenase activity accelerates programmed spore germination in aspergillus fumigatus. Front Microbiol 8:831. doi:10.3389/fmicb.2017.00831 PMID:28536571 PMCID:PMC5422543
  • Flitter B, Hvorecny KL, Ono E, Eddens TJ, Yang J, Kwak D, Bahl CD, Hampton TH, Morisseau C, Hammock BD, Liu X, Lee JS, Kolls J, Levy BD, Madden DR, Bomberger JM. 2017. Pseudomonas aeruginosa sabotages the generation of host proresolving lipid mediators. Proc Natl Acad Sci U S A 114(1):136-141. doi:10.1073/pnas.1610242114 PMID:27980032 PMCID:PMC5224368
  • Goswami SK, Rand A, Wan DB, Yang J, Inceoglu B, Thomas M, Morisseau C, Yang G, Hammock BD. 2017. Pharmacological inhibition of soluble epoxide hydrolase or genetic deletion reduces diclofenac-induced gastric ulcers. Life Sciences 180:114-122. doi:10.1016/j.lfs.2017.05.018 PMID:28522175 PMCID:PMC5659729
  • Guedes AP, Galuppo L, Hood D, Hwang SH, Morisseau C, Hammock BD. 2017. Soluble epoxide hydrolase activity and pharmacologic inhibition in horses with chronic severe laminitis. Equine Vet J 49(3):345-351. doi:10.1111/evj.12603 PMID:27338788
  • Hasegawa E, Inafuku S, Mulki L, Okunuki Y, Yanai R, Smith KE, Kim CB, Klokman G, Bielenberg DR, Puli N, Falck JR, Husain D, Miller JW, Edin ML, Zeldin DC, Lee KS, Hammock BD, Schunck W, Connor KM. 2017. Cytochrome P450 monooxygenase lipid metabolites are significant second messengers in the resolution of choroidal neovascularization. Proc Natl Acad Sci U S A 114:e7545-e7553. doi:10.1073/pnas.1620898114 PMID:28827330 PMCID:PMC5594641
  • Hennebelle M, Otoki Y, Yang J, Hammock BD, Levitt AJ, Taha AY, Swardfager W. 2017. Altered soluble epoxide hydrolase-derived oxylipins in patients with seasonal major depression: An exploratory study. Psychiatry Res 252:94-101. doi:10.1016/j.psychres.2017.02.056 PMID:28259037
  • Hennebelle M, Zhang Z, Metherel AH, Kitson AP, Otoki Y, Richardson CE, Yang J, Lee KS, Hammock BD, Zhang L, Bazinet RP, Taha AY. 2017. Linoleic acid participates in the response to ischemic brain injury through oxidized metabolites that regulate neurotransmission. Sci Rep 7:4342. doi:10.1038/s41598-017-02914-7 PMID:28659576 PMCID:PMC5489485
  • Hu P, Wu X, Khandelwal AR, Yu W, Xu Z, Chen L, Yang J, Weisbrod RM, Lee KS, Seta F, Hammock BD, Cohen RA, Zeng C, Tong X. 2017. Endothelial Nox4-based NADPH oxidase regulates atherosclerosis via soluble epoxide hydrolase. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1863:1382-1391. doi:10.1016/j.bbadis.2017.02.004 PMID:28185955
  • Hvorecny KL, Bahl CD, Kitamura S, Lee KS, Hammock BD, Morisseau C, Madden DR. 2017. Active-site flexibility and substrate specificity in a bacterial virulence factor: Crystallographic snapshots of an epoxide hydrolase. Structure 25(5):697-707. doi:10.1016/j.str.2017.03.002 PMID:28392259
  • Hwang SH, Wagner KM, Xu J, Yang J, Li X, Cao Z, Morisseau C, Lee K, Hammock BD. 2017. Chemical synthesis and biological evaluation of ω-hydroxy polyunsaturated fatty acids. Bioorg Med Chem Lett 27(3):620-625. doi:10.1016/j.bmcl.2016.12.002 PMID:28025003
  • Islam O, Patil P, Goswami SK, Razdan R, Inamdar MN, Rizwan M, Mathew J, Inceoglu B, Stephen Lee KS, Hwang SH, Hammock BD. 2017. Inhibitors of soluble epoxide hydrolase minimize ischemia-reperfusion-induced cardiac damage in normal, hypertensive, and diabetic rats. Cardiovasc Ther 35(3):e12259. doi:10.1111/1755-5922.12259 PMID:28296232
  • Kandhi S, Zhang B, Froogh G, Qin J, Alruwaili N, Le Y, Yang Y, Hwang SH, Hammock BD, Wolin MS, Huang A, Sun D. 2017. EETs promote hypoxic pulmonary vasoconstriction via constrictor prostanoids. Am J Physiol Lung Cell Mol Physiol 313:L350-L359. PMID:28450284
  • Kitamura S, Morisseau C, Harris TR, Inceoglu B, Hammock BD. 2017. Occurrence of urea-based soluble epoxide hydrolase inhibitors from the plants in the order Brassicales. PLoS One 12(5):e0176571. doi:10.1371/journal.pone.0176571 PMID:28472063 PMCID:PMC5417501
  • Kodani SD, Barthelemy M, Kamita SG, Hammock BD, Morisseau C. 2017. Development of amide-based fluorescent probes for selective measurement of carboxylesterase 1 activity in tissue extracts. Anal Biochem 539:81-89. doi:10.1016/j.ab.2017.10.014 PMID:29054529 PMCID:PMC5696082
  • Lee KS, Henriksen NM, Ng CJ, Yang J, Jia W, Morisseau C, Andaya A, Gilson MK, Hammock BD. 2017. Probing the orientation of inhibitor and epoxy-eicosatrienoic acid binding in the active site of soluble epoxide hydrolase. Arch Biochem Biophys 613:1-11. doi:10.1016/ PMID:27983948 PMCID:PMC5172606
  • Liu X, Tang Z, Duan Z, He Z, Shu M, Wang X, Gee SJ, Hammock BD, Xu Y. 2017. Nanobody-based enzyme immunoassay for ochratoxin A in cereal with high resistance to matrix interference. Talanta 164:154-158. doi:10.1016/j.talanta.2016.11.039 PMID:28107910 PMCID:PMC5862147
  • Orcholski ME, Khurshudyan A, Shamskhou EA, Yuan K, Chen IY, Kodani SD, Morisseau C, Hammock BD, Hong EM, Alexandrova L, Alastalo T, Berry G, Zamanian RT, de Jesus Perez VA. 2017. Reduced carboxylesterase 1 is associated with endothelial injury in methamphetamine-induced pulmonary arterial hypertension. Am J Physiol Lung Cell Mol Physiol 313:L252-L266. doi:10.1152/ajplung.00453.2016 PMID:28473326
  • Rand A, Barnych B, Morisseau C, Cajka T, Lee KS, Panigrahy D, Hammock BD. 2017. Cyclooxygenase-derived proangiogenic metabolites of epoxyeicosatrienoic acids. Proc Natl Acad Sci U S A 114:4370-4375. doi:10.1073/pnas.1616893114 PMID:28396419 PMCID:PMC5410821
  • Richardson CE, Hennebelle M, Otoki Y, Zamora D, Yang J, Hammock BD, Taha AY. 2017. Lipidomic analysis of oxidized fatty acids in plant and algae oils. J Agric Food Chem 65(9):1941-1951. doi:10.1021/acs.jafc.6b05559 PMID:28157307
  • Sethi S, Chen X, Kass PH, Puschner B. 2017. Polychlorinated biphenyl and polybrominated diphenyl ether profiles in serum from cattle, sheep, and goats across California. Chemosphere 181:63-73. doi:10.1016/j.chemosphere.2017.04.059 PMID:28239905 PMCID:PMC5418122
  • Shih P. 2017. Integrating multi-omics biomarkers and postprandial metabolism to develop personalized treatment for anorexia nervosa. Prostaglandins Other Lipid Mediat 132:69-76. doi:10.1016/j.prostaglandins.2017.02.002 PMID:28232135 PMCID:PMC5565718
  • Vasylieva N, Barnych B, Rand A, Inceoglu B, Gee SJ, Hammock BD. 2017. Sensitive immunoassay for detection and quantification of the neurotoxin, tetramethylenedisulfotetramine. Anal Chem 89(10):5612-5619. doi:10.1021/acs.analchem.7b00846 PMID:28398746
  • Vasylieva N, Barnych B, Wan D, El-Sheikh EA, Nguyen HM, Wulff H, McMahen R, Strynar M, Gee SJ, Hammock BD. 2017. Hydroxy-fipronil is a new urinary biomarker of exposure to fipronil. Environ Int 103:91-98. doi:10.1016/j.envint.2017.03.012 PMID:28343720 PMCID:PMC5432128
  • Wagner KM, Gilda JE, Yang J, Wan D, Morisseau C, Gomes AV, Hammock BD. 2017. Soluble epoxide hydrolase inhibition alleviates neuropathy in Akita (Ins2 Akita) mice. Behav Brain Res 326:69-76. doi:10.1016/j.bbr.2017.02.048 PMID:28259677 PMCID:PMC5409858
  • Wagner KM, McReynolds C, Schmidt WK, Hammock BD. 2017. Soluble epoxide hydrolase as a therapeutic target for pain, inflammatory and neurodegenerative diseases. Pharmacol Ther 180:62-76. doi:10.1016/j.pharmthera.2017.06.006 PMID:28642117 PMCID:PMC5677555
  • Wagner SD, Kurobe T, Hammock BG, Lam CH, Wu G, Vasylieva N, Gee SJ, Hammock BD, Teh SJ. 2017. Developmental effects of fipronil on Japanese Medaka (Oryzias latipes) embryos. Chemosphere 166:511-520. doi:10.1016/j.chemosphere.2016.09.069 PMID:27710886
  • Wan D, Yang J, Barnych B, Hwang SH, Lee KS, Cui Y, Niu J, Watsky MA, Hammock BD. 2017. A new sensitive LC/MS/MS analysis of vitamin D metabolites using a click derivatizatization reagent, 2-nitrosopyridine. J Lipid Res 58(4):798-808. doi:10.1194/jlr.D073536 PMID:28148721 PMCID:PMC5392736
  • Wang W, Yang J, Qi W, Yang H, Wang C, Tan B, Hammock BD, Park Y, Kim D, Zhang G. 2017. Lipidomic profiling of high-fat diet-induced obesity in mice: importance of cytochrome P450-derived fatty acid epoxides. Obesity (Silver Spring) 25(1):132-140. doi:10.1002/oby.21692 PMID:27891824 PMCID:PMC5182168
  • Xu Z, Li Y, Sun Y, Beier RC, Lei H, Gee SJ, Hammock BD, Shen Y, Yang J, Wang H. 2017. Immunochemical techniques for multianalyte analysis of chemical residues in food and the environment: a review. Trends in Analytical Chemistry 88:25-40. doi:10.1016/j.trac.2016.12.010
  • Yang J, Oh YT, Wan D, Watanabe RM, Hammock BD, Youn JH. 2017. Postprandial effect to decrease soluble epoxide hydrolase activity: roles of insulin and gut microbiota. J Nutr Biochem 49:8-14. doi:10.1016/j.jnutbio.2017.07.006 PMID:28863368
  • Zhang Y, Hong G, Lee K, Hammock BD, Gebremedhin D, Harder DR, Koehler RC, Sapirstein A. 2017. Inhibition of soluble epoxide hydrolase augments astrocyte release of vascular endothelial growth factor and neuronal recovery after oxygen-glucose deprivation. J Neurochem 140(5):814-825. doi:10.1111/jnc.13933 PMID:28002622 PMCID:PMC5310989


