Superfund Research Program
Inhibition of Glutathione Transferase by Haloenol Lactones
Patent Status: Issued
Authors: Jones, A.D., A.E. Mitchell, B.D. Hammock, J. Zheng
This invention relates to novel haloenol lactone compounds. These compounds have the following general structure: ##STR1## in which Ar is an aryl group and Y is a haloenol lactone moiety. The compounds of the invention are useful for the specific measurement of particular isoenzymes of glutathione S-transferase. Measurement of glutathione S-transferase isoenzymes has importance in diagnostic medicine. The compounds of the invention are also useful for treatment of drug resistance in cancer and for preventing herbicide resistance in plants.
- University of California-Davis: Immunoassays for Human and Environmental Health Monitoring