Title: Association Between Increased Oxidative Stress, Anti-Inflammatory Fatty Acid Formation, and Airway Infection in People With Asthma and Chronic Obstructive Pulmonary Disease

Accession Number: NCT00595114

Repository: ClinicalTrials.gov

Data Type(s): Clinical Trials

Experiment Type(s): Interventional

Organism(s): Homo sapiens

Summary: Chronic obstructive pulmonary disease (COPD) and asthma are common respiratory diseases in which people experience long-term inflammation of the lungs. Exacerbations, or prolonged worsening of symptoms, of asthma and COPD are often life-threatening and can lead to frequent need for hospitalization. Even with the proper use of bronchodilators, corticosteroids, and other currently available medications, clinical responses among people with COPD and asthma are variable. There remains a significant unmet clinical need for new therapeutic approaches and insights, including the identification of biomarkers to accurately assess the presence of airway infection and intensity of airway inflammation. This study will investigate potential natural biological causes and new biomarkers for increased susceptibility to persistent airway infection in asthma and COPD.

Publication(s) associated with this dataset:

• Ono E, Dutile S, Kazani S, Weschsler ME, Yang J, Hammock BD, Douda DN, Tabet Y, Khaddaj-Mallat R, Sirois M, Sirois C, Rizcallah E, Rousseau E, Martin R, Sutherland E, Castro M, Jarjour NN, Israel E, Levy BD. 2014. Lipoxin generation is related to soluble epoxide hydrolase activity in severe asthma. Am J Respir Crit Care Med 190(8):886-897. doi:10.1164/rccm.201403-0544OC PMID:25162465 PMCID:PMC4299578

Project(s) associated with this dataset:

• University of California-Davis: Development and Application of Integrated In Vitro and Cell-Based Bioassays
• University of California-Davis: Analytical Chemistry Core