  • Ahn K, Ranganathan A, Bever C, Hwang SH, Holland EB, Morisseau K, Pessah IN, Hammock BD, Gee SJ. 2016. Detection of the antimicrobial triclosan in environmental samples by immunoassay. Environ Sci Technol 50(7):3754-3761. doi:10.1021/acs.est.5b05357 PMID:26937944 PMCID:PMC4821808
  • Akintoye E, Wu JH, Hou T, Song X, Yang J, Hammock BD, Mozaffarian D. 2016. Effect of fish oil on monoepoxides derived from fatty acids during cardiac surgery. J Lipid Res 57(3):492-498. doi:10.1194/jlr.P062398 PMID:26749073 PMCID:PMC4766998
  • Bever C, Dong J, Vasylieva N, Barnych B, Cui Y, Hammock BD, Gee SJ. 2016. VHH antibodies: emerging reagents for the analysis of environmental chemicals. Anal Bioanal Chem 408(22):5985-6002. doi:10.1007/s00216-016-9585-x PMID:27209591 PMCID:PMC4983233
  • Cajka T, Davis R, Austin KJ, Newman JW, German JB, Smilowitz JT, Fiehn O. 2016. Using a lipidomics approach for nutritional phenotyping in response to a test meal containing gamma-linolenic acid. Metabolomics 12:127. doi:10.1007/s11306-016-1075-9
  • Ghosh R, Goswami SK, Feitoza LB, Hammock BD, Gomes AV. 2016. Diclofenac induces proteasome and mitochondrial dysfunction in murine cardiomyocytes and hearts. Int J Cardiol 223:923-935. doi:10.1016/j.ijcard.2016.08.233 PMID:27589040 PMCID:PMC5076377
  • Gong Y, Fu Z, Edin ML, Liu C, Wang Z, Shao Z, Fredrick TW, Saba NJ, Morss PC, Burnim SB, Meng SS, Lih FB, Lee KS, Moran EP, SanGiovanni JP, Hellstrom A, Hammock BD, Zeldin DC, Smith LE. 2016. Cytochrome P450 oxidase 2C inhibition adds to omega-3 long-chain polyunsaturated fatty acids protection against retinal and choroidal neovascularization. Arterioscler Thromb Vasc Biol 36(9):1919-1927. doi:10.1161/ATVBAHA.116.307558 PMID:27417579 PMCID:PMC5010176
  • Goswami SK, Wan D, Yang J, Trindade da Silva CA, Morisseau C, Kodani SD, Yang G, Inceoglu B, Hammock BD. 2016. Anti-ulcer efficacy of soluble epoxide hydrolase inhibitor TPPU on diclofenac-induced intestinal ulcers. J Pharmacol Exp Ther 357(3):529-536. doi:10.1124/jpet.116.232108 PMID:26989141 PMCID:PMC4885505
  • Harris TR, Kodani SD, Yang J, Imai DM, Hammock BD. 2016. An ω-3-enriched diet alone does not attenuate CCl4-induced hepatic fibrosis. J Nutr Biochem 38:93-101. doi:10.1016/j.jnutbio.2016.08.010 PMID:27732914 PMCID:PMC5102762
  • Hye Khan A, Hwang SH, Sharma A, Corbett JA, Hammock BD, Imig JD. 2016. A dual COX-2/sEH inhibitor improves the metabolic profile and reduces kidney injury in Zucker diabetic fatty rat. Prostaglandins Other Lipid Mediat 125:40-47. doi:10.1016/j.prostaglandins.2016.07.003 PMID:27432695 PMCID:PMC5035206
  • Kamita SG, Mulligan S, Cornel AJ, Hammock BD. 2016. Quantification of GST and esterase activities in pyrethrin-resistant mosquitoes using pyrethroid-like fluorescent substrates. Int J Pest Manag 62:276-283. doi:10.1080/09670874.2016.1175685 PMID:28736488 PMCID:PMC5516934
  • Kim J, Ulu A, Wan DB, Yang J, Hammock BD, Weiss RH. 2016. Addition of DHA synergistically enhances the efficacy of regorafenib for kidney cancer therapy. Mol Cancer Ther 15(5):890-898. doi:10.1158/1535-7163.MCT-15-0847 PMID:26921392 PMCID:PMC4873345
  • Kitamura S, Hvorecny KL, Niu J, Hammock BD, Madden DR, Morisseau C. 2016. Rational design of potent and selective inhibitors of an epoxide hydrolase virulence factor from Pseudomonas aeruginosa. J Med Chem 59(10):4790-4799. doi:10.1021/acs.jmedchem.6b00173 PMID:27120257 PMCID:PMC4957648
  • Li D, Liu Y, Zhang X, Lv H, Pang W, Sun X, Gan L, Hammock BD, Ai D, Zhu Y. 2016. Inhibition of soluble epoxide hydrolase alleviated atherosclerosis by reducing monocyte infiltration in Ldlr(-/-) mice. J Mol Cell Cardiol 98:128-137. doi:10.1016/j.yjmcc.2016.08.001 PMID:27496380
  • Liu J, Morisseau C, Huang H, Hammock BD. 2016. Screening of soluble epoxide hydrolase inhibitory ingredients from traditional Chinese medicines for anti-inflammatory use. J Ethnopharmacol 194:475-482. doi:10.1016/j.jep.2016.09.044 PMID:27702689
  • McLellan GJ, Aktas Z, Hennes-Beean E, Kolb AW, Larsen IV, Schmitz EJ, Clausius HR, Yang J, Hwang SH, Morisseau C, Inceoglu B, Hammock BD, Brandt CR. 2016. Effect of a soluble epoxide hydrolase inhibitor, UC1728, on LPS-induced uveitis in the rabbit. J Ocul Biol 4(1):PMID:28066796 PMCID:PMC5218821
  • Mouchlis VD, Morisseau C, Hammock BD, Li S, McCammon JA, Dennis EA. 2016. Computer-aided drug design guided by hydrogen/deuterium exchange mass spectrometry: A powerful combination for the development of potent and selective inhibitors of Group VIA calcium-independent phospholipase A2. Bioorg Med Chem 24(20):4801-4811. doi:10.1016/j.bmc.2016.05.009 PMID:27320659 PMCID:PMC5053890
  • Ren Q, Ma M, Ishima T, Morisseau C, Yang J, Wagner KM, Zhang J, Yao W, Dong C, Han M, Hammock BD, Hashimoto K. 2016. Gene deficiency and pharmacological inhibition of soluble epoxide hydrolase confers resilience to repeated social defeat stress. Proc Natl Acad Sci U S A 113(13):E1944-E1952. doi:10.1073/pnas.1601532113 PMID:26976569 PMCID:PMC4822604
  • Sharma A, Hye Khan A, Levick SP, Sing K, Hammock BD, Imig JD. 2016. Novel omega-3 fatty acid epoxygenase metabolite reduces kidney fibrosis. Int J Mol Sci 17(5):751. doi:10.3390/ijms17050751 PMID:27213332 PMCID:PMC4881572
  • Shih P, Yang J, Morisseau C, German JB, Zeeland AA, Armando AM, Quehenberger O, Bergen AW, Magistretti P, Berrettini W, Halmi KA, Schork N, Hammock BD, Kaye W. 2016. Dysregulation of soluble epoxide hydrolase and lipidomic profiles in anorexia nervosa. Mol Psychiatry 21(4):537-546. doi:10.1038/mp.2015.26 PMID:25824304 PMCID:PMC4591075
  • Tong X, Khandelwal AR, Wu X, Xu Z, Yu W, Chen C, Zhao W, Yang J, Qin Z, Weisbrod RM, Seta F, Ago T, Sing K, Lee S, Hammock BD, Sadoshima J, Cohen RA, Zeng C. 2016. Pro-atherogenic role of smooth muscle Nox4-based NADPH oxidase. J Mol Cell Cardiol 92:30-40. doi:10.1016/j.yjmcc.2016.01.020 PMID:26812119 PMCID:PMC5008453
  • Ulu A, Inceoglu B, Yang J, Singh V, Vito S, Wulff H, Hammock BD. 2016. Inhibition of soluble epoxide hydrolase as a novel approach to high dose diazepam induced hypotension. J Clin Toxicol 6(3):1000300. doi:10.4172/2161-0495.1000300 PMID:28255523 PMCID:PMC5328659
  • Wagner KM, Lee KS, Yang J, Hammock BD. 2016. Epoxy fatty acids mediate analgesia in murine diabetic neuropathy. Eur J Pain 21:456-465. doi:10.1002/ejp.939 PMID:27634339 PMCID:PMC5300894
  • Wu X, Yang J, Morisseau C, Robertson LW, Hammock BD, Lehmler H. 2016. 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) decreases hepatic and systemic ratios of epoxide to diol metabolites of unsaturated fatty acids in male rats. Toxicol Sci 152(2):309-322. doi:10.1093/toxsci/kfw084 PMID:27208083 PMCID:PMC4960907
  • Xu J, Morisseau C, Yang J, Lee KS, Kamita SG, Hammock BD. 2016. Ingestion of the epoxide hydrolase inhibitor AUDA modulates immune responses of the mosquito, Culex quinquefasciatus during blood feeding. Insect Biochem Mol Biol 76:62-69. doi:10.1016/j.ibmb.2016.06.011 PMID:27369469 PMCID:PMC5010450
  • Zhao Y, Wan D, Yang J, Hammock BD, Ortiz de Montellano P. 2016. Catalytic activities of tumor-specific human cytochrome P450 CYP2W1 toward endogenous substrates. Drug Metab Dispos 44(5):771-780. doi:10.1124/dmd.116.069633 PMID:26936974 PMCID:PMC4851306


  • Bahl CD, Hvorecny KL, Bomberger JM, Stanton BA, Hammock BD, Morisseau C, Madden DR. 2015. Inhibiting an epoxide hydrolase virulence factor from Pseudomonas aeruginosa protects CFTR. Angew Chem Int Ed Engl 54(34):9881-9885. doi:10.1002/anie.201503983 PMID:26136396 PMCID:PMC4556431
  • Berthelot CC, Kamita SG, Sacchi R, Yang J, Nording ML, Georgi K, Karbowski CH, German JB, Weiss RH, Hogg RJ, Hammock BD, Zivkovic AM. 2015. Changes in PTGS1 and ALOX12 gene expression in peripheral blood mononuclear cells are associated with changes in arachidonic acid, oxylipins, and oxylipin/fatty acid ratios in response to omega-3 fatty acid supplementation. PLoS One 10(12):e0144996. doi:10.1371/journal.pone.0144996 PMID:26672987 PMCID:PMC4681469
  • Bettaieb A, Chahed S, Bachaalany S, Griffey S, Hammock BD, Haj FG. 2015. Soluble epoxide hydrolase pharmacological inhibition ameliorates experimental acute pancreatitis in mice. Mol Pharmacol 88(2):281-290. doi:10.1124/mol.114.097501 PMID:25993999 PMCID:PMC4518092
  • Burmistrov V, Morisseau C, Danilov D, Harris TR, Dalinger I, Vatsadze I, Shkineva T, Butov GM, Hammock BD. 2015. 1,3-Disubstituted and 1,3,3-trisubstituted adamantyl-ureas with isoxazole as soluble epoxide hydrolase inhibitors. Bioorg Med Chem Lett 25(23):5514-5519. doi:10.1016/j.bmcl.2015.10.066 PMID:26520661 PMCID:PMC4654407
  • Cui Y, Li D, Morisseau C, Dong J, Yang J, Wan D, Rossotti MA, Gee SJ, Gonzalez-Sapienza GG, Hammock BD. 2015. Heavy chain single-domain antibodies to detect native human soluble epoxide hydrolase. Anal Bioanal Chem 407(24):7275-7283. doi:10.1007/s00216-015-8889-6 PMID:26229025 PMCID:PMC4573264
  • Fahrmann J, Grapov D, Yang J, Hammock BD, Fiehn O, Bell GI, Hara M. 2015. Systemic alterations in the metabolome of diabetic NOD mice delineate increased oxidative stress accompanied by reduced inflammation and hypertriglyceremia. Am J Physiol Endocrinol Metab 308(11):E978-E989. doi:10.1152/ajpendo.00019.2015 PMID:25852003 PMCID:PMC4451288
  • Flannery BM, Silverman JL, Bruun DA, Puhger KR, McCoy MR, Hammock BD, Crawley JN, Lein PJ. 2015. Behavioral assessment of NIH Swiss mice acutely intoxicated with tetramethylenedisulfotetramine. Neurotoxicol Teratol 47:36-45. doi:10.1016/ PMID:25446016 PMCID:PMC4291292
  • Goswami SK, Inceoglu B, Yang J, Wan D, Kodani SD, Trindade da Silva CA, Morisseau C, Hammock BD. 2015. Omeprazole increases the efficacy of a soluble epoxide hydrolase inhibitor in a PGE₂ induced pain model. Toxicol Appl Pharmacol 289(3):419-427. doi:10.1016/j.taap.2015.10.018 PMID:26522832 PMCID:PMC4666679
  • Hammock BD, Hobbs JA, Slater SB, Acuna S, Teh SJ. 2015. Contaminant and food limitation stress in an endangered estuarine fish. Sci Total Environ 532:316-326. doi:10.1016/j.scitotenv.2015.06.018 PMID:26081734 PMCID:PMC4843802
  • Harris TR, Bettaieb A, Kodani SD, Dong H, Myers R, Chiamvimonvat N, Haj FG, Hammock BD. 2015. Inhibition of soluble epoxide hydrolase attenuates hepatic fibrosis and endoplasmic reticulum stress induced by carbon tetrachloride in mice. Toxicol Appl Pharmacol 286(2):102-111. doi:10.1016/j.taap.2015.03.022 PMID:25827057 PMCID:PMC4458210
  • Hua X, Zhou L, Feng L, Ding Y, Shi H, Wang L, Gee SJ, Hammock BD, Wang M. 2015. Competitive and noncompetitive phage immunoassays for the determination of benzothiostrobin. Anal Chim Acta 890:150-156. doi:10.1016/j.aca.2015.07.056 PMID:26347177 PMCID:PMC4791039
  • Hwang VJ, Kim J, Rand A, Yang C, Sturdivant S, Hammock BD, Bell P, Guay-Woodford LM, Weiss RH. 2015. The cpk model of recessive PKD shows glutamine dependence associated with the production of the oncometabolite 2-hydroxyglutarate. Am J Physiol Renal Physiol 309(6):F492-F498. doi:10.1152/ajprenal.00238.2015 PMID:26155843 PMCID:PMC4572393
  • Inceoglu B, Bettaieb A, Trindade da Silva CA, Lee KS, Haj FG, Hammock BD. 2015. Endoplasmic reticulum stress in the peripheral nervous system is a significant driver of neuropathic pain. Proc Natl Acad Sci U S A 112(29):9082-9087. doi:10.1073/pnas.1510137112 PMID:26150506 PMCID:PMC4517273
  • Kim J, Yoon SP, Toews ML, Imig JD, Hwang SH, Hammock BD, Padanilam BJ. 2015. Pharmacological inhibition of soluble epoxide hydrolase prevents renal interstitial fibrogenesis in obstructive nephropathy. Am J Physiol Renal Physiol 308(2):F131-F139. doi:10.1152/ajprenal.00531.2014 PMID:25377915 PMCID:PMC4338924
  • Kitamura S, Morisseau C, Inceoglu B, Kamita SG, De Nicola GR, Nyegue M, Hammock BD. 2015. Potent natural soluble epoxide hydrolase inhibitors from Pentadiplandra brazzeana baillon: synthesis, quantification, and measurement of biological activities in vitro and in vivo. PLoS One 10(2):e0117438. doi:10.1371/journal.pone.0117438 PMID:25659109 PMCID:PMC4319826
  • Liu X, Xu Y, Wan D, Xiong Y, He Z, Wang X, Gee SJ, Ryu D, Hammock BD. 2015. Development of a nanobody-alkaline phosphatase fusion protein and its application in a highly sensitive direct competitive fluorescence enzyme immunoassay for detection of ochratoxin A in cereal. Anal Chem 87(2):1387-1394. doi:10.1021/ac504305z PMID:25531426 PMCID:PMC4476795
  • Lopez-Vicario C, Alcaraz-Quiles J, Garcia-Alonso V, Rius B, Hwang SH, Titos E, Lopategi A, Hammock BD, Arroyo V, Claria J. 2015. Inhibition of soluble epoxide hydrolase modulates inflammation and autophagy in obese adipose tissue and liver: role for omega-3 epoxides. Proc Natl Acad Sci U S A 112(2):536-541. doi:10.1073/pnas.1422590112 PMID:25550510 PMCID:PMC4299190
  • Nording M, Yang J, Hoang L, Zamora V, Uyeminami DL, Espiritu I, Pinkerton KE, Hammock BD, Luria A. 2015. Bioactive lipid profiling reveals drug target engagement of a soluble epoxide hydrolase inhibitor in a murine model of tobacco smoke exposure. Metabolomics 1:doi:10.7243/2059-0008-1-1 PMID:27076918 PMCID:PMC4827720
  • Ostermann AI, Herbers J, Willenberg I, Chen R, Hwang SH, Greite R, Morisseau C, Gueler F, Hammock BD, Schebb N. 2015. Oral treatment of rodents with soluble epoxide hydrolase inhibitor 1-(1-propanoylpiperidin-4-yl)-3-[4-(trifluoromethoxy)phenyl]urea (TPPU): Resulting drug levels and modulation of oxylipin pattern. Prostaglandins Other Lipid Mediat 121(PtA):131-137. doi:10.1016/j.prostaglandins.2015.06.005 PMID:26117215 PMCID:PMC4688279
  • Ranganathan A, Gee SJ, Hammock BD. 2015. An immunoassay for the detection of triclosan-O-glucuronide, a primary human urinary metabolite of triclosan. Anal Bioanal Chem 407(24):7263-7273. doi:10.1007/s00216-015-8918-5 PMID:26255293 PMCID:PMC4580343
  • Roche C, Guerrot D, Harouki N, Duflot T, Besnier M, Remy-Jouet I, Renet S, Dumesnil A, Lejeune A, Morisseau C, Richard V, Bellien J. 2015. Impact of soluble epoxide hydrolase inhibition on early kidney damage in hyperglycemic overweight mice. Prostaglandins Other Lipid Mediat 120:148-154. doi:10.1016/j.prostaglandins.2015.04.011 PMID:26022136 PMCID:PMC4575616
  • Rochman CM, Tahir A, Williams SL, Baxa DV, Lam R, Miller JT, Teh F, Werorilangi S, Teh SJ. 2015. Anthropogenic debris in seafood: plastic debris and fibers from textiles in fish and bivalves sold for human consumption. Sci Rep 5:14340. doi:10.1038/srep14340 PMID:26399762 PMCID:PMC4585829
  • Rossotti MA, Pirez M, Gonzalez-Techera A, Cui Y, Bever C, Lee KS, Morisseau C, Leizagoyen C, Gee SJ, Hammock BD, Gonzalez-Sapienza GG. 2015. Method for sorting and pairwise selection of nanobodies for the development of highly sensitive sandwich immunoassays. Anal Chem 87(23):11907-11914. doi:10.1021/acs.analchem.5b03561 PMID:26544909 PMCID:PMC4666776
  • Samokhvalov V, Zlobine I, Jamieson KL, Jurasz P, Chen C, Lee KS, Hammock BD, Seubert JM. 2015. PPARδ signaling mediates the cytotoxicity of DHA in H9c2 cells. Toxicol Lett 232(1):10-20. doi:10.1016/j.toxlet.2014.09.029 PMID:25300478 PMCID:PMC4486642
  • Sasso O, Wagner KM, Morisseau C, Inceoglu B, Hammock BD, Piomelli D. 2015. Peripheral FAAH and soluble epoxide hydrolase inhibitors are synergistically antinociceptive. Pharmacol Res 97:7-15. doi:10.1016/j.phrs.2015.04.001 PMID:25882247 PMCID:PMC4464910
  • Shihadih DS, Harris TR, Yang J, Merzlikin O, Lee KS, Hammock BD, Morisseau C. 2015. Identification of potent inhibitors of the chicken soluble epoxide hydrolase. Bioorg Med Chem Lett 25(2):276-279. doi:10.1016/j.bmcl.2014.11.053 PMID:25479771 PMCID:PMC4277729
  • Walkowska A, Kuczeriszka M, Sadowski J, Olszyñski KH, Dobrowolski L, Červenka L, Hammock BD, Kompanowska-Jezierska E. 2015. High salt intake increases blood pressure in normal rats: putative role of 20-HETE and no evidence on changes in renal vascular reactivity. Kidney Blood Press Res 40(3):323-334. doi:10.1159/000368508 PMID:26067851 PMCID:PMC4583220
  • Wang J, Majkova Z, Bever C, Yang J, Gee SJ, Li J, Xu T, Hammock BD. 2015. One-step immunoassay for tetrabromobisphenol a using a camelid single domain antibody-alkaline phosphatase fusion protein. Anal Chem 87(9):4741-4748. doi:10.1021/ac504735p PMID:25849972 PMCID:PMC4476793
  • Wecksler AT, Hwang SH, Liu J, Wettersten HI, Morisseau C, Wu J, Weiss RH, Hammock BD. 2015. Biological evaluation of a novel sorafenib analogue, t-CUPM. Cancer Chemother Pharmacol 75(1):161-171. doi:10.1007/s00280-014-2626-2 PMID:25413440 PMCID:PMC4400119
  • Xu J, Morisseau C, Yang J, Mamatha DM, Hammock BD. 2015. Epoxide hydrolase activities and epoxy fatty acids in the mosquito Culex quinquefasciatus. Insect Biochem Mol Biol 59:41-49. doi:10.1016/j.ibmb.2015.02.004 PMID:25686802 PMCID:PMC4387068
  • Yang J, Bratt J, Franzi L, Liu J, Zhang G, Zeki AA, Vogel CF, Williams K, Dong H, Lin Y, Hwang SH, Kenyon NJ, Hammock BD. 2015. Soluble epoxide hydrolase inhibitor attenuates inflammation and airway hyperresponsiveness in mice. Am J Respir Cell Mol Biol 52(1):46-55. doi:10.1165/rcmb.2013-0440OC PMID:24922186 PMCID:PMC4370250


