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Patent Detail: Method and kits for detecting a polymorphism in .delta.-aminolevulinate dehydratase gene which is associated with an altered susceptibility to lead poisoning

Patent Detail

Superfund Research Program

Method and kits for detecting a polymorphism in .delta.-aminolevulinate dehydratase gene which is associated with an altered susceptibility to lead poisoning

Number: 5,639,607
Year: 1997
Patent Status: Issued
Authors: Desnick, R.J., J.G. Wetmur

A method is disclosed for detecting a polymorphism in the .delta.-aminolevulinate dehydratase gene which is associated with an altered susceptibility to lead poisoning. A point mutation which generates an MspI restriction endonuclease recognition site was found in the ALAD2 allele of the .delta.-aminolevulinate dehydratase gene which is not present in the ALAD1 allele. Kit containing primers for the amplification of the polymorphic region of the ALAD gene are provided.

Associated Projects:

  • Mount Sinai School of Medicine: Genetic Analysis
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