Superfund Research Program
Title: Fat Regulatory T Cells Drive Age-Associated Insulin Resistance
Accession Number: SRP053799
Link to Dataset: https://trace.ncbi.nlm.nih.gov/Traces/sra/?study=SRP053799
Repository: Sequence Read Archive (SRA)
Data Type(s): Nucleotide Sequence
Experiment Type(s): Transcriptome analysis
Organism(s): Mus musculus
Summary: We show that fat-resident regulatory T cells, termed fTregs, drive age-associated insulin resistance and can be specifically depleted to increase adipose insulin sensitivity. Comparative AdipoImmune profiling in young, aged, and obese mice reveals that fTregs progressively enrich in adipose as a function of age, but not obesity. fTreg-deficient mice are protected from age-associated insulin resistance and its accompanying physiological hallmarks. In contrast, fTreg-deficiency offers no protection from obesity-associated insulin resistance.
Publication(s) associated with this dataset:- Bapat SP, Suh J, Fang S, Liu S, Zhang Y, Cheng A, Zhou C, Liang Y, Leblanc M, Liddle C, Atkins AR, Yu RT, Downes M, Evans RM, Zheng Y. 2015. Depletion of fat-resident Treg cells prevents age-associated insulin resistance. Nature 528(7580):137-141. doi:10.1038/nature16151 PMID:26580014 PMCID:PMC4670283
- University of California-San Diego: Toxicogenomic Analysis of Nuclear Xenobiotic Receptors