  • Bettaieb A, Chahed S, Tabet G, Yang J, Morisseau C, Griffey S, Hammock BD, Haj FG. 2014. Effects of soluble epoxide hydrolase deficiency on acute pancreatitis in mice. PLoS One 9(11):e113019. doi:10.1371/journal.pone.0113019 PMID:25402489 PMCID:PMC4234494
  • Bever C, Majkova Z, Radhakrishnan R, Suni II, McCoy MR, Wang Y, Dechant JE, Gee SJ, Hammock BD. 2014. Development and utilization of camelid VHH antibodies from alpaca for 2,2',4,4'-tetrabrominated diphenyl ether detection. Anal Chem 86(15):7875-7882. doi:10.1021/ac501807j PMID:25005746 PMCID:PMC4144723
  • Burmistrov V, Morisseau C, Lee KS, Shihadih DS, Harris TR, Butov GM, Hammock BD. 2014. Symmetric adamantyl-diureas as soluble epoxide hydrolase inhibitors. Bioorg Med Chem Lett 24(9):2193-2197. doi:10.1016/j.bmcl.2014.03.016 PMID:24685540 PMCID:PMC4019751
  • Charles RL, Rudyk O, Prysyazhna O, Kamynina A, Yang J, Morisseau C, Hammock BD, Freeman BA, Eaton P. 2014. Protection from hypertension in mice by the Mediterranean diet is mediated by nitro fatty acid inhibition of soluble epoxide hydrolase. Proc Natl Acad Sci U S A 111(22):8167-8172. doi:10.1073/pnas.1402965111 PMID:24843165 PMCID:PMC4050620
  • Despa S, Sharma S, Harris TR, Dong H, Li N, Chiamvimonvat N, Taegtmeyer H, Margulies KB, Hammock BD, Despa F. 2014. Cardioprotection by controlling hyperamylinemia in a "humanized" diabetic rat model. J Am Heart Assoc 3(4):doi:10.1161/JAHA.114.001015 PMID:25146704 PMCID:PMC4310392
  • Dong J, Xu C, Wang H, Xiao Z, Gee SJ, Li Z, Wang F, Wu W, Shen Y, Yang J, Sun Y, Hammock BD. 2014. Enhanced sensitive immunoassay: noncompetitive phage anti-immune complex assay for the determination of malachite green and leucomalachite green. J Agric Food Chem 62(34):8752-8758. doi:10.1021/jf5019824 PMID:25077381 PMCID:PMC4150606
  • Hua X, Yin W, Shi H, Li M, Wang Y, Wang H, Ye Y, Kim H, Gee SJ, Wang M, Liu F, Hammock BD. 2014. Development of phage immuno-loop-mediated isothermal amplification assays for organophosphorus pesticides in agro-products. Anal Chem 86(16):8441-8447. doi:10.1021/ac5020657 PMID:25135320 PMCID:PMC4139188
  • Kim J, Imig JD, Yang J, Hammock BD, Padanilam BJ. 2014. Inhibition of soluble epoxide hydrolase prevents renal interstitial fibrosis and inflammation. Am J Physiol Renal Physiol 307(8):F971-F980. doi:10.1152/ajprenal.00256.2014 PMID:25164080 PMCID:PMC4200297
  • Kujal P, Chabova VC, Skaroupkova P, Huskova Z, Vernerova Z, Kramer HJ, Walkowska A, Kompanowska-Jezierska E, Sadowski J, Kitada K, Nishiyama A, Hwang SH, Hammock BD, Imig JD, Cervenka L. 2014. Inhibition of soluble epoxide hydrolase is renoprotective in 5/6 nephrectomized Ren-2 transgenic hypertensive rats. Clin Exp Pharmacol Physiol 41(3):227-237. doi:10.1111/1440-1681.12204 PMID:24471737 PMCID:PMC4038339
  • Lee KS, Liu J, Wagner KM, Pakhomova S, Dong H, Morisseau C, Fu SH, Yang J, Wang P, Ulu A, Mate CA, Nguyen LV, Hwang SH, Edin ML, Mara AA, Wulff H, Newcomer ME, Zeldin DC, Hammock BD. 2014. Optimized inhibitors of soluble epoxide hydrolase improve in vitro target residence time and in vivo efficacy. J Med Chem 57(16):7016-7030. doi:10.1021/jm500694p PMID:25079952 PMCID:PMC4148150
  • Liu X, Xu Y, Xiong Y, Tu Z, Li Y, He Z, Qiu Y, Fu J, Gee SJ, Hammock BD. 2014. VHH phage-based competitive real-time immuno-polymerase chain reaction for ultrasensitive detection of ochratoxin A in cereal. Anal Chem 86(15):7471-7477. doi:10.1021/ac501202d PMID:24992514 PMCID:PMC4306448
  • Mehra R, Barile D, Marotta M, Lebrilla CB, Chu C, German JB. 2014. Novel high-molecular weight fucosylated milk oligosaccharides identified in dairy streams. PLoS One 9:doi:10.1371/journal.pone.0096040 PMID:24810963 PMCID:PMC4014476
  • Morisseau C, Wecksler AT, Deng C, Dong H, Yang J, Lee KS, Kodani SD, Hammock BD. 2014. Effect of soluble epoxide hydrolase polymorphism on substrate and inhibitor selectivity and dimer formation. J Lipid Res 55(6):1131-1138. doi:10.1194/jlr.M049718 PMID:24771868 PMCID:PMC4031944
  • Ono E, Dutile S, Kazani S, Weschsler ME, Yang J, Hammock BD, Douda DN, Tabet Y, Khaddaj-Mallat R, Sirois M, Sirois C, Rizcallah E, Rousseau E, Martin R, Sutherland E, Castro M, Jarjour NN, Israel E, Levy BD. 2014. Lipoxin generation is related to soluble epoxide hydrolase activity in severe asthma. Am J Respir Crit Care Med 190(8):886-897. doi:10.1164/rccm.201403-0544OC PMID:25162465 PMCID:PMC4299578
  • Radhakrishnan R, Suni II, Bever C, Hammock BD. 2014. Impedance biosensors: applications to sustainability and remaining technical challenges. ACS Sustain Chem Eng 2(7):1649-1655. doi:10.1021/sc500106y PMID:25068095 PMCID:PMC4105195
  • Schebb N, Muvvala JB, Morin D, Buckpitt AR, Hammock BD, Rice RH. 2014. Metabolic activation of the antibacterial agent triclocarban by cytochrome P450 1A1 yielding glutathione adducts. Drug Metab Dispos 42(7):1098-1102. doi:10.1124/dmd.114.058206 PMID:24733789 PMCID:PMC4170114
  • Schebb N, Ostermann AI, Yang J, Hammock BD, Hahn A, Schuchardt J. 2014. Comparison of the effects of long-chain omega-3 fatty acid supplementation on plasma levels of free and esterified oxylipins. Prostaglandins Other Lipid Mediat 113-115:21-29. doi:10.1016/j.prostaglandins.2014.05.002 PMID:24880049 PMCID:PMC4247815
  • Schuchardt J, Schmidt S, Kressel G, Willenberg I, Hammock BD, Hahn A, Schebb N. 2014. Modulation of blood oxylipin levels by long-chain omega-3 fatty acid supplementation in hyper- and normolipidemic men. Prostaglandins Leukot Essent Fatty Acids 90:27-37. doi:10.1016/j.plefa.2013.12.008 PMID:24411718 PMCID:PMC4130704
  • Schuchardt J, Schneider I, Willenberg I, Yang J, Hammock BD, Hahn A, Schebb N. 2014. Increase of EPA-derived hydroxy, epoxy and dihydroxy fatty acid levels in human plasma after a single dose of long-chain omega-3 PUFA. Prostaglandins Other Lipid Mediat 109-111:23-31. doi:10.1016/j.prostaglandins.2014.03.001 PMID:24667634 PMCID:PMC4172375
  • Sporkova A, Jichova S, Huskova Z, Kopkan L, Nishiyama A, Hwang SH, Hammock BD, Imig JD, Kompanowska-Jezierska E, Sadowski J, Kramer HJ, Cervenka L. 2014. Different mechanisms of acute versus long-term antihypertensive effects of soluble epoxide hydrolase inhibition: studies in Cyp1a1-Ren-2 transgenic rats. Clin Exp Pharmacol Physiol 41(12):1003-1013. doi:10.1111/1440-1681.12310 PMID:25224811 PMCID:PMC4347520
  • Thiphom S, Prapamontol T, Chantara S, Mangklabruks A, Suphavilai C, Ahn K, Gee SJ, Hammock BD. 2014. Determination of the pyrethroid insecticide metabolite 3-PBA in plasma and urine samples from farmer and consumer groups in northern Thailand. J Environ Sci Health B 49(1):15-22. doi:10.1080/03601234.2013.836862 PMID:24138464 PMCID:PMC4020914
  • Trunnelle KJ, Bennett DH, Ahn K, Schenker MB, Tancredi DJ, Gee SJ, Stoecklin-Marois MT, Hammock BD. 2014. Concentrations of the urinary pyrethroid metabolite 3-phenoxybenzoic acid in farm worker families in the MICASA study. Environ Res 131:153-159. doi:10.1016/j.envres.2014.03.003 PMID:24721133 PMCID:PMC4152318
  • Ulu A, Lee S, Miyabe C, Yang J, Hammock BG, Dong H, Hammock BD. 2014. An omega-3 epoxide of docosahexaenoic acid lowers blood pressure in angiotensin-II-dependent hypertension. J Cardiovasc Pharmacol 64(1):87-99. doi:10.1097/FJC.0000000000000094 PMID:24691274 PMCID:PMC4092041
  • Wagner KM, Vito S, Inceoglu B, Hammock BD. 2014. The role of long chain fatty acids and their epoxide metabolites in nociceptive signaling. Prostaglandins Other Lipid Mediat 113-115:2-12. doi:10.1016/j.prostaglandins.2014.09.001 PMID:25240260 PMCID:PMC4254344
  • Wagner KM, Yang J, Inceoglu B, Hammock BD. 2014. Soluble epoxide hydrolase inhibition is antinociceptive in a mouse model of diabetic neuropathy. J Pain 15(9):907-914. doi:10.1016/j.jpain.2014.05.008 PMID:24924124 PMCID:PMC4150748
  • Wang J, Bever C, Majkova Z, Dechant JE, Yang J, Gee SJ, Xu T, Hammock BD. 2014. Heterologous antigen selection of camelid heavy chain single domain antibodies against tetrabromobisphenol A. Anal Chem 86(16):8296-8302. doi:10.1021/ac5017437 PMID:25068372 PMCID:PMC4139172
  • Wang W, Zhu J, Lyu F, Panigrahy D, Ferrara KW, Hammock BD, Zhang G. 2014. ω-3 polyunsaturated fatty acids-derived lipid metabolites on angiogenesis, inflammation and cancer. Prostaglandins Other Lipid Mediat 113-115:13-20. doi:10.1016/j.prostaglandins.2014.07.002 PMID:25019221 PMCID:PMC4306447
  • Wecksler AT, Hwang SH, Wettersten HI, Gilda JE, Patton A, Leon LJ, Carraway KL, Gomes AV, Baar K, Weiss RH, Hammock BD. 2014. Novel sorafenib-based structural analogues: in-vitro anticancer evaluation of t-MTUCB and t-AUCMB. Anticancer Drugs 25(4):433-446. doi:10.1097/CAD.0000000000000079 PMID:24525589 PMCID:PMC3947856
  • Xu J, Morisseau C, Hammock BD. 2014. Expression and characterization of an epoxide hydrolase from Anopheles gambiae with high activity on epoxy fatty acids. Insect Biochem Mol Biol 54:42-52. doi:10.1016/j.ibmb.2014.08.004 PMID:25173592 PMCID:PMC4252830
  • Yueh MF, Taniguchi K, Chen S, Evans RM, Hammock BD, Karin M, Tukey RH. 2014. The commonly used antimicrobial additive triclosan is a liver tumor promoter. Proc Natl Acad Sci U S A 111(48):17200-17205. doi:10.1073/pnas.1419119111 PMID:25404284 PMCID:PMC4260592
  • Zamuruyev KO, Bardaweel HK, Carron CJ, Kenyon NJ, Brand O, Delplanque J, Davis CE. 2014. Continuous droplet removal upon dropwise condensation of humid air on a hydrophobic micropatterned surface. Langmuir 30:10133-10142. doi:10.1021/la5004462 PMID:25073014 PMCID:PMC4148149
  • Zhang G, Kodani SD, Hammock BD. 2014. Stabilized epoxygenated fatty acids regulate inflammation, pain, angiogenesis and cancer. Prog Lipid Res 53:108-123. doi:10.1016/j.plipres.2013.11.003 PMID:24345640 PMCID:PMC3914417
  • Zhang G, Panigrahy D, Hwang SH, Yang J, Mahakian LM, Wettersten HI, Liu J, Wang Y, Ingham ES, Tam S, Kieran MW, Weiss RH, Ferrara KW, Hammock BD. 2014. Dual inhibition of cyclooxygenase-2 and soluble epoxide hydrolase synergistically suppresses primary tumor growth and metastasis. Proc Natl Acad Sci U S A 111(30):11127-11132. doi:10.1073/pnas.1410432111 PMID:25024195 PMCID:PMC4121808


