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Dataset Details

Superfund Research Program

Title: Data from: The genomic landscape of rapid repeated evolutionary adaptation to toxic pollution in wild fish

Accession Number: 68n87

Link to Dataset: https://datadryad.org/resource/doi:10.5061/dryad.68n87

Repository: Dryad

Data Type(s): Genotype/Phenotype

Organism(s): Fundulus heteroclitus

Summary: Atlantic killifish populations have rapidly adapted to normally lethal levels of pollution in four urban estuaries. Through analysis of 384 whole killifish genome sequences and comparative transcriptomics in four pairs of sensitive and tolerant populations, we identify the aryl hydrocarbon receptor based signaling pathway as a shared target of selection. This suggests evolutionary constraint on adaptive solutions to complex toxicant mixtures at each site. However, distinct molecular variants apparently contribute to adaptive pathway modification among tolerant populations. Selection also targets other toxicity-mediating genes and genes of connected signaling pathways; this indicates complex tolerance phenotypes and potentially compensatory adaptations. Molecular changes are consistent with selection on standing genetic variation. In killifish, high nucleotide diversity has likely been a crucial substrate for selective sweeps to propel rapid adaptation.

Publication(s) associated with this dataset:
  • Reid N, Proestou DA, Clark BW, Warren WC, Colbourne JK, Shaw JR, Karchner SI, Hahn ME, Nacci DE, Oleksiak MF, Crawford DL, Whitehead A. 2016. The genomic landscape of rapid repeated evolutionary adaptation to toxic pollution in wild fish. Science 354(6317):1305-1308. doi:10.1126/science.aah4993 PMID:27940876 PMCID:PMC5206662
Project(s) associated with this dataset:
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