Title: Effects of trichloroethylene in males of 17 inbred mouse strains

Accession Number: Rusyn2

Link to Dataset: https://phenome.jax.org/projects/Rusyn2

Repository: Mouse Phenome Database (MPD)

Data Type(s): Genotype/Phenotype

Experiment Type(s): Phenotype measurements

Organism(s): Mus musculus

Summary: An investigation into the effects of trichloroethylene. There were 3 cohorts: 1) naive mice; 2) control group orally administered vehicle (corn oil); 3) treated group orally administered trichloroethylene (TCE 2100 mg/kg) in vehicle.

Publication(s) associated with this dataset:

• Yoo HS, Bradford BU, Kosyk O, Shymonyak S, Uehara T, Collins LB, Bodnar WM, Ball LM, Gold A, Rusyn I. 2015. Comparative analysis of the relationship between trichloroethylene metabolism and tissue-specific toxicity among inbred mouse strains: liver effects. J Toxicol Environ Health A 78(1):15-31. doi:10.1080/15287394.2015.958417 PMID:25424544 PMCID:PMC4281929
• Yoo HS, Bradford BU, Kosyk O, Uehara T, Shymonyak S, Collins LB, Bodnar WM, Ball LM, Gold A, Rusyn I. 2015. Comparative analysis of the relationship between trichloroethylene metabolism and tissue-specific toxicity among inbred mouse strains: kidney effects. J Toxicol Environ Health A 78(1):32-49. doi:10.1080/15287394.2015.958418 PMID:25424545 PMCID:PMC4281933

Project(s) associated with this dataset:

• University of North Carolina-Chapel Hill: Genomic and Genetic Analysis of Liver and Kidney Toxicity of Trichloroethylene
• University of North Carolina-Chapel Hill: Chemistry and Analytical Core