  • Bettaieb A, Nagata N, AbouBechara D, Chahed S, Morisseau C, Hammock BD, Haj FG. 2013. Soluble epoxide hydrolase deficiency or inhibition attenuates diet-induced endoplasmic reticulum stress in liver and adipose tissue. J Biol Chem 288:14189-14199. doi:10.1074/jbc.M113.458414 PMID:23576437 PMCID:PMC3656275
  • Chen T, Takrouri K, Hee-Hwang S, Rana S, Yefidoff-Freedman R, Halperin J, Natarajan A, Morisseau C, Hammock BD, Chorev M, Aktas BH. 2013. Explorations of substituted urea functionality for the discovery of new activators of the heme-regulated inhibitor kinase. J Med Chem 56(23):9457-9470. doi:10.1021/jm400793v PMID:24261904 PMCID:PMC3938169
  • Falck D, Schebb N, Prihatiningtyas S, Zhang J, Heus F, Morisseau C, Kool J, Hammock BD, Niessen WM. 2013. Development of on-line liquid chromatography-biochemical detection for soluble epoxide hydrolase inhibitors in mixtures. Chromatographia 76:13-21. doi:10.1007/s10337-012-2343-0 PMID:23526703 PMCID:PMC3601784
  • Frolov A, Dong H, Jiang M, Yang L, Cook EC, Matnani R, Hammock BD, Crofford LJ. 2013. Niemann-pick type C2 deficiency in human fibroblasts confers robust and selective activation of prostaglandin E2 biosynthesis. J Biol Chem 288:23696-23703. doi:10.1074/jbc.M112.445916 PMID:23814065 PMCID:PMC3745317
  • Frolov A, Yang L, Dong H, Hammock BD, Crofford LJ. 2013. Anti-inflammatory properties of prostaglandin E2: deletion of microsomal prostaglandin E synthase-1 exacerbates non-immune inflammatory arthritis in mice. Prostaglandins Leukot Essent Fatty Acids 89(5):351-358. doi:10.1016/j.plefa.2013.08.003 PMID:24055573 PMCID:PMC3897272
  • Gardell AM, Yang J, Sacchi R, Fangue NA, Hammock BD, Kültz D. 2013. Tilapia (Oreochromis mossambicus) brain cells respond to hyperosmotic challenge by inducing myo-inositol biosynthesis. J Exp Biol 216(24):4615-4625. doi:10.1242/jeb.088906 PMID:24072790 PMCID:PMC3851147
  • Guedes AP, Morisseau C, Sole A, Soares JN, Ulu A, Dong H, Hammock BD. 2013. Use of a soluble epoxide hydrolase inhibitor as an adjunctive analgesic in a horse with laminitis. Vet Anaesth Analg 40(4):440-448. doi:10.1111/vaa.12030 PMID:23463912 PMCID:PMC3956586
  • Han J, Kim H, Sudheendra L, Gee SJ, Hammock BD, Kennedy IM. 2013. Photonic crystal lab-on-a-chip for detecting staphylococcal entertoxin B at low attomolar concentration. Anal Chem 85(6):3104-3109. doi:10.1021/ac303016h PMID:23418954 PMCID:PMC3608201
  • Han J, Kim H, Sudheendra L, Hass EA, Gee SJ, Hammock BD, Kennedy IM. 2013. Electrophoretic build-up of multi nanoparticle array for a highly sensitive immunoassay. Biosens Bioelectron 41:302-308. doi:10.1016/j.bios.2012.08.042 PMID:23021853 PMCID:PMC3525773
  • Hwang SH, Wecksler AT, Wagner KM, Hammock BD. 2013. Rationally designed multitarget agents against inflammation and pain. Curr Med Chem 20(13):1783-1799. doi:10.2174/0929867311320130013 PMID:23410172 PMCID:PMC4113248
  • Hwang SH, Wecksler AT, Zhang G, Morisseau C, Nguyen LV, Fu SH, Hammock BD. 2013. Synthesis and biological evaluation of sorafenib- and regorafenib- like sEH inhibitors. Bioorg Med Chem Lett 23(13):3732-3737. doi:10.1016/j.bmcl.2013.05.011 PMID:23726028 PMCID:PMC3744640
  • Inceoglu B, Zolkowska D, Yoo H, Wagner KM, Yang J, Hackett E, Hwang SH, Lee KS, Rogawski MA, Morisseau C, Hammock BD. 2013. Epoxy fatty acids and inhibition of the soluble epoxide hydrolase selectively modulate GABA mediated neurotransmission to delay onset of seizures. PLoS One 8(12):doi:10.1371/journal.pone.0080922 PMID:24349022 PMCID:PMC3862847
  • Kamita SG, Oshita GH, Wang P, Morisseau C, Hammock BD, Nandety R, Falk BW. 2013. Characterization of HOVI-MEH1, a microsomal epoxide hydrolase from the Glassy-Winged Sharpshooter Homalodisca vitripennis. Arch Insect Biochem Physiol 83(4):171-179. doi:10.1002/arch.21100 PMID:23704009 PMCID:PMC3846607
  • Kamita SG, Yamamoto K, Dadala MM, Pha K, Morisseau C, Escaich A, Hammock BD. 2013. Cloning and characterization of a microsomal epoxide hydrolase from Heliothis virescens. Insect Biochem Mol Biol 43(3):219-228. doi:10.1016/j.ibmb.2012.12.002 PMID:23276675 PMCID:PMC3577957
  • Lee KS, Morisseau C, Yang J, Wang P, Hwang SH, Hammock BD. 2013. Forster resonance energy transfer competitive displacement assay for human soluble epoxide hydrolase. Anal Biochem 434(2):259-268. doi:10.1016/j.ab.2012.11.015 PMID:23219719 PMCID:PMC3632402
  • Liu J, Lin Y, Qiu H, Morisseau C, Rose TE, Hwang SH, Chiamvimonvat N, Hammock BD. 2013. Substituted phenyl groups improve the pharmacokinetic profile and anti-inflammatory effect of urea-based soluble epoxide hydrolase inhibitors in murine models. European Journal of Pharmaceutical Sciences 48(4-5):619-627. doi:10.1016/j.ejps.2012.12.013 PMID:23291046 PMCID:PMC3596469
  • Lundstrom SL, Yang J, Brannan JD, Haeggstrom JZ, Nair P, O'Byrne P, Dahlen SE, Wheelock CE. 2013. Lipid mediator serum profiles in asthmatics significantly shift following dietary supplementation with omega-3 fatty acids. Mol Nutr Food Res 57(8):1378-1789. doi:10.1002/mnfr.201200827 PMID:23824870 PMCID:PMC3943463
  • Morisseau C. 2013. Role of epoxide hydrolases in lipid metabolism. Biochimie 95(1):91-95. doi:10.1016/j.biochi.2012.06.011 PMID:22722082 PMCID:PMC3495083
  • Morisseau C, Hammock BD. 2013. Impact of soluble epoxide hydrolase and epoxyeicosanoids on human health. Annu Rev Pharmacol Toxicol 53:37-58. doi:10.1146/annurev-pharmtox-011112-140244 PMID:23020295 PMCID:PMC3578707
  • Morisseau C, Pakhomova S, Hwang SH, Newcomer ME, Hammock BD. 2013. Inhibition of soluble epoxide hydrolase by fulvestrant and sulfoxides. Bioorg Med Chem Lett 23(13):3818-3821. doi:10.1016/j.bmcl.2013.04.083 PMID:23684894 PMCID:PMC3703951
  • Morisseau C, Sahdeo S, Cortopassi GA, Hammock BD. 2013. Development of an HTS assay for EPHX2 phosphatase activity and screening of nontargeted libraries. Anal Biochem 434(1):105-111. doi:10.1016/j.ab.2012.11.017 PMID:23219563 PMCID:PMC3557602
  • Nording ML, Yang J, Georgi K, Karbowski CH, German JB, Weiss RH, Hogg RJ, Trygg J, Hammock BD, Zivkovic AM. 2013. Individual variation in lipidomic profiles of healthy subjects in response to omega-3 Fatty acids. PLoS One 8:e76575. doi:10.1371/journal.pone.0076575 PMID:24204640 PMCID:PMC3811983
  • Panigrahy D, Kalish BT, Huang S, Bielenberg DR, Le HD, Yang J, Edin ML, Lee CR, Benny O, Mudge DK, Butterfield CE, Mammoto A, Mammoto T, Inceoglu B, Jenkins RL, Simpson MA, Akino T, Lih FB, Tomer KB, Ingber DE, Hammock BD, Falck JR, Manthati VL, Kaipainen A, D'Amore PA, Puder M, Zeldin DC, Kieran MW. 2013. Epoxyeicosanoids promote organ and tissue regeneration. Proc Natl Acad Sci U S A 110(33):13528-13533. doi:10.1073/pnas.1311565110 PMID:23898174 PMCID:PMC3746918
  • Poli G, Corda E, Martino P, Dall'Ara P, Bareggi SR, Bondiolotti G, Iulini B, Mazza M, Casalone C, Hwang SH, Hammock BD, Inceoglu B. 2013. Therapeutic activity of inhibition of the soluble epoxide hydrolase in a mouse model of scrapie. Life Sciences 92(23):1145-1150. doi:10.1016/j.lfs.2013.04.014 PMID:23651659 PMCID:PMC3806320
  • Ranganathan A, Paradise GA, Hansen CA, McCoy MR, Gee SJ, Zhong P, Chang D, Hammock BD. 2013. Indirect homologous competitive enzyme-linked immunosorbent assay for the detection of a class of glycosylated dihydrochalcones. J Agric Food Chem 61(28):6964-6970. doi:10.1021/jf401302y PMID:23767873 PMCID:PMC3723731
  • Schuchardt J, Schmidt S, Kressel G, Dong H, Willenberg I, Hammock BD, Hahn A, Schebb N. 2013. Comparison of free serum oxylipin concentrations in hyper- vs. normolipidemic men. Prostaglandins Leukot Essent Fatty Acids 89(1):19-29. doi:10.1016/j.plefa.2013.04.001 PMID:23694766 PMCID:PMC4057063
  • Sirish P, Li N, Liu J, Lee KS, Hwang SH, Qiu H, Zhao C, Ma S, Lopez JE, Hammock BD, Chiamvimonvat N. 2013. Unique mechanistic insights into the beneficial effects of soluble epoxide hydrolase inhibitors in the prevention of cardiac fibrosis. Proc Natl Acad Sci U S A 110(14):5618-5623. doi:10.1073/pnas.1221972110 PMID:23493561 PMCID:PMC3619365
  • Smilowitz JT, Zivkovic AM, Wan YY, Watkins SM, Nording M, Hammock BD, German JB. 2013. Nutritional lipidomics: molecular metabolism, analytics, and diagnostics. Mol Nutr Food Res 57(8):1319-1335. doi:10.1002/mnfr.201200808 PMID:23818328 PMCID:PMC3806310
  • Stewart DN, Lango J, Nambiar KP, Falso MS, Fitzgerald PG, Rocke DM, Hammock BD, Buchholz BA. 2013. Carbon turnover in the water-soluble protein of the adult human lens. Mol Vis 19:463-475. PMID:23441119 PMCID:PMC3580966
  • Trunnelle KJ, Bennett DH, Tancredi DJ, Gee SJ, Stoecklin-Marois MT, Hennessy-Burt TE, Hammock BD, Schenker MB. 2013. Pyrethroids in house dust from the homes of farm worker families in the MICASA study. Environ Int 61:57-63. doi:10.1016/j.envint.2013.09.007 PMID:24096042 PMCID:PMC4059492
  • Ulu A, Harris TR, Morisseau C, Miyabe C, Inoue H, Schuster G, Dong H, Iosif A, Liu J, Weiss RH, Chiamvimonvat N, Imig JD, Hammock BD. 2013. Anti-inflammatory effects of omega-3 polyunsaturated fatty acids and soluble epoxide hydrolase inhibitors in angiotensin-II dependent hypertension. J Cardiovasc Pharmacol 62(3):285-297. doi:10.1097/FJC.0b013e318298e460 PMID:23676336 PMCID:PMC3773051
  • Van Bogaert I, Zhang G, Yang J, Liu J, Ye Y, Soetaert W, Hammock BD. 2013. Preparation of 20- HETE using multifunctional enzyme type 2-negative Starmerella bombicola. J Lipid Res 54(11):3215-3219. doi:10.1194/jlr.D042226 PMID:23966667 PMCID:PMC3793626
  • Vanrell L, Gonzalez-Techera A, Hammock BD, Gonzalez-Sapienza GG. 2013. Nanopeptamers for the development of small-analyte lateral flow tests with a positive readout. Anal Chem 85(2):1177-1182. doi:10.1021/ac3031114 PMID:23214940 PMCID:PMC3904493
  • Wagner KM, Inceoglu B, Dong H, Yang J, Hwang SH, Jones PD, Morisseau C, Hammock BD. 2013. Comparative efficacy of 3 soluble epoxide hydrolase inhibitors in rat neuropathic and inflammatory pain models. Eur J Pharmacol 700(1-3):93-101. doi:10.1016/j.ejphar.2012.12.015 PMID:23276668 PMCID:PMC3578047
  • Wang Y, Li P, Majkova Z, Bever C, Kim H, Zhang Q, Dechant JE, Gee SJ, Hammock BD. 2013. Isolation of alpaca anti-idiotypic heavy-chain single-domain antibody for the aflatoxin immunoassay. Anal Chem 85(17):8298-8303. doi:10.1021/ac4015885 PMID:23965250 PMCID:PMC3787825
  • Wang Y, Wang H, Li P, Zhang Q, Kim H, Gee SJ, Hammock BD. 2013. Correction to: Phage- displayed peptide that mimics aflatoxins and its application in immunoassay. J Agric Food Chem 61(16):3994. doi:10.1021/jf401235p
  • Wang Y, Wang H, Li P, Zhang Q, Kim H, Gee SJ, Hammock BD. 2013. Phage-displayed peptide that mimics aflatoxins and its application in immunoassay. J Agric Food Chem 61(10):2426–2433. doi:10.1021/jf4004048 PMID:23394544 PMCID:PMC3830680
  • Wettersten HI, Hwang SH, Li C, Shiu EY, Wecksler AT, Hammock BD, Weiss RH. 2013. A novel p21 attenuator which is structurally related to sorafenib. Cancer Biol Ther 14:278-285. doi:10.4161/cbt.23374 PMID:23298903 PMCID:PMC3595311
  • Yang J, Solaimani P, Dong H, Hammock BD, Hankinson O. 2013. Treatment of mice with 2,3,7,8-Tetrachlorodibenzo-p-dioxin markedly increases the levels of a number of cytochrome P450 metabolites of omega-3 polyunsaturated fatty acids in the liver and lung. Toxicol Sci 38(6):833-836. PMID:24213002 PMCID:PMC4068614
  • Zhang G, Panigrahy D, Mahakian LM, Yang J, Liu J, Lee KS, Wettersten HI, Ulu A, Hu X, Tam S, Hwang SH, Ingham ES, Kieran MW, Weiss RH, Ferrara KW, Hammock BD. 2013. Epoxy metabolites of docosahexaenoic acid (DHA) inhibit angiogenesis, tumor growth, and metastasis. Proc Natl Acad Sci U S A 110(16):6530-6535. doi:10.1073/pnas.1304321110 PMID:23553837 PMCID:PMC3631682
  • Zhang W, Li H, Dong H, Liao J, Hammock BD, Yang G. 2013. Soluble epoxide hydrolase deficiency inhibits dextran sulfate sodium-induced colitis and carcinogenesis in mice. Anticancer Res 33(12):5261-5271. PMID:24324059 PMCID:PMC4076172


