Title: Trichloroethylene metabolism and tissue-specific toxicity in males of 7 inbred strains of mice

Accession Number: Rusyn6

Link to Dataset: http://phenome.jax.org/db/q?rtn=projects/details&sym=RUSYN6

Repository: Mouse Phenome Database (MPD)

Data Type(s): Genotype/Phenotype

Experiment Type(s): Phenotype measurements

Organism(s): Mus musculus

Summary: A population-based approach was used to test the hypothesis that trichloroethylene (TCE) induced toxicity is associated with the formation of oxidative TCE metabolites. Liver, kidney and serum samples were tested. Major metabolizing enzymes responsible for oxidative biotransformation of TCE, as well as markers of liver and kidney cell proliferation and kidney damage were examined.

Publication(s) associated with this dataset:

• Yoo HS, Bradford BU, Kosyk O, Shymonyak S, Uehara T, Collins LB, Bodnar WM, Ball LM, Gold A, Rusyn I. 2015. Comparative analysis of the relationship between trichloroethylene metabolism and tissue-specific toxicity among inbred mouse strains: liver effects. J Toxicol Environ Health A 78(1):15-31. doi:10.1080/15287394.2015.958417 PMID:25424544 PMCID:PMC4281929
• Yoo HS, Bradford BU, Kosyk O, Uehara T, Shymonyak S, Collins LB, Bodnar WM, Ball LM, Gold A, Rusyn I. 2015. Comparative analysis of the relationship between trichloroethylene metabolism and tissue-specific toxicity among inbred mouse strains: kidney effects. J Toxicol Environ Health A 78(1):32-49. doi:10.1080/15287394.2015.958418 PMID:25424545 PMCID:PMC4281933

Project(s) associated with this dataset:

• University of North Carolina-Chapel Hill: Genomic and Genetic Analysis of Liver and Kidney Toxicity of Trichloroethylene
• University of North Carolina-Chapel Hill: Chemistry and Analytical Core