Title: Trichloroethylene exposure in males of 45 Collaborative

Accession Number: Rusyn8

Link to Dataset: https://phenome.jax.org/projects/Rusyn8

Repository: Mouse Phenome Database (MPD)

Data Type(s): Genotype/Phenotype

Experiment Type(s): Phenotype measurements

Organism(s): Mus musculus

Summary: Measures taken at baseline, 24, 80, 240, and 800 mg/kg trichloroethylene (TCE). Measured phenotypes include liver trichloroacetic acid (TCA) levels; liver gene expression, protein levels and enzyme activity; body weight and liver, kidney, and brain weight.

Publication(s) associated with this dataset:

• Venkatratnam A, Furuya S, Kosyk O, Gold A, Bodnar WM, Konganti K, Threadgill DW, Gillespie DA, Aylor DL, Wright FA, Chiu WA, Rusyn I. 2017. Editor's Highlight: Collaborative Cross mouse population enables refinements to characterization of the variability in toxicokinetics of trichloroethylene and provides genetic evidence for the role of PPAR pathway in its oxidative metabolism. Toxicol Sci 158(1):48-62. doi:10.1093/toxsci/kfx065 PMID:28369613

Project(s) associated with this dataset:

• University of North Carolina-Chapel Hill: Genomic and Genetic Analysis of Liver and Kidney Toxicity of Trichloroethylene