  • Ahn K, Kasagami T, Tsai H, Schebb N, Ogunyoku TA, Gee SJ, Young TM, Hammock BD. 2012. An immunoassay to evaluate human/environmental exposure to the antimicrobial triclocarban. Environ Sci Technol 46:374-381. doi:10.1021/es202494d PMID:22077920 PMCID:PMC3258304 (Completed with ARRA Funds)
  • Cao Z, Hammock BD, McCoy MR, Rogawski MA, Lein PJ, Pessah IN. 2012. Tetramethylenedisulfotetramine alters Ca2+ dynamics in cultured hippocampal neurons: mitigation by NMDA receptor blockade and GABA(A) receptor-positive modulation. Toxicol Sci 130(2):362-372. doi:10.1093/toxsci/kfs244 PMID:22889812 PMCID:PMC3529644
  • Charrier JG, Anastasio C. 2012. On dithiothreitol (DTT) as a measure of oxidative potential for ambient particles: evidence for the importance of soluble transition metals. Atmos Chem Phys 12:9321-9333. doi:10.5194/acp-12-9321-2012 PMID:23393494 PMCID:PMC3564657
  • Cherednichenko G, Zhang R, Bannister RA, Timofeyev V, Li N, Fritsch EB, Feng W, Barrientos G, Schebb N, Hammock BD, Beam KG, Chiamvimonvat N, Pessah IN. 2012. Triclosan impairs excitation-contraction coupling and Ca2+ dynamics in striated muscle. Proc Natl Acad Sci U S A 109(35):14158-14163. doi:10.1073/pnas.1211314109 PMID:22891308 PMCID:PMC3435154
  • Eiserich JP, Yang J, Morrissey BM, Hammock BD, Cross CE. 2012. Omics approaches in cystic fibrosis research: a focus on oxylipin profiling in airway secretions. Ann N Y Acad Sci 1259:1-9. doi:10.1111/j.1749-6632.2012.06580.x PMID:22758630 PMCID:PMC3403728
  • Inceoglu AB, Clifton HL, Yang J, Hegedus C, Hammock BD, Schaefer S. 2012. Inhibition of soluble epoxide hydrolase limits niacin-induced vasodilation in mice. J Cardiovasc Pharmacol 60:70-75. doi:10.1097/FJC.0b013e3182580a5d PMID:22526297 PMCID:PMC3396292
  • Inceoglu B, Wagner KM, Yang J, Bettaieb A, Schebb N, Hwang SH, Morisseau C, Haj FG, Hammock BD. 2012. Acute augmentation of epoxygenated fatty acid levels rapidly reduces pain-related behavior in a rat model of Type I Diabetes. Proc Natl Acad Sci U S A 109(28):11390-11395. doi:10.1073/pnas.1208708109 PMID:22733772 PMCID:PMC3396532
  • Jorgenson BC, Wissel-Tyson C, Young TM. 2012. Factors contributing to the off-target transport of pyrethroid insecticides from urban surfaces. J Agric Food Chem 60(30):7333-7340. doi:10.1021/jf301241n PMID:22784034 PMCID:PMC3646940
  • Kim H, McCoy MR, Majkova Z, Dechant JE, Gee SJ, Tabares-da Rosa S, Gonzalez-Sapienza GG, Hammock BD. 2012. Correction to isolation of alpaca antihapten heavy chain single domain antibodies for development of sensitive immunioassay. Anal Chem 84(15):6919–6919. doi:10.1021/ac301927h PMID:22830304 PMCID:PMC3460544
  • Kim I, Nishi K, Kasagami T, Morisseau C, Liu J, Tsai H, Hammock BD. 2012. Biologically active ester derivatives as potent inhibitors of the soluble epoxide hydrolase. Bioorg Med Chem Lett 22(18):5889-5892. doi:10.1016/j.bmcl.2012.07.074 PMID:22901393 PMCID:PMC3432147
  • Lin Y, Ubels JL, Schotanus MP, Yin Z, Pintea V, Hammock BD, Watsky MA. 2012. Enhancement of vitamin D metabolites in the eye following vitamin D3 supplementation and UV-B irradiation. Curr Eye Res 37(10):871-878. doi:10.3109/02713683.2012.688235 PMID:22632164 PMCID:PMC3572765
  • McCoy MR, Yang Z, Fu X, Ahn K, Gee SJ, Bom DC, Zhong P, Chang D, Hammock BD. 2012. Monitoring of total type II pyrethroid pesticides in citrus oils and water by converting to a common product 3-phenoxybenzoic acid. J Agric Food Chem 60:5065-5070. doi:10.1021/jf2051653 PMID:22486225 PMCID:PMC3412423
  • Morisseau C, Schebb N, Dong H, Ulu A, Aronov PA, Hammock BD. 2012. Role of soluble epoxide hydrolase phosphatase activity in the metabolism of lysophosphatidic acids. Biochem Biophys Res Commun 419:796-800. doi:10.1016/j.bbrc.2012.02.108 PMID:22387545 PMCID:PMC3313618
  • Qiu H, Liu J, Wei D, Li N, Yamoah EN, Hammock BD, Chiamvimonvat N. 2012. Cardiac-generated prostanoids mediate cardiac myocyte apoptosis after myocardial ischaemia. Cardiovasc Res 95(3):336-345. doi:10.1093/cvr/cvs191 PMID:22707158 PMCID:PMC3400359
  • Schebb N, Ahn K, Dong H, Gee SJ, Hammock BD. 2012. Whole blood is the sample matrix of choice for monitoring systemic triclocarbon levels. Chemosphere 87(7):825-827. doi:10.1016/j.chemosphere.2011.12.077 PMID:22273184 PMCID:PMC3538789 (Completed with ARRA Funds)
  • Schebb N, Buchholz BA, Hammock BD, Rice RH. 2012. Metabolism of the antibacterial triclocarban by human epidermal keratinocytes to yield protein adducts. J Biochem Mol Toxicol 26(6):230-234. doi:10.1002/jbt.21411 PMID:22711420 PMCID:PMC3522462
  • Schebb N, Franze B, Maul R, Ranganathan A, Hammock BD. 2012. In vitro glucuronidation of the antibacterial triclocarban and its oxidative metabolites. Drug Metab Dispos 40:25-31. doi:10.1124/dmd.111.042283 PMID:21953915 PMCID:PMC3250046 (Completed with ARRA Funds)
  • Thiphom S, Prapamontol T, Chantara S, Mangklabruks A, Suphavilai C, Ahn K, Gee SJ, Hammock BD. 2012. An enzyme-linked immunosorbent assay for detecting 3-phenoxybenzoic acid in plasma and its application to farmers and consumers. Analytical Methods 4:3772-3778. doi:10.1039/c2ay25642h PMID:23667388 PMCID:PMC3646417
  • Yang J, Eiserich JP, Cross CE, Morrissey BM, Hammock BD. 2012. Metabolomic profiling of regulatory lipid mediators in sputum from adult cystic fibrosis patients. Free Radic Biol Med 53(1):160-171. doi:10.1016/j.freeradbiomed.2012.05.001 PMID:22580336 PMCID:PMC3412514
  • Yao H, Liu J, Samra AI, Kamita SG, Cornel AJ, Hammock BD, Huang H. 2012. Development of pyrethroid-like fluorescent substrates for glutathione S-transferase. Anal Biochem 431:77-83. doi:10.1016/j.ab.2012.09.011 PMID:23000005 PMCID:PMC3489985
  • Yueh MF, Li T, Evans RM, Hammock BD, Tukey RH. 2012. Triclocarban mediates induction of xenobiotic metabolism through activation of the constitutive androstane receptor and the estrogen receptor alpha. PLoS One 7(6):e37705. doi:10.1371/journal.pone.0037705 PMID:22761658 PMCID:PMC3376094 (Completed with ARRA Funds)
  • Zhang W, Yang AL, Liao J, Li H, Dong H, Chung Y, Bai H, Matkowskyj KA, Hammock BD, Yang G. 2012. Soluble epoxide hydrolase gene deficiency or inhibition attenuates chronic active inflammatory bowel disease in IL-10(-/-) mice. Dig Dis 57(10):2580-2591. doi:10.1007/s10620-012-2217-1 PMID:22588244 PMCID:PMC3664520
  • Zivkovic AM, Yang J, Georgi K, Hegedus C, Nording ML, O'Sullivan A, German JB, Hogg RJ, Weiss RH, Bay C, Hammock BD. 2012. Serum oxylipin profiles in lgA nephropathy patients reflect kidney functional alterations. Metabolomics 8(6):1102-1113. doi:10.1007/s11306-012-0417-5 PMID:23833568 PMCID:PMC3700377
  • Zolkowska D, Banks CN, Dhir A, Inceoglu B, Sanborn JR, McCoy MR, Bruun DA, Hammock BD, Lein PJ, Rogawski MA. 2012. Characterization of seizures induced by acute and repeated exposure to tetramethylenedisulfotetramine. J Pharmacol Exp Ther 341(2):435-446. doi:10.1124/jpet.111.190579 PMID:22328574 PMCID:PMC3336809


  • Abdu E, Bruun DA, Yang DR, Yang J, Inceoglu B, Hammock BD, Alkayed NJ, Lein PJ. 2011. Epoxyeicosatrienoic acids enhance axonal growth in primary sensory and cortical neuronal cell cultures. J Neurochem 117:632-642. doi:10.1111/j.1471-4159.2010.07139.x PMID:21155804 PMCID:PMC3081369
  • Barhoumi R, Mouneimne Y, Hammock BD, Safe SH, Burghardt RC, Parrish AR, Ramos E. 2011. Multiphoton spectral analysis of benzo a pyrene uptake and metabolism in a rat liver cell line. Toxicol Appl Pharmacol 253:45-56. doi:10.1016/j.taap.2011.03.009 PMID:21420996 PMCID:PMC3081912
  • Barile D, Guinard J, Meyrand M, German JB. 2011. Examining bioactive components of mil Complex oligosaccharides (Part 1). Agro Food Ind Hi Tech 22:34-36.
  • Charles RL, Burgoyne JR, Mayr M, Weldon SM, Hubner N, Dong H, Morisseau C, Hammock BD, Landar A, Eaton P. 2011. Redox regulation of soluble epoxide hydrolase by 15-Deoxy-AProstaglandin J2 controls coronary hypoxic vasodilation. Circ. Res. Circ Res 108:324-334. doi:10.1161/CIRCRESAHA.110.235879 PMID:21164107 PMCID:PMC3259859
  • Dallas DC, Martin WF, Strum JS, Zivkovic AM, Smilowitz JT, Underwood MA, Affolter M, Lebrilla CB, German JB. 2011. N-linked glycan profiling of mature human milk by high-performance microfluidic chip liquid chromatography time-of-flight tandem mass spectrometry. J Agric Food Chem 59(8):4255-4263. doi:10.1021/jf104681p PMID:21384928 PMCID:PMC4422756
  • Davis BB, Liu J, Tancredi DJ, Wang L, Simon SI, Hammock BD, Pinkerton KE. 2011. The anti-inflammatory effects of soluble epoxide hydrolase inhibitors are independent of leukocyte recruitment. Biochem Biophys Res Commun 410:494-500. doi:10.1016/j.bbrc.2011.06.008 PMID:21683067 PMCID:PMC3166856
  • Gee SJ, Gonazlez-Sapienza GG, Hammock BD, Kim H, McCoy MR. 2011. Noncompetitive phage anti-immunocomplex real-time polymerase chain reaction for sensitive detection of small molecules. Anal Chem 83(1):246-253. doi:10.1021/ac102353z PMID:21141939 PMCID:PMC3031424
  • Honetschlagerova Z, Huskova Z, Vanourkova Z, Sporkova A, Kramer HJ, Hwang SH, Tsai H, Hammock BD, Imig JD, Cervenka L, Kopkan L. 2011. Renal mechanisms contributing to the antihypertensive action of soluble epoxide hydrolase inhibition in Ren-2 transgenic rats with inducible hypertension. J Physiol 589(Pt1):207-219. doi:10.1113/jphysiol.2010.199505 PMID:21078594 PMCID:PMC3039270
  • Hwang SH, Wagner KM, Morisseau C, Liu J, Dong H, Wecksler AT, Hammock BD. 2011. Synthesis and structure-activity relationship studies of urea-containing pyrazoles as dual inhibitors of cyclooxygenase-2 and soluble epoxide hydrolase. J Med Chem 54:3037-3050. doi:10.1021/jm2001376 PMID:21434686 PMCID:PMC3281519
  • Inoue H, Hwang SH, Wecksler AT, Hammock BD, Weiss RH. 2011. Sorafenib attenuates p21 in kidney cancer cells and augments cell death in combination with DNA-damaging chemotherapy. Cancer Biol Ther 12:827-836. doi:10.4161/cbt.12.9.17680 PMID:21878748 PMCID:PMC3225758
  • Kamita SG, Samra AI, Liu J, Cornel AJ, Hammock BD. 2011. Juvenile hormone (JH) esterase of the mosquito Culex quinquefasciatus is not a target of the JH analog insecticide methoprene. PLoS One 6:doi:10.1371/journal.pone.0028392 PMID:22174797 PMCID:PMC3235118
  • Li YY, Liu J, Harris TR, Sirish P, Hammock BD, Chiamvimonvat N. 2011. Use of metabolomics profiling in the study of arachidonic acid metabolism in cardiovascular disease. American Journal of Cardiology 17:42-46. doi:10.1111/j.1751-7133.2010.00209.x PMID:21272227 PMCID:PMC3583533
  • Luria A, Bettaieb A, Xi Y, Shieh G, Liu H, Inoue H, Tsai H, Imig JD, Haj FG, Hammock BD. 2011. Soluble epoxide hydrolase deficiency alters pancreatic islet size and improves glucose homeostasis in a model of insulin resistance. Proc Natl Acad Sci U S A 108(22):9038-9043. doi:10.1073/pnas.1103482108 PMID:21571638 PMCID:PMC3107315
  • Morisseau C, Bernay M, Escaich A, Sanborn JR, Lango J, Hammock BD. 2011. Development of fluorescent substrates for microsomal epoxide hydrolase and application to inhibition studies. Anal Biochem 414(1):154-162. doi:10.1016/j.ab.2011.02.038 PMID:21371418 PMCID:PMC3090455
  • Qiu H, Li N, Liu J, Harris TR, Hammock BD, Chiamvimonvat N. 2011. Soluble epoxide hydrolase inhibitors and heart failure. Cardiovasc Ther 29(2):99-111. doi:10.1111/j.1755-5922.2010.00150.x PMID:20433684 PMCID:PMC3325372
  • Schebb N, Huby M, Morisseau C, Hwang SH, Hammock BD. 2011. Development of an online SPE-LC-MS-based assay using endogenous substrate for investigation of soluble epoxide hydrolase (sEH) inhibitors. Anal Bioanal Chem 400(5):1359-1366. doi:10.1007/s00216-011-4861-2 PMID:21479549 PMCID:PMC3081056
  • Schebb N, Inceoglu B, Rose TE, Wagner KM, Hammock BD. 2011. Development of an ultra fast online-solid phase extraction (SPE) liquid chromatography electrospray tandem mass spectrometry (LC-ESI-MS/MS) based approach for the determination of drugs in pharmacokinetic studies. Analytical Methods 3:420-428. doi:10.1039/c0ay00714e PMID:21660124 PMCID:PMC3110015
  • Schebb N, Kurobe T, Franze B, Ranganathan A, Hammock BD, Teh SJ, Flores I. 2011. Bioconcentration, metabolism and excretion of triclocarban in larval Qurt medaka (Oryzias latipes). Aquat Toxicol 105:448-454. doi:10.1016/j.aquatox.2011.07.020 PMID:21872556 PMCID:PMC3236035
  • Sporkova A, Kopkan L, Varcabova S, Huskova Z, Hwang SH, Hammock BD, Imig JD, Kramer HJ, Cervenka L. 2011. Role of cytochrome P-450 metabolites in the regulation of renal function and blood pressure in 2-kidney 1-clip hypertensive rats. Am J Physiol Regul Integr Comp Physiol 300:R1468-R1475. doi:10.1152/ajpregu.00215.2010 PMID:21411763 PMCID:PMC3119161
  • Wagner KM, Inceoglu B, Gill S, Hammock BD. 2011. Epoxygenated fatty acids and soluble epoxide hydrolase inhibition: novel mediators of pain reduction. J Agric Food Chem 59:2816-2824. doi:10.1021/jf102559q PMID:20958046 PMCID:PMC3483885
  • Wagner KM, Inceoglu B, Hammock BD. 2011. Soluble epoxide hydrolase inhibition, epoxygenated fatty acids and nociception. Prostaglandins Other Lipid Mediat 96:76-83. doi:10.1016/j.prostaglandins.2011.08.001 PMID:21854866 PMCID:PMC3215909
  • Yang J, Dong H, Hammock BD. 2011. Profiling the regulatory lipids: another systemic way to unveil the biological mystery. Curr Opin Lipidol 22:197-203. doi:10.1097/MOL.0b013e3283468c10 PMID:21537174 PMCID:PMC3498048
  • Yin Z, Pintea V, Lin Y, Hammock BD, Watsky MA. 2011. Vitamin D enhances corneal epithelial barrier function. Invest Ophthalmol Vis Sci 52:7359-7364. doi:10.1167/iovs.11-7605 PMID:21715350 PMCID:PMC3183972


  • Alihosseini F, Lango J, Ju K, Hammock BD, Sun G. 2010. Mutation of bacterium Vibrio gazogenes for selective preparation of colorants. Biotechnol Prog 26(2):352-360. doi:10.1002/btpr.346 PMID:19902486 PMCID:PMC2864118
  • Argov-Argaman N, Smilowitz JT, Bricarello DA, Barboza M, Lerno L, Froehlich JW, Lee H, Zivkovic AM, Lemay DG, Freeman S, Lebrilla CB, Parikh AN, German JB. 2010. Lactosomes: Structural and compositional classification of unique nanometer-sized protein lipid particles of human milk. J Agric Food Chem 58(21):11234-11242. doi:10.1021/jf102495s PMID:20925428 PMCID:PMC3039697
  • Baumann A, Lohmann W, Rose TE, Ahn K, Hammock BD, Karst U, Schebb N. 2010. Electrochemistry-mass spectrometry unveils the formation of reactive triclocarban metabolites. Drug Metab Dispos 38(12):2130-2138. doi:10.1124/dmd.110.034546 PMID:20861155 PMCID:PMC2993458 (Completed with ARRA Funds)
  • Buchholz BA, Haack KW, Sporty JL, Buckpitt AR, Morin D. 2010. Free flow electrophoresis separation and AMS quantitation of 14C-naphthalene-protein adducts. Nucl Instrum Methods Phys Res B 268(7-8):1324-1327. doi:10.1016/j.nimb.2009.10.164 PMID:20454606 PMCID:PMC2864045
  • Buchholz BA, Zermeno P, Hwang H, Guilderson TP, Young TM. 2010. Measuring submicron-size fractionated particulate matter on aluminum impactor disks. Radiocarbon 52(2):278-285. PMID:22228915 PMCID:PMC3252030
  • Carlomagno M, Matho C, Cantou G, Sanborn JR, Last JA, Hammock BD, Roel A, Gonzalez D, Gonzalez-Sapienza GG. 2010. A clomazone immunoassay to study the environmental fate of the herbicide in rice (Oryza sativa) agriculture. J Agric Food Chem 58(7):4367-4371. doi:10.1021/jf9043259 PMID:20302341 PMCID:PMC2878771
  • Chabova VC, Walkowska A, Kompanowska-Jezierska E, Sadowski J, Kujal P, Vernerova Z, Vanourkova Z, Kopkan L, Kramer HJ, Imig JD, Hammock BD, Vaneckova I, Cervenka L, Falck JR. 2010. Combined inhibition of 20-hydroxyeicosatetraenoic acid formation and of epoxyeicosatrienoic acids degradation attenuates hypertension and hypertension-induced end-organ damage in Ren-2 transgenic rats. Clin Sci (Lond) 118(10):617-632. doi:10.1042/CS20090459 PMID:20050826 PMCID:PMC2854172
  • Froehlich JW, Dodds ED, Barboza M, McJimpsey EL, Seipert RR, Francis J, An HJ, Freeman S, German JB, Lebrilla CB. 2010. Glycoprotein expression in human milk during lactation. J Agric Food Chem 58(10):6440-6448. doi:10.1021/jf100112x PMID:20415418 PMCID:PMC2882031
  • Garcia-Nieto E, Nichkova MJ, Yanez L, Costilla-Salazar R, Torres-Dosal A, Gee SJ, Hammock BD, Juarez-Santacruz L, Diaz-Barriga F. 2010. Assessment of dioxin-like soil contamination in Mexico by enzyme-linked immunosorbent assay. Arch Environ Contam Toxicol 58(4):918-926. doi:10.1007/s00244-009-9422-8 PMID:20091164 PMCID:PMC3033344
  • Hall LM, Kimlin M, Aronov PA, Hammock BD, Slusser J, Woodhouse L, Stephensen CB. 2010. Vitamin D intake needed to maintain target serum 25-hydroxyvitamin D concentrations in participants with low sun exposure and dark skin pigmentation is substantially higher than current recommendations. J Nutr 140(3):542-550. doi:10.3945/jn.109.115253 PMID:20053937 PMCID:PMC2821886
  • Kim H, Rossotti MA, Ahn K, Gonzalez-Sapienza GG, Gee SJ, Musker R, Hammock BD. 2010. Development of a noncompetitive phage anti-immunocomplex assay for brominated diphenyl ether 47. Anal Biochem 401(1):38-46. doi:10.1016/j.ab.2010.01.040 PMID:20152791 PMCID:PMC2861364
  • Kubala L, Schmelzer KR, Klinke A, Kolarova H, Baldus S, Hammock BD, Eiserich JP. 2010. Modulation of arachidonic and linoleic acid metabolites in myeloperoxidase-deficient mice during acute inflammation. Free Radic Biol Med 48(10):1311-1320. doi:10.1016/j.freeradbiomed.2010.02.010 PMID:20156554 PMCID:PMC2856720
  • Liu J, Li N, Yang J, Li N, Qiu H, Ai D, Chiamvimonvat N, Zhu Y, Hammock BD. 2010. Metabolic profiling of murine plasma reveals an unexpected biomarker in rofecoxib-mediated cardiovascular events. Proc Natl Acad Sci U S A 107(39):17017-17022. doi:10.1073/pnas.1011278107 PMID:20837537 PMCID:PMC2947894
  • Morisseau C, Inceoglu B, Schmelzer KR, Tsai H, Jinks SL, Hegedus CM, Hammock BD. 2010. Naturally occurring monoepoxides of eicosapentaenoic acid and docosahexaenoic acid are bioactive antihyperalgesic lipids. J Lipid Res 51:3481-3490. doi:10.1194/jlr.M006007 PMID:20664072 PMCID:PMC2975720
  • Nording ML, Yang J, Hegedus CM, Bhushan A, Kenyon NJ, Davis CE, Hammock BD. 2010. Endogenous levels of five fatty acid metabolites in exhaled breath condensate to monitor asthma by high-performance liquid chromatography: Electrospray tandem mass spectrometry. IEEE/ACM Trans Comput Biol Bioinform 10(1):123-130. doi:10.1109/JSEN.2009.2035736 PMID:21103452 PMCID:PMC2981865
  • Rayo J, Munoz L, Rosell G, Hammock BD, Guerrero A, Luque FJ, Pouplana R. 2010. Reactivity versus steric effects in fluorinated ketones as esterase inhibitors: a quantum mechanical and molecular dynamics study. J Mol Model 16(11):1753-1764. doi:10.1007/s00894-010-0807-4 PMID:20676708 PMCID:PMC3014912
  • Rose TE, Morisseau C, Liu J, Inceoglu B, Jones PD, Sanborn JR, Hammock BD. 2010. 1-Aryl-3-(1-acylpiperidin-4-yl)urea inhibitors of human and murine soluble epoxide hydrolase: structure-activity relationships, pharmacokinetics, and reduction of inflammatory pain. J Med Chem 53(19):7067-7075. doi:10.1021/jm100691c PMID:20812725 PMCID:PMC3285450
  • Rossotti MA, Carlomagno M, Gonzalez-Techera A, Hammock BD, Last JA, Gonzalez-Sapienza GG. 2010. Phage anti-immunocomplex assay for clomazone: two-site recognition increasing assay specificity and facilitating adaptation into an on-site format. Anal Chem 82(21):8838-8843. doi:10.1021/ac101476f PMID:20886819 PMCID:PMC3025275
  • Tsai H, Hwang SH, Morisseau C, Yang J, Jones PD, Kasagami T, Kim I, Hammock BD. 2010. Pharmacokinetic screening of soluble epoxide hydrolase inhibitors in dogs. European Journal of Pharmaceutical Sciences 40(3):222-238. doi:10.1016/j.ejps.2010.03.018 PMID:20359531 PMCID:PMC3285443
  • Wang Y, Ulu A, Zhang L, Hammock BD. 2010. Soluble epoxide hydrolase in atherosclerosis. Curr Atheroscler Rep 12(3):174-183. doi:10.1007/s11883-010-0108-5 PMID:20425256 PMCID:PMC2857794


  • Ahn K, Gee SJ, Tsai H, Bennett DH, Nishioka M, Blum A, Fishman E, Hammock BD. 2009. Immunoassay for monitoring environmental and human exposure to the polybrominated diphenyl ether BDE-47. Environ Sci Technol 43(20):7784-7790. doi:10.1021/es9009037 PMID:19921894 PMCID:PMC3528349
  • Ai D, Pang W, Li N, Xu M, Jones PD, Yang J, Zhang Y, Chiamvimonvat N, Shyy JY, Hammock BD, Zhu Y. 2009. Soluble epoxide hydrolase plays an essential role in angiotensin II-induced cardiac hypertrophy. Proc Natl Acad Sci U S A 106(2):564-569. doi:10.1073/pnas.0811022106 PMID:19126686 PMCID:PMC2626743
  • Barbosa-Sicard E, Fromel T, Keseru B, Brandes RP, Morisseau C, Hammock BD, Braun T, Kruger M, Fleming I. 2009. Inhibition of the soluble epoxide hydrolase by tyrosine nitration. J Biol Chem 284:28156-28163. doi:10.1074/jbc.M109.054759 PMID:19704161 PMCID:PMC2788866
  • Chawengsub Y, Gauthier KM, Nithipatikom K, Hammock BD, Falck JR, Narsimhaswamy D, Campbell WB. 2009. Identification of 13-hydroxy-14,15-epoxyeicosatrienoic acid as an acid-stable endothelium-derived hyperpolarizing factor in rabbit arteries. J Biol Chem 284(45):31280-31290. doi:10.1074/jbc.M109.025627 PMID:19737933 PMCID:PMC2781526
  • Falck JR, Kodela R, Manne R, Atcha KR, Puli N, Dubasi N, Manthati VL, Capdevila JH, Yi X, Goldman DH, Morisseau C, Hammock BD, Campbell WB. 2009. 14,15-Epoxyeicosa-5,8,11-trienoic acid (14,15-EET) surrogates containing epoxide bioisosteres: influence upon vascular relaxation and soluble epoxide hydrolase inhibition. J Med Chem 52(16):5069-5075. doi:10.1021/jm900634w PMID:19653681 PMCID:PMC2888647
  • Huang H, Tanaka H, Hammock BD, Morisseau C. 2009. Novel and highly sensitive fluorescent assay for leucine aminopeptidases. Anal Biochem 391(1):11-16. doi:10.1016/j.ab.2009.05.004 PMID:19433052 PMCID:PMC2748848
  • Kasagami T, Kim I, Tsai H, Nishi K, Hammock BD, Morisseau C. 2009. Salicylate-urea-based soluble epoxide hydrolase inhibitors with high metabolic and chemical stabilities. Bioorg Med Chem Lett 19(6):1784-1789. doi:10.1016/j.bmcl.2009.01.069 PMID:19216074 PMCID:PMC2900318
  • Kim HJ, Ahn K, Gonzalez-Techera A, Gonzalez-Sapienza GG, Gee SJ, Hammock BD. 2009. Magnetic bead-based phage anti-immunocomplex assay (PHAIA) for the detection of the urinary biomarker 3-phenoxybenzoic acid to assess human exposure to pyrethroid insecticides. Anal Biochem 386(1):45-52. doi:10.1016/j.ab.2008.12.003 PMID:19101498 PMCID:PMC2863013
  • Li N, Liu J, Timofeyev V, Qiu H, Hwang SH, Tuteja D, Lu L, Yang J, Mochida H, Low R, Hammock BD, Chiamvimonvat N. 2009. Beneficial effects of soluble epoxide hydrolase inhibitors in myocardial infarction model: Insight gained using metabolomic approaches. J Mol Cell Cardiol 47(6):835-845. doi:10.1016/j.yjmcc.2009.08.017 PMID:19716829 PMCID:PMC3290524
  • Liu J, Park S, Morisseau C, Hwang SH, Hammock BD, Weiss RH. 2009. Sorafenib has soluble epoxide hydrolase inhibitory activity, which contributes to its effect profile in vivo. Mol Cancer Ther 8(8):2193-2203. doi:10.1158/1535-7163.MCT-09-0119 PMID:19671760 PMCID:PMC2728155
  • Liu J, Tsai H, Hwang SH, Jones PD, Morisseau C, Hammock BD. 2009. Pharmacokinetic optimization of four soluble epoxide hydrolase inhibitors for use in a murine model of inflammation. Br J Pharmacol 156(2):284-296. doi:10.1111/j.1476-5381.2008.00009.x PMID:19154430 PMCID:PMC2697843
  • Lu C, Schoenfeld R, Shan Y, Tsai H, Hammock BD, Cortopassi GA. 2009. Frataxin deficiency induces Schwann cell inflammation and death. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1792(11):1052-1061. doi:10.1016/j.bbadis.2009.07.011 PMID:19679182 PMCID:PMC3563672
  • Luria A, Morisseau C, Tsai H, Yang J, Inceoglu B, De Taeye B, Wiest MM, German JB, Hammock BD, Watkins SM. 2009. Alteration in plasma testosterone levels in male mice lacking soluble epoxide hydrolase. Am J Physiol Endocrinol Metab 297(2):E375-E383. doi:10.1152/ajpendo.00131.2009 PMID:19458064 PMCID:PMC2724109
  • Ma Z, Dosev D, Nichkova MJ, Gee SJ, Hammock BD, Kennedy IM. 2009. Synthesis and bio-functionalization of multifunctional magnetic Fe3O4@Y2O3:Eu nanocomposites. J Mater Chem 19:4695-4700. doi:10.1039/B901427F PMID:20357905 PMCID:PMC2847302
  • Matveeva EG, Morisseau C, Goodrow MH, Mullin C, Hammock BD. 2009. Tryptophan fluorescence quenching by enzyme inhibitors as a tool for enzyme active site structure investigation: epoxide hydrolase. Curr Pharm Biotechnol 10(6):589-599. doi:10.2174/138920109789069260 PMID:19619123 PMCID:PMC2861369
  • Morisseau C, Merzlikin O, Lin A, He G, Feng W, Padilla I, Denison MS, Pessah IN, Hammock BD. 2009. Toxicology in the fast lane: application of high-throughput bioassays to detect modulation of key enzymes and receptors. Environ Health Perspect 117(12):1867-1872. doi:10.1289/ehp.0900834 PMID:20049205 PMCID:PMC2799460
  • Nichkova MJ, Fu X, Yang Z, Zhong P, Sanborn JR, Chang D, Gee SJ, Hammock BD. 2009. Immunochemical screening of pesticides (simazine and cypermethrin) in orange oil. J Agric Food Chem 57(13):56735679. doi:10.1021/jf900652a PMID:19526986 PMCID:PMC3033343
  • Parrish AR, Chen G, Burghardt RC, Watanabe T, Hammock BD, Morisseau C. 2009. Attenuation of cisplatin nephrotoxicity by inhibition of soluble epoxide hydrolase. Cell Biol Toxicol 25(3):217-225. doi:10.1007/s10565-008-9071-0 PMID:18386137 PMCID:PMC3033346
  • Shen S, Zhang F, Zeng S, Tian Y, Chai X, Gee SJ, Hammock BD, Zheng J. 2009. Development of enantioselective polyclonal antibodies to detect styrene oxide protein adducts. Anal Chem 81(7):2668-2677. doi:10.1021/ac8023262 PMID:19245253 PMCID:PMC3463234
  • Yang J, Schmelzer KR, Georgi K, Hammock BD. 2009. Quantitative profiling method for oxylipin metabolome by liquid chromatography electrospray ionization tandem mass spectrometry. Anal Chem 81(19):8085-8093. doi:10.1021/ac901282n PMID:19715299 PMCID:PMC3290520


  • Aronov PA, Hall LM, Dettmer K, Stephensen CB, Hammock BD. 2008. Metabolic profiling of major vitamin D metabolites using Diels-Alder derivatization and ultra-performance liquid chromatography-tandem mass spectrometry. Anal Bioanal Chem 391(5):1917-1930. doi:10.1007/s00216-008-2095-8 PMID:18437365 PMCID:PMC3587164
  • Barbosa-Sicard E, Popp R, Fisslthaler B, Hammock BD, Falck JR, Busse R, Fleming I, Keseru B, Dietrich A, Gudermann T, Weissmann N. 2008. Epoxyeicosatrienoic acids and the soluble epoxide hydrolase are determinants of pulmonary artery pressure and the acute hypoxic pulmonary vasoconstrictor response. FASEB J 22(12):4306-4315. doi:10.1096/fj.08-112821 PMID:18725458 PMCID:PMC2614611
  • Bradbury JA, Graves J, Degraff LM, Zhao X, Imig JD, Pedersen TL, Newman JW, Hammock BD, Conley AJ, Korach KS, Zeldin DC, Athirakul K, Ma J, Zhao Y, Couse JF, Quigley R, Harder DR, Coffman TM. 2008. Increased blood pressure in mice lacking cytochrome P450 2J5. FASEB J 22(12):4096-4108. doi:10.1096/fj.08-114413 PMID:18716027 PMCID:PMC2614614
  • Chawengsub Y, Aggarwal N, Nithipatikom K, Gauthier KM, Anjaiah S, Hammock BD, Falck JR, Campbell WB. 2008. Identification of 15-hydroxy-11,12-epoxyeicosatrienoic acid as a vasoactive 15-lipoxygenase metabolite in rabbit aorta. Am J Physiol Heart Circ Physiol 294(3):H1348-H1356. doi:10.1152/ajpheart.01326.2007 PMID:18192225
  • Hwang H, Park E, Young TM, Hammock BD. 2008. Occurrence of endocrine-disrupting chemicals in indoor dust. Sci Total Environ 404(1):26-35. doi:10.1016/j.scitotenv.2008.05.031 PMID:18632138 PMCID:PMC2858057
  • Morisseau C, Hammock BD. 2008. Gerry Brooks and epoxide hydrolases: four decades to a pharmaceutical. Pest Manag Sci 64(6):594-609. doi:10.1002/ps.1583 PMID:18383502
  • Neumann RB, LaBolle EM, Harvey CF. 2008. The effects of dual-domain mass transfer on the tritium-helium-3 dating method. Environ Sci Technol 42(13):4837-43. doi:10.1021/es7025246 PMID:18678014
  • Tanaka H, Kamita SG, Wolf NM, Harris TR, Wu Z, Morisseau C, Hammock BD. 2008. Transcriptional regulation of the human soluble epoxide hydrolase gene EPHX2. Biochim Biophys Acta 1779(1):17-27. doi:10.1016/j.bbagrm.2007.11.005 PMID:18078836 PMCID:PMC2699939
  • Wheelock CE, Forshed J, Goto S, Hammock BD, Newman JW. 2008. Effects of pyridine exposure upon structural lipid metabolism in Swiss Webster mice. Chem Res Toxicol 21(3):583-590. doi:10.1021/tx7002454 PMID:18251509
  • Wheelock CE, Nishi K, Jones PD, Colvin ME, Olmstead MM, Hammock BD. 2008. Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hydrolase (FAAH). Bioorg Med Chem 16(4):2114-2130. doi:10.1016/j.bmc.2007.10.081 PMID:18023188 PMCID:PMC2720161


  • Ai D, Fu Y, Guo D, Tanaka H, Wang N, Tang C, Hammock BD, Shyy JY, Zhu Y. 2007. Angiotensin II up-regulates soluble epoxide hydrolase in vascular endothelium in vitro and in vivo. Proc Natl Acad Sci U S A 104(21):9018-23. PMID:17495027
  • Akatsuka T, Ishikawa T, Kobayashi N, Saito T, Shindo M, Yamauchi M, Kurokohchi K, Miyazawa H, Duan H, Matsunaga T, Komoda T, Morisseau C, Hammock BD. 2007. Autoantibody response to microsomal epoxide hydrolase in hepatitis C and A. J Autoimmun 28(1):7-18. doi:10.1016/j.jaut.2006.12.005 PMID:17296285 PMCID:PMC1892246
  • Chiappe C, Leandri E, Hammock BD, Morisseau C. 2007. Effect of ionic liquids on epoxide hydrolase-catalyzed synthesis of chiral 1,2-diols. Green Chem 2007(9):162-168. doi:10.1039/b612106c PMID:18160974 PMCID:PMC2153531
  • Dettmer K, Aronov PA, Hammock BD. 2007. Mass spectrometry-based metabolomics. Mass Spectrom Rev 26(1):51-78. PMID:16921475
  • Dosev D, Nichkova MJ, Dumas RK, Gee SJ, Hammock BD, Liu K, Kennedy IM. 2007. Magnetic/luminescent core/shell particles synthesized by spray pyrolysis and their application in immunoassays with internal standard. Nanotechnology 18(5):055102(6pp). PMID:18974844
  • Endsley MP, Aggarwal N, Isbell MA, Wheelock CE, Hammock BD, Flack JR, Nithipatikom K, Campbell WB. 2007. Diverse roles of 2-arachidonoylglycerol in invasion of prostate carcinoma cells: Location, hydrolysis and 12-lipoxygenase metabolism. Int J Cancer 121(5):984-991. doi:10.1002/ijc.22761 PMID:17443494 PMCID:PMC2565646
  • Fleming I, Rueben A, Popp R, Fisslthaler B, Sander A, Haendeler J, Falck JR, Morisseau C, Hammock BD, Busse R. 2007. Epoxyeicosatrienoic acids regulate Trp channel dependent Ca2+ signaling and hyperpolarization in endothelial cells. Arterioscler Thromb Vasc Biol 27(12):2612-2618. doi:10.1161/ATVBAHA.107.152074 PMID:17872452
  • Gonzalez-Techera A, Vanrell L, Last JA, Hammock BD, Gonzalez-Sapienza GG. 2007. Phage anti-immune complex assay: general strategy for noncompetitive immunodetection of small molecules. Anal Chem 79(20):7799-7806. doi:10.1021/ac071323h PMID:17845007 PMCID:PMC2519879
  • Huang H, Nishi K, Tsai H, Hammock BD. 2007. Development of highly sensitive fluorescent assays for fatty acid amide hydrolase. Anal Biochem 363(1):12-21. PMID:17291440
  • Hwang SH, Tsai H, Liu J, Morisseau C, Hammock BD. 2007. Orally bioavailable potent soluble epoxide hydrolase inhibitors. J Med Chem 50(16):3825-3840. doi:10.1021/jm070270t PMID:17616115 PMCID:PMC2596069
  • Kim HJ, Ahn K, Ma S, Gee SJ, Hammock BD. 2007. Development of sensitive immunoassays for the detection of the glucuronide conjugate of 3-phenoxybenzyl alcohol, a putative human urinary biomarker for pyrethroid exposure. J Agric Food Chem 55(10):3750-7. PMID:17455946
  • Kim I, Nishi K, Tsai H, Bradford T, Koda Y, Watanabe T, Morisseau C, Blanchfield J, Toth I, Hammock BD. 2007. Design of bioavailable derivatives of 12-(3-adamantan-1-yl-ureido)dodecanoic acid, a potent inhibitor of the soluble epoxide hydrolase. Bioorg Med Chem 15(1):312-23. PMID:17046265
  • Kim I, Tsai H, Nishi K, Kasagami T, Morisseau C, Hammock BD. 2007. 1,3-disubstituted ureas functionalized with ether groups are potent inhibitors of the soluble epoxide hydrolase with improved pharmacokinetic properties. J Med Chem 50(21):5217-5226. doi:10.1021/jm070705c PMID:17894481 PMCID:PMC2543935
  • Loch D, Hoey A, Morisseau C, Hammock BD, Brown L. 2007. Prevention of hypertension in DOCA-salt rats by an inhibitor of soluble epoxide hydrolase. Cell Biochem Biophys 47:87-97. PMID:17406062
  • Luria A, Weldon SM, Kabcenell AK, Ingraham RH, Matera D, Jiang H, Gill R, Morisseau C, Newman JW, Hammock BD. 2007. Compensatory mechanism for homeostatic blood pressure regulation in Ephx2 gene-disrupted mice. J Biol Chem 282(5):2891-8. PMID:17135253
  • Newman JW, Kaysen GA, Hammock BD, Shearer GC. 2007. Proteinuria increases oxylipid concentrations in VLDL and HDL, but not LDL particles in the rat. J Lipid Res 48:1792-1800. PMID:17496268
  • Park E, Mak SK, Hammock BD, Kültz D. 2007. Evaluation of cytotoxicity attributed to thimerosal on murine and human kidney cells. J Toxicol Environ Health A 70(24):2092-5. PMID:18049999
  • Thompson DA, Hammock BD. 2007. Dihydroxyoctadecamonoenoate esters inhibit the neutrophil respiratory burst. J Biosci 32(2):279-291. PMID:17435320 PMCID:PMC1904342
  • Wadkins RM, Hyatt JL, Edwards CC, Tsurkan L, Redinbo MR, Wheelock CE, Jones PD, Hammock BD, Potter PM. 2007. Analysis of mammalian carboxylesterase inhibition by trifluoromethylketone-containing compounds. Mol Pharmacol 71(3):713-723. PMID:17167034
  • Wheelock CE, Goto S, Hammock BD, Newman JW. 2007. Clofibrate-induced changes in the liver, heart, brain and white adipose lipid metabolome of Swiss-Webster mice. Metabolomics 3(2):137-145. doi:10.1007/s11306-007-0052-8 PMID:19079556 PMCID:PMC2597807
  • Zhang W, Koerner IP, Noppens R, Grafe M, Tsai H, Morisseau C, Luria A, Hammock BD, Falck JR, Alkayed NJ. 2007. Soluble epoxide hydrolase: a novel therapeutic target in stroke. J Cereb Blood Flow Metab 27(12):1931-1940. doi:10.1038/sj.jcbfm.9600494 PMID:17440491 PMCID:PMC2664093


  • Ahn K, Ma S, Tsai H, Gee SJ, Hammock BD. 2006. An immunoassay for a urinary metabolite as a biomarker of human exposure to the pyrethroid insecticide permethrin. Anal Bioanal Chem 384(3):713-722. PMID:16416099
  • An HJ, Tillinghast JS, Woodruff DL, Rocke DM, Lebrilla CB. 2006. A new computer program (GlycoX) to determine simultaneously the glycosylation sites and oligosaccharide heterogeneity of glycoproteins. J Proteome Res 5(10):2800-2808. PMID:17022651
  • Carkeet C, Dueker SR, Lango J, Buchholz BA, Miller JW, Green R, Hammock BD, Roth JR, Anderson PJ. 2006. Human vitamin B12 absorption measurement by accelerator mass spectrometry using specifically labeled 14C-cobalamin. Proc Natl Acad Sci U S A 103(15):5694-5699. PMID:16585531
  • Goldberg Z, Rocke DM, Schwietert C, Berglund SR, Santana A, Jones A, Lehmann J, Stern RL, Lu R, Hartmann Siantar CL. 2006. Human in vivo dose response to controlled, low-dose low LET ionizing radiation exposure. Clin Cancer Res 12(12):3723-3729. PMID:16778099
  • Nording M, Nichkova MJ, Spinnel E, Persson Y, Gee SJ, Hammock BD, Haglund P. 2006. Rapid screening of dioxin-contaminated soil by accelerated solvent extraction/purification followed by immunochemical detection. Anal Bioanal Chem 385(2):357-366. PMID:16598456
  • Schmelzer KR, Wheelock AM, Dettmer K, Morin D, Hammock BD. 2006. The role of inflammatory mediators in the synergistic toxicity of ozone and 1-nitronaphthalene in rat airways. Environ Health Perspect 114(9):1354-1360. PMID:16966088 PMCID:PMC1570074
  • Watanabe T, Schulz D, Morisseau C, Hammock BD. 2006. High-throughput pharmacokinetic method: cassette dosing in mice associated with minuscule serial bleedings and LC/MS/MS analysis. Anal Chim Acta 559(1):37-44. doi:10.1016/j.aca.2005.11.049 PMID:16636700 PMCID:PMC1447531
  • Xi Y, de Ropp JS, Viant MR, Woodruff DL, Yu P. 2006. Automated screening for metabolites in complex mixtures using 2D COSY NMR spectroscopy. Metabolomics 2(4):221-233.


  • Aronov PA, Dettmer K, Christiansen JA, Cornel AJ, Hammock BD. 2005. Development of a HPLC/tandem-MS method for the analysis of the larvicides methoprene, hydroprene, and kinoprene at trace levels using Diels-Alder derivatization. J Agric Food Chem 53(9):3306-3312. doi:10.1021/jf0485842 PMID:15853364 PMCID:PMC1479544


  • Dey A, Williams RS, Pollock DM, Stepp DW, Newman JW, Hammock BD, Imig JD. 2004. Altered kidney CYP2C and cyclooxygenase-2 levels are associated with obesity-related albuminuria. Obes Res 12(8):1278-1289. doi:10.1038/oby.2004.162 PMID:15340111
  • Seubert JM, Yang B, Bradbury JA, Graves J, Degraff LM, Gabel S, Gooch R, Foley J, Newman JW, Mao L, Rockman HA, Hammock BD, Murphy E, Zeldin DC. 2004. Enhanced postischemic functional recovery in CYP2J2 transgenic hearts involves mitochondrial ATP-sensitive K+ channels and p42/p44 MAPK pathway. Circ Res 95(5):506-514. PMID:15256482
  • Zhao X, Yamamoto T, Newman JW, Kim I, Watanabe T, Hammock BD, Stewart J, Imig JD. 2004. Soluble epoxide hydrolase inhibition protects the kidney from hypertension-induced damage. J Am Soc Nephrol 15(5):1244-53. PMID:15100364


  • Denton DL, Wheelock CE, Murray SA, Deanovic LA, Hammock BD, Hinton DE. 2003. Joint acute toxicity of esfenvalerate and diazinon to fathead minnow (Pimephales promelas) larvae. Environ Toxicol Chem 22(2):336-341. PMID:12558165
  • Inceoglu B, Lango J, Jing J, Chen L, Doymaz F, Pessah IN, Hammock BD. 2003. One scorpion, two venoms: prevenom of Parabuthus transvaalicus acts as an alternative type of venom with distinct mechanism of action. Proc Natl Acad Sci U S A 100(3):922-927. PMID:12552107
  • Koivunen ME, Morisseau C, Newman JW, Horwath WR, Hammock BD. 2003. Purification and characterization of a methylene urea-hydrolyzing enzyme from Rhizobium radiobacter (Agrobacterium tumefaciens). Soil Biol Biochem 35(11):1433-1442.
  • Newman JW, Morisseau C, Harris TR, Hammock BD. 2003. The soluble epoxide hydrolase encoded by EPXH2 is a bifunctional enzyme with novel lipid phosphate phosphatase activity. Proc Natl Acad Sci U S A 100(4):1558-1563. PMID:12574510
  • Przybyla-Zawislak BD, Srivastava PK, Vazquez-Matias J, Mohrenweiser HW, Maxwell JE, Hammock BD, Bradbury JA, Enayetallah AE, Zeldin DC, Grant DF. 2003. Polymorphisms in human soluble epoxide hydrolase. Mol Pharmacol 64(2):482-490. PMID:12869654
  • Sather PJ, Newman JW, Ikonomou MG. 2003. Congener-based aroclor quantification and speciation techniques: A comparison of the strengths, weaknesses, and proper use of two alternative approaches. Environ Sci Technol 37(24):5678-5686. PMID:14717180
  • Viswanathan S, Hammock BD, Newman JW, Meerarani P, Toborek M, Hennig B. 2003. Involvement of CYP 2C9 in mediating the proinflammatory effects of linoleic acid in vascular endothelial cells. J Am Coll Nutr 22(6):502-510. PMID:14684755
  • Watanabe T, Morisseau C, Newman JW, Hammock BD. 2003. In vitro metabolism of the mammalian soluble epoxide hydrolase inhibitor, 1-cyclohexyl-3-dodecyl-urea. Drug Metab Dispos 31(7):846-853. doi:10.1124/dmd.31.7.846 PMID:12814960
  • Wheelock CE, Wheelock AM, Zhang RH, Stok JE, Morisseau C, Le Valley SE, Green CE, Hammock BD. 2003. Evaluation of alpha-cyanoesters as fluorescent substrates for examining interindividual variation in general and pyrethroid-selective esterases in human liver microsomes. Anal Biochem 315(2):208-222. PMID:12689831
  • Zhang RH, Kang K, Shan G, Hammock BD. 2003. Design, synthesis and evaluation of novel P450 fluorescent probes bearing -cyanoether. Tetrahedron Lett 44(23):4331-4334.


  • Cureton-Chinn S, Kelly PB, Augustine MP. 2002. Magnetic sublevel specific stimulated Raman pumping of molecular H-2. J Chem Phys 116(12):4837-4841.
  • Inceoglu B, Hayashida Y, Lango J, Ishida AT, Hammock BD. 2002. A single charged surface residue modifies the activity of ikitoxin, a beta-type Na+ channel toxin from Parabuthus transvaalicus. FEBS J 269(22):5369-5376. PMID:12423335
  • Morisseau C, Goodrow MH, Newman JW, Wheelock CE, Dowdy DL, Hammock BD. 2002. Structural refinement of inhibitors of urea based soluble epoxide hydrolases. Biochem Pharmacol 63(9):1599-1608. PMID:12007563
  • Nagy SR, Sanborn JR, Hammock BD, Denison MS. 2002. Development of a green fluorescent protein based cell bioassay for the rapid and inexpensive detection and characterization of AhR agonists. Toxicol Sci 65(2):200-210. PMID:11812924
  • Newman JW, Watanabe T, Hammock BD. 2002. The simultaneous quantification of cytochrome P450 dependent linoleate and arachidonate metabolites in urine by HPLC-MS/MS. J Lipid Res 43(9):1563-1578. PMID:12235189
  • Pakehham G, Lango J, Buonarati M, Morin D, Buckpitt AR. 2002. Urinary naphthalene mercapturates as biomarkers of exposure and stereoselectivity of naphthalene epoxidation. Drug Metab Dispos 30(3):247-253. PMID:11854141
  • Severson T, Goodrow MH, Morisseau C, Dowdy DL, Hammock BD. 2002. Urea and amide-based inhibitors of the juvenile hormone epoxide hydrolase of the tobacco hornworm(Manduca sexta: Sphingidae). Insect Biochem Mol Biol 32:1741-1756. PMID:12429126
  • Stanton B, Watkins SM, German JB, Lasley BL. 2002. Effect of estrogen and 2,3,7,8-tetrachlorodibenzo-rho-dioxin (TCDD) on plasma fatty acids of immature male chickens (Gallus domesticus). Comp Biochem Physiol C Toxicol Pharmacol 132(2):129-142. PMID:12106890
  • Vogel JS, Keating GA, Buchholz BA. 2002. Protein binding of isofluorophate in vivo after coexposure to multiple chemicals. Environ Health Perspect 110(Suppl.6):1031-1036. PMID:12634135
  • Wheelock CE, Colvin ME, Uemura I, Olmstead MM, Sanborn JR, Nakagawa Y, Jones AD, Hammock BD. 2002. Use of ab initio calculations to predict the biological potency of carboxylesterase inhibitors. J Med Chem 45(25):5576-5593. PMID:12459025
  • Zhang Y, Kelly PB, Kennedy IM. 2002. Resonant Raman-scattering measurements of trichloroethene in a thermal boundary layer. Appl Opt 41(15):2962-2972. PMID:12027186


  • Buchholz BA, Vogel JS, Gilman DS, Gee SJ, Hammock BD, Hui X, Wester RC, Maibach HI. 2001. Determining an occupational dermal exposure biomarker for atrazine through measurement of metabolites in human urine by HPLC-accelerator mass spectrometry. In: Toxicology of Skin. Taylor & Francis, Philadelphia, PA. pp.145-157.
  • Inceoglu B, Lango J, Wu J, Hawkins P, Southern J, Hammock BD. 2001. Isolation and characterization of a novel type of neurotoxic peptide from the venom of the South African scorpion Parabuthus transvaalicus (Buthidae). FEBS J 268(20):5407-5413. PMID:11606203
  • Miyashita M, Presley JM, Buchholz BA, Lam KS, Lee YM, Vogel JS, Hammock BD. 2001. Attomole level protein sequencing by Edman degradation coupled with accelerator mass spectrometry. Proc Natl Acad Sci U S A 98(8):4403-4408. PMID:11287636
  • Newman JW, Hammock BD. 2001. Optimized thiol derivatizing reagent for the mass spectral analysis of disubstituted epoxy fatty acids. J Chromatogr A 925(1-2):223-240. PMID:11519808
  • Shan G, Leeman WR, Gee SJ, Sanborn JR, Jones AD, Chang DP, Hammock BD. 2001. Highly sensitive dioxin immunoassay and its application to soil and biota samples. Anal Chim Acta 444:169-178.
  • Stanton B, El-Sabeawy F, Fang Yang X, Enan E, Lasley BL. 2001. Interaction of estrogen and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in immature male chickens (Gallus domesticus). Comp Biochem Physiol C Toxicol Pharmacol 129(1):35-47. PMID:11369299
  • Stanton B, Watkins SM, German JB, Lasley BL. 2001. Interaction of estrogen and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) with hepatic fatty acid synthesis and metabolism of male chickens (Gallus domesticus). Comp Biochem Physiol C Toxicol Pharmacol 129(2):137-150. PMID:11423386
  • Vogel JS, Grant PG, Buchholz BA, Dingley KH, Turteltaub KW. 2001. Attomole quantitation of protein separations with accelerator mass spectrometry. Electrophoresis 22(10):2037-2045. PMID:11465504
  • Watanabe T, Hammock BD. 2001. Rapid determination of soluble epoxide hydrolase inhibitors in rat hepatic microsomes by high performance liquid chromatography with electrospray tandem mass spectrometry. Anal Biochem 299(2):227-234. PMID:11730347
  • Watkins SM, Hammock BD, Newman JW, German JB. 2001. Individual metabolism should guide agriculture toward foods for improved health and nutrition. Am J Clin Nutr 74(3):283-286. PMID:11522549
  • Wheelock CE, Severson T, Hammock BD. 2001. Synthesis of new carboxylesterase inhibitors and evaluation of potency and water solubility. Chem Res Toxicol 14(12):1563-1572. PMID:11743738
  • Wudayagiri R, Inceoglu B, Herrmann R, Derbel M, Choudary P, Hammock BD. 2001. Isolation and characterization of a novel lepidopteran-selective toxin from the venom of South Indian red scorpion, Mesobuthus tamulus. BMC Biochem 2:16. PMID:11782289


  • Cureton-Chinn S, Vyas S, Kelly PB, Augustine MP. 2000. Measurement of the Raman polarizability anisotropy for the v = 1 pure rotational Raman transition in H2 by rotational Raman spectroscopy. Molecular Physics 98(6):349-353.
  • Lohse C, Jaeger LL, Staimer N, Sanborn JR, Jones AD, Lango J, Gee SJ, Hammock BD. 2000. Development of a class selective enzyme-linked immunosorbent assay for mercapturic acids in human urine. J Agric Food Chem 48(12):5913-5923. PMID:11312767
  • Shan G, Huang W, Gee SJ, Buchholz BA, Vogel JS, Hammock BD. 2000. Isotope-labeled immunoassays without radiation waste. Proc Natl Acad Sci U S A 97(6):2445-2449. PMID:10706612


  • Buchholz BA, Fultz E, Haack KW, Vogel JS, Gilman DS, Gee SJ, Hammock BD, Hui X, Wester RC, Maibach HI. 1999. HPLC-accelerator MS measurement of atrazine metabolites in human urine after dermal exposure. Anal Chem 71(16):3519-3525. PMID:10464479


  • Witter AE, Jones AD. 1998. Comparison of methods for inorganic sulfur speciation in a petroleum production effluent. Environ Toxicol Chem 17(11):2176-2184.
  • Witter AE, Mabury SA, Jones AD. 1998. Copper (II) complexation in northern California rice field waters: an investigation using differential pulse anodic and cathodic stripping voltammetry. Sci Total Environ 212(1):21-37. PMID:9525045
  • Yang G, Jones AD, Kennedy IM. 1998. The impact of turbulent mixing on the oxidation of a chlorinated hydrocarbon. Environ Sci Technol 32(9):1265-1268.


  • Bezabeh DZ, Allen TM, McCauley EM, Kelly PB, Jones AD. 1997. Negative ion laser desorption ionization time-of-flight mass spectrometry of nitrated polycyclic aromatic hydrocarbons. J Am Soc Mass Spectrom 8(6):630-636.
  • Mitchell AE, Morin D, Lakritz J, Jones AD. 1997. Quantitative profiling of tissue- and gender-related expression of glutathione S-transferase isoenzymes in the mouse. Biochemistry 325(Pt.1):207-216. PMID:9224648
  • Oberth CH, Jones AD. 1997. Fragmentation of protonated thioether conjugates of acrolein using low collision energies. J Am Soc Mass Spectrom 8(7):727-736.


  • Allen TM, Bezabeh DZ, Smith CH, McCauley EM, Jones AD, Chang DP, Kennedy IM, Kelly PB. 1996. Speciation of arsenic oxides using laser desorption/ionization time-of-flight mass spectrometry. Anal Chem 68(22):4052-4059. PMID:8916457
  • Bruenner BA, Jones AD, German JB. 1996. Simultaneous determination of multiple aldehydes in biological tissues and fluids using gas chromatography/stable isotope dilution mass spectrometry. Anal Biochem 241(2):212-219. PMID:8921190
  • Dotter RN, Smith CH, Young MK, Kelly PB, Jones AD, McCauley EM, Chang DP. 1996. Laser desporption/ionization time-of-flight-mass spectrometry of nitrated polycyclic aromatic hydrocarbons. Anal Chem 68:2319-2324. PMID:8686925


  • Bruenner BA, Jones AD, German JB. 1995. Direct characterization of protein adducts of the lipid peroxidation product 4-hydroxy-2-nonenal using electrospray mass spectrometry. Chem Res Toxicol 8(4):552-559. PMID:7548735
  • Caldas ED, Jones AD, Winter CK, Ward BL, Gilchrist DG. 1995. Electrospray ionization mass spectrometry of sphinganine analog mycotoxins. Anal Chem 67(1):196-207.
  • Mitchell AE, Morin D, Lame MW, Jones AD. 1995. Purification, mass spectrometric characterization, and covalent modification of murine glutathione S-transferases. Chem Res Toxicol 8(8):1054-1062. PMID:8